UniProtKB - Q62422 (OSTF1_MOUSE)
Protein
Osteoclast-stimulating factor 1
Gene
Ostf1
Organism
Mus musculus (Mouse)
Status
Functioni
Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.By similarity
GO - Molecular functioni
- SH3 domain binding Source: MGI
GO - Biological processi
- signal transduction Source: GO_Central
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Osteoclast-stimulating factor 1Alternative name(s): SH3 domain protein 3 |
Gene namesi | Name:Ostf1 Synonyms:Sh3d3, Sh3p2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:700012, Ostf1 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000067036 | 2 – 215 | Osteoclast-stimulating factor 1Add BLAST | 214 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 201 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 203 | PhosphoserineBy similarity | 1 | |
Modified residuei | 214 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q62422 |
jPOSTi | Q62422 |
MaxQBi | Q62422 |
PaxDbi | Q62422 |
PeptideAtlasi | Q62422 |
PRIDEi | Q62422 |
2D gel databases
UCD-2DPAGEi | Q62422 |
PTM databases
iPTMneti | Q62422 |
PhosphoSitePlusi | Q62422 |
SwissPalmi | Q62422 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024725, Expressed in granulocyte and 300 other tissues |
ExpressionAtlasi | Q62422, baseline and differential |
Genevisiblei | Q62422, MM |
Interactioni
Subunit structurei
Interacts with C-SRC and SMN1.
Interacts with FASLG (By similarity).
By similarityGO - Molecular functioni
- SH3 domain binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203211, 2 interactors |
IntActi | Q62422, 1 interactor |
MINTi | Q62422 |
STRINGi | 10090.ENSMUSP00000025631 |
Miscellaneous databases
RNActi | Q62422, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 71 | SH3PROSITE-ProRule annotationAdd BLAST | 60 | |
Repeati | 72 – 101 | ANK 1Add BLAST | 30 | |
Repeati | 105 – 135 | ANK 2Add BLAST | 31 | |
Repeati | 139 – 168 | ANK 3Add BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 4 – 11 | Pro-rich | 8 |
Domaini
The SH3 domain mediates interaction with SMN1.By similarity
Keywords - Domaini
ANK repeat, Repeat, SH3 domainPhylogenomic databases
eggNOGi | ENOG502QTZB, Eukaryota |
GeneTreei | ENSGT00920000149159 |
HOGENOMi | CLU_092255_0_0_1 |
InParanoidi | Q62422 |
OMAi | DTSDTNW |
OrthoDBi | 1453481at2759 |
PhylomeDBi | Q62422 |
TreeFami | TF314534 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR01415, ANKYRIN PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00248, ANK, 3 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q62422-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKPPPKPVK PGQVKVFRAL YTFEPRTPDE LYFEEGDIIY ITDMSDTSWW
60 70 80 90 100
KGTCKGRTGL IPSNYVAEQA ESIDNPLHEA AKRGNLSWLR ECLDNRVGVN
110 120 130 140 150
GLDKAGSTAL YWACHGGHKD IVEVLFTQPN VELNQQNKLG DTALHAAAWK
160 170 180 190 200
GYADIVQLLL AKGARTDLRN NEKKLALDMA TNAACASLLK KKQQGTDGAR
210
TLSNAEDYLD DEDSD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A494BA97 | A0A494BA97_MOUSE | Osteoclast-stimulating factor 1 | Ostf1 | 212 | Annotation score: | ||
A0A494B943 | A0A494B943_MOUSE | Osteoclast-stimulating factor 1 | Ostf1 | 38 | Annotation score: |
Sequence cautioni
The sequence AAC52641 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U58888 mRNA Translation: AAC52641.1 Different initiation. AK002899 mRNA Translation: BAB22442.1 AK005525 mRNA Translation: BAB24098.1 AK008123 mRNA Translation: BAB25477.1 AK008467 mRNA Translation: BAB25685.1 AK010074 mRNA Translation: BAB26683.1 AK145949 mRNA Translation: BAE26777.1 AK149175 mRNA Translation: BAE28756.1 AK150145 mRNA Translation: BAE29340.1 AK155028 mRNA Translation: BAE33000.1 BC060986 mRNA Translation: AAH60986.1 |
CCDSi | CCDS37930.1 |
RefSeqi | NP_059071.1, NM_017375.3 |
Genome annotation databases
Ensembli | ENSMUST00000025631; ENSMUSP00000025631; ENSMUSG00000024725 |
GeneIDi | 20409 |
KEGGi | mmu:20409 |
UCSCi | uc008gxs.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U58888 mRNA Translation: AAC52641.1 Different initiation. AK002899 mRNA Translation: BAB22442.1 AK005525 mRNA Translation: BAB24098.1 AK008123 mRNA Translation: BAB25477.1 AK008467 mRNA Translation: BAB25685.1 AK010074 mRNA Translation: BAB26683.1 AK145949 mRNA Translation: BAE26777.1 AK149175 mRNA Translation: BAE28756.1 AK150145 mRNA Translation: BAE29340.1 AK155028 mRNA Translation: BAE33000.1 BC060986 mRNA Translation: AAH60986.1 |
CCDSi | CCDS37930.1 |
RefSeqi | NP_059071.1, NM_017375.3 |
3D structure databases
SMRi | Q62422 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203211, 2 interactors |
IntActi | Q62422, 1 interactor |
MINTi | Q62422 |
STRINGi | 10090.ENSMUSP00000025631 |
PTM databases
iPTMneti | Q62422 |
PhosphoSitePlusi | Q62422 |
SwissPalmi | Q62422 |
2D gel databases
UCD-2DPAGEi | Q62422 |
Proteomic databases
EPDi | Q62422 |
jPOSTi | Q62422 |
MaxQBi | Q62422 |
PaxDbi | Q62422 |
PeptideAtlasi | Q62422 |
PRIDEi | Q62422 |
Protocols and materials databases
Antibodypediai | 27176, 217 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000025631; ENSMUSP00000025631; ENSMUSG00000024725 |
GeneIDi | 20409 |
KEGGi | mmu:20409 |
UCSCi | uc008gxs.2, mouse |
Organism-specific databases
CTDi | 26578 |
MGIi | MGI:700012, Ostf1 |
Phylogenomic databases
eggNOGi | ENOG502QTZB, Eukaryota |
GeneTreei | ENSGT00920000149159 |
HOGENOMi | CLU_092255_0_0_1 |
InParanoidi | Q62422 |
OMAi | DTSDTNW |
OrthoDBi | 1453481at2759 |
PhylomeDBi | Q62422 |
TreeFami | TF314534 |
Enzyme and pathway databases
Reactomei | R-MMU-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 20409, 0 hits in 17 CRISPR screens |
ChiTaRSi | Ostf1, mouse |
PROi | PR:Q62422 |
RNActi | Q62422, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024725, Expressed in granulocyte and 300 other tissues |
ExpressionAtlasi | Q62422, baseline and differential |
Genevisiblei | Q62422, MM |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR01415, ANKYRIN PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00248, ANK, 3 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OSTF1_MOUSE | |
Accessioni | Q62422Primary (citable) accession number: Q62422 Secondary accession number(s): Q3UF05 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | December 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot