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Entry version 162 (12 Aug 2020)
Sequence version 2 (31 Aug 2004)
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Protein

Transcription elongation factor SPT6

Gene

Supt6h

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processmRNA processing, mRNA splicing, mRNA transport, Transcription, Transcription regulation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-112382, Formation of RNA Pol II elongation complex
R-MMU-674695, RNA Polymerase II Pre-transcription Events
R-MMU-75955, RNA Polymerase II Transcription Elongation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription elongation factor SPT6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Supt6h
Synonyms:Kiaa0162, Supt6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107726, Supt6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1358R → K: Loss of binding to POLR2A. Retains the ability to support transcription elongation but the resulting transcripts contain splicing defects and accumulate to high levels within the nucleus. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000721722 – 1726Transcription elongation factor SPT6Add BLAST1725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei73PhosphoserineCombined sources1
Modified residuei78PhosphoserineCombined sources1
Modified residuei91PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei267PhosphoserineBy similarity1
Modified residuei743N6-acetyllysineBy similarity1
Modified residuei1515PhosphotyrosineBy similarity1
Modified residuei1523PhosphothreonineBy similarity1
Modified residuei1526PhosphoserineBy similarity1
Modified residuei1532PhosphothreonineCombined sources1
Modified residuei1535PhosphoserineCombined sources1
Modified residuei1539PhosphothreonineCombined sources1
Modified residuei1676N6-acetyllysineBy similarity1
Modified residuei1697PhosphothreonineBy similarity1
Modified residuei1701PhosphoserineCombined sources1
Modified residuei1703PhosphoserineCombined sources1
Modified residuei1709PhosphothreonineCombined sources1
Modified residuei1718PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q62383

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q62383

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q62383

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62383

PeptideAtlas

More...
PeptideAtlasi
Q62383

PRoteomics IDEntifications database

More...
PRIDEi
Q62383

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62383

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62383

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000002052, Expressed in midbrain and 317 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q62383, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RNA polymerase II and the DRB sensitivity-inducing factor complex (DSIF complex), which is composed of SUPT5H and SUPT4H1 or SUPT4H2 (By similarity).

Interacts with PAAF1 (By similarity).

Interacts with histone H2B and H3 (By similarity).

Interacts (via SH2 domain) with POLR2A phosphorylated at 'Ser-2'.

Interacts (via SH2 domain) with SETD1A.

Interacts with IWS1, KDM6A and AICDA.

Interacts with WDR43 (PubMed:31128943).

By similarity6 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
203576, 7 interactors

Protein interaction database and analysis system

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IntActi
Q62383, 5 interactors

Molecular INTeraction database

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MINTi
Q62383

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000002121

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q62383, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q62383

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1213 – 1282S1 motifPROSITE-ProRule annotationAdd BLAST70
Domaini1325 – 1431SH2PROSITE-ProRule annotationAdd BLAST107

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 916Interaction with PAAF1By similarityAdd BLAST915
Regioni2 – 485Interaction with IWS1Add BLAST484
Regioni317 – 1300Interaction with KDM6A1 PublicationAdd BLAST984
Regioni1633 – 1726Interaction with histone H2B and H3By similarityAdd BLAST94

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3 – 51Sequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi6 – 250Asp/Glu-richAdd BLAST245

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SPT6 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1856, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000047446

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001680_4_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q62383

KEGG Orthology (KO)

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KOi
K11292

Identification of Orthologs from Complete Genome Data

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OMAi
NTSPHSM

Database of Orthologous Groups

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OrthoDBi
56990at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q62383

