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Protein

Sodium channel protein

Gene

Scn7a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • sodium channel activity Source: MGI
  • voltage-gated ion channel activity Source: UniProtKB-KW
  • voltage-gated sodium channel activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Scn7aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:102965 Scn7a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei238 – 261HelicalUniRule annotationAdd BLAST24
Transmembranei370 – 394HelicalUniRule annotationAdd BLAST25
Transmembranei507 – 525HelicalUniRule annotationAdd BLAST19
Transmembranei537 – 555HelicalUniRule annotationAdd BLAST19
Transmembranei576 – 604HelicalUniRule annotationAdd BLAST29
Transmembranei624 – 644HelicalUniRule annotationAdd BLAST21
Transmembranei708 – 734HelicalUniRule annotationAdd BLAST27
Transmembranei934 – 953HelicalUniRule annotationAdd BLAST20
Transmembranei974 – 993HelicalUniRule annotationAdd BLAST20
Transmembranei1059 – 1081HelicalUniRule annotationAdd BLAST23
Transmembranei1169 – 1193HelicalUniRule annotationAdd BLAST25
Transmembranei1252 – 1270HelicalUniRule annotationAdd BLAST19
Transmembranei1282 – 1300HelicalUniRule annotationAdd BLAST19
Transmembranei1312 – 1333HelicalUniRule annotationAdd BLAST22
Transmembranei1369 – 1397HelicalUniRule annotationAdd BLAST29
Transmembranei1476 – 1499HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62467

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62467

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q62467 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q62467, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q62467

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini118 – 404Ion_transInterPro annotationAdd BLAST287
Domaini505 – 730Ion_transInterPro annotationAdd BLAST226
Domaini743 – 927Na_trans_assocInterPro annotationAdd BLAST185
Domaini933 – 1200Ion_transInterPro annotationAdd BLAST268
Domaini1250 – 1497Ion_transInterPro annotationAdd BLAST248

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili420 – 440Sequence analysisAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INF4 Eukaryota
ENOG410Y1Z2 LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053100

KEGG Orthology (KO)

More...
KOi
K04839

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR028812 Na_channel_a7su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037:SF14 PTHR10037:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00170 NACHANNEL

