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Entry version 160 (13 Feb 2019)
Sequence version 2 (16 May 2006)
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Protein

Striated muscle-specific serine/threonine-protein kinase

Gene

Speg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.

Miscellaneous

Expression is under the tight control of the locus control region (LCRs).

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1635ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1724Proton acceptorBy similarity1
Active sitei3080Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1612 – 1620ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: GO_Central
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Striated muscle-specific serine/threonine-protein kinase (EC:2.7.11.1)
Alternative name(s):
Aortic preferentially expressed protein 1
Short name:
APEG-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Speg
Synonyms:Apeg1, Kiaa1297
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109282 Speg

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice lacking SPEG demonstrate dilation of right and left atria and ventricles, cardiac hypertrophy, myofibril degeneration, and a marked decrease in cardiac function. Moreover, mutant mice exhibit significant neonatal mortality.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000726671 – 3262Striated muscle-specific serine/threonine-protein kinaseAdd BLAST3262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei33Omega-N-methylarginineCombined sources1
Modified residuei141PhosphoserineBy similarity1
Modified residuei368PhosphoserineBy similarity1
Modified residuei375PhosphoserineCombined sources1
Modified residuei379PhosphothreonineCombined sources1
Modified residuei382PhosphoserineCombined sources1
Modified residuei385PhosphoserineBy similarity1
Modified residuei423PhosphoserineBy similarity1
Modified residuei453PhosphothreonineCombined sources1
Modified residuei457PhosphoserineCombined sources1
Modified residuei463PhosphoserineBy similarity1
Modified residuei493PhosphoserineBy similarity1
Modified residuei511PhosphoserineBy similarity1
Modified residuei531PhosphoserineCombined sources1
Modified residuei554PhosphoserineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi994 ↔ 1046PROSITE-ProRule annotation
Modified residuei1133PhosphoserineCombined sources1
Modified residuei1177PhosphoserineCombined sources1
Disulfide bondi1413 ↔ 1469PROSITE-ProRule annotation
Modified residuei1993PhosphoserineCombined sources1
Modified residuei2004PhosphoserineCombined sources1
Modified residuei2019PhosphoserineCombined sources1
Modified residuei2020PhosphoserineCombined sources1
Modified residuei2042PhosphoserineBy similarity1
Modified residuei2060Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei2060Omega-N-methylarginine; alternateCombined sources1
Modified residuei2114PhosphoserineBy similarity1
Modified residuei2135PhosphoserineBy similarity1
Modified residuei2144Omega-N-methylarginineCombined sources1
Modified residuei2182PhosphoserineBy similarity1
Modified residuei2207PhosphoserineBy similarity1
Modified residuei2379PhosphoserineCombined sources1
Modified residuei2383PhosphothreonineCombined sources1
Modified residuei2413PhosphoserineBy similarity1
Modified residuei2417PhosphoserineBy similarity1
Modified residuei2441PhosphoserineBy similarity1
Modified residuei2442PhosphoserineCombined sources1
Modified residuei2447PhosphoserineCombined sources1
Modified residuei2451PhosphoserineCombined sources1
Modified residuei2524PhosphoserineCombined sources1
Modified residuei2527PhosphoserineCombined sources1
Modified residuei2562PhosphoserineBy similarity1
Disulfide bondi2608 ↔ 2660PROSITE-ProRule annotation
Modified residuei2774PhosphothreonineCombined sources1
Modified residuei2777PhosphoserineBy similarity1
Modified residuei2944PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be autophosphorylated.1 Publication

Keywords - PTMi

Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62407

PeptideAtlas

More...
PeptideAtlasi
Q62407

PRoteomics IDEntifications database

More...
PRIDEi
Q62407

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62407

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62407

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis. Isoform 1 and isoform 4 are expressed in cardiomyocytes of the developing heart.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Isoform 3 is quickly down-regulated in response to vascular injury, when ASMC cells change from a quiescent to a proliferative phenotype.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026207 Expressed in 281 organ(s), highest expression level in ascending aorta

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q62407 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q62407 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MTM1 (By similarity). Isoform 3 is found as a monomer or homodimer.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
198144, 1 interactor

Protein interaction database and analysis system

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IntActi
Q62407, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000084361