TreeFam database of animal gene trees

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TreeFami
TF105956

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09928, SH2_Cterm_SPT6_like, 1 hit
cd09918, SH2_Nterm_SPT6_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.505.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR041692, HHH_9
IPR012340, NA-bd_OB-fold
IPR012337, RNaseH-like_sf
IPR010994, RuvA_2-like
IPR022967, S1_dom
IPR003029, S1_domain
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR028083, Spt6_acidic_N_dom
IPR032706, Spt6_HHH
IPR028088, Spt6_HTH_DNA-bd_dom
IPR035420, Spt6_SH2
IPR035018, Spt6_SH2_C
IPR035019, Spt6_SH2_N
IPR028231, Spt6_YqgF
IPR017072, TF_Spt6
IPR006641, YqgF/RNaseH-like_dom

The PANTHER Classification System

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PANTHERi
PTHR10145, PTHR10145, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF14635, HHH_7, 1 hit
PF17674, HHH_9, 1 hit
PF14641, HTH_44, 1 hit
PF00575, S1, 1 hit
PF14633, SH2_2, 1 hit
PF14632, SPT6_acidic, 1 hit
PF14639, YqgF, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF036947, Spt6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00316, S1, 1 hit
SM00252, SH2, 1 hit
SM00732, YqgFc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47781, SSF47781, 2 hits
SSF50249, SSF50249, 1 hit
SSF53098, SSF53098, 1 hit
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50126, S1, 1 hit
PS50001, SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q62383-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDFVESEAE ESEEEYNHEG EVVPRVTKKF VEEEDDDEEE EEENLDDQDE
60 70 80 90 100
RGNLKDFIND DDDEEEGEED EGSDSGDSED DVGHKKRKRP SFDDRLEDDD
110 120 130 140 150
FDLIEENLGV KVKRGQKYRR VKKMSDDDED DEEEYGKEEH EKEAIAGEIF
160 170 180 190 200
QDEEGEEGQE AVEAPMAPPD EEEEDDEESD IDDFIVDDDG QPLKKPKWRK
210 220 230 240 250
KLPGYTDAAL QEAQEIFGVD FDYDEFEKYN EYDEELEEDY EYEDDETEGE
260 270 280 290 300
IRVRPKKTTK KRVSRRSIFE MYEPSELESS HLTDQDNEIR ATDLPERFQL
310 320 330 340 350
RSIPVKAAED DELEEEADWI YRNAFATPTI SLQDSCDYLD RGQPTSSFSR
360 370 380 390 400
KGPSTVQKIK EALGFMRNQH FEVPFIAFYR KEYVEPELHI NDLWRVWQWD
410 420 430 440 450
EKWTQLRIRK ENLTRLFEKM QAYQYEQISA DPDKPLADGI RALDTTDMER
460 470 480 490 500
LKDVQSMDEL KDVYNHFLLY YGRDIPKMQN AAKASRKKLK RIKEDGDEEG
510 520 530 540 550
EGEEAEDEEQ RGPELKQASR RDMYTICQSA GLDGLAKKFG LTPEQFGENL
560 570 580 590 600
RDSYQRHETE QFPAEPLELA KDYVCSQFPT PEAVLEGARY MVALQIAREP
610 620 630 640 650
LVRQVLRQTF QERAKLNITP TKKGRKDVDE AHYAYSFKYL KNKPVKELRD
660 670 680 690 700
DQFLKIGLAE DEGLLTIDIS IDMKGVEGYG NDQTYFEEIK QFYYRDEFSH
710 720 730 740 750
QVQEWNRQRT MAIERALQQF LYVQMAKELK NKLLAEARES VVKACSRKLY
760 770 780 790 800
NWLRVAPYRP DQQVEEDDDF MDENQGKGIR VLGIAFSSAR DHPVFCALVN
810 820 830 840 850
GEGEVTDFLR LPHFTKRRTA WREEEREKKA QDIETLKKFL VNKKPHVVTI
860 870 880 890 900
AGENRDAQML TEDVKRIVHE LDQGQQLSSI GVELVDNELA ILYMNSKKSE
910 920 930 940 950
AEFRDYPPVL RQAVSLARRI QDPLIEFAQV CSSDEDILCL KFHPLQEHVV