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q62467-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTSPEPKGL VPFTTESLEL IENHIAKKCN EDPEEEEGLK PSRNLEAGKR
60 70 80 90 100
LPIPYGTLPR GTVSEPLEDV DPYYYVKRNT FMVLNRSRVI FRFNAVSIFC
110 120 130 140 150
TLSPLNSLRR AAIKALVHPL FRLLILISVL TDSILMCMSN LPEWILAIEN
160 170 180 190 200
TLLGIYAFEI LVKVIARGIW AGSFSFLGDL WNWLDFSVTL FELITRFSPL
210 220 230 240 250
SSFLMLKTIR TFRILKIIPL NHGLQSIVMT LAQCLKKLFG AIALALFFLA
260 270 280 290 300
VFSLLGMGLF MGNLKHKCLR WPEENENETL HNRTGSLNYS PERINFYYME
310 320 330 340 350
GAKYALLCGN RTDAGQCPEG YVCVKEGTNP DNGFTSFDNF GWSLLAMFRL
360 370 380 390 400
MTQDYPELLY HQILYASGKV YMIFFVMISF WFAFYLTSLF LGILTMTYEK
410 420 430 440 450
EKQRACEESG GLDPKCQQTV KELDEENDAA EMETTQIEMK KRSPTSINTT
460 470 480 490 500
LDILEDTTLG HREEPETSRK KCPICWHKFI KTCFIWKCSP CWVKLNEFAD
510 520 530 540 550
RVITHPLADL FLVICIVLNI CFLALEHFPM SEELRSLLHV GNLVFIGIYT
560 570 580 590 600
IELILKIIAM HPYGYFQISW NIFDSILVVL ELTEILLADV EGLAVLITVP
610 620 630 640 650
LIFIKLGKYG PPFKSLMRIL GSSLMALKDL VLLLCIFVYF SAVFGMKLFG
660 670 680 690 700
RSYKDCVCHI KEDCQPQRWH MSDFLHAYMT VFRILCGEWI ETLWECMEVA
710 720 730 740 750
GQAWCIPFYM MVILIGNLLI LYLFVTLVSS FSYYDATSEV NKEAKNLQLA
760 770 780 790 800
MARIKSGINS MLLKLMCTER SVPTEATDQI CDPSVKENIS GHTLSELSNT
810 820 830 840 850
QTFLRYKDQS SSTEKTPVTE SESQSLIASP SASETVPIAS GESDIENLDN
860 870 880 890 900
KETRSKSGNG GSKEKMKQSS SSECSTVDIA ISEEEEMVYE HEKSKLHKNG
910 920 930 940 950
YERKSSTGQI SRESRNGKIW KNIRKTCCKI VENSWFECFI GLVTLLCTGT
960 970 980 990 1000
LALEDIYIDQ RKTTKILLEY ADMIFAYIFI LEMLLKWVAY GFKAFFSNNW
1010 1020 1030 1040 1050
YKLDFMVVIV FCLSLIGKTR EDLNPLTSIK FLRALRVLSQ FERMKVVLRA
1060 1070 1080 1090 1100
LIKTTLPTVS VFLVCLMIWL LFSVIGVQLF AGKFYECIDP TKGERFPVFE
1110 1120 1130 1140 1150
VMNKSQCEKL LFNESMPWEN AKLNFDNVGN GFLSLLQVAT FNGWISIMNS
1160 1170 1180 1190 1200
AIDSVGVNMQ PSFEYNLYMY SYFIIFVIFG LFLPLCMLIG VIIRNFNKQK
1210 1220 1230 1240 1250
IKQGGSNIFI TVKQKKQYRA LKKLLYADVQ KPTPRPRNKF QGFLFDLVTH
1260 1270 1280 1290 1300
RVFNVIIILL ICFQATTIMI QKDEQSPQME TAIFWMNSIF VMLFTLECIL
1310 1320 1330 1340 1350
KLTAFRCHYF TSAWNVHDFM VVIFSITGLL LPLTIGQYFV PPSLVQLILL
1360 1370 1380 1390 1400
SRVIHILRPG KGPKVFHDLM LPLILALPAL LNISLLIFLV MFIYAIFGMY
1410 1420 1430 1440 1450
NFAYVKKEAG INDVSNFETF GSSMLCLFQV TTFSGWDGML DAIFNSQWSD
1460 1470 1480 1490 1500
CDPDKINPGT QVKGDCGSPS VGISYFVSYI LISWLIIVNM YIVLIMEFLS
1510 1520 1530 1540 1550
IPSQKKSRTL SEDDFRRFFR VWNRFDPDRT QYIDSSKLSD FAAALDPPLF
1560 1570 1580 1590 1600
MAKPNKGQLV AMDLPMAAGD RIHCLDILLA FTKRVMGKDE RVEKILSEIE
1610 1620 1630 1640 1650
SGFMLANPFK ITYEPITTTL KRKQEAVSAT IIQRAYKSYR LRQNDKNVSD
1660 1670 1680
TPAIDDRRDD LTSKGAHSGK IEEKASIQTQ I
Length:1,681
Mass (Da):192,159
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD1EFACE9BFA92C8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L36179 mRNA Translation: AAA66192.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A55138

NCBI Reference Sequences

More...
RefSeqi
NP_033161.2, NM_009135.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.38127

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20272

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:20272

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36179 mRNA Translation: AAA66192.1
PIRiA55138
RefSeqiNP_033161.2, NM_009135.2
UniGeneiMm.38127

3D structure databases

ProteinModelPortaliQ62467
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62467, 1 interactor

PTM databases

iPTMnetiQ62467
PhosphoSitePlusiQ62467

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20272
KEGGimmu:20272

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6332
MGIiMGI:102965 Scn7a

Phylogenomic databases

eggNOGiENOG410INF4 Eukaryota
ENOG410Y1Z2 LUCA
HOVERGENiHBG053100
KOiK04839

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiQ62467 MM

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR028812 Na_channel_a7su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF14 PTHR10037:SF14, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PRINTSiPR00170 NACHANNEL

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ62467_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62467
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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