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Protein

Osteoclast-stimulating factor 1

Gene

Ostf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.By similarity

GO - Molecular functioni

  • SH3 domain binding Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Osteoclast-stimulating factor 1
Alternative name(s):
SH3 domain protein 3
Gene namesi
Name:Ostf1
Synonyms:Sh3d3, Sh3p2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:700012 Ostf1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000670362 – 215Osteoclast-stimulating factor 1Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei201PhosphothreonineCombined sources1
Modified residuei203PhosphoserineBy similarity1
Modified residuei214PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ62422
MaxQBiQ62422
PaxDbiQ62422
PeptideAtlasiQ62422
PRIDEiQ62422

2D gel databases

UCD-2DPAGEiQ62422

PTM databases

iPTMnetiQ62422
PhosphoSitePlusiQ62422

Expressioni

Gene expression databases

BgeeiENSMUSG00000024725
CleanExiMM_OSTF1
GenevisibleiQ62422 MM

Interactioni

Subunit structurei

Interacts with C-SRC and SMN1. Interacts with FASLG (By similarity).By similarity

GO - Molecular functioni

  • SH3 domain binding Source: MGI

Protein-protein interaction databases

IntActiQ62422, 1 interactor
MINTiQ62422
STRINGi10090.ENSMUSP00000025631

Structurei

3D structure databases

ProteinModelPortaliQ62422
SMRiQ62422
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 71SH3PROSITE-ProRule annotationAdd BLAST60
Repeati72 – 101ANK 1Add BLAST30
Repeati105 – 135ANK 2Add BLAST31
Repeati139 – 168ANK 3Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 11Pro-rich8

Domaini

The SH3 domain mediates interaction with SMN1.By similarity

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410IIWQ Eukaryota
ENOG410XR45 LUCA
GeneTreeiENSGT00920000149159
HOGENOMiHOG000286040
HOVERGENiHBG053379
InParanoidiQ62422
OMAiALYWGCH
OrthoDBiEOG091G0HJ5
PhylomeDBiQ62422
TreeFamiTF314534

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR01415 ANKYRIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00326 SH3, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62422-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPPPKPVK PGQVKVFRAL YTFEPRTPDE LYFEEGDIIY ITDMSDTSWW
60 70 80 90 100
KGTCKGRTGL IPSNYVAEQA ESIDNPLHEA AKRGNLSWLR ECLDNRVGVN
110 120 130 140 150
GLDKAGSTAL YWACHGGHKD IVEVLFTQPN VELNQQNKLG DTALHAAAWK
160 170 180 190 200
GYADIVQLLL AKGARTDLRN NEKKLALDMA TNAACASLLK KKQQGTDGAR
210
TLSNAEDYLD DEDSD
Length:215
Mass (Da):23,783
Last modified:December 1, 2000 - v2
Checksum:iDAB682C371929B8A
GO

Sequence cautioni

The sequence AAC52641 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58888 mRNA Translation: AAC52641.1 Different initiation.
AK002899 mRNA Translation: BAB22442.1
AK005525 mRNA Translation: BAB24098.1
AK008123 mRNA Translation: BAB25477.1
AK008467 mRNA Translation: BAB25685.1
AK010074 mRNA Translation: BAB26683.1
AK145949 mRNA Translation: BAE26777.1
AK149175 mRNA Translation: BAE28756.1
AK150145 mRNA Translation: BAE29340.1
AK155028 mRNA Translation: BAE33000.1
BC060986 mRNA Translation: AAH60986.1
CCDSiCCDS37930.1
RefSeqiNP_059071.1, NM_017375.3
UniGeneiMm.172222

Genome annotation databases

EnsembliENSMUST00000025631; ENSMUSP00000025631; ENSMUSG00000024725
GeneIDi20409
KEGGimmu:20409
UCSCiuc008gxs.2 mouse

Similar proteinsi

Entry informationi

Entry nameiOSTF1_MOUSE
AccessioniPrimary (citable) accession number: Q62422
Secondary accession number(s): Q3UF05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: July 18, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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