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Protein

Neuronal pentraxin-1

Gene

Nptx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi280Calcium 1By similarity1
Metal bindingi358Calcium 1By similarity1
Metal bindingi358Calcium 2PROSITE-ProRule annotation1
Metal bindingi359Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi360Calcium 1By similarity1
Metal bindingi360Calcium 2PROSITE-ProRule annotation1
Metal bindingi370Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin-1
Short name:
NP1
Alternative name(s):
Neuronal pentraxin I
Short name:
NP-I
Gene namesi
Name:Nptx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:107811 Nptx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002354823 – 432Neuronal pentraxin-1Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi256 ↔ 316PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ62443
PaxDbiQ62443
PRIDEiQ62443

PTM databases

PhosphoSitePlusiQ62443

Expressioni

Gene expression databases

BgeeiENSMUSG00000025582 Expressed in 187 organ(s), highest expression level in dentate gyrus of hippocampal formation
CleanExiMM_NPTX1
ExpressionAtlasiQ62443 baseline and differential
GenevisibleiQ62443 MM

Interactioni

Subunit structurei

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026670

Structurei

3D structure databases

ProteinModelPortaliQ62443
SMRiQ62443
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini226 – 428Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST203

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFF Eukaryota
ENOG410XR4W LUCA
GeneTreeiENSGT00760000119128
HOGENOMiHOG000231267
HOVERGENiHBG003608
InParanoidiQ62443
OMAiGASKWTF
OrthoDBiEOG091G0AHP
PhylomeDBiQ62443
TreeFamiTF330208

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62443-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAGRAARTC ALLALCLLGS GAQDFGPTRF ICTSVPVDAD MCAASVAAGG
60 70 80 90 100
AEELRSNVLQ LRETVLQQKE TILSQKETIR ELTTKLGRCE SQSTLDSGPG
110 120 130 140 150
EARSGGGRKQ PGSGKNTMGD LSRTPAAETL SQLGQTLQSL KTRLENLEQY
160 170 180 190 200
SRLNSSSQTN SLKDLLQSKI DDLERQVLSR VNTLEEGKGG PKNDTEERAK
210 220 230 240 250
IESALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY AKVKKSLPEM
260 270 280 290 300
YAFTVCMWLK SSAAPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV
310 320 330 340 350
AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGNGEN LAPYHPIKPQ
360 370 380 390 400
GVLVLGQEQD TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSSK
410 420 430
ALSGNVIAWA ESQIEIFGGA TKWTFEACRQ IN
Length:432
Mass (Da):47,117
Last modified:November 1, 1997 - v1
Checksum:i0698B8BAE4948923
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62021 Genomic DNA Translation: AAC52826.1
CCDSiCCDS25719.1
RefSeqiNP_032756.1, NM_008730.2
UniGeneiMm.5142

Genome annotation databases

EnsembliENSMUST00000026670; ENSMUSP00000026670; ENSMUSG00000025582
GeneIDi18164
KEGGimmu:18164
UCSCiuc007mqv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62021 Genomic DNA Translation: AAC52826.1
CCDSiCCDS25719.1
RefSeqiNP_032756.1, NM_008730.2
UniGeneiMm.5142

3D structure databases

ProteinModelPortaliQ62443
SMRiQ62443
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026670

PTM databases

PhosphoSitePlusiQ62443

Proteomic databases

MaxQBiQ62443
PaxDbiQ62443
PRIDEiQ62443

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026670; ENSMUSP00000026670; ENSMUSG00000025582
GeneIDi18164
KEGGimmu:18164
UCSCiuc007mqv.1 mouse

Organism-specific databases

CTDi4884
MGIiMGI:107811 Nptx1

Phylogenomic databases

eggNOGiENOG410IFFF Eukaryota
ENOG410XR4W LUCA
GeneTreeiENSGT00760000119128
HOGENOMiHOG000231267
HOVERGENiHBG003608
InParanoidiQ62443
OMAiGASKWTF
OrthoDBiEOG091G0AHP
PhylomeDBiQ62443
TreeFamiTF330208

Miscellaneous databases

PROiPR:Q62443
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025582 Expressed in 187 organ(s), highest expression level in dentate gyrus of hippocampal formation
CleanExiMM_NPTX1
ExpressionAtlasiQ62443 baseline and differential
GenevisibleiQ62443 MM

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPTX1_MOUSE
AccessioniPrimary (citable) accession number: Q62443
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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