UniProtKB - Q62452 (UD19_MOUSE)
UDP-glucuronosyltransferase 1A9
Ugt1a9
Functioni
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan. Also metabolizes mycophenolic acid, an immunosuppressive agent.
By similarityCatalytic activityi
- EC:2.4.1.17By similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-hydroxy-17β-estradiol + UDP-α-D-glucuronate = 2-hydroxy-17β-estradiol 3-O-(β-D-glucuronate) + H+ + UDPBy similarityThis reaction proceeds in the forwardBy similarity direction.
- 4-hydroxy-17β-estradiol + UDP-α-D-glucuronate = 17β-estradiol 4-O-(β-D-glucuronate) + H+ + UDPBy similarityThis reaction proceeds in the forwardBy similarity direction.
- 2-hydroxyestrone + UDP-α-D-glucuronate = 2-hydroxyestrone 3-O-(β-D-glucuronate) + H+ + UDPBy similarityThis reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
GO - Molecular functioni
- enzyme binding Source: MGI
- enzyme inhibitor activity Source: MGI
- fatty acid binding Source: MGI
- glucuronosyltransferase activity Source: MGI
- protein heterodimerization activity Source: MGI
- protein homodimerization activity Source: MGI
- protein kinase C binding Source: MGI
- steroid binding Source: MGI
GO - Biological processi
- flavonoid glucuronidation Source: GO_Central
- lipid metabolic process Source: UniProtKB-KW
- xenobiotic glucuronidation Source: GO_Central
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Lipid metabolism |
Enzyme and pathway databases
Reactomei | R-MMU-156588, Glucuronidation |
Protein family/group databases
CAZyi | GT1, Glycosyltransferase Family 1 |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-glucuronosyltransferase 1A9Curated (EC:2.4.1.17By similarity)Short name: UGT1A9 Alternative name(s): UDP-glucuronosyltransferase 1-7 Short name: UDPGT UDP-glucuronosyltransferase 1-9 Short name: UDPGT 1-9 Short name: UGT1*9 Short name: UGT1-09 Short name: UGT1.9 UGT1A12 UGTP4 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3576092, Ugt1a9 |
VEuPathDBi | HostDB:ENSMUSG00000090175 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 486 – 506 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000036020 | 24 – 528 | UDP-glucuronosyltransferase 1A9Add BLAST | 505 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 69 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 97 | N6-succinyllysineCombined sources | 1 | |
Glycosylationi | 290 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 428 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q62452 |
MaxQBi | Q62452 |
PaxDbi | Q62452 |
PeptideAtlasi | Q62452 |
PRIDEi | Q62452 |
ProteomicsDBi | 298467 [Q62452-1] |
PTM databases
GlyGeni | Q62452, 3 sites |
iPTMneti | Q62452 |
PhosphoSitePlusi | Q62452 |
SwissPalmi | Q62452 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000090175, Expressed in multi-cellular organism and 36 other tissues |
Genevisiblei | Q62452, MM |
Interactioni
Subunit structurei
Homodimer. Homooligomer.
Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A10 to form heterodimers.
By similarityGO - Molecular functioni
- enzyme binding Source: MGI
- protein heterodimerization activity Source: MGI
- protein homodimerization activity Source: MGI
- protein kinase C binding Source: MGI
Protein-protein interaction databases
IntActi | Q62452, 1 interactor |
STRINGi | 10090.ENSMUSP00000073444 |
Miscellaneous databases
RNActi | Q62452, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1192, Eukaryota |
GeneTreei | ENSGT00940000163976 |
HOGENOMi | CLU_012949_3_2_1 |
InParanoidi | Q62452 |
OMAi | LLLCRVM |
OrthoDBi | 508327at2759 |
PhylomeDBi | Q62452 |
TreeFami | TF315472 |
Family and domain databases
CDDi | cd03784, GT1_Gtf-like, 1 hit |
InterProi | View protein in InterPro IPR002213, UDP_glucos_trans IPR035595, UDP_glycos_trans_CS |
Pfami | View protein in Pfam PF00201, UDPGT, 1 hit |
PROSITEi | View protein in PROSITE PS00375, UDPGT, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 1 produced by isoform ialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAPVAFPTSF FLCLLLASGL AQAGRLLVVP MDGSHWFTMQ MVVEKLIHRG
60 70 80 90 100
HEVVVVIPEV SWQLGKSLNC TVKTYSISHT LEDLDREFKY LSYTQWKTPE
110 120 130 140 150
