UniProtKB - Q62442 (VAMP1_MOUSE)

BLAST

>sp|Q62442|VAMP1_MOUSE Vesicle-associated membrane protein 1 OS=Mus musculus OX=10090 GN=Vamp1 PE=1 SV=1
MSAPAQPPAEGTEGAAPGGGPPGPPPNMTSNRRLQQTQAQVEEVVDIMRVNVDKVLERDQ
KLSELDDRADALQAGASQFESSAAKLKRKYWWKNCKMMIMLGAICAIIVVVIVIYFFT

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History
Entry version 153 (07 Nov 2018)
Sequence version 1 (01 Nov 1996)
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Protein

Vesicle-associated membrane protein 1

Gene

Vamp1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in the targeting and/or fusion of transport vesicles to their target membrane.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	68 – 69	(Microbial infection) Cleavage; by C.botulinum neurotoxin type X (BoNT/X)1 Publication		2

GO - Biological processⁱ

regulation of synaptic vesicle fusion to presynaptic active zone membrane
Source: SynGO
Inferred from mutant phenotypeⁱ
- 21282288
SNARE complex assembly
Source: BHF-UCL
Inferred from direct assayⁱ
- 21151919
synaptic vesicle priming
Source: SynGO
Inferred from direct assayⁱ
- 24944211

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Vesicle-associated membrane protein 1 Short name: VAMP-1 Alternative name(s): Synaptobrevin-1
Gene namesⁱ	Name:Vamp1 Synonyms:Syb1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:1313276 Vamp1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 96	CytoplasmicSequence analysisAdd BLAST	96
Transmembraneⁱ	97 – 116	Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST	20
Topological domainⁱ	117 – 118	VesicularSequence analysis	2

Keywords - Cellular componentⁱ

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000206720	1 – 118	Vesicle-associated membrane protein 1Add BLAST		118

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	63	PhosphoserineCombined sources		1

Post-translational modificationⁱ

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which hydrolyzes the 68-Arg-|-Ala-69 bond and probably inhibits neurotransmitter release (PubMed:28770820). It remains unknown whether BoNT/X is ever produced, or what organisms it targets.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q62442
PRIDEⁱ	Q62442

PTM databases

iPTMnetⁱ	Q62442
PhosphoSitePlusⁱ	Q62442

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030337 Expressed in 209 organ(s), highest expression level in spinal cord
CleanExⁱ	MM_VAMP1
ExpressionAtlasⁱ	Q62442 baseline and differential
Genevisibleⁱ	Q62442 MM

Interactionⁱ

Subunit structureⁱ

Interacts with VAPA and VAPB.By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000032487

STRINGⁱ

10090.ENSMUSP00000032487

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q62442
SMRⁱ	Q62442
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	33 – 93	v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST		61

Sequence similaritiesⁱ

Belongs to the synaptobrevin family.Curated

Keywords - Domainⁱ

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0860 Eukaryota COG5143 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074449
HOGENOMⁱ	HOG000042711
HOVERGENⁱ	HBG006675
InParanoidⁱ	Q62442
KEGG Orthology (KO) More...KOⁱ	K08510
OMAⁱ	VIVIHEQ
PhylomeDBⁱ	Q62442
TreeFamⁱ	TF313666

Family and domain databases

InterProⁱ	View protein in InterPro IPR001388 Synaptobrevin IPR016444 Synaptobrevin/VAMP
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00957 Synaptobrevin, 1 hit
PIRSFⁱ	PIRSF005409 Synaptobrevin_euk, 1 hit
PRINTSⁱ	PR00219 SYNAPTOBREVN
PROSITEⁱ	View protein in PROSITE PS00417 SYNAPTOBREVIN, 1 hit PS50892 V_SNARE, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q62442-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAPAQPPAE GTEGAAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIMRV 
        60         70         80         90        100
NVDKVLERDQ KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCKMMIM 
       110 
LGAICAIIVV VIVIYFFT

Length:118

Mass (Da):12,890

Last modified:November 1, 1996 - v1

Checksum:ⁱ31CB8701446A7FB0

Isoform 2 (identifier: Q62442-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
114-118: IYFFT → SKYR

« Hide

        10         20         30         40         50
MSAPAQPPAE GTEGAAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIMRV 
        60         70         80         90        100
NVDKVLERDQ KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCKMMIM 
       110 
LGAICAIIVV VIVSKYR

Show »

Length:117

Mass (Da):12,753

Checksum:ⁱA65589318A7FB071

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3YTU0	D3YTU0_MOUSE	Vesicle-associated membrane protein... Vesicle-associated membrane protein 1	Vamp1	171	Annotation score:
A0A0N4SUV3	A0A0N4SUV3_MOUSE	Vesicle-associated membrane protein... Vesicle-associated membrane protein 1	Vamp1	116	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_029186	114 – 118	IYFFT → SKYR in isoform 2. 1 Publication		5

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U61751 mRNA Translation: AAB03491.1 AF007167 mRNA Translation: AAB62930.1 AK018783 mRNA Translation: BAB31407.1 AK078156 mRNA Translation: BAC37151.1 BC049902 mRNA Translation: AAH49902.2 BC057587 mRNA Translation: AAH57587.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS20546.1 [Q62442-1] CCDS39637.1 [Q62442-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001074026.1, NM_001080557.1 [Q62442-2] NP_033522.1, NM_009496.3 [Q62442-1]
UniGeneⁱ	Mm.32321

