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Protein

Synaptic vesicle membrane protein VAT-1 homolog

Gene

Vat1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation (By similarity). Possesses ATPase activity. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2) (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle membrane protein VAT-1 homolog (EC:1.-.-.-)
Gene namesi
Name:Vat1
Synonyms:Vat-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1349450 Vat1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001609192 – 406Synaptic vesicle membrane protein VAT-1 homologAdd BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei33PhosphoserineBy similarity1
Modified residuei42PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ62465
MaxQBiQ62465
PaxDbiQ62465
PRIDEiQ62465
TopDownProteomicsiQ62465

PTM databases

iPTMnetiQ62465
PhosphoSitePlusiQ62465
SwissPalmiQ62465

Expressioni

Gene expression databases

BgeeiENSMUSG00000034993 Expressed in 260 organ(s), highest expression level in supraoptic nucleus
ExpressionAtlasiQ62465 baseline and differential
GenevisibleiQ62465 MM

Interactioni

Protein-protein interaction databases

BioGridi205084, 6 interactors
IntActiQ62465, 5 interactors
MINTiQ62465
STRINGi10090.ENSMUSP00000048350

Structurei

3D structure databases

ProteinModelPortaliQ62465
SMRiQ62465
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1198 Eukaryota
COG0604 LUCA
GeneTreeiENSGT00550000074483
HOGENOMiHOG000294681
HOVERGENiHBG002466
InParanoidiQ62465
OMAiTLRVRAC
OrthoDBiEOG091G0EEJ
PhylomeDBiQ62465
TreeFamiTF314255

Family and domain databases

InterProiView protein in InterPro
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR002364 Quin_OxRdtase/zeta-crystal_CS
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01162 QOR_ZETA_CRYSTAL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62465-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAEREAAEA ATVAAATEAG AETGTGAGEG APSQPPTVEV ASDPQPPPAP
60 70 80 90 100
EASASASAPP LRCLVLTGFG GYDKVKLQSR PAVPPAPGPG QLTLRVRACG
110 120 130 140 150
LNFADLMGRQ GLYDRLPPLP VTPGMEGAGV VVAVGEGVGD RKAGDRVMVL
160 170 180 190 200
NRSGMWQEEV TVPSAQTFLM PEAMTFEEAA ALLVNYITAY MVLFDFGNLR
210 220 230 240 250
PGHSVLVHMA AGGVGMAALQ LCRTVENVTV FGTASASKHE VLKENGVTHP
260 270 280 290 300
IDYHTTDYVD EIKKISPKGV DIVMDPLGGS DTAKGYHLLK PMGKVVTYGM
310 320 330 340 350
ANLLTGPKRN LMAMARTWWN QFSVTALQLL QANRAVCGFH LGYLDGEVEL
360 370 380 390 400
VNSVVTRLVA LYNQGHIKPR IDSVWPFEKV ADAMKQMQEK KNIGKVLLVP

GPEKET
Length:406
Mass (Da):43,097
Last modified:September 27, 2004 - v3
Checksum:i3F704C3667C21E37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034795 mRNA Translation: BAC28833.1
BC024586 mRNA Translation: AAH24586.1
BC025496 mRNA Translation: AAH25496.1
X95562 mRNA Translation: CAA64807.1
CCDSiCCDS25472.1
RefSeqiNP_036167.1, NM_012037.2
UniGeneiMm.29210

Genome annotation databases

EnsembliENSMUST00000040430; ENSMUSP00000048350; ENSMUSG00000034993
GeneIDi26949
KEGGimmu:26949
UCSCiuc007loy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034795 mRNA Translation: BAC28833.1
BC024586 mRNA Translation: AAH24586.1
BC025496 mRNA Translation: AAH25496.1
X95562 mRNA Translation: CAA64807.1
CCDSiCCDS25472.1
RefSeqiNP_036167.1, NM_012037.2
UniGeneiMm.29210

3D structure databases

ProteinModelPortaliQ62465
SMRiQ62465
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205084, 6 interactors
IntActiQ62465, 5 interactors
MINTiQ62465
STRINGi10090.ENSMUSP00000048350

PTM databases

iPTMnetiQ62465
PhosphoSitePlusiQ62465
SwissPalmiQ62465

Proteomic databases

EPDiQ62465
MaxQBiQ62465
PaxDbiQ62465
PRIDEiQ62465
TopDownProteomicsiQ62465

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040430; ENSMUSP00000048350; ENSMUSG00000034993
GeneIDi26949
KEGGimmu:26949
UCSCiuc007loy.1 mouse

Organism-specific databases

CTDi10493
MGIiMGI:1349450 Vat1

Phylogenomic databases

eggNOGiKOG1198 Eukaryota
COG0604 LUCA
GeneTreeiENSGT00550000074483
HOGENOMiHOG000294681
HOVERGENiHBG002466
InParanoidiQ62465
OMAiTLRVRAC
OrthoDBiEOG091G0EEJ
PhylomeDBiQ62465
TreeFamiTF314255

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiVat1 mouse
PROiPR:Q62465
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034993 Expressed in 260 organ(s), highest expression level in supraoptic nucleus
ExpressionAtlasiQ62465 baseline and differential
GenevisibleiQ62465 MM

Family and domain databases

InterProiView protein in InterPro
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR002364 Quin_OxRdtase/zeta-crystal_CS
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01162 QOR_ZETA_CRYSTAL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVAT1_MOUSE
AccessioniPrimary (citable) accession number: Q62465
Secondary accession number(s): Q8R3G0, Q8R3T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2004
Last modified: September 12, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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