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Protein

C-C motif chemokine 12

Gene

Ccl12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.

GO - Molecular functioni

  • CCR2 chemokine receptor binding Source: BHF-UCL
  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: GO_Central
  • phospholipase activator activity Source: Ensembl
  • protein kinase activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 12
Alternative name(s):
MCP-1-related chemokine
Monocyte chemoattractant protein 5
Monocyte chemotactic protein 5
Short name:
MCP-5
Small-inducible cytokine A12
Gene namesi
Name:Ccl12
Synonyms:Mcp5, Scya12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:108224 Ccl12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000000519923 – 104C-C motif chemokine 12Add BLAST82

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 58By similarity
Disulfide bondi34 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ62401
PeptideAtlasiQ62401
PRIDEiQ62401

Expressioni

Tissue specificityi

Predominantly expressed in the lymph nodes and thymus. Also found in the salivary glands containing lymph nodes, breast, heart, lung, brain, small intestine, kidney and colon.

Inductioni

By interferon gamma and lipopolysaccharides (LPS).

Gene expression databases

BgeeiENSMUSG00000035352 Expressed in 91 organ(s), highest expression level in spinal cord
CleanExiMM_CCL12
ExpressionAtlasiQ62401 baseline and differential
GenevisibleiQ62401 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000194

Structurei

3D structure databases

ProteinModelPortaliQ62401
SMRiQ62401
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036686
HOVERGENiHBG017871
InParanoidiQ62401
KOiK14624
OMAiCCFSTIN
OrthoDBiEOG091G14KV
PhylomeDBiQ62401
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62401-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKISTLLCLL LIATTISPQV LAGPDAVSTP VTCCYNVVKQ KIHVRKLKSY
60 70 80 90 100
RRITSSQCPR EAVIFRTILD KEICADPKEK WVKNSINHLD KTSQTFILEP

SCLG
Length:104
Mass (Da):11,659
Last modified:November 1, 1997 - v1
Checksum:i8D102F4FF4CC3DBF
GO

Polymorphismi

The polymorphism in strain SJL/J may be associated with severity of clinical symptoms of experimental allergic encephalomyelitis, an animal model of multiple sclerosis, and susceptibility to the monophasic remitting/nonrelapsing form of the disease.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti94 – 104QTFILEPSCLG → RT in strain: SJL/J. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50712 mRNA Translation: AAB50053.1
U66670 mRNA Translation: AAB49424.1
AF065934 mRNA Translation: AAF15384.1
AF065935 mRNA Translation: AAF15385.1
AF065936 mRNA Translation: AAF15386.1
AF065937 mRNA Translation: AAF15387.1
AF065938 mRNA Translation: AAF15388.1
BC027520 mRNA Translation: AAH27520.1
CCDSiCCDS36247.1
RefSeqiNP_035461.2, NM_011331.2
UniGeneiMm.867

Genome annotation databases

EnsembliENSMUST00000000194; ENSMUSP00000000194; ENSMUSG00000035352
GeneIDi20293
KEGGimmu:20293
UCSCiuc007kms.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50712 mRNA Translation: AAB50053.1
U66670 mRNA Translation: AAB49424.1
AF065934 mRNA Translation: AAF15384.1
AF065935 mRNA Translation: AAF15385.1
AF065936 mRNA Translation: AAF15386.1
AF065937 mRNA Translation: AAF15387.1
AF065938 mRNA Translation: AAF15388.1
BC027520 mRNA Translation: AAH27520.1
CCDSiCCDS36247.1
RefSeqiNP_035461.2, NM_011331.2
UniGeneiMm.867

3D structure databases

ProteinModelPortaliQ62401
SMRiQ62401
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000194

Proteomic databases

PaxDbiQ62401
PeptideAtlasiQ62401
PRIDEiQ62401

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000194; ENSMUSP00000000194; ENSMUSG00000035352
GeneIDi20293
KEGGimmu:20293
UCSCiuc007kms.1 mouse

Organism-specific databases

CTDi20293
MGIiMGI:108224 Ccl12

Phylogenomic databases

eggNOGiENOG410J1ST Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036686
HOVERGENiHBG017871
InParanoidiQ62401
KOiK14624
OMAiCCFSTIN
OrthoDBiEOG091G14KV
PhylomeDBiQ62401
TreeFamiTF334888

Miscellaneous databases

PROiPR:Q62401
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035352 Expressed in 91 organ(s), highest expression level in spinal cord
CleanExiMM_CCL12
ExpressionAtlasiQ62401 baseline and differential
GenevisibleiQ62401 MM

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL12_MOUSE
AccessioniPrimary (citable) accession number: Q62401
Secondary accession number(s): Q9QYD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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