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Protein

Vesicle-associated membrane protein 1

Gene

Vamp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the targeting and/or fusion of transport vesicles to their target membrane.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei68 – 69(Microbial infection) Cleavage; by C.botulinum neurotoxin type X (BoNT/X)1 Publication2

GO - Biological processi

  • regulation of synaptic vesicle fusion to presynaptic active zone membrane Source: SynGO
  • SNARE complex assembly Source: BHF-UCL
  • synaptic vesicle priming Source: SynGO

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein 1
Short name:
VAMP-1
Alternative name(s):
Synaptobrevin-1
Gene namesi
Name:Vamp1
Synonyms:Syb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1313276 Vamp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 96CytoplasmicSequence analysisAdd BLAST96
Transmembranei97 – 116Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST20
Topological domaini117 – 118VesicularSequence analysis2

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002067201 – 118Vesicle-associated membrane protein 1Add BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphoserineCombined sources1

Post-translational modificationi

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which hydrolyzes the 68-Arg-|-Ala-69 bond and probably inhibits neurotransmitter release (PubMed:28770820). It remains unknown whether BoNT/X is ever produced, or what organisms it targets.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ62442
PRIDEiQ62442

PTM databases

iPTMnetiQ62442
PhosphoSitePlusiQ62442

Expressioni

Gene expression databases

BgeeiENSMUSG00000030337 Expressed in 209 organ(s), highest expression level in spinal cord
CleanExiMM_VAMP1
ExpressionAtlasiQ62442 baseline and differential
GenevisibleiQ62442 MM

Interactioni

Subunit structurei

Interacts with VAPA and VAPB.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032487

Structurei

3D structure databases

ProteinModelPortaliQ62442
SMRiQ62442
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 93v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0860 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00550000074449
HOGENOMiHOG000042711
HOVERGENiHBG006675
InParanoidiQ62442
KOiK08510
OMAiVIVIHEQ
PhylomeDBiQ62442
TreeFamiTF313666

Family and domain databases

InterProiView protein in InterPro
IPR001388 Synaptobrevin
IPR016444 Synaptobrevin/VAMP
PfamiView protein in Pfam
PF00957 Synaptobrevin, 1 hit
PIRSFiPIRSF005409 Synaptobrevin_euk, 1 hit
PRINTSiPR00219 SYNAPTOBREVN
PROSITEiView protein in PROSITE
PS00417 SYNAPTOBREVIN, 1 hit
PS50892 V_SNARE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q62442-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAPAQPPAE GTEGAAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIMRV
60 70 80 90 100
NVDKVLERDQ KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCKMMIM
110
LGAICAIIVV VIVIYFFT
Length:118
Mass (Da):12,890
Last modified:November 1, 1996 - v1
Checksum:i31CB8701446A7FB0
GO
Isoform 2 (identifier: Q62442-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-118: IYFFT → SKYR

Show »
Length:117
Mass (Da):12,753
Checksum:iA65589318A7FB071
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YTU0D3YTU0_MOUSE
Vesicle-associated membrane protein...
Vamp1
171Annotation score:
A0A0N4SUV3A0A0N4SUV3_MOUSE
Vesicle-associated membrane protein...
Vamp1
116Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029186114 – 118IYFFT → SKYR in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61751 mRNA Translation: AAB03491.1
AF007167 mRNA Translation: AAB62930.1
AK018783 mRNA Translation: BAB31407.1
AK078156 mRNA Translation: BAC37151.1
BC049902 mRNA Translation: AAH49902.2
BC057587 mRNA Translation: AAH57587.1
CCDSiCCDS20546.1 [Q62442-1]
CCDS39637.1 [Q62442-2]
RefSeqiNP_001074026.1, NM_001080557.1 [Q62442-2]
NP_033522.1, NM_009496.3 [Q62442-1]
UniGeneiMm.32321

Genome annotation databases

EnsembliENSMUST00000032487; ENSMUSP00000032487; ENSMUSG00000030337 [Q62442-1]
ENSMUST00000100942; ENSMUSP00000098503; ENSMUSG00000030337 [Q62442-2]
GeneIDi22317
KEGGimmu:22317
UCSCiuc009dtx.1 mouse [Q62442-1]
uc009dty.1 mouse [Q62442-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61751 mRNA Translation: AAB03491.1
AF007167 mRNA Translation: AAB62930.1
AK018783 mRNA Translation: BAB31407.1
AK078156 mRNA Translation: BAC37151.1
BC049902 mRNA Translation: AAH49902.2
BC057587 mRNA Translation: AAH57587.1
CCDSiCCDS20546.1 [Q62442-1]
CCDS39637.1 [Q62442-2]
RefSeqiNP_001074026.1, NM_001080557.1 [Q62442-2]
NP_033522.1, NM_009496.3 [Q62442-1]
UniGeneiMm.32321

3D structure databases

ProteinModelPortaliQ62442
SMRiQ62442
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032487

PTM databases

iPTMnetiQ62442
PhosphoSitePlusiQ62442

Proteomic databases

PaxDbiQ62442
PRIDEiQ62442

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032487; ENSMUSP00000032487; ENSMUSG00000030337 [Q62442-1]
ENSMUST00000100942; ENSMUSP00000098503; ENSMUSG00000030337 [Q62442-2]
GeneIDi22317
KEGGimmu:22317
UCSCiuc009dtx.1 mouse [Q62442-1]
uc009dty.1 mouse [Q62442-2]

Organism-specific databases

CTDi6843
MGIiMGI:1313276 Vamp1

Phylogenomic databases

eggNOGiKOG0860 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00550000074449
HOGENOMiHOG000042711
HOVERGENiHBG006675
InParanoidiQ62442
KOiK08510
OMAiVIVIHEQ
PhylomeDBiQ62442
TreeFamiTF313666

Miscellaneous databases

ChiTaRSiVamp1 mouse
PROiPR:Q62442
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030337 Expressed in 209 organ(s), highest expression level in spinal cord
CleanExiMM_VAMP1
ExpressionAtlasiQ62442 baseline and differential
GenevisibleiQ62442 MM

Family and domain databases

InterProiView protein in InterPro
IPR001388 Synaptobrevin
IPR016444 Synaptobrevin/VAMP
PfamiView protein in Pfam
PF00957 Synaptobrevin, 1 hit
PIRSFiPIRSF005409 Synaptobrevin_euk, 1 hit
PRINTSiPR00219 SYNAPTOBREVN
PROSITEiView protein in PROSITE
PS00417 SYNAPTOBREVIN, 1 hit
PS50892 V_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVAMP1_MOUSE
AccessioniPrimary (citable) accession number: Q62442
Secondary accession number(s): Q6PFF3, Q810K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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