Vat1

Functionⁱ

Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation (By similarity). Possesses ATPase activity. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2) (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

oxidoreductase activity Source: UniProtKB-KW
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of mitochondrial fusion Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase

Molecular function

Oxidoreductase

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Synaptic vesicle membrane protein VAT-1 homolog (EC:1.-.-.-)
Gene namesⁱ	Name:Vat1 Synonyms:Vat-1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:1349450 Vat1

Keywords - Cellular componentⁱ

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000160919	2 – 406	Synaptic vesicle membrane protein VAT-1 homologAdd BLAST		405

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineBy similarity	1
Modified residueⁱ	2	PhosphoserineBy similarity	1
Modified residueⁱ	33	PhosphoserineBy similarity	1
Modified residueⁱ	42	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q62465
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q62465
PaxDbⁱ	Q62465
PRIDEⁱ	Q62465
TopDownProteomicsⁱ	Q62465

PTM databases

iPTMnetⁱ	Q62465
PhosphoSitePlusⁱ	Q62465
SwissPalmⁱ	Q62465

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000034993 Expressed in 260 organ(s), highest expression level in supraoptic nucleus
ExpressionAtlasⁱ	Q62465 baseline and differential
Genevisibleⁱ	Q62465 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	205084, 6 interactors
IntActⁱ	Q62465, 5 interactors
Molecular INTeraction database More...MINTⁱ	Q62465
STRINGⁱ	10090.ENSMUSP00000048350

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q62465
SMRⁱ	Q62465
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG1198 Eukaryota COG0604 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074483
HOGENOMⁱ	HOG000294681
HOVERGENⁱ	HBG002466
InParanoidⁱ	Q62465
OMAⁱ	TLRVRAC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EEJ
PhylomeDBⁱ	Q62465
TreeFamⁱ	TF314255

Family and domain databases

InterProⁱ	View protein in InterPro IPR013154 ADH_N IPR011032 GroES-like_sf IPR036291 NAD(P)-bd_dom_sf IPR020843 PKS_ER IPR002364 Quin_OxRdtase/zeta-crystal_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08240 ADH_N, 1 hit
SMARTⁱ	View protein in SMART SM00829 PKS_ER, 1 hit
SUPFAMⁱ	SSF50129 SSF50129, 1 hit SSF51735 SSF51735, 1 hit
PROSITEⁱ	View protein in PROSITE PS01162 QOR_ZETA_CRYSTAL, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q62465-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSAEREAAEA ATVAAATEAG AETGTGAGEG APSQPPTVEV ASDPQPPPAP 
        60         70         80         90        100
EASASASAPP LRCLVLTGFG GYDKVKLQSR PAVPPAPGPG QLTLRVRACG 
       110        120        130        140        150
LNFADLMGRQ GLYDRLPPLP VTPGMEGAGV VVAVGEGVGD RKAGDRVMVL 
       160        170        180        190        200
NRSGMWQEEV TVPSAQTFLM PEAMTFEEAA ALLVNYITAY MVLFDFGNLR 
       210        220        230        240        250
PGHSVLVHMA AGGVGMAALQ LCRTVENVTV FGTASASKHE VLKENGVTHP 
       260        270        280        290        300
IDYHTTDYVD EIKKISPKGV DIVMDPLGGS DTAKGYHLLK PMGKVVTYGM 
       310        320        330        340        350
ANLLTGPKRN LMAMARTWWN QFSVTALQLL QANRAVCGFH LGYLDGEVEL 
       360        370        380        390        400
VNSVVTRLVA LYNQGHIKPR IDSVWPFEKV ADAMKQMQEK KNIGKVLLVP 

GPEKET

Length:406

Mass (Da):43,097

Last modified:September 27, 2004 - v3

Checksum:ⁱ3F704C3667C21E37

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK034795 mRNA Translation: BAC28833.1 BC024586 mRNA Translation: AAH24586.1 BC025496 mRNA Translation: AAH25496.1 X95562 mRNA Translation: CAA64807.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25472.1
NCBI Reference Sequences More...RefSeqⁱ	NP_036167.1, NM_012037.2
UniGeneⁱ	Mm.29210

