UniProtKB - Q62392 (PHLA1_MOUSE)
Protein
Pleckstrin homology-like domain family A member 1
Gene
Phlda1
Organism
Mus musculus (Mouse)
Status
Functioni
Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. Required for TCR-induced apoptosis and expression of TNFRSF6/FAS in a T-cell hybridoma cell line. May be involved in translational regulation.2 Publications
GO - Molecular functioni
- phosphatidylinositol phosphate binding Source: InterPro
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- FasL biosynthetic process Source: MGI
- positive regulation of apoptotic process Source: MGI
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
Reactomei | R-MMU-8854521, Interaction between PHLDA1 and AURKA |
Names & Taxonomyi
Protein namesi | Recommended name: Pleckstrin homology-like domain family A member 1Alternative name(s): Proline- and glutamine-rich protein Short name: PQ-rich protein Short name: PQR protein T-cell death-associated gene 51 protein |
Gene namesi | Name:Phlda1 Synonyms:Tdag51 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1096880, Phlda1 |
Subcellular locationi
Nucleus
- nucleolus By similarity
Other locations
- Cytoplasm By similarity
- Cytoplasmic vesicle By similarity
Note: Colocalizes with intracellular vesicles.By similarity
Nucleus
- nucleolus Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Other locations
- cytoplasmic vesicle Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesicle, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053898 | 1 – 405 | Pleckstrin homology-like domain family A member 1Add BLAST | 405 |
Proteomic databases
jPOSTi | Q62392 |
MaxQBi | Q62392 |
PaxDbi | Q62392 |
PeptideAtlasi | Q62392 |
PRIDEi | Q62392 |
PTM databases
iPTMneti | Q62392 |
PhosphoSitePlusi | Q62392 |
Expressioni
Tissue specificityi
Widely expressed with very high levels in adult liver and high levels in adult lung. According to PubMed:10428057 expressed at low levels in liver. Expressed at increased levels in atherosclerotic lesions observed in hyperhomocysteinema.3 Publications
Inductioni
Induced by IGF-I.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000020205, Expressed in saliva-secreting gland and 340 other tissues |
Genevisiblei | Q62392, MM |
Interactioni
Subunit structurei
Interacts with RPL14, EIF3S7 and PABPC4.
By similarityBinary interactionsi
Hide detailsQ62392
With | #Exp. | IntAct |
---|---|---|
DNAJB1 [P25685] from Homo sapiens. | 2 | EBI-309727,EBI-357034 |
HSPH1 [Q92598] from Homo sapiens. | 2 | EBI-309727,EBI-356829 |
P08107 From a different organism. | 2 | EBI-309727,EBI-629985 |
Protein-protein interaction databases
IntActi | Q62392, 4 interactors |
MINTi | Q62392 |
STRINGi | 10090.ENSMUSP00000132815 |
Miscellaneous databases
RNActi | Q62392, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 153 – 277 | PHAdd BLAST | 125 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 309 – 344 | 16 X 2 AA repeats of P-QAdd BLAST | 36 | |
Regioni | 354 – 377 | 11 X 2 AA repeats of P-HAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 189 – 198 | Poly-Gln | 10 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502RZ5Q, Eukaryota |
GeneTreei | ENSGT00440000039564 |
HOGENOMi | CLU_062639_0_0_1 |
InParanoidi | Q62392 |
OMAi | GRQEPPF |
OrthoDBi | 1412115at2759 |
PhylomeDBi | Q62392 |
TreeFami | TF332320 |
Family and domain databases
InterProi | View protein in InterPro IPR001849, PH_domain IPR042832, PHLA1/2/3 |
PANTHERi | PTHR15478, PTHR15478, 2 hits |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
i Sequence
Sequence statusi: Complete.
