Sh3gl2

Functionⁱ

Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth (PubMed:21849472). Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (PubMed:21849472).2 Publications

Caution

Was originally thought to have lysophosphatidic acid acyltransferase activity, but has since been experimentally shown not to have this activity.1 Publication

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 18940612
lipid binding Source: MGI
protein C-terminus binding Source: MGI
protein homodimerization activity Source: MGI
protein kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to brain-derived neurotrophic factor stimulus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21849472
dendrite extension
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21849472
lipid tube assembly Source: MGI
membrane bending Source: MGI
membrane tubulation Source: MGI
neuron projection development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21849472
positive regulation of membrane tubulation Source: MGI
regulation of clathrin-dependent endocytosis Source: MGI
regulation of receptor internalization
Source: MGI
Inferred from direct assayⁱ
- 16164598
synaptic vesicle endocytosis
Source: MGI
Inferred from genetic interactionⁱ
- 19481455
synaptic vesicle uncoating
Source: SynGO
Inferred from genetic interactionⁱ
- 22099461
vesicle scission Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Endocytosis
Ligand	Lipid-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-177504 Retrograde neurotrophin signalling R-MMU-182971 EGFR downregulation R-MMU-2132295 MHC class II antigen presentation R-MMU-432720 Lysosome Vesicle Biogenesis R-MMU-432722 Golgi Associated Vesicle Biogenesis R-MMU-437239 Recycling pathway of L1 R-MMU-6807004 Negative regulation of MET activity R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828 Clathrin-mediated endocytosis

Reactomeⁱ

R-MMU-177504 Retrograde neurotrophin signalling
R-MMU-182971 EGFR downregulation
R-MMU-2132295 MHC class II antigen presentation
R-MMU-432720 Lysosome Vesicle Biogenesis
R-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-437239 Recycling pathway of L1
R-MMU-6807004 Negative regulation of MET activity
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Protein family/group databases

TCDBⁱ	8.A.34.1.1 the endophilin (endophilin) family

TCDBⁱ

8.A.34.1.1 the endophilin (endophilin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Endophilin-A11 Publication Alternative name(s): Endophilin-1 SH3 domain protein 2A SH3 domain-containing GRB2-like protein 2 SH3p4
Gene namesⁱ	Name:Sh3gl2 Synonyms:Een11 Publication, Sh3d2a
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 4

Organism-specific databases

MGIⁱ	MGI:700009 Sh3gl2

Keywords - Cellular componentⁱ

Cytoplasm, Endosome, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000146748	1 – 352	Endophilin-A1Add BLAST		352

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	262	PhosphoserineCombined sources		1
Modified residueⁱ	299	PhosphotyrosineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q62420
PaxDbⁱ	Q62420
PRIDEⁱ	Q62420

PTM databases

iPTMnetⁱ	Q62420
PhosphoSitePlusⁱ	Q62420
SwissPalmⁱ	Q62420

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000028488 Expressed in 227 organ(s), highest expression level in urinary bladder urothelium
CleanExⁱ	MM_SH3GL2
ExpressionAtlasⁱ	Q62420 baseline and differential
Genevisibleⁱ	Q62420 MM

Interactionⁱ

Subunit structureⁱ

Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity). Interacts with SYNJ1 and DNM1. Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation. Interacts with OPHN1 (By similarity). Interacts with PDCD6IP. Interacts with BIN2 (By similarity). Interacts with ATX2. Interacts with ADAM9 and ADAM15 cytoplasmic tails. Interacts with TMEM108 (PubMed:21849472). Inte.racts with ADGRB2 (PubMed:28891236).By similarity5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-77971,EBI-77971
Dennd1a	Q8K382	2	EBI-77971,EBI-7186684

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 18940612
protein C-terminus binding Source: MGI
protein homodimerization activity Source: MGI
protein kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	203206, 12 interactors
Database of interacting proteins More...DIPⁱ	DIP-30992N
IntActⁱ	Q62420, 15 interactors
Molecular INTeraction database More...MINTⁱ	Q62420
STRINGⁱ	10090.ENSMUSP00000030212

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	31 – 58	Combined sources	28
Turnⁱ	62 – 64	Combined sources	3
Helixⁱ	89 – 104	Combined sources	16
Beta strandⁱ	106 – 109	Combined sources	4
Helixⁱ	110 – 138	Combined sources	29
Helixⁱ	140 – 148	Combined sources	9
Helixⁱ	150 – 173	Combined sources	24
Turnⁱ	174 – 177	Combined sources	4
Helixⁱ	180 – 206	Combined sources	27
Helixⁱ	209 – 245	Combined sources	37

Show more details

3D structure databases

ProteinModelPortalⁱ	Q62420
SMRⁱ	Q62420
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q62420

EvolutionaryTraceⁱ

Q62420

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	18 – 249	BARPROSITE-ProRule annotationAdd BLAST		232
Domainⁱ	290 – 349	SH3PROSITE-ProRule annotationAdd BLAST		60