Genome annotation databases

Ensemblⁱ	ENSMUST00000040430; ENSMUSP00000048350; ENSMUSG00000034993
GeneIDⁱ	26949
KEGGⁱ	mmu:26949
UCSC genome browser More...UCSCⁱ	uc007loy.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q62465	Vesicle amine transport protein 1 homolog (T californica)		MOUSE		406	UniRef100_Q62465
Vat1 protein (Fragment)		MOUSE		401

Protein	Similar proteins		Species	Score	Length	Source
Q62465	Synaptic vesicle membrane protein VAT-1 homolog		RAT		404	UniRef90_Q3MIE4
Uncharacterized protein		NEOLE		409
Vesicle amine transport protein 1 homolog (T californica)		MOUSE		406
UPI000B4EB95B		MERUN		408
UPI000A317BD1		MUSCR		407
+6

Protein	Similar proteins		Species	Score	Length	Source
Q62465	Synaptic vesicle membrane protein VAT-1 homolog		HUMAN		393	UniRef50_Q99536
Synaptic vesicle membrane protein VAT-1 homolog		RAT		404
synaptic vesicle membrane protein VAT-1 homolog		BALAS		410
Uncharacterized protein		ICTTR		402
Vesicle amine transport 1		BOVIN		402
+191

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK034795 mRNA Translation: BAC28833.1 BC024586 mRNA Translation: AAH24586.1 BC025496 mRNA Translation: AAH25496.1 X95562 mRNA Translation: CAA64807.1
CCDSⁱ	CCDS25472.1
RefSeqⁱ	NP_036167.1, NM_012037.2
UniGeneⁱ	Mm.29210

3D structure databases

ProteinModelPortalⁱ	Q62465
SMRⁱ	Q62465
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	205084, 6 interactors
IntActⁱ	Q62465, 5 interactors
MINTⁱ	Q62465
STRINGⁱ	10090.ENSMUSP00000048350

PTM databases

iPTMnetⁱ	Q62465
PhosphoSitePlusⁱ	Q62465
SwissPalmⁱ	Q62465

Proteomic databases

EPDⁱ	Q62465
MaxQBⁱ	Q62465
PaxDbⁱ	Q62465
PRIDEⁱ	Q62465
TopDownProteomicsⁱ	Q62465

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000040430; ENSMUSP00000048350; ENSMUSG00000034993
GeneIDⁱ	26949
KEGGⁱ	mmu:26949
UCSCⁱ	uc007loy.1 mouse

Organism-specific databases

CTDⁱ	10493
MGIⁱ	MGI:1349450 Vat1

Phylogenomic databases

eggNOGⁱ	KOG1198 Eukaryota COG0604 LUCA
GeneTreeⁱ	ENSGT00550000074483
HOGENOMⁱ	HOG000294681
HOVERGENⁱ	HBG002466
InParanoidⁱ	Q62465
OMAⁱ	TLRVRAC
OrthoDBⁱ	EOG091G0EEJ
PhylomeDBⁱ	Q62465
TreeFamⁱ	TF314255

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSⁱ	Vat1 mouse
Protein Ontology More...PROⁱ	PR:Q62465
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000034993 Expressed in 260 organ(s), highest expression level in supraoptic nucleus
ExpressionAtlasⁱ	Q62465 baseline and differential
Genevisibleⁱ	Q62465 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR013154 ADH_N IPR011032 GroES-like_sf IPR036291 NAD(P)-bd_dom_sf IPR020843 PKS_ER IPR002364 Quin_OxRdtase/zeta-crystal_CS
Pfamⁱ	View protein in Pfam PF08240 ADH_N, 1 hit
SMARTⁱ	View protein in SMART SM00829 PKS_ER, 1 hit
SUPFAMⁱ	SSF50129 SSF50129, 1 hit SSF51735 SSF51735, 1 hit
PROSITEⁱ	View protein in PROSITE PS01162 QOR_ZETA_CRYSTAL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VAT1_MOUSE
Accessionⁱ	Q62465Primary (citable) accession number: Q62465 Secondary accession number(s): Q8R3G0, Q8R3T8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	September 27, 2004
	Last modified:	September 12, 2018
	This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q62465 (VAT1_MOUSE)

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Synaptic vesicle membrane protein VAT-1 homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Other locations

Mitochondrion

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