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q62407

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 126Ig-like 1Add BLAST82
Domaini727 – 815Ig-like 2Add BLAST89
Domaini874 – 963Ig-like 3Add BLAST90
Domaini968 – 1062Ig-like 4Add BLAST95
Domaini1069 – 1157Ig-like 5Add BLAST89
Domaini1193 – 1283Ig-like 6Add BLAST91
Domaini1290 – 1387Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST98
Domaini1389 – 1485Ig-like 7Add BLAST97
Domaini1490 – 1578Ig-like 8Add BLAST89
Domaini1606 – 1859Protein kinase 1PROSITE-ProRule annotationAdd BLAST254
Domaini2586 – 2676Ig-like 9Add BLAST91
Domaini2683 – 2777Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95
Domaini2865 – 2968Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST104
Domaini2946 – 3213Protein kinase 2PROSITE-ProRule annotationAdd BLAST268

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi277 – 348Pro-richAdd BLAST72
Compositional biasi530 – 639Pro-richAdd BLAST110
Compositional biasi1924 – 1929Poly-Ser6
Compositional biasi1930 – 1936Poly-Glu7
Compositional biasi2180 – 2320Pro-richAdd BLAST141
Compositional biasi2775 – 2962Pro-richAdd BLAST188
Compositional biasi3241 – 3244Poly-Arg4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0032 Eukaryota
KOG0613 Eukaryota
ENOG410XQFD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161126

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG083339

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q62407

KEGG Orthology (KO)

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KOi
K08809

Identification of Orthologs from Complete Genome Data

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OMAi
PDANERG

Database of Orthologous Groups

More...
OrthoDBi
7796at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q62407

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 11 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR015726 Ser/Thr_kin_striated-sp
IPR008271 Ser/Thr_kinase_AS

The PANTHER Classification System

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PANTHERi
PTHR45065 PTHR45065, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF07679 I-set, 8 hits
PF00069 Pkinase, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 9 hits
SM00408 IGc2, 8 hits
SM00220 S_TKc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 9 hits
SSF49265 SSF49265, 1 hit
SSF56112 SSF56112, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 8 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00108 PROTEIN_KINASE_ST, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q62407-1) [UniParc]FASTAAdd to basket
Also known as: SPEG-beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQKARGTRGE DAGTRAPPSP GVPPKRAKVG AGRGVLVTGD GAGAPVFLRP
60 70 80 90 100
LKNAAVCAGS DVRLRVVVSG TPQPSLSWFR DGQLLPPPAP EPSCLWLRSC
110 120 130 140 150
GAQDAGVYSC SAQNERGQAS CEAVLTVLEV RDSETAEDDI SDVPGTQRLE
160 170 180 190 200
LRDDRAFSTP TGGSDTLVGT SLDTPPTSVT GTSEEQVSWW GSGQTVLEQE
210 220 230 240 250
AGSGGGTRPL PGSPRQAQTT GAGPRHLGVE PLVRASRANL VGASWGSEDS
260 270 280 290 300
LSVASDLYGS AFSLYRGRAL SIHVSIPPSG LHREEPDLQP QPASDALRPR
310 320 330 340 350
PALPPPSKSA LLPPPSPRVG KRALPGPSTQ PPATPTSPHR RAQEPSLPED
360 370 380 390 400
ITTTEEKRGK KPKSSGPSLA GTVESRPQTP LSEASGRLSA LGRSPRLVRA
410 420 430 440 450
GSRILDKLQF FEERRRSLER SDSPPAPLRP WVPLRKARSL EQPKSEGGAA
460 470 480 490 500
WGTPEASQEE LRSPRGSVAE RRRLFQQKAA SLDERTRQRS ATSDLELRFA
510 520 530 540 550
QELGRIRRST SREELVRSHE SLRATLQRAP SPREPGEPPL FSRPSTPKTS
560 570 580 590 600
RAVSPAATQP PPPSGAGKSG DEPGRPRSRG PVGRTEPGEG PQQEIKRRDQ
610 620 630 640 650
FPLTRSRAIQ ECRSPVPPYT ADPPESRTKA PSGRKREPPA QAVRFLPWAT
660 670 680 690 700
PGVEDSVLPQ TLEKNRAGPE AEKRLRRGPE EDGPWGPWDR RGTRSQGKGR
710 720 730 740 750
RARPTSPELE SSDDSYVSAG EEPLEAPVFE IPLQNMVVAP GADVLLKCII
760 770 780 790 800
TANPPPQVSW KKDGSMLHSE GRLLIRAEGE RHTLLLREAQ AADAGSYTAT
810 820 830 840 850
ATNELGQATC ASSLAVRPGG STSPFSSPIT SDEEYLSPPE EFPEPGETWP
860 870 880 890 900
RTPTMKLSPS QDHDSSDSSS KAPPTFKVSL MDQSVREGQD VIMSIRVQGE
910 920 930 940 950
PKPVVSWLRN RQPVRPDQRR FAEEAEGGLC RLRILAAERG DAGFYTCKAV
960 970 980 990 1000
NEYGARQCEA RLEVRAHPES RSLAVLAPLQ DVDVGAGEMA LFECLVAGPA
1010 1020 1030 1040 1050
DVEVDWLCRG RLLQPALLKC KMHFDGRKCK LLLTSVHEDD SGVYTCKLST
1060 1070 1080 1090 1100
AKDELTCSAR LTVRPSLAPL FTRLLEDVEV LEGRAARLDC KISGTPPPSV
1110 1120 1130 1140 1150
TWTHFGHPVN EGDNLRLRQD GGLHSLHIAR VGSEDEGLYE VSATNTHGQA
1160 1170 1180 1190 1200
HCSAQLYVEE PRTAASGPSS KLEKMPSIPE EPEHGDLERL SIPDFLRPLQ
1210 1220 1230 1240 1250
DLEVGLAKEA MLECQVTGLP YPTISWFHNG HRIQSSDDRR MTQYRDIHRL
1260 1270 1280 1290 1300
VFPAVGPQHA GVYKSVIANK LGKAACYAHL YVTDVVPGPP DGAPEVVAVT
1310 1320 1330 1340 1350
GRMVTLSWNP PRSLDMAIDP DSLTYTVQHQ VLGSDQWTAL VTGLREPAWA
1360 1370 1380 1390 1400
ATGLKKGIQH IFRVLSSSGK SSSKPSAPSE PVQLLEHGPP LEEAPAVLDK
1410 1420 1430 1440 1450
QDIVYVVEGQ PACVTVTFNH VEAQVVWRSC RGALLEARTG VYELSQPDDD
1460 1470 1480 1490 1500
QYCLRICRVS RRDLGPLTCS ARNRHGTKAC SVTLELAEAP RFESIMEDVE
1510 1520 1530 1540 1550
