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Protein

Cytochrome c oxidase subunit NDUFA4

Gene

Ndufa4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase (COX, complex IV) is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Required for complex IV maintenance (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit NDUFA4
Gene namesi
Name:Ndufa4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107686 Ndufa4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188221 – 82Cytochrome c oxidase subunit NDUFA4Add BLAST82

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10N6-acetyllysineCombined sources1
Modified residuei67PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ62425
MaxQBiQ62425
PaxDbiQ62425
PeptideAtlasiQ62425
PRIDEiQ62425
TopDownProteomicsiQ62425

PTM databases

iPTMnetiQ62425
PhosphoSitePlusiQ62425

Expressioni

Gene expression databases

BgeeiENSMUSG00000029632 Expressed in 323 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasiQ62425 baseline and differential
GenevisibleiQ62425 MM

Interactioni

Subunit structurei

Component of the cytochrome c oxidase complex (COX, complex IV).1 Publication

Protein-protein interaction databases

BioGridi201717, 5 interactors
CORUMiQ62425
IntActiQ62425, 9 interactors
MINTiQ62425
STRINGi10090.ENSMUSP00000031637

Structurei

3D structure databases

ProteinModelPortaliQ62425
SMRiQ62425
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ62425

Family & Domainsi

Sequence similaritiesi

Belongs to the complex IV NDUFA4 subunit family.Curated

Phylogenomic databases

eggNOGiENOG410J0TX Eukaryota
ENOG41124SW LUCA
GeneTreeiENSGT00390000010457
HOGENOMiHOG000261679
HOVERGENiHBG006548
InParanoidiQ62425
KOiK03948
OMAiTWNRSSN
OrthoDBiEOG091G1352
PhylomeDBiQ62425
TreeFamiTF106383

Family and domain databases

InterProiView protein in InterPro
IPR010530 B12D
PANTHERiPTHR14256 PTHR14256, 1 hit
PfamiView protein in Pfam
PF06522 B12D, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q62425-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRQILGQAK KHPSLIPLFV FIGAGGTGAA LYVMRLALFN PDVSWDRKNN
60 70 80
PEPWNKLGPN EQYKFYSVNV DYSKLKKEGP DF
Length:82
Mass (Da):9,327
Last modified:September 19, 2002 - v2
Checksum:i6E29865845807C7B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SVQ1A0A0N4SVQ1_MOUSE
Cytochrome c oxidase subunit NDUFA4
Ndufa4
49Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005084 mRNA No translation available.
AK008357 mRNA Translation: BAB25627.1
AK008506 mRNA Translation: BAB25706.1
AK076036 mRNA Translation: BAC36137.1
BC011114 mRNA Translation: AAH11114.1
U59509 mRNA Translation: AAB03395.1
CCDSiCCDS39427.1
RefSeqiNP_035016.1, NM_010886.2
UniGeneiMm.415865

Genome annotation databases

EnsembliENSMUST00000204714; ENSMUSP00000145413; ENSMUSG00000029632
ENSMUST00000204978; ENSMUSP00000144932; ENSMUSG00000029632
GeneIDi17992
KEGGimmu:17992
UCSCiuc009ayd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005084 mRNA No translation available.
AK008357 mRNA Translation: BAB25627.1
AK008506 mRNA Translation: BAB25706.1
AK076036 mRNA Translation: BAC36137.1
BC011114 mRNA Translation: AAH11114.1
U59509 mRNA Translation: AAB03395.1
CCDSiCCDS39427.1
RefSeqiNP_035016.1, NM_010886.2
UniGeneiMm.415865

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LEGX-ray1.75P61-68[»]
1LEKX-ray2.15P61-68[»]
1MWAX-ray2.40P/Q61-68[»]
2CKBX-ray3.00P/Q61-68[»]
ProteinModelPortaliQ62425
SMRiQ62425
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201717, 5 interactors
CORUMiQ62425
IntActiQ62425, 9 interactors
MINTiQ62425
STRINGi10090.ENSMUSP00000031637

PTM databases

iPTMnetiQ62425
PhosphoSitePlusiQ62425

Proteomic databases

EPDiQ62425
MaxQBiQ62425
PaxDbiQ62425
PeptideAtlasiQ62425
PRIDEiQ62425
TopDownProteomicsiQ62425

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000204714; ENSMUSP00000145413; ENSMUSG00000029632
ENSMUST00000204978; ENSMUSP00000144932; ENSMUSG00000029632
GeneIDi17992
KEGGimmu:17992
UCSCiuc009ayd.1 mouse

Organism-specific databases

CTDi4697
MGIiMGI:107686 Ndufa4

Phylogenomic databases

eggNOGiENOG410J0TX Eukaryota
ENOG41124SW LUCA
GeneTreeiENSGT00390000010457
HOGENOMiHOG000261679
HOVERGENiHBG006548
InParanoidiQ62425
KOiK03948
OMAiTWNRSSN
OrthoDBiEOG091G1352
PhylomeDBiQ62425
TreeFamiTF106383

Miscellaneous databases

EvolutionaryTraceiQ62425
PROiPR:Q62425
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029632 Expressed in 323 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasiQ62425 baseline and differential
GenevisibleiQ62425 MM

Family and domain databases

InterProiView protein in InterPro
IPR010530 B12D
PANTHERiPTHR14256 PTHR14256, 1 hit
PfamiView protein in Pfam
PF06522 B12D, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNDUA4_MOUSE
AccessioniPrimary (citable) accession number: Q62425
Secondary accession number(s): Q9CQP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 19, 2002
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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