Phlda1

Functionⁱ

Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. Required for TCR-induced apoptosis and expression of TNFRSF6/FAS in a T-cell hybridoma cell line. May be involved in translational regulation.2 Publications

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
FasL biosynthetic process
Source: MGI
Inferred from direct assayⁱ
- 8673705
positive regulation of apoptotic process Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis

Biological process

Apoptosis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-8854521 Interaction between PHLDA1 and AURKA

Reactomeⁱ

R-MMU-8854521 Interaction between PHLDA1 and AURKA

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pleckstrin homology-like domain family A member 1 Alternative name(s): Proline- and glutamine-rich protein Short name: PQ-rich protein Short name: PQR protein T-cell death-associated gene 51 protein
Gene namesⁱ	Name:Phlda1 Synonyms:Tdag51
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:1096880 Phlda1

Keywords - Cellular componentⁱ

Cytoplasm, Cytoplasmic vesicle, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053898	1 – 405	Pleckstrin homology-like domain family A member 1Add BLAST		405

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q62392
PaxDbⁱ	Q62392
PeptideAtlas More...PeptideAtlasⁱ	Q62392
PRIDEⁱ	Q62392

PTM databases

iPTMnetⁱ	Q62392
PhosphoSitePlusⁱ	Q62392

Expressionⁱ

Tissue specificityⁱ

Widely expressed with very high levels in adult liver and high levels in adult lung. According to PubMed:10428057 expressed at low levels in liver. Expressed at increased levels in atherosclerotic lesions observed in hyperhomocysteinema.3 Publications

Inductionⁱ

Induced by IGF-I.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000020205 Expressed in 325 organ(s), highest expression level in saliva-secreting gland
Genevisibleⁱ	Q62392 MM

Interactionⁱ

Subunit structureⁱ

Interacts with RPL14, EIF3S7 and PABPC4.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DNAJB1	P25685	2	EBI-309727,EBI-357034	From Homo sapiens.
HSPA1B	P08107	2	EBI-309727,EBI-629985	From a different organism.
HSPH1	Q92598	2	EBI-309727,EBI-356829	From Homo sapiens.

Protein-protein interaction databases

IntActⁱ	Q62392, 4 interactors
Molecular INTeraction database More...MINTⁱ	Q62392
STRINGⁱ	10090.ENSMUSP00000132815

Structureⁱ

3D structure databases

SMRⁱ	Q62392
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	153 – 277	PHAdd BLAST		125

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	309 – 344	16 X 2 AA repeats of P-QAdd BLAST		36
Regionⁱ	354 – 377	11 X 2 AA repeats of P-HAdd BLAST		24

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	189 – 198	Poly-Gln		10

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IXHQ Eukaryota ENOG4111IXF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000039564
HOGENOMⁱ	HOG000171183
HOVERGENⁱ	HBG108249
InParanoidⁱ	Q62392
OMAⁱ	QPHGHRL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FTL
PhylomeDBⁱ	Q62392
TreeFamⁱ	TF332320

Family and domain databases

InterProⁱ	View protein in InterPro IPR001849 PH_domain
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q62392-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRRTPAAERL SELGFPPRRG RQEPPFPLGV TRGWGGWPIE KRREGPRPVP 
        60         70         80         90        100
FSERSPEDGR EQPAHGSGIL WRVRTRLSLC RDPEPPPPPP PLCLLRVSLL 
       110        120        130        140        150
CALRAGGRGS RWGEDGAGLL LLPPAGASGS LKAERSSSTP YAGRMLENSG 
       160        170        180        190        200
CKALKEGVLE KRSDGLLQLW KKKCCILTEE GLLLIPPKQL QQQQQQQQPG 
       210        220        230        240        250
QGTAEPSQPS GPTVASLEPP VKLKELHFSN MKTVDCVERK GKYMYFTVVM 
       260        270        280        290        300
TEGKEIDFRC PQDQGWNAEI TLQMVQYKNR QAILAVKSTR QKQQHLVQQQ 
       310        320        330        340        350
PPQTQQIQPQ PQPQIQPQPQ PQIQPQPQPQ PQPQPQPQPQ PQPQQLHSYP 
       360        370        380        390        400
HPHPHPYSHP HQHPHPHPHP HPHPHPHPYQ LQHAHQPLHS QPQGHRLLRS 