VGPGETARFA VVVEGKPLPD IMWYKDEVLL AESNHVSFVY EENECSLVLL
1560 1570 1580 1590 1600
SAGSQDGGVY TCTARNLAGE VSCKAELSVL SAQTAMEVEG VGEDEEHRGR
1610 1620 1630 1640 1650
RLSDYYDIHQ EIGRGAFSYL RRVVERSSGL EFAAKFIPSQ AKPKASARRE
1660 1670 1680 1690 1700
ARLLARLQHG CVLYFHEAFE RRRGLVIVTE LCTEELLERM ARKPTVCESE
1710 1720 1730 1740 1750
TRTYMRQVLE GICYLHQSHV LHLDVKPENL LVWDGAGGEE QVRICDFGNA
1760 1770 1780 1790 1800
QELTPGEPQY CQYGTPEFVA PEIVNQSPVS GVTDIWPVGV VAFLCLTGIS
1810 1820 1830 1840 1850
PFVGENDRTT LMNIRNYNVA FEETTFLSLS REARGFLIKV LVQDRLRPTA
1860 1870 1880 1890 1900
EETLEHPWFK TEAKGAEVST DHLKLFLSRR RWQRSQISYK CHLVLRPIPE
1910 1920 1930 1940 1950
LLRAPPERVW VAMPRRQPPS GGLSSSSDSE EEELEELPSV PRPLQPEFSG
1960 1970 1980 1990 2000
SRVSLTDIPT EDEALGTPEA GAATPMDWQE QERTPSKDQE APSPEALPSP
2010 2020 2030 2040 2050
GQESPDGPSP RRPELRRGSS AESALPRVGS REPGRSLHKA ASVELPQRRS
2060 2070 2080 2090 2100
PSPGATRLTR GGLGEGEYAQ RLQALRQRLL RGGPEDGKVS GLRGPLLESL
2110 2120 2130 2140 2150
GGRARDPRMA RAASSEAAPH HQPPPESRGL QKSSSFSQGE AEPRGRHRRA
2160 2170 2180 2190 2200
GAPLEIPVAR LGARRLQESP SLSALSETQP PSPARPSVPK LSITKSPEPS
2210 2220 2230 2240 2250
AVTSRDSPQP PEPQPVPEKV PEPKPEPVRA AKPAQPPLAL QMPTQPLTPY
2260 2270 2280 2290 2300
AQIMQSLQLS SPTLSPQDPA VPPSEPKPHA AVFARVASPP PGVSEKRVPS
2310 2320 2330 2340 2350
ARTPPVLAEK ARVPTVPPRP GSSLSGSIEN LESEAVFEAK FKRSRESPLS
2360 2370 2380 2390 2400
RGLRLLSRSR SEERGPFRGA EDDGIYRPSP AGTPLELVRR PERSRSVQDL
2410 2420 2430 2440 2450
RVAGEPGLVR RLSLSLSQKL RRTPPGQRHP AWESRSGDGE SSEGGSSARA
2460 2470 2480 2490 2500
SPVLAVRRRL SSTLERLSSR LQRSGSSEDS GGASGRSTPL FGRLRRATSE
2510 2520 2530 2540 2550
GESLRRLGVP HNQLGSQTGA TTPSAESLGS EASGTSGSSA PGESRSRHRW
2560 2570 2580 2590 2600
GLSRLRKDKG LSQPNLSSSV QEDLGHQYVP SESDFPPVFH IKLKDQVLLE
2610 2620 2630 2640 2650
GEAATLLCLP AACPAPRISW MKDKQSLRSE PSVVIVSCKD GRQLLSIPRA
2660 2670 2680 2690 2700
GKRHAGLYEC SATNVLGSIT SSCTVAVARI PGKLAPPEVP QTYHDTALVV
2710 2720 2730 2740 2750
WKPGDGRAPC TYTLERRVDG ESVWHPVSSG IPDCYYNVTQ LPVGVTVRFR
2760 2770 2780 2790 2800
VACSNRAGQG PFSNPSEKVF IRGTPDSPAQ PAAAPRDAPV TSGPTRAPPP
2810 2820 2830 2840 2850
DSPTSLAPTP ALAPPASQAS TLSPSTSSMS ANQALSSLKA VGPPPATPPR
2860 2870 2880 2890 2900
KHRGLLATQQ AEPSPPSIVV TPSEPRSFVP DTGTLTPTSS PQGVKPAPSS
2910 2920 2930 2940 2950
TSLYMVTSFV SAPPAPQAPA PEPPPEPTKV TVRSLSPAKE VVSSPTPEST
2960 2970 2980 2990 3000
TLRQGPPQKP YTFLEEKARG RFGVVRSCRE NATGRTFVAK IVPYAAEGKR
3010 3020 3030 3040 3050
RVLQEYEVLR TLHHERLMSL HEAYITPRYL VLIAESCGNR ELLCGLSDRF
3060 3070 3080 3090 3100
RYSEDDVATY VVQLLQGLDY LHGHHVLHLD IKPDNLLLAA DNALKIVDFG
3110 3120 3130 3140 3150
SAQPYNPQAL KPLGHRTGTL EFMAPEMVKG DPIGSATDIW GAGVLTYIML
3160 3170 3180 3190 3200
SGYSPFYEPD PQETEARIVG GRFDAFQLYP NTSQSATLFL RKVLSVHPWS
3210 3220 3230 3240 3250
RPSLQDCLAH PWLQDAYLMK LRRQTLTFTT NRLKEFLGEQ RRRRAEAATR
3260
HKVLLRSYPG SP
Length:3,262
Mass (Da):354,343
Last modified:May 16, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0387BDD6518B7BB7
GO
Isoform 2 (identifier: Q62407-2) [UniParc]FASTAAdd to basket
Also known as: BPEG

