Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor Sp4

Gene

Sp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to GT and GC boxes promoters elements. Probable transcriptional activator. Required for normal male reproductive behavior.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri645 – 669C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri675 – 699C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri705 – 727C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • regulation of heart contraction Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp4
Gene namesi
Name:Sp4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107595 Sp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471451 – 782Transcription factor Sp4Add BLAST782

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ62445
PaxDbiQ62445
PeptideAtlasiQ62445
PRIDEiQ62445

PTM databases

iPTMnetiQ62445
PhosphoSitePlusiQ62445

Expressioni

Tissue specificityi

Expressed in many tissues.

Developmental stagei

Highly expressed in embryos in the developing central nervous system (CNS). Expression is seen as early as day 9 of development, where transcripts are abundant in the posterior neuropore. Expression in later embryos is detected throughout the CNS as well as in other structures.

Gene expression databases

CleanExiMM_SP4

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026367

Structurei

3D structure databases

ProteinModelPortaliQ62445
SMRiQ62445
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 11Poly-Glu5
Compositional biasi12 – 17Poly-Ala6
Compositional biasi120 – 128Poly-Ser9
Compositional biasi285 – 288Poly-Thr4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri645 – 669C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri675 – 699C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri705 – 727C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234295
HOVERGENiHBG008933
InParanoidiQ62445

Family and domain databases

InterProiView protein in InterPro
IPR030453 SP4
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR23235:SF17 PTHR23235:SF17, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q62445-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDQKKEEEE EAAAAMATEG GKTSEPENNN KKPKTSGSQD SHPSPLALLA
60 70 80 90 100
ATCSKIGTPG ENQATGQQQI IIDPSQGLVQ LQNQPQQLEL VTTQLAGNAW
110 120 130 140 150
QLVASTPPAS KENNVSQPAS SSSSSSSSNN GSSSPTKTKS GNPSTPNQFQ
160 170 180 190 200
VIQVQNPSGS VQYQVIPQLQ TVEGQQIQIN PTSSSSLQDL QGQIQLISAG
210 220 230 240 250
NNQAILTAAN RTASGNILAQ NLANQTVPVQ IRPGVSIPLQ LQTLPGTQAQ
260 270 280 290 300
VVTTLPINIG GVTLALPVIN NVTAGGGTGQ VGQPTTTTDS GTSNGNQLVS
310 320 330 340 350
TPTTSTAPAS TMPESPSSST TCTTTASTTL TSSDTLVSSA DTGQYASTSA
360 370 380 390 400
SSSERTIEEP QTPAATESEA QSSSQLQSNG IQNAQDQSNS LQQVQIVGQP
410 420 430 440 450
ILQQIQIQQP QQQIIQAIPP QSFQLQSGQT IQTIQQQPLQ NVQLQAVNPT
460 470 480 490 500
QVLIRAPTLT PSGQISWQTV QVQNIQSLSN LQVQNAGLSQ QLTITPVSSS
510 520 530 540 550
GGTTLAQIAP VAVAGAPITL NTAQLASVPN LQTVSVANLG AAGVQVQGVP
560 570 580 590 600
VTITSVAGQQ QGQDGVKVQQ ATIAPVTVAV GGIANATIGA VSPDQLTQVH
610 620 630 640 650
LQQGQQTSDA EVQPGKRLRR VACSCPNCRE GEGRGSSEPG KKKQHVCHIE
660 670 680 690 700
GCGKVYGKTS HLRAHLRWHT GERPFICNWM FCGKRFTRSD ELQRHRRTHT
710 720 730 740 750
GEKRFECPEC SKRFMRSDHL SKHVKTHQNK KGGGTALAIV TSGELDSSVT
760 770 780
EVLGSPRIVT VAAISQDSNP ATPNVSTNME EF
Length:782
Mass (Da):81,906
Last modified:July 27, 2011 - v2
Checksum:iCAFFF89C759EA9BC
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VJR5A0A1Y7VJR5_MOUSE
Transcription factor Sp4
Sp4
782Annotation score:
K4DI62K4DI62_MOUSE
Transcription factor Sp4
Sp4
780Annotation score:
A0A1Y7VNB3A0A1Y7VNB3_MOUSE
Transcription factor Sp4
Sp4
57Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42H → Q in AAC52653 (PubMed:8660867).Curated1
Sequence conflicti183S → R in AAC52653 (PubMed:8660867).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62522 mRNA Translation: AAC52653.1
AC163032 Genomic DNA No translation available.
AC163034 Genomic DNA No translation available.
CCDSiCCDS36579.1
UniGeneiMm.259312
Mm.34699

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62522 mRNA Translation: AAC52653.1
AC163032 Genomic DNA No translation available.
AC163034 Genomic DNA No translation available.
CCDSiCCDS36579.1
UniGeneiMm.259312
Mm.34699

3D structure databases

ProteinModelPortaliQ62445
SMRiQ62445
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026367

PTM databases

iPTMnetiQ62445
PhosphoSitePlusiQ62445

Proteomic databases

MaxQBiQ62445
PaxDbiQ62445
PeptideAtlasiQ62445
PRIDEiQ62445

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:107595 Sp4

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000234295
HOVERGENiHBG008933
InParanoidiQ62445

Miscellaneous databases

PROiPR:Q62445
SOURCEiSearch...

Gene expression databases

CleanExiMM_SP4

Family and domain databases

InterProiView protein in InterPro
IPR030453 SP4
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR23235:SF17 PTHR23235:SF17, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSP4_MOUSE
AccessioniPrimary (citable) accession number: Q62445
Secondary accession number(s): E9QNI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again