TSNSA

Length:405

Mass (Da):45,583

Last modified:May 5, 2009 - v2

Checksum:ⁱ87F50D81EFC44C55

GO

Sequence cautionⁱ

The sequence AAC52674 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH10295 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAE34715 differs from that shown. Reason: Frameshift at position 176.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	209	P → R in BAE28322 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U44088 mRNA Translation: AAC52674.1 Different initiation. AK148063 mRNA Translation: BAE28322.1 AK158890 mRNA Translation: BAE34715.1 Sequence problems. BC010295 mRNA Translation: AAH10295.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24167.2
NCBI Reference Sequences More...RefSeqⁱ	NP_033370.2, NM_009344.3
UniGeneⁱ	Mm.3117

Genome annotation databases

Ensemblⁱ	ENSMUST00000164773; ENSMUSP00000132815; ENSMUSG00000020205
GeneIDⁱ	21664
KEGGⁱ	mmu:21664
UCSC genome browser More...UCSCⁱ	uc007haf.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q62392	Pleckstrin homology-like domain family A member 1		RAT		407	UniRef90_Q62392
pleckstrin homology-like domain family A member 1		MESAU		407
UPI000A310BF6		MUSPA		420
UPI00038C57E8		MICOH		417
UPI000A31615D		MUSCR		414
+1

Protein	Similar proteins		Species	Score	Length	Source
Q62392	Pleckstrin homology-like domain family A member 1		HUMAN		401	UniRef50_Q8WV24
Pleckstrin homology-like domain family A member 1		RAT		407
Uncharacterized protein		AOTNA		421
Uncharacterized protein		MACMU		415
Uncharacterized protein		MACFA		407
+102

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U44088 mRNA Translation: AAC52674.1 Different initiation. AK148063 mRNA Translation: BAE28322.1 AK158890 mRNA Translation: BAE34715.1 Sequence problems. BC010295 mRNA Translation: AAH10295.1 Different initiation.
CCDSⁱ	CCDS24167.2
RefSeqⁱ	NP_033370.2, NM_009344.3
UniGeneⁱ	Mm.3117

3D structure databases

SMRⁱ	Q62392
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q62392, 4 interactors
MINTⁱ	Q62392
STRINGⁱ	10090.ENSMUSP00000132815

PTM databases

iPTMnetⁱ	Q62392
PhosphoSitePlusⁱ	Q62392

Proteomic databases

MaxQBⁱ	Q62392
PaxDbⁱ	Q62392
PeptideAtlasⁱ	Q62392
PRIDEⁱ	Q62392

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000164773; ENSMUSP00000132815; ENSMUSG00000020205
GeneIDⁱ	21664
KEGGⁱ	mmu:21664
UCSCⁱ	uc007haf.2 mouse

Organism-specific databases

CTDⁱ	22822
MGIⁱ	MGI:1096880 Phlda1

Phylogenomic databases

eggNOGⁱ	ENOG410IXHQ Eukaryota ENOG4111IXF LUCA
GeneTreeⁱ	ENSGT00440000039564
HOGENOMⁱ	HOG000171183
HOVERGENⁱ	HBG108249
InParanoidⁱ	Q62392
OMAⁱ	QPHGHRL
OrthoDBⁱ	EOG091G0FTL
PhylomeDBⁱ	Q62392
TreeFamⁱ	TF332320

Enzyme and pathway databases

Reactomeⁱ	R-MMU-8854521 Interaction between PHLDA1 and AURKA

Reactomeⁱ

R-MMU-8854521 Interaction between PHLDA1 and AURKA

Miscellaneous databases

ChiTaRSⁱ	Phlda1 mouse
Protein Ontology More...PROⁱ	PR:Q62392
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020205 Expressed in 325 organ(s), highest expression level in saliva-secreting gland
Genevisibleⁱ	Q62392 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR001849 PH_domain
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PHLA1_MOUSE
Accessionⁱ	Q62392Primary (citable) accession number: Q62392 Secondary accession number(s): Q3TY48, Q3UG87
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
	Last sequence update:	May 5, 2009
	Last modified:	November 7, 2018
	This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q62392 (PHLA1_MOUSE)

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Pleckstrin homology-like domain family A member 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