UniProtKB - Q62440 (TLE1_MOUSE)
Transducin-like enhancer protein 1
Tle1
Functioni
GO - Molecular functioni
- chromatin binding Source: MGI
- identical protein binding Source: MGI
- repressing transcription factor binding Source: GO_Central
- transcription corepressor activity Source: MGI
- transcription factor binding Source: MGI
GO - Biological processi
- negative regulation of anoikis Source: MGI
- negative regulation of canonical Wnt signaling pathway Source: GO_Central
- negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of gene expression Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation, Wnt signaling pathway |
Enzyme and pathway databases
Reactomei | R-MMU-201722, Formation of the beta-catenin:TCF transactivating complex R-MMU-3769402, Deactivation of the beta-catenin transactivating complex R-MMU-4641265, Repression of WNT target genes |
Names & Taxonomyi
Protein namesi | Recommended name: Transducin-like enhancer protein 1Alternative name(s): Groucho-related protein 1 Short name: Grg-1 |
Gene namesi | Name:Tle1 Synonyms:Grg1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:104636, Tle1 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Note: Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- beta-catenin-TCF complex Source: MGI
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051277 | 1 – 770 | Transducin-like enhancer protein 1Add BLAST | 770 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 237 | Phosphoserine; by CK2Sequence analysisBy similarity | 1 | |
Modified residuei | 257 | Phosphoserine; by CDK1Sequence analysis | 1 | |
Modified residuei | 261 | Phosphoserine; by CDK1Sequence analysis | 1 | |
Modified residuei | 265 | Phosphoserine; by CDK1Sequence analysis | 1 | |
Modified residuei | 284 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q62440 |
PeptideAtlasi | Q62440 |
PRIDEi | Q62440 |
PTM databases
iPTMneti | Q62440 |
PhosphoSitePlusi | Q62440 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000008305, Expressed in rostral migratory stream and 343 other tissues |
ExpressionAtlasi | Q62440, baseline and differential |
Genevisiblei | Q62440, MM |
Interactioni
Subunit structurei
Homooligomer and heterooligomer with other family members. Binds RUNX1, RUNX2, FOXA2, KDM6A, UTY, histone H3, HESX1, ESRRG and the NF-kappa-B subunit RELA.
Interacts with HES1 (via WRPW motif) (By similarity). Binds TCF7, LEF1, TCF7L1 and TCF7L2.
Interacts with SIX3 (By similarity).
Interacts with EFNB1.
By similarity2 PublicationsGO - Molecular functioni
- identical protein binding Source: MGI
- repressing transcription factor binding Source: GO_Central
- transcription factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204216, 13 interactors |
CORUMi | Q62440 |
IntActi | Q62440, 6 interactors |
MINTi | Q62440 |
STRINGi | 10090.ENSMUSP00000072481 |
Miscellaneous databases
RNActi | Q62440, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 470 – 501 | WD 1Add BLAST | 32 | |
Repeati | 528 – 558 | WD 2Add BLAST | 31 | |
Repeati | 572 – 602 | WD 3Add BLAST | 31 | |
Repeati | 614 – 644 | WD 4Add BLAST | 31 | |
Repeati | 696 – 726 | WD 5Add BLAST | 31 | |
Repeati | 737 – 767 | WD 6Add BLAST | 31 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 131 | Q domainBy similarityAdd BLAST | 131 | |
Regioni | 132 – 199 | GP domainBy similarityAdd BLAST | 68 | |
Regioni | 200 – 266 | CcN domainBy similarityAdd BLAST | 67 | |
Regioni | 267 – 450 | SP domainBy similarityAdd BLAST | 184 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 225 – 228 | Nuclear localization signalSequence analysis | 4 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0639, Eukaryota |
GeneTreei | ENSGT01010000222312 |
InParanoidi | Q62440 |
OrthoDBi | 546143at2759 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR005617, Groucho/TLE_N IPR009146, Groucho_enhance IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10814, PTHR10814, 1 hit |
Pfami | View protein in Pfam PF03920, TLE_N, 1 hit PF00400, WD40, 2 hits |
PRINTSi | PR01850, GROUCHOFAMLY |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 2 hits |
s (8+)i Sequence
Sequence statusi: Complete.
This entry describes 8 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 8 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL
60 70 80 90 100
ASEKTEMQRH YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH
110 120 130 140 150
QQQVAQAVER AKQVTMAELN AIIGQQQLQA QHLSHGHGPP VPLTPHPSGL
160 170 180 190 200
QPPGIPPLGG SASLLALSSA LSGQSHLAIK DDKKHHDAER HRDRESGTSN
210 220 230 240 250
SLLVPDSLRS TDKRRNGPEF SSDIKKRKVD DKDNYDSDGD KSDDNLVVDV
260 270 280 290 300
SNEDPSSPHA SPTHSPRENG IDKNRLLKKD ASGSPASTAS SGSSSSLKSK
310 320 330 340 350
EVSLHEKANT PVLKSSTPTP RSDMPTPGTS ATPGLRPGLG KPPAMEPLVN
360 370 380 390 400
QAAAGLRTPL AVPGPYPAPF GMVPHAGMNG ELTSPGAAYA GLHSMSPQMS
410 420 430 440 450
AAAAAAAAAV VAYGRSPMVG FDPPPHMRVP SIPPNLAGIP GGKPAYSFHV
460 470 480 490 500
TADGQMQPVP FPPDALIGPG IPRHARQINT LNHGEVVCAV TISNPTRHVY
510 520 530 540 550
TGGKGCVKVW DISHPGNKSP VSQLDCLNRD NYIRSCKLLP DGCTLIVGGE
560 570 580 590 600
ASTLSIWDLA APTPRIKAEL TSSAPACYAL AISPDSKVCF SCCSDGNIAV
610 620 630 640 650
WDLHNQTLVR QFQGHTDGAS CIDISNDGTK LWTGGLDNTV RSWDLREGRQ
660 670 680 690 700
LQQHDFTSQI FSLGYCPTGE WLAVGMESSN VEVLHVNKPD KYQLHLHESC
710 720 730 740 750
VLSLKFAYCG KWFVSTGKDN LLNAWRTPYG ASIFQSKESS SVLSCDISVD
760 770
DKYIVTGSGD KKATVYEVIY
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5SQA2 | Q5SQA2_MOUSE | Transducin-like enhancer protein 1 | Tle1 | 770 | Annotation score: | ||
Q5SQA4 | Q5SQA4_MOUSE | Transducin-like enhancer protein 1 | Tle1 | 777 | Annotation score: | ||
Q5SQA3 | Q5SQA3_MOUSE | Transducin-like enhancer protein 1 | Tle1 | 780 | Annotation score: | ||
Q5SQA5 | Q5SQA5_MOUSE | Transducin-like enhancer protein 1 | Tle1 | 194 | Annotation score: | ||
E9Q2Q6 | E9Q2Q6_MOUSE | Transducin-like enhancer protein 1 | Tle1 | 770 | Annotation score: | ||
Q5SQA7 | Q5SQA7_MOUSE | Transducin-like enhancer protein 1 | Tle1 | 167 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 48 | E → G in AAN77514 (PubMed:12359720).Curated | 1 | |
Sequence conflicti | 92 | V → D in AAB49934 (PubMed:8892234).Curated | 1 | |
Sequence conflicti | 122 | I → T in AAN77518 (PubMed:12359720).Curated | 1 | |
Sequence conflicti | 163 | S → G in AAB49934 (PubMed:8892234).Curated | 1 | |
Sequence conflicti | 196 | S → P (PubMed:8892234).Curated | 1 | |
Sequence conflicti | 196 | S → P in AAN77514 (PubMed:12359720).Curated | 1 | |
Sequence conflicti | 196 | S → P in AAN77518 (PubMed:12359720).Curated | 1 | |
Sequence conflicti | 196 | S → P in BAC35221 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 210 | S → G (PubMed:8892234).Curated | 1 | |
Sequence conflicti | 210 | S → G in AAN77519 (PubMed:12359720).Curated | 1 | |
Sequence conflicti | 210 | S → G in BAC35221 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 210 | S → G in BAC38509 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 247 | V → I in AAN77514 (PubMed:12359720).Curated | 1 | |
Sequence conflicti | 258 | P → S in AAN77514 (PubMed:12359720).Curated | 1 | |
Sequence conflicti | 258 | P → S in AAN77518 (PubMed:12359720).Curated | 1 | |
Sequence conflicti | 428 | R → S in AAN77518 (PubMed:12359720).Curated | 1 | |
Sequence conflicti | 464 – 465 | DA → MP in AAB49934 (PubMed:8892234).Curated | 2 | |
Sequence conflicti | 471 | I → F in AAB49934 (PubMed:8892234).Curated | 1 | |
Sequence conflicti | 535 | S → T in AAB49934 (PubMed:8892234).Curated | 1 | |
Sequence conflicti | 542 | G → D in AAB49934 (PubMed:8892234).Curated | 1 | |
Sequence conflicti | 551 | A → T in AAN77517 (PubMed:12359720).Curated | 1 | |
Sequence conflicti | 612 | F → Y in BAC35221 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006987 | 1 – 41 | MFPQS…QAQYH → MFTLSCLFCFP in isoform 5. 1 PublicationAdd BLAST | 41 | |
Alternative sequenceiVSP_006988 | 79 – 198 | Missing in isoform 3. 1 PublicationAdd BLAST | 120 | |
Alternative sequenceiVSP_006989 | 125 – 198 | Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST | 74 | |
Alternative sequenceiVSP_006990 | 127 | Missing in isoform 8. 1 Publication | 1 | |
Alternative sequenceiVSP_006992 | 193 – 200 | DRESGTSN → GERPGKPD in isoform 7 and isoform 8. 2 Publications | 8 | |
Alternative sequenceiVSP_006993 | 201 – 770 | Missing in isoform 7 and isoform 8. 2 PublicationsAdd BLAST | 570 | |
