UniProtKB - Q62386 (IL17_MOUSE)
Interleukin-17A
Il17a
Functioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- cellular response to glucocorticoid stimulus Source: MGI
- cellular response to interleukin-1 Source: MGI
- defense response to fungus Source: UniProtKB
- defense response to Gram-negative bacterium Source: UniProtKB
- defense response to Gram-positive bacterium Source: UniProtKB
- fibroblast activation Source: MGI
- granulocyte migration Source: ARUK-UCL
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- interleukin-17-mediated signaling pathway Source: MGI
- intestinal epithelial structure maintenance Source: UniProtKB
- positive regulation of antimicrobial peptide production Source: UniProtKB
- positive regulation of bicellular tight junction assembly Source: UniProtKB
- positive regulation of chemokine (C-X-C motif) ligand 1 production Source: UniProtKB
- positive regulation of cytokine production involved in inflammatory response Source: MGI
- positive regulation of interleukin-12 production Source: MGI
- positive regulation of interleukin-16 production Source: MGI
- positive regulation of interleukin-1 beta production Source: MGI
- positive regulation of interleukin-23 production Source: MGI
- positive regulation of interleukin-6 production Source: UniProtKB
- positive regulation of necrotic cell death Source: MGI
- positive regulation of osteoclast differentiation Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of tumor necrosis factor biosynthetic process Source: MGI
Keywordsi
Molecular function | Cytokine |
Biological process | Adaptive immunity, Immunity, Inflammatory response, Innate immunity |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-17AShort name: IL-17 Short name: IL-17A Alternative name(s): Cytotoxic T-lymphocyte-associated antigen 8 Short name: CTLA-8 |
Gene namesi | Name:Il17a Synonyms:Ctla8, Il17 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107364, Il17a |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular space Source: UniProtKB
Plasma Membrane
- external side of plasma membrane Source: MGI
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
SecretedPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000015424 | 26 – 158 | Interleukin-17AAdd BLAST | 133 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 71 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 97 ↔ 147 | By similarity | ||
Disulfide bondi | 102 ↔ 149 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q62386 |
PRIDEi | Q62386 |
PTM databases
GlyGeni | Q62386, 1 site |
PhosphoSitePlusi | Q62386 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000025929, Expressed in liver and 28 other tissues |
Genevisiblei | Q62386, MM |
Interactioni
Subunit structurei
Homodimer (PubMed:18025225). Forms complexes with IL17RA and IL17RC receptors with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule (By similarity). IL17A homodimer preferentially drives the formation of IL17RA-IL17RC heterodimeric receptor complex (By similarity). IL17A homodimer adopts an asymmetrical ternary structure with one IL17RA molecule, allowing for high affinity interactions of one IL17A monomer with one IL17RA molecule (via D1 and D2 domains), while disfavoring binding of a second IL17RA molecule on the other IL17A monomer (By similarity). Heterodimer with IL17F (PubMed:18025225). IL17A-IL17F forms complexes with IL17RA-IL17RC, but with lower affinity when compared to IL17A homodimer (By similarity). IL17RA and IL17RC chains can not distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (By similarity).
By similarity1 PublicationGO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
IntActi | Q62386, 2 interactors |
STRINGi | 10090.ENSMUSP00000027061 |
Miscellaneous databases
RNActi | Q62386, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S5A0, Eukaryota |
GeneTreei | ENSGT00940000161882 |
HOGENOMi | CLU_118641_0_0_1 |
InParanoidi | Q62386 |
OMAi | CPHSFRL |
OrthoDBi | 1469254at2759 |
PhylomeDBi | Q62386 |
TreeFami | TF314701 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR020440, IL-17_chr IPR010345, IL-17_fam |
Pfami | View protein in Pfam PF06083, IL17, 1 hit |
PRINTSi | PR01932, INTRLEUKIN17 |
SUPFAMi | SSF57501, SSF57501, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MSPGRASSVS LMLLLLLSLA ATVKAAAIIP QSSACPNTEA KDFLQNVKVN
60 70 80 90 100
LKVFNSLGAK VSSRRPSDYL NRSTSPWTLH RNEDPDRYPS VIWEAQCRHQ
110 120 130 140 150
RCVNAEGKLD HHMNSVLIQQ EILVLKREPE SCPFTFRVEK MLVGVGCTCV
ASIVRQAA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U43088 mRNA Translation: AAB05222.1 U35108 Genomic DNA Translation: AAA93253.1 |
CCDSi | CCDS14842.1 |
PIRi | JC4628 |
RefSeqi | NP_034682.1, NM_010552.3 |
Genome annotation databases
Ensembli | ENSMUST00000027061; ENSMUSP00000027061; ENSMUSG00000025929 |
GeneIDi | 16171 |
KEGGi | mmu:16171 |
UCSCi | uc007aky.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U43088 mRNA Translation: AAB05222.1 U35108 Genomic DNA Translation: AAA93253.1 |
CCDSi | CCDS14842.1 |
PIRi | JC4628 |
RefSeqi | NP_034682.1, NM_010552.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q62386, 2 interactors |
STRINGi | 10090.ENSMUSP00000027061 |
PTM databases
GlyGeni | Q62386, 1 site |
PhosphoSitePlusi | Q62386 |
Proteomic databases
PaxDbi | Q62386 |
PRIDEi | Q62386 |
Protocols and materials databases
Antibodypediai | 17132, 1814 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000027061; ENSMUSP00000027061; ENSMUSG00000025929 |
GeneIDi | 16171 |
KEGGi | mmu:16171 |
UCSCi | uc007aky.1, mouse |
Organism-specific databases
CTDi | 3605 |
MGIi | MGI:107364, Il17a |
Phylogenomic databases
eggNOGi | ENOG502S5A0, Eukaryota |
GeneTreei | ENSGT00940000161882 |
HOGENOMi | CLU_118641_0_0_1 |
InParanoidi | Q62386 |
OMAi | CPHSFRL |
OrthoDBi | 1469254at2759 |
PhylomeDBi | Q62386 |
TreeFami | TF314701 |
Miscellaneous databases
BioGRID-ORCSi | 16171, 0 hits in 19 CRISPR screens |
PROi | PR:Q62386 |
RNActi | Q62386, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025929, Expressed in liver and 28 other tissues |
Genevisiblei | Q62386, MM |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR020440, IL-17_chr IPR010345, IL-17_fam |
Pfami | View protein in Pfam PF06083, IL17, 1 hit |
PRINTSi | PR01932, INTRLEUKIN17 |
SUPFAMi | SSF57501, SSF57501, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL17_MOUSE | |
Accessioni | Q62386Primary (citable) accession number: Q62386 Secondary accession number(s): Q60971 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families