Q62392-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRTPAAERL SELGFPPRRG RQEPPFPLGV TRGWGGWPIE KRREGPRPVP
60 70 80 90 100
FSERSPEDGR EQPAHGSGIL WRVRTRLSLC RDPEPPPPPP PLCLLRVSLL
110 120 130 140 150
CALRAGGRGS RWGEDGAGLL LLPPAGASGS LKAERSSSTP YAGRMLENSG
160 170 180 190 200
CKALKEGVLE KRSDGLLQLW KKKCCILTEE GLLLIPPKQL QQQQQQQQPG
210 220 230 240 250
QGTAEPSQPS GPTVASLEPP VKLKELHFSN MKTVDCVERK GKYMYFTVVM
260 270 280 290 300
TEGKEIDFRC PQDQGWNAEI TLQMVQYKNR QAILAVKSTR QKQQHLVQQQ
310 320 330 340 350
PPQTQQIQPQ PQPQIQPQPQ PQIQPQPQPQ PQPQPQPQPQ PQPQQLHSYP
360 370 380 390 400
HPHPHPYSHP HQHPHPHPHP HPHPHPHPYQ LQHAHQPLHS QPQGHRLLRS
TSNSA
Sequence cautioni
The sequence AAC52674 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH10295 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE34715 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 209 | P → R in BAE28322 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U44088 mRNA Translation: AAC52674.1 Different initiation. AK148063 mRNA Translation: BAE28322.1 AK158890 mRNA Translation: BAE34715.1 Sequence problems. BC010295 mRNA Translation: AAH10295.1 Different initiation. |
CCDSi | CCDS24167.2 |
RefSeqi | NP_033370.2, NM_009344.3 |
Genome annotation databases
Ensembli | ENSMUST00000164773; ENSMUSP00000132815; ENSMUSG00000020205 |
GeneIDi | 21664 |
KEGGi | mmu:21664 |
UCSCi | uc007haf.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U44088 mRNA Translation: AAC52674.1 Different initiation. AK148063 mRNA Translation: BAE28322.1 AK158890 mRNA Translation: BAE34715.1 Sequence problems. BC010295 mRNA Translation: AAH10295.1 Different initiation. |
CCDSi | CCDS24167.2 |
RefSeqi | NP_033370.2, NM_009344.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q62392, 4 interactors |
MINTi | Q62392 |
STRINGi | 10090.ENSMUSP00000132815 |
PTM databases
iPTMneti | Q62392 |
PhosphoSitePlusi | Q62392 |
Proteomic databases
jPOSTi | Q62392 |
MaxQBi | Q62392 |
PaxDbi | Q62392 |
PeptideAtlasi | Q62392 |
PRIDEi | Q62392 |
Protocols and materials databases
Antibodypediai | 4254, 222 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000164773; ENSMUSP00000132815; ENSMUSG00000020205 |
GeneIDi | 21664 |
KEGGi | mmu:21664 |
UCSCi | uc007haf.2, mouse |
Organism-specific databases
CTDi | 22822 |
MGIi | MGI:1096880, Phlda1 |
Phylogenomic databases
eggNOGi | ENOG502RZ5Q, Eukaryota |
GeneTreei | ENSGT00440000039564 |
HOGENOMi | CLU_062639_0_0_1 |
InParanoidi | Q62392 |
OMAi | GRQEPPF |
OrthoDBi | 1412115at2759 |
PhylomeDBi | Q62392 |
TreeFami | TF332320 |
Enzyme and pathway databases
Reactomei | R-MMU-8854521, Interaction between PHLDA1 and AURKA |
Miscellaneous databases
BioGRID-ORCSi | 21664, 2 hits in 19 CRISPR screens |
ChiTaRSi | Phlda1, mouse |
PROi | PR:Q62392 |
RNActi | Q62392, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020205, Expressed in saliva-secreting gland and 340 other tissues |
Genevisiblei | Q62392, MM |
Family and domain databases
InterProi | View protein in InterPro IPR001849, PH_domain IPR042832, PHLA1/2/3 |
PANTHERi | PTHR15478, PTHR15478, 2 hits |
SMARTi | View protein in SMART SM00233, PH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PHLA1_MOUSE | |
Accessioni | Q62392Primary (citable) accession number: Q62392 Secondary accession number(s): Q3TY48, Q3UG87 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | May 5, 2009 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot