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Protein

Peptidyl-prolyl cis-trans isomerase FKBP3

Gene

Fkbp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Activity regulationi

Inhibited preferentially by rapamycin over FK506.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP3 (EC:5.2.1.8)
Short name:
PPIase FKBP3
Alternative name(s):
25 kDa FK506-binding protein
Short name:
25 kDa FKBP
Short name:
FKBP-25
FK506-binding protein 3
Short name:
FKBP-3
Immunophilin FKBP25
Rapamycin-selective 25 kDa immunophilin
Rotamase
Gene namesi
Name:Fkbp3
Synonyms:Fkbp25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1353460 Fkbp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000753082 – 224Peptidyl-prolyl cis-trans isomerase FKBP3Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei99N6-acetyllysineCombined sources1
Modified residuei152PhosphoserineBy similarity1
Modified residuei170N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ62446
MaxQBiQ62446
PaxDbiQ62446
PRIDEiQ62446

PTM databases

iPTMnetiQ62446
PhosphoSitePlusiQ62446

Expressioni

Gene expression databases

BgeeiENSMUSG00000020949 Expressed in 314 organ(s), highest expression level in optic fissure
CleanExiMM_FKBP3
ExpressionAtlasiQ62446 baseline and differential
GenevisibleiQ62446 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MDM2Q009874EBI-8313562,EBI-389668From Homo sapiens.

Protein-protein interaction databases

IntActiQ62446, 5 interactors
MINTiQ62446
STRINGi10090.ENSMUSP00000021332

Structurei

Secondary structure

1224
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ62446
SMRiQ62446
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 224PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated

Phylogenomic databases

eggNOGiKOG0544 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00760000119159
HOGENOMiHOG000007963
HOVERGENiHBG105391
InParanoidiQ62446
KOiK09570
OrthoDBiEOG091G02W1
PhylomeDBiQ62446
TreeFamiTF105293

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q62446-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ DHGSDSFLAE HKLLGNIKNV
60 70 80 90 100
AKTANKDHLV NAYNHLFESK RFKGTETISK VSEQVKNVKL SDDKPKDSKS
110 120 130 140 150
EETLDEGPPK YTKSILKKGD KTNFPKKGDV VHCWYTGTLP DGTVFDTNIQ
160 170 180 190 200
TSSKKKKNAK PLSFKVGVGK VIRGWDEALL TMSKGEKARL EIEPEWAYGK
210 220
KGQPDAKIPP NTKLIFEVEL VDID
Length:224
Mass (Da):25,148
Last modified:January 11, 2001 - v2
Checksum:iFCA2058CC4E97DAC
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VLK0A0A1Y7VLK0_MOUSE
Peptidylprolyl isomerase
Fkbp3
188Annotation score:
A0A1Y7VJ86A0A1Y7VJ86_MOUSE
Peptidylprolyl isomerase
Fkbp3
88Annotation score:
A0A1Y7VP01A0A1Y7VP01_MOUSE
Peptidylprolyl isomerase
Fkbp3
149Annotation score:
A0A1Y7VMJ9A0A1Y7VMJ9_MOUSE
Peptidyl-prolyl cis-trans isomerase...
Fkbp3
76Annotation score:
A0A1Y7VLV3A0A1Y7VLV3_MOUSE
Peptidyl-prolyl cis-trans isomerase...
Fkbp3
82Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219E → G in AAB05769 (PubMed:8956998).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135595 mRNA Translation: AAD25097.1
AF110812 mRNA Translation: AAD20598.1
BC002122 mRNA Translation: AAH02122.1
U62545 mRNA Translation: AAB05769.1
CCDSiCCDS25940.1
RefSeqiNP_038930.1, NM_013902.4
UniGeneiMm.28480

Genome annotation databases

EnsembliENSMUST00000021332; ENSMUSP00000021332; ENSMUSG00000020949
GeneIDi30795
KEGGimmu:30795
UCSCiuc007nrb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135595 mRNA Translation: AAD25097.1
AF110812 mRNA Translation: AAD20598.1
BC002122 mRNA Translation: AAH02122.1
U62545 mRNA Translation: AAB05769.1
CCDSiCCDS25940.1
RefSeqiNP_038930.1, NM_013902.4
UniGeneiMm.28480

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KZ7X-ray1.95A106-224[»]
ProteinModelPortaliQ62446
SMRiQ62446
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62446, 5 interactors
MINTiQ62446
STRINGi10090.ENSMUSP00000021332

PTM databases

iPTMnetiQ62446
PhosphoSitePlusiQ62446

Proteomic databases

EPDiQ62446
MaxQBiQ62446
PaxDbiQ62446
PRIDEiQ62446

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021332; ENSMUSP00000021332; ENSMUSG00000020949
GeneIDi30795
KEGGimmu:30795
UCSCiuc007nrb.1 mouse

Organism-specific databases

CTDi2287
MGIiMGI:1353460 Fkbp3

Phylogenomic databases

eggNOGiKOG0544 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00760000119159
HOGENOMiHOG000007963
HOVERGENiHBG105391
InParanoidiQ62446
KOiK09570
OrthoDBiEOG091G02W1
PhylomeDBiQ62446
TreeFamiTF105293

Miscellaneous databases

ChiTaRSiFkbp3 mouse
PROiPR:Q62446
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020949 Expressed in 314 organ(s), highest expression level in optic fissure
CleanExiMM_FKBP3
ExpressionAtlasiQ62446 baseline and differential
GenevisibleiQ62446 MM

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP3_MOUSE
AccessioniPrimary (citable) accession number: Q62446
Secondary accession number(s): Q9WTJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 11, 2001
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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