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 125	Binds and tubulates liposomesBy similarityAdd BLAST	125
Regionⁱ	1 – 21	Membrane-binding amphipathic helixBy similarityAdd BLAST	21
Regionⁱ	60 – 87	Required for dimerization upon membrane associationBy similarityAdd BLAST	28

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	181 – 248	Sequence analysisAdd BLAST		68

Domainⁱ

An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes (By similarity). The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface.By similarity1 Publication

Sequence similaritiesⁱ

Belongs to the endophilin family.Curated

Keywords - Domainⁱ

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG1118 Eukaryota ENOG410XNYB LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074464
HOGENOMⁱ	HOG000231641
HOVERGENⁱ	HBG052866
InParanoidⁱ	Q62420
KEGG Orthology (KO) More...KOⁱ	K11247
TreeFamⁱ	TF313281

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11803 SH3_Endophilin_A, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR004148 BAR_dom IPR028501 Endophilin-A IPR035824 Endophilin_A_SH3 IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
PANTHERⁱ	PTHR43965 PTHR43965, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03114 BAR, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00452 SH3DOMAIN
SMARTⁱ	View protein in SMART SM00721 BAR, 1 hit SM00326 SH3, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 1 hit SSF50044 SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS51021 BAR, 1 hit PS50002 SH3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.ⁱShow all

Q62420-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSVAGLKKQF HKATQKVSEK VGGAEGTKLD DDFKEMERKV DVTSRAVMEI 
        60         70         80         90        100
MTKTIEYLQP NPASRAKLSM INTMSKIRGQ EKGPGYPQAE ALLAEAMLKF 
       110        120        130        140        150
GRELGDDCNF GPALGEVGEA MRELSEVKDS LDMEVKQNFI DPLQNLHDKD 
       160        170        180        190        200
LREIQHHLKK LEGRRLDFDY KKKRQGKIPD EELRQALEKF DESKEIAESS 
       210        220        230        240        250
MFNLLEMDIE QVSQLSALVQ AQLEYHKQAV QILQQVTVRL EERIRQASSQ 
       260        270        280        290        300
PRREYQPKPR MSLEFATGDS TQPNGGLSHT GTPKPPGVQM DQPCCRALYD 
       310        320        330        340        350
FEPENEGELG FKEGDIITLT NQIDENWYEG MLHGQSGFFP INYVEILVAL 

PH

Length:352

Mass (Da):39,955

Last modified:October 23, 2007 - v2

Checksum:ⁱ8C2B6F0FB245DCD3

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
A2ALV3	A2ALV3_MOUSE	Endophilin-A1 Endophilin-A1	Sh3gl2	431	Annotation score:
F6ZL13	F6ZL13_MOUSE	Endophilin-A1 Endophilin-A1	Sh3gl2	231	Annotation score:
A2ALV1	A2ALV1_MOUSE	Endophilin-A1 Endophilin-A1	Sh3gl2	182	Annotation score:
Q8BXU5	Q8BXU5_MOUSE	Endophilin-A1 Endophilin-A1	Sh3gl2	245	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	28	K → N in BAC31888 (PubMed:16141072).Curated	1
Sequence conflictⁱ	54	T → K in BAE23963 (PubMed:16141072).Curated	1
Sequence conflictⁱ	69	S → G in BAE23963 (PubMed:16141072).Curated	1
Sequence conflictⁱ	169	D → G in AAC71774 (PubMed:9630982).Curated	1
Sequence conflictⁱ	301	F → L in AAC71774 (PubMed:9630982).Curated	1
Sequence conflictⁱ	310	G → A in AAC71774 (PubMed:9630982).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U58886 mRNA Translation: AAC71774.1 AF326561 mRNA Translation: AAL37407.1 AF326562 mRNA Translation: AAL37408.1 AK044370 mRNA Translation: BAC31888.1 AK134970 mRNA Translation: BAE22364.1 AK139337 mRNA Translation: BAE23963.1 AL805970, AL806524 Genomic DNA Translation: CAM24397.1 AL806524, AL805970 Genomic DNA Translation: CAM15712.1 BC018385 mRNA Translation: AAH18385.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS18303.1
NCBI Reference Sequences More...RefSeqⁱ	NP_062408.2, NM_019535.2
UniGeneⁱ	Mm.143603

Genome annotation databases

Ensemblⁱ	ENSMUST00000030212; ENSMUSP00000030212; ENSMUSG00000028488
GeneIDⁱ	20404
KEGGⁱ	mmu:20404
UCSC genome browser More...UCSCⁱ	uc008tlo.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q62420	Endophilin-A1	)	RAT		352	UniRef90_O35179
Endophilin-A1		MOUSE		431
SH3 domain containing GRB2 like 2, endophilin A1		Cebus capucinus imitator		352
endophilin-A1		Florida manatee		352
Endophilin-A1		HETGA		352
+47