HSIRSFLTGS ARGFFELTFS HCRSLFNDKK LVEYLKQRFF DAVFLDPFDV
160 170 180 190 200
CGLIVAKYFS LPSVIFARGV FCDYLEEGAQ CPSLPSYVPR LFSKYTDTMT
210 220 230 240 250
FKERVWNHLI YIEEHAFCSY FLRTAVEVAS EILQTPVTMT DLFSPVSIWL
260 270 280 290 300
LRTDFVLEFP RPVMPNMVFI GGINCLQKKS LSKEFEAYVN ASGEHGIVVF
310 320 330 340 350
SLGSMVSEIP EKKAMEIAEA LGRIPQTVLW RYTGTRPSNL AKNTILVKWL
360 370 380 390 400
PQNDLLGHPK TRAFITHSGS HGIYEGICNG VPMVMMPLFG DQMDNAKRME
410 420 430 440 450
TRGAGVTLNV LEMTADDLEN ALKTVINNKS YKENIMRLSS LHKDRPIEPL
460 470 480 490 500
DLAVFWVEYV MRHKGAPHLR PAAHDLTWYQ YHSLDVIGFL LAIVLTVVFI
510 520
VFKCCAYGCR KCFGGKGRVK KSHKSKTH
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 139 | F → S in AAP48599 (PubMed:14672974).Curated | 1 | |
Sequence conflicti | 139 | F → S in AAI46022 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 139 | F → S in AAI38700 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 179 | A → G in AAP48599 (PubMed:14672974).Curated | 1 | |
Sequence conflicti | 179 | A → G in AAI46022 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 179 | A → G in AAI38700 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 356 | L → I in AAA40524 (PubMed:8464825).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY227200 mRNA Translation: AAP48599.1 AC087780 Genomic DNA No translation available. AC087801 Genomic DNA No translation available. BC138699 mRNA Translation: AAI38700.1 BC146021 mRNA Translation: AAI46022.1 L27122 mRNA Translation: AAA40524.1 Different initiation. |
CCDSi | CCDS15138.1 [Q62452-1] |
RefSeqi | NP_964006.2, NM_201644.2 [Q62452-1] |
Genome annotation databases
Ensembli | ENSMUST00000073772; ENSMUSP00000073444; ENSMUSG00000090175 [Q62452-1] |
GeneIDi | 394434 |
KEGGi | mmu:394434 |
UCSCi | uc007byb.1, mouse [Q62452-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY227200 mRNA Translation: AAP48599.1 AC087780 Genomic DNA No translation available. AC087801 Genomic DNA No translation available. BC138699 mRNA Translation: AAI38700.1 BC146021 mRNA Translation: AAI46022.1 L27122 mRNA Translation: AAA40524.1 Different initiation. |
CCDSi | CCDS15138.1 [Q62452-1] |
RefSeqi | NP_964006.2, NM_201644.2 [Q62452-1] |
3D structure databases
AlphaFoldDBi | Q62452 |
SMRi | Q62452 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q62452, 1 interactor |
STRINGi | 10090.ENSMUSP00000073444 |
Protein family/group databases
CAZyi | GT1, Glycosyltransferase Family 1 |
PTM databases
GlyGeni | Q62452, 3 sites |
iPTMneti | Q62452 |
PhosphoSitePlusi | Q62452 |
SwissPalmi | Q62452 |
Proteomic databases
jPOSTi | Q62452 |
MaxQBi | Q62452 |
PaxDbi | Q62452 |
PeptideAtlasi | Q62452 |
PRIDEi | Q62452 |
ProteomicsDBi | 298467 [Q62452-1] |
Protocols and materials databases
DNASUi | 394434 |
Genome annotation databases
Ensembli | ENSMUST00000073772; ENSMUSP00000073444; ENSMUSG00000090175 [Q62452-1] |
GeneIDi | 394434 |
KEGGi | mmu:394434 |
UCSCi | uc007byb.1, mouse [Q62452-1] |
Organism-specific databases
CTDi | 54600 |
MGIi | MGI:3576092, Ugt1a9 |
VEuPathDBi | HostDB:ENSMUSG00000090175 |
Phylogenomic databases
eggNOGi | KOG1192, Eukaryota |
GeneTreei | ENSGT00940000163976 |
HOGENOMi | CLU_012949_3_2_1 |
InParanoidi | Q62452 |
OMAi | LLLCRVM |
OrthoDBi | 508327at2759 |
PhylomeDBi | Q62452 |
TreeFami | TF315472 |
Enzyme and pathway databases
Reactomei | R-MMU-156588, Glucuronidation |
Miscellaneous databases
BioGRID-ORCSi | 394434, 3 hits in 74 CRISPR screens |
PROi | PR:Q62452 |
RNActi | Q62452, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000090175, Expressed in multi-cellular organism and 36 other tissues |
Genevisiblei | Q62452, MM |
Family and domain databases
CDDi | cd03784, GT1_Gtf-like, 1 hit |
InterProi | View protein in InterPro IPR002213, UDP_glucos_trans IPR035595, UDP_glycos_trans_CS |
Pfami | View protein in Pfam PF00201, UDPGT, 1 hit |
PROSITEi | View protein in PROSITE PS00375, UDPGT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UD19_MOUSE | |
Accessioni | Q62452Primary (citable) accession number: Q62452 Secondary accession number(s): A6H6W3, E9QN27, Q6XL44 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 155 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families