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Protein

Interleukin-17A

Gene

Il17a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for IL17RA (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (By similarity). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to glucocorticoid stimulus Source: MGI
  • cellular response to interleukin-1 Source: MGI
  • defense response to fungus Source: UniProtKB
  • fibroblast activation Source: MGI
  • inflammatory response Source: InterPro
  • positive regulation of cytokine production involved in inflammatory response Source: MGI
  • positive regulation of interleukin-23 production Source: MGI
  • positive regulation of interleukin-6 secretion Source: UniProtKB
  • positive regulation of necrotic cell death Source: MGI
  • positive regulation of osteoclast differentiation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-MMU-448424 Interleukin-17 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17A
Short name:
IL-17
Short name:
IL-17A
Alternative name(s):
Cytotoxic T-lymphocyte-associated antigen 8
Short name:
CTLA-8
Gene namesi
Name:Il17a
Synonyms:Ctla8, Il17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:107364 Il17a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001542426 – 158Interleukin-17AAdd BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 147By similarity
Disulfide bondi102 ↔ 149By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ62386
PRIDEiQ62386

PTM databases

PhosphoSitePlusiQ62386

Expressioni

Tissue specificityi

Restricted to a subset of activated T-cells.1 Publication

Inductioni

Induced upon antigen receptor ligation in the presence of IL6 and TGB1.1 Publication

Gene expression databases

BgeeiENSMUSG00000025929
CleanExiMM_IL17A
ExpressionAtlasiQ62386 baseline and differential
GenevisibleiQ62386 MM

Interactioni

Subunit structurei

Homodimer. Heterodimer with IL17F.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ62386, 2 interactors
STRINGi10090.ENSMUSP00000027061

Structurei

3D structure databases

ProteinModelPortaliQ62386
SMRiQ62386
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J12P Eukaryota
ENOG410YS4N LUCA
GeneTreeiENSGT00920000149108
HOGENOMiHOG000064520
HOVERGENiHBG006143
InParanoidiQ62386
KOiK05489
OMAiHMNSVPI
OrthoDBiEOG091G0RG1
PhylomeDBiQ62386
TreeFamiTF314701

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020440 IL-17_chr
IPR010345 IL-17_fam
PfamiView protein in Pfam
PF06083 IL17, 1 hit
PRINTSiPR01932 INTRLEUKIN17
SUPFAMiSSF57501 SSF57501, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62386-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPGRASSVS LMLLLLLSLA ATVKAAAIIP QSSACPNTEA KDFLQNVKVN
60 70 80 90 100
LKVFNSLGAK VSSRRPSDYL NRSTSPWTLH RNEDPDRYPS VIWEAQCRHQ
110 120 130 140 150
RCVNAEGKLD HHMNSVLIQQ EILVLKREPE SCPFTFRVEK MLVGVGCTCV

ASIVRQAA
Length:158
Mass (Da):17,490
Last modified:November 1, 1996 - v1
Checksum:i3505C143435F4653
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43088 mRNA Translation: AAB05222.1
U35108 Genomic DNA Translation: AAA93253.1
CCDSiCCDS14842.1
PIRiJC4628
RefSeqiNP_034682.1, NM_010552.3
UniGeneiMm.5419

Genome annotation databases

EnsembliENSMUST00000027061; ENSMUSP00000027061; ENSMUSG00000025929
GeneIDi16171
KEGGimmu:16171
UCSCiuc007aky.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIL17_MOUSE
AccessioniPrimary (citable) accession number: Q62386
Secondary accession number(s): Q60971
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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