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.
     107-131: VYSCSAQNERGQASCEAVLTVLEVR → MKKLWVKKRFQKTGHSRRAFGRLTH
     966-967: AH → GE
     968-3262: Missing.

Show »
Length:861
Mass (Da):93,689
Checksum:iEA162A24DDC7C597
GO
Isoform 3 (identifier: Q62407-3) [UniParc]FASTAAdd to basket
Also known as: APEG1

The sequence of this isoform differs from the canonical sequence as follows:
     1-854: Missing.
     966-967: AH → GE

Note: Produced by alternative promoter usage.
Show »
Length:2,408
Mass (Da):262,876
Checksum:i639C18C8D114F389
GO
Isoform 4 (identifier: Q62407-4) [UniParc]FASTAAdd to basket
Also known as: SPEG-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-854: Missing.

Note: No experimental confirmation available. Produced by alternative promoter usage.
Show »
Length:2,408
Mass (Da):262,899
Checksum:i9086EDEF4F90F288
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QQ25E9QQ25_MOUSE
Striated muscle-specific serine/thr...
Speg
3,262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J1J0A0A0R4J1J0_MOUSE
SPEG complex locus, isoform CRA_a
Speg mCG_133866
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WSE3A0A087WSE3_MOUSE
Striated muscle-specific serine/thr...
Speg
3,010Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z7T0D3Z7T0_MOUSE
Striated muscle-specific serine/thr...
Speg
301Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RU40F6RU40_MOUSE
Striated muscle-specific serine/thr...
Speg
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RI69D6RI69_MOUSE
Striated muscle-specific serine/thr...
Speg
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG34791 differs from that shown. Reason: Frameshift at positions 2957 and 2992.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3237L → R in BAC65770 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0182641 – 854Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST854
Alternative sequenceiVSP_0182651 – 106Missing in isoform 2. 3 PublicationsAdd BLAST106
Alternative sequenceiVSP_018266107 – 131VYSCS…VLEVR → MKKLWVKKRFQKTGHSRRAF GRLTH in isoform 2. 3 PublicationsAdd BLAST25
Alternative sequenceiVSP_018267966 – 967AH → GE in isoform 2 and isoform 3. 4 Publications2
Alternative sequenceiVSP_018268968 – 3262Missing in isoform 2. 3 PublicationsAdd BLAST2295

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U57098 mRNA Translation: AAC52666.1
AF215896 mRNA Translation: AAG34791.1 Frameshift.
AK035543 mRNA Translation: BAC29098.1
AK164360 mRNA Translation: BAE37758.1
BC048698 mRNA Translation: AAH48698.3
BC062643 mRNA Translation: AAH62643.1
AK122488 mRNA Translation: BAC65770.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35626.1 [Q62407-1]
CCDS48292.1 [Q62407-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001078839.1, NM_001085370.1
NP_001078840.1, NM_001085371.1 [Q62407-2]
NP_001166948.1, NM_001173477.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.275397

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000113590; ENSMUSP00000109220; ENSMUSG00000026207 [Q62407-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11790

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:11790

UCSC genome browser

More...
UCSCi
uc007bpa.1 mouse [Q62407-2]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57098 mRNA Translation: AAC52666.1
AF215896 mRNA Translation: AAG34791.1 Frameshift.
AK035543 mRNA Translation: BAC29098.1
AK164360 mRNA Translation: BAE37758.1
BC048698 mRNA Translation: AAH48698.3
BC062643 mRNA Translation: AAH62643.1
AK122488 mRNA Translation: BAC65770.1
CCDSiCCDS35626.1 [Q62407-1]
CCDS48292.1 [Q62407-2]
RefSeqiNP_001078839.1, NM_001085370.1
NP_001078840.1, NM_001085371.1 [Q62407-2]
NP_001166948.1, NM_001173477.1
UniGeneiMm.275397

3D structure databases

ProteinModelPortaliQ62407
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198144, 1 interactor
IntActiQ62407, 2 interactors
STRINGi10090.ENSMUSP00000084361

PTM databases

iPTMnetiQ62407
PhosphoSitePlusiQ62407

Proteomic databases

PaxDbiQ62407
PeptideAtlasiQ62407
PRIDEiQ62407

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113590; ENSMUSP00000109220; ENSMUSG00000026207 [Q62407-2]
GeneIDi11790
KEGGimmu:11790
UCSCiuc007bpa.1 mouse [Q62407-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10290
MGIiMGI:109282 Speg

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
KOG0613 Eukaryota
ENOG410XQFD LUCA
GeneTreeiENSGT00940000161126
HOVERGENiHBG083339
InParanoidiQ62407
KOiK08809
OMAiPDANERG
OrthoDBi7796at2759
PhylomeDBiQ62407

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Speg mouse

Protein Ontology

More...
PROi
PR:Q62407

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026207 Expressed in 281 organ(s), highest expression level in ascending aorta
ExpressionAtlasiQ62407 baseline and differential
GenevisibleiQ62407 MM

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 11 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR015726 Ser/Thr_kin_striated-sp
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR45065 PTHR45065, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 8 hits
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 9 hits
SM00408 IGc2, 8 hits
SM00220 S_TKc, 2 hits
SUPFAMiSSF48726 SSF48726, 9 hits
SSF49265 SSF49265, 1 hit
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 8 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS00108 PROTEIN_KINASE_ST, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPEG_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62407
Secondary accession number(s): Q3TPH8
, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 16, 2006
Last modified: February 13, 2019
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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