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Protein

Zinc finger protein ZPR1

Gene

Zpr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H2O2-induced neuronal cell death.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri51 – 83C4-type 1Add BLAST33
Zinc fingeri259 – 291C4-type 2Add BLAST33

GO - Molecular functioni

  • receptor tyrosine kinase binding Source: UniProtKB
  • translation initiation factor binding Source: UniProtKB
  • zinc ion binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, mRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZPR1
Alternative name(s):
Zinc finger protein 259
Gene namesi
Name:Zpr1
Synonyms:Zfp259, Znf259
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1330262 Zpr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

May contribute to the severity of spinal muscular atrophy by increasing spinal motor neurons degeneration.1 Publication

Disruption phenotypei

Die during early embryonic development. Embryos show growth delay, failed to form normal trophectoderm and to expand the inner cell mass.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190371 – 459Zinc finger protein ZPR1Add BLAST459

Proteomic databases

EPDiQ62384
MaxQBiQ62384
PaxDbiQ62384
PeptideAtlasiQ62384
PRIDEiQ62384

PTM databases

iPTMnetiQ62384
PhosphoSitePlusiQ62384

Expressioni

Tissue specificityi

Expressed in brain. Expressed in the spinal cord motor neurons (at protein level). Expressed in spleen, liver, muscle, kidney and testis. Expressed in the frontal cortex, cornus ammonis, dentate gyrus of the hippocampus and in Purkinje cells of the cerebellum.3 Publications

Inductioni

Up-regulated by high fat diet.1 Publication

Gene expression databases

BgeeiENSMUSG00000032078 Expressed in 277 organ(s), highest expression level in female gonad
CleanExiMM_ZFP259
ExpressionAtlasiQ62384 baseline and differential
GenevisibleiQ62384 MM

Interactioni

Subunit structurei

Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Interacts (via C-terminal region) with SMN1 (via C-terminal region); the interaction occurs after treatment with serum (By similarity). Interacts with elongation factor 1-alpha EEF1A1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner. Interacts (via zinc fingers) with EGFR (via C-terminal cytoplasmic kinase domain); the interaction is negatively regulated in response to epidermal growth factor (EGF) stimulation and EGFR kinase activity. May also bind to the PDGFR receptor.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TEF2P029942EBI-11566629,EBI-6314From Saccharomyces cerevisiae (strain ATCC 204508 / S288c).

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204651, 1 interactor
DIPiDIP-46465N
IntActiQ62384, 4 interactors
STRINGi10090.ENSMUSP00000117725

Structurei

Secondary structure

1459
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ62384
SMRiQ62384
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ62384

Family & Domainsi

Sequence similaritiesi

Belongs to the ZPR1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri51 – 83C4-type 1Add BLAST33
Zinc fingeri259 – 291C4-type 2Add BLAST33

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2703 Eukaryota
COG1779 LUCA
GeneTreeiENSGT00390000005306
HOVERGENiHBG002608
InParanoidiQ62384
KOiK06874
OMAiECNAPAQ
OrthoDBiEOG091G07KC
TreeFamiTF313084

Family and domain databases

InterProiView protein in InterPro
IPR004457 Znf_ZPR1
PfamiView protein in Pfam
PF03367 zf-ZPR1, 2 hits
SMARTiView protein in SMART
SM00709 Zpr1, 2 hits
TIGRFAMsiTIGR00310 ZPR1_znf, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q62384-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSASGAVQPG HPGAAVGPSP AAAASPATGP LFRPLSAEDE EQQPTEIESL
60 70 80 90 100
CMNCYRNGTT RLLLTKIPFF REIIVSSFSC EHCGWNNTEI QSAGRIQDQG
110 120 130 140 150
VRYTLTVRSQ EDMNREVVKT DSATTRIPEL DFEIPAFSQK GALTTVEGLI
160 170 180 190 200
SRAISGLEQD QPTRRAVEGA IAERIDEFIG KLKDLKQMAS PFTLVIDDPS
210 220 230 240 250
GNSFVENPHA PQKDNALVIT YYDRTPQQAE MLGLQAEAPE EKAEEEDLRN
260 270 280 290 300
EVLQFNTNCP ECNAPAQTNM KLVQIPHFKE VIIMATNCEN CGHRTNEVKS
310 320 330 340 350
GGAVEPLGTR ITLHITDPSD MTRDLLKSET CSVEIPELEF ELGMAVLGGK
360 370 380 390 400
FTTLEGLLKD IRELVTKNPF TLGDSSNPDQ SEKLQEFSQK LGQIIEGKMK
410 420 430 440 450
AHFIMNDPAG NSYLQNVYAP EDDPEMKVER YKRTFDQNEE LGLNDMKTEG

YEAGLAPQR
Length:459
Mass (Da):50,715
Last modified:November 1, 1996 - v1
Checksum:i771D38C7B806044F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WHU9F8WHU9_MOUSE
Zinc finger protein ZPR1
Zpr1
386Annotation score:
F6WPJ5F6WPJ5_MOUSE
Zinc finger protein ZPR1
Zpr1
62Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41287 mRNA Translation: AAC52662.1
BC021397 mRNA Translation: AAH21397.1
CCDSiCCDS23144.1
RefSeqiNP_035882.1, NM_011752.2
UniGeneiMm.17519

Genome annotation databases

EnsembliENSMUST00000156440; ENSMUSP00000117725; ENSMUSG00000032078
GeneIDi22687
KEGGimmu:22687
UCSCiuc009phh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41287 mRNA Translation: AAC52662.1
BC021397 mRNA Translation: AAH21397.1
CCDSiCCDS23144.1
RefSeqiNP_035882.1, NM_011752.2
UniGeneiMm.17519

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QKDX-ray2.00A47-440[»]
ProteinModelPortaliQ62384
SMRiQ62384
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204651, 1 interactor
DIPiDIP-46465N
IntActiQ62384, 4 interactors
STRINGi10090.ENSMUSP00000117725

PTM databases

iPTMnetiQ62384
PhosphoSitePlusiQ62384

Proteomic databases

EPDiQ62384
MaxQBiQ62384
PaxDbiQ62384
PeptideAtlasiQ62384
PRIDEiQ62384

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000156440; ENSMUSP00000117725; ENSMUSG00000032078
GeneIDi22687
KEGGimmu:22687
UCSCiuc009phh.1 mouse

Organism-specific databases

CTDi8882
MGIiMGI:1330262 Zpr1

Phylogenomic databases

eggNOGiKOG2703 Eukaryota
COG1779 LUCA
GeneTreeiENSGT00390000005306
HOVERGENiHBG002608
InParanoidiQ62384
KOiK06874
OMAiECNAPAQ
OrthoDBiEOG091G07KC
TreeFamiTF313084

Miscellaneous databases

ChiTaRSiZpr1 mouse
EvolutionaryTraceiQ62384
PROiPR:Q62384
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032078 Expressed in 277 organ(s), highest expression level in female gonad
CleanExiMM_ZFP259
ExpressionAtlasiQ62384 baseline and differential
GenevisibleiQ62384 MM

Family and domain databases

InterProiView protein in InterPro
IPR004457 Znf_ZPR1
PfamiView protein in Pfam
PF03367 zf-ZPR1, 2 hits
SMARTiView protein in SMART
SM00709 Zpr1, 2 hits
TIGRFAMsiTIGR00310 ZPR1_znf, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZPR1_MOUSE
AccessioniPrimary (citable) accession number: Q62384
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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