Protein	Similar proteins		Species	Score	Length	Source
Q62420	Endophilin-A1	)	RAT		352	UniRef50_O35179
Endophilin-A2		CHICK		367
Endophilin-A2		HUMAN		368
Endophilin-A2		MOUSE		368
Endophilin-A2		BOVIN		368
+737

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U58886 mRNA Translation: AAC71774.1 AF326561 mRNA Translation: AAL37407.1 AF326562 mRNA Translation: AAL37408.1 AK044370 mRNA Translation: BAC31888.1 AK134970 mRNA Translation: BAE22364.1 AK139337 mRNA Translation: BAE23963.1 AL805970, AL806524 Genomic DNA Translation: CAM24397.1 AL806524, AL805970 Genomic DNA Translation: CAM15712.1 BC018385 mRNA Translation: AAH18385.1
CCDSⁱ	CCDS18303.1
RefSeqⁱ	NP_062408.2, NM_019535.2
UniGeneⁱ	Mm.143603

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1ZWW	X-ray	2.30	A/B	1-256	[»]
ProteinModelPortalⁱ	Q62420
SMRⁱ	Q62420
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	203206, 12 interactors
DIPⁱ	DIP-30992N
IntActⁱ	Q62420, 15 interactors
MINTⁱ	Q62420
STRINGⁱ	10090.ENSMUSP00000030212

Protein family/group databases

TCDBⁱ	8.A.34.1.1 the endophilin (endophilin) family

TCDBⁱ

8.A.34.1.1 the endophilin (endophilin) family

PTM databases

iPTMnetⁱ	Q62420
PhosphoSitePlusⁱ	Q62420
SwissPalmⁱ	Q62420

Proteomic databases

MaxQBⁱ	Q62420
PaxDbⁱ	Q62420
PRIDEⁱ	Q62420

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000030212; ENSMUSP00000030212; ENSMUSG00000028488
GeneIDⁱ	20404
KEGGⁱ	mmu:20404
UCSCⁱ	uc008tlo.1 mouse

Organism-specific databases

CTDⁱ	6456
MGIⁱ	MGI:700009 Sh3gl2

Phylogenomic databases

eggNOGⁱ	KOG1118 Eukaryota ENOG410XNYB LUCA
GeneTreeⁱ	ENSGT00550000074464
HOGENOMⁱ	HOG000231641
HOVERGENⁱ	HBG052866
InParanoidⁱ	Q62420
KOⁱ	K11247
TreeFamⁱ	TF313281

Enzyme and pathway databases

Reactomeⁱ	R-MMU-177504 Retrograde neurotrophin signalling R-MMU-182971 EGFR downregulation R-MMU-2132295 MHC class II antigen presentation R-MMU-432720 Lysosome Vesicle Biogenesis R-MMU-432722 Golgi Associated Vesicle Biogenesis R-MMU-437239 Recycling pathway of L1 R-MMU-6807004 Negative regulation of MET activity R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828 Clathrin-mediated endocytosis

Reactomeⁱ

R-MMU-177504 Retrograde neurotrophin signalling
R-MMU-182971 EGFR downregulation
R-MMU-2132295 MHC class II antigen presentation
R-MMU-432720 Lysosome Vesicle Biogenesis
R-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-437239 Recycling pathway of L1
R-MMU-6807004 Negative regulation of MET activity
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRSⁱ	Sh3gl2 mouse
EvolutionaryTraceⁱ	Q62420
Protein Ontology More...PROⁱ	PR:Q62420
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000028488 Expressed in 227 organ(s), highest expression level in urinary bladder urothelium
CleanExⁱ	MM_SH3GL2
ExpressionAtlasⁱ	Q62420 baseline and differential
Genevisibleⁱ	Q62420 MM

Family and domain databases

CDDⁱ	cd11803 SH3_Endophilin_A, 1 hit
Gene3Dⁱ	1.20.1270.60, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR004148 BAR_dom IPR028501 Endophilin-A IPR035824 Endophilin_A_SH3 IPR036028 SH3-like_dom_sf IPR001452 SH3_domain
PANTHERⁱ	PTHR43965 PTHR43965, 1 hit
Pfamⁱ	View protein in Pfam PF03114 BAR, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00452 SH3DOMAIN
SMARTⁱ	View protein in SMART SM00721 BAR, 1 hit SM00326 SH3, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 1 hit SSF50044 SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS51021 BAR, 1 hit PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SH3G2_MOUSE
Accessionⁱ	Q62420Primary (citable) accession number: Q62420 Secondary accession number(s): Q3UTL7 , Q3UY49, Q8BXS6, Q8VBV1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	October 23, 2007
	Last modified:	September 12, 2018
	This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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Supporting data

UniProtKB - Q62420 (SH3G2_MOUSE)

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Endophilin-A1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Other locations

Cytosol

Endosome

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