Alternative sequenceiVSP_006991 | 477 – 658 | Missing in isoform 4. CuratedAdd BLAST | 182 | |
Alternative sequenceiVSP_006994 | 649 – 653 | RQLQQ → NKSYQ in isoform 6. 1 Publication | 5 | |
Alternative sequenceiVSP_006995 | 654 – 770 | Missing in isoform 6. 1 PublicationAdd BLAST | 117 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U61362 mRNA Translation: AAB49934.1 AY155195 mRNA Translation: AAN77514.1 AY155196 mRNA Translation: AAN77515.1 AY155197 mRNA Translation: AAN77516.1 AY155198 mRNA Translation: AAN77517.1 AY155199 mRNA Translation: AAN77518.1 AY155200 mRNA Translation: AAN77519.1 AK046402 mRNA Translation: BAC32708.1 AK052961 mRNA Translation: BAC35221.1 AK076750 mRNA Translation: BAC36464.1 AK082499 mRNA Translation: BAC38509.1 AL773513 Genomic DNA No translation available. |
CCDSi | CCDS18274.1 [Q62440-1] CCDS71407.1 [Q62440-7] |
RefSeqi | NP_001272459.1, NM_001285530.1 NP_001272460.1, NM_001285531.1 [Q62440-7] NP_001272461.1, NM_001285532.1 [Q62440-8] NP_035729.3, NM_011599.5 |
Genome annotation databases
Ensembli | ENSMUST00000107337; ENSMUSP00000102960; ENSMUSG00000008305 [Q62440-7] |
GeneIDi | 21885 |
KEGGi | mmu:21885 |
UCSCi | uc008tic.2, mouse [Q62440-1] uc008tii.3, mouse [Q62440-2] uc008tij.3, mouse [Q62440-7] uc008tik.3, mouse [Q62440-8] uc012dgd.2, mouse [Q62440-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U61362 mRNA Translation: AAB49934.1 AY155195 mRNA Translation: AAN77514.1 AY155196 mRNA Translation: AAN77515.1 AY155197 mRNA Translation: AAN77516.1 AY155198 mRNA Translation: AAN77517.1 AY155199 mRNA Translation: AAN77518.1 AY155200 mRNA Translation: AAN77519.1 AK046402 mRNA Translation: BAC32708.1 AK052961 mRNA Translation: BAC35221.1 AK076750 mRNA Translation: BAC36464.1 AK082499 mRNA Translation: BAC38509.1 AL773513 Genomic DNA No translation available. |
CCDSi | CCDS18274.1 [Q62440-1] CCDS71407.1 [Q62440-7] |
RefSeqi | NP_001272459.1, NM_001285530.1 NP_001272460.1, NM_001285531.1 [Q62440-7] NP_001272461.1, NM_001285532.1 [Q62440-8] NP_035729.3, NM_011599.5 |
3D structure databases
SMRi | Q62440 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204216, 13 interactors |
CORUMi | Q62440 |
IntActi | Q62440, 6 interactors |
MINTi | Q62440 |
STRINGi | 10090.ENSMUSP00000072481 |
PTM databases
iPTMneti | Q62440 |
PhosphoSitePlusi | Q62440 |
Proteomic databases
PaxDbi | Q62440 |
PeptideAtlasi | Q62440 |
PRIDEi | Q62440 |
Protocols and materials databases
Antibodypediai | 3147, 540 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000107337; ENSMUSP00000102960; ENSMUSG00000008305 [Q62440-7] |
GeneIDi | 21885 |
KEGGi | mmu:21885 |
UCSCi | uc008tic.2, mouse [Q62440-1] uc008tii.3, mouse [Q62440-2] uc008tij.3, mouse [Q62440-7] uc008tik.3, mouse [Q62440-8] uc012dgd.2, mouse [Q62440-3] |
Organism-specific databases
CTDi | 7088 |
MGIi | MGI:104636, Tle1 |
Phylogenomic databases
eggNOGi | KOG0639, Eukaryota |
GeneTreei | ENSGT01010000222312 |
InParanoidi | Q62440 |
OrthoDBi | 546143at2759 |
Enzyme and pathway databases
Reactomei | R-MMU-201722, Formation of the beta-catenin:TCF transactivating complex R-MMU-3769402, Deactivation of the beta-catenin transactivating complex R-MMU-4641265, Repression of WNT target genes |
Miscellaneous databases
BioGRID-ORCSi | 21885, 1 hit in 18 CRISPR screens |
ChiTaRSi | Tle1, mouse |
PROi | PR:Q62440 |
RNActi | Q62440, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000008305, Expressed in rostral migratory stream and 343 other tissues |
ExpressionAtlasi | Q62440, baseline and differential |
Genevisiblei | Q62440, MM |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR005617, Groucho/TLE_N IPR009146, Groucho_enhance IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10814, PTHR10814, 1 hit |
Pfami | View protein in Pfam PF03920, TLE_N, 1 hit PF00400, WD40, 2 hits |
PRINTSi | PR01850, GROUCHOFAMLY |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TLE1_MOUSE | |
Accessioni | Q62440Primary (citable) accession number: Q62440 Secondary accession number(s): Q5SQA8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | March 25, 2003 | |
Last modified: | December 2, 2020 | |
This is version 184 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families