UniProtKB - Q62465 (VAT1_MOUSE)
Protein
Synaptic vesicle membrane protein VAT-1 homolog
Gene
Vat1
Organism
Mus musculus (Mouse)
Status
Functioni
Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation (By similarity). Possesses ATPase activity. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2) (By similarity).By similarity1 Publication
GO - Molecular functioni
- oxidoreductase activity Source: UniProtKB-KW
- zinc ion binding Source: InterPro
GO - Biological processi
- negative regulation of mitochondrial fusion Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Vat1 Synonyms:Vat-1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1349450, Vat1 |
Subcellular locationi
Mitochondrion
Other locations
Note: The majority is localized in the cytoplasm a small amount is associated with mitochondria.By similarity
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000160919 | 2 – 406 | Synaptic vesicle membrane protein VAT-1 homologAdd BLAST | 405 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 2 | PhosphoserineBy similarity | 1 | |
Modified residuei | 33 | PhosphoserineBy similarity | 1 | |
Modified residuei | 42 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q62465 |
jPOSTi | Q62465 |
MaxQBi | Q62465 |
PaxDbi | Q62465 |
PRIDEi | Q62465 |
TopDownProteomicsi | Q62465 |
PTM databases
iPTMneti | Q62465 |
PhosphoSitePlusi | Q62465 |
SwissPalmi | Q62465 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000034993, Expressed in supraoptic nucleus and 278 other tissues |
ExpressionAtlasi | Q62465, baseline and differential |
Genevisiblei | Q62465, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 205084, 11 interactors |
IntActi | Q62465, 5 interactors |
MINTi | Q62465 |
STRINGi | 10090.ENSMUSP00000048350 |
Miscellaneous databases
RNActi | Q62465, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.Curated
Phylogenomic databases
eggNOGi | KOG1197, Eukaryota |
GeneTreei | ENSGT00940000157579 |
HOGENOMi | CLU_026673_3_1_1 |
InParanoidi | Q62465 |
OMAi | INYRTDR |
OrthoDBi | 1085436at2759 |
PhylomeDBi | Q62465 |
TreeFami | TF314255 |
Family and domain databases
InterProi | View protein in InterPro IPR013154, ADH_N IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER IPR002364, Quin_OxRdtase/zeta-crystal_CS |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS01162, QOR_ZETA_CRYSTAL, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q62465-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAEREAAEA ATVAAATEAG AETGTGAGEG APSQPPTVEV ASDPQPPPAP
60 70 80 90 100
EASASASAPP LRCLVLTGFG GYDKVKLQSR PAVPPAPGPG QLTLRVRACG
110 120 130 140 150
LNFADLMGRQ GLYDRLPPLP VTPGMEGAGV VVAVGEGVGD RKAGDRVMVL
160 170 180 190 200
NRSGMWQEEV TVPSAQTFLM PEAMTFEEAA ALLVNYITAY MVLFDFGNLR
210 220 230 240 250
PGHSVLVHMA AGGVGMAALQ LCRTVENVTV FGTASASKHE VLKENGVTHP
260 270 280 290 300
IDYHTTDYVD EIKKISPKGV DIVMDPLGGS DTAKGYHLLK PMGKVVTYGM
310 320 330 340 350
ANLLTGPKRN LMAMARTWWN QFSVTALQLL QANRAVCGFH LGYLDGEVEL
360 370 380 390 400
VNSVVTRLVA LYNQGHIKPR IDSVWPFEKV ADAMKQMQEK KNIGKVLLVP
GPEKET
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK034795 mRNA Translation: BAC28833.1 BC024586 mRNA Translation: AAH24586.1 BC025496 mRNA Translation: AAH25496.1 X95562 mRNA Translation: CAA64807.1 |
CCDSi | CCDS25472.1 |
RefSeqi | NP_036167.1, NM_012037.2 |
Genome annotation databases
Ensembli | ENSMUST00000040430; ENSMUSP00000048350; ENSMUSG00000034993 |
GeneIDi | 26949 |
KEGGi | mmu:26949 |
UCSCi | uc007loy.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK034795 mRNA Translation: BAC28833.1 BC024586 mRNA Translation: AAH24586.1 BC025496 mRNA Translation: AAH25496.1 X95562 mRNA Translation: CAA64807.1 |
CCDSi | CCDS25472.1 |
RefSeqi | NP_036167.1, NM_012037.2 |
3D structure databases
SMRi | Q62465 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 205084, 11 interactors |
IntActi | Q62465, 5 interactors |
MINTi | Q62465 |
STRINGi | 10090.ENSMUSP00000048350 |
PTM databases
iPTMneti | Q62465 |
PhosphoSitePlusi | Q62465 |
SwissPalmi | Q62465 |
Proteomic databases
EPDi | Q62465 |
jPOSTi | Q62465 |
MaxQBi | Q62465 |
PaxDbi | Q62465 |
PRIDEi | Q62465 |
TopDownProteomicsi | Q62465 |
Protocols and materials databases
Antibodypediai | 29494, 80 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000040430; ENSMUSP00000048350; ENSMUSG00000034993 |
GeneIDi | 26949 |
KEGGi | mmu:26949 |
UCSCi | uc007loy.1, mouse |
Organism-specific databases
CTDi | 10493 |
MGIi | MGI:1349450, Vat1 |
Phylogenomic databases
eggNOGi | KOG1197, Eukaryota |
GeneTreei | ENSGT00940000157579 |
HOGENOMi | CLU_026673_3_1_1 |
InParanoidi | Q62465 |
OMAi | INYRTDR |
OrthoDBi | 1085436at2759 |
PhylomeDBi | Q62465 |
TreeFami | TF314255 |
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 26949, 2 hits in 17 CRISPR screens |
ChiTaRSi | Vat1, mouse |
PROi | PR:Q62465 |
RNActi | Q62465, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034993, Expressed in supraoptic nucleus and 278 other tissues |
ExpressionAtlasi | Q62465, baseline and differential |
Genevisiblei | Q62465, MM |
Family and domain databases
InterProi | View protein in InterPro IPR013154, ADH_N IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER IPR002364, Quin_OxRdtase/zeta-crystal_CS |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS01162, QOR_ZETA_CRYSTAL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VAT1_MOUSE | |
Accessioni | Q62465Primary (citable) accession number: Q62465 Secondary accession number(s): Q8R3G0, Q8R3T8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | September 27, 2004 | |
Last modified: | February 10, 2021 | |
This is version 146 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families