Genome annotation databases

Ensemblⁱ	ENSMUST00000032487; ENSMUSP00000032487; ENSMUSG00000030337 [Q62442-1] ENSMUST00000100942; ENSMUSP00000098503; ENSMUSG00000030337 [Q62442-2]
GeneIDⁱ	22317
KEGGⁱ	mmu:22317
UCSC genome browser More...UCSCⁱ	uc009dtx.1 mouse [Q62442-1] uc009dty.1 mouse [Q62442-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q62442	Vesicle associated membrane protein 1		CAVPO		118	UniRef100_Q62442
UPI000A35241D		HETGA		91
UPI00038EE34D		CHILA		201

Protein	Similar proteins		Species	Score	Length	Source
Q62442	Vesicle associated membrane protein 1		CAVPO		118	UniRef90_Q62442
UPI000A35241D		HETGA		91
UPI00038EE34D		CHILA		201
Q62442-2	Uncharacterized protein		MACMU		128	UniRef90_Q62442-2
Uncharacterized protein		RABIT		120
UPI000A31B25C		MUSCR		120
UPI00083C11EE		RHIBE		150
UPI000B7B2ED2		PAPAN		122
+3

Protein	Similar proteins		Species	Score	Length	Source
Q62442	Vesicle associated membrane protein 1		CAVPO		118	UniRef50_Q62442
Uncharacterized protein		AILME		243
vesicle-associated membrane protein 1 isoform X1		NEOSC		218
vesicle-associated membrane protein 1 isoform X1		Yangtze finless porpoise		213
Uncharacterized protein		PROCO		117
+11
Q62442-2	Vesicle-associated membrane protein 1		HUMAN		118	UniRef50_P23763
Vesicle-associated membrane protein 1		RAT		118
Vesicle-associated membrane protein 1		BOVIN		118
VAMP1 isoform 3		PANTR		118
Uncharacterized protein		PANPA		118
+128

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U61751 mRNA Translation: AAB03491.1 AF007167 mRNA Translation: AAB62930.1 AK018783 mRNA Translation: BAB31407.1 AK078156 mRNA Translation: BAC37151.1 BC049902 mRNA Translation: AAH49902.2 BC057587 mRNA Translation: AAH57587.1
CCDSⁱ	CCDS20546.1 [Q62442-1] CCDS39637.1 [Q62442-2]
RefSeqⁱ	NP_001074026.1, NM_001080557.1 [Q62442-2] NP_033522.1, NM_009496.3 [Q62442-1]
UniGeneⁱ	Mm.32321

3D structure databases

ProteinModelPortalⁱ	Q62442
SMRⁱ	Q62442
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000032487

STRINGⁱ

10090.ENSMUSP00000032487

PTM databases

iPTMnetⁱ	Q62442
PhosphoSitePlusⁱ	Q62442

Proteomic databases

PaxDbⁱ	Q62442
PRIDEⁱ	Q62442

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000032487; ENSMUSP00000032487; ENSMUSG00000030337 [Q62442-1] ENSMUST00000100942; ENSMUSP00000098503; ENSMUSG00000030337 [Q62442-2]
GeneIDⁱ	22317
KEGGⁱ	mmu:22317
UCSCⁱ	uc009dtx.1 mouse [Q62442-1] uc009dty.1 mouse [Q62442-2]

Organism-specific databases

CTDⁱ	6843
MGIⁱ	MGI:1313276 Vamp1

Phylogenomic databases

eggNOGⁱ	KOG0860 Eukaryota COG5143 LUCA
GeneTreeⁱ	ENSGT00550000074449
HOGENOMⁱ	HOG000042711
HOVERGENⁱ	HBG006675
InParanoidⁱ	Q62442
KOⁱ	K08510
OMAⁱ	VIVIHEQ
PhylomeDBⁱ	Q62442
TreeFamⁱ	TF313666

Miscellaneous databases

ChiTaRSⁱ	Vamp1 mouse
Protein Ontology More...PROⁱ	PR:Q62442
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030337 Expressed in 209 organ(s), highest expression level in spinal cord
CleanExⁱ	MM_VAMP1
ExpressionAtlasⁱ	Q62442 baseline and differential
Genevisibleⁱ	Q62442 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR001388 Synaptobrevin IPR016444 Synaptobrevin/VAMP
Pfamⁱ	View protein in Pfam PF00957 Synaptobrevin, 1 hit
PIRSFⁱ	PIRSF005409 Synaptobrevin_euk, 1 hit
PRINTSⁱ	PR00219 SYNAPTOBREVN
PROSITEⁱ	View protein in PROSITE PS00417 SYNAPTOBREVIN, 1 hit PS50892 V_SNARE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VAMP1_MOUSE
Accessionⁱ	Q62442Primary (citable) accession number: Q62442 Secondary accession number(s): Q6PFF3, Q810K6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

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Supporting data

UniProtKB - Q62442 (VAMP1_MOUSE)

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Vesicle-associated membrane protein 1

Vamp1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Mitochondrion

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