960 970 980 990 1000
KEELLNALYC EFINRVNEVG VDVNRAIAHP YSQALIQYVC GLGPRKGTHL
1010 1020 1030 1040 1050
LKILKQNNTR LESRTQLVTM CHMGPKVFMN CAGFLKIDTA SLGDSTDSYI
1060 1070 1080 1090 1100
EVLDGSRVHP ETYEWARKMA VDALEYDESA EDANPAGALE EILENPERLK
1110 1120 1130 1140 1150
DLDLDAFAEE LERQGYGDKH ITLYDIRAEL SCRYKDLRTA YRSPNTEEIF
1160 1170 1180 1190 1200
NMLTKETPET FYIGKLIICN VTGIAHRRPQ GESYDQAIRN DETGLWQCPF
1210 1220 1230 1240 1250
CQQDNFPELS EVWNHFDSGS CPGQAIGVKT RLDNGVTGFI PTKFLSDKVV
1260 1270 1280 1290 1300
KRPEERVKVG MTVHCRIMKI DIEKFSADLT CRTSDLMDRN NEWKLPKDTY
1310 1320 1330 1340 1350
YDFDAEAADH KQEEDMKRKQ QRTTYIKRVI AHPSFHNINF KQAEKMMETM
1360 1370 1380 1390 1400
DQGDVIIRPS SKGENHLTVT WKVSAGIYQH VDVREEGKEN AFSLGATLWI
1410 1420 1430 1440 1450
NSEEFEDLDE IVARYVQPMA SFARDLLNHK YYQDCSGGDR KKLEELLIKT
1460 1470 1480 1490 1500
KKEKPTFIPY FICACKELPG KFLLGYQPRG KPRIEYVTVT PEGFRYRGQI
1510 1520 1530 1540 1550
FPTVNGLFRW FKDHYQDPVP GITPSSSNRT RTPASINATP ANINLADLTR
1560 1570 1580 1590 1600
AVNALPQNMT SQMFSAIAAV TGQGQNPNAT PAQWASSQYG YGGSGGGSSA
1610 1620 1630 1640 1650
YHVFPTPAQQ PVATPLMTPS YSYTTPSQPI TTPQYHQLQA STTPQSTQAQ
1660 1670 1680 1690 1700
PQPSSSSRQR QQQPKSNSHA AIDWGKMAEQ WLQEKEAERR KQKQRLTPRP
1710 1720
SPSPMIESTP MSIAGDATPL LDEMDR
Length:1,726
Mass (Da):199,086
Last modified:August 31, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98BD891493372166
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti609T → A in AAB18950 (PubMed:8786132).Curated1
Sequence conflicti1520P → Q in BAC32616 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U40375 mRNA Translation: AAB18950.1
AL591070 Genomic DNA No translation available.
BC072657 mRNA Translation: AAH72657.1
AK129069 mRNA Translation: BAC97879.1
AK046156 mRNA Translation: BAC32616.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS25095.1

Protein sequence database of the Protein Information Resource

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PIRi
T30810

NCBI Reference Sequences

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RefSeqi
NP_033323.2, NM_009297.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000002121; ENSMUSP00000002121; ENSMUSG00000002052

Database of genes from NCBI RefSeq genomes

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GeneIDi
20926

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:20926

UCSC genome browser

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UCSCi
uc007kip.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40375 mRNA Translation: AAB18950.1
AL591070 Genomic DNA No translation available.
BC072657 mRNA Translation: AAH72657.1
AK129069 mRNA Translation: BAC97879.1
AK046156 mRNA Translation: BAC32616.1
CCDSiCCDS25095.1
PIRiT30810
RefSeqiNP_033323.2, NM_009297.2

3D structure databases

SMRiQ62383
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi203576, 7 interactors
IntActiQ62383, 5 interactors
MINTiQ62383
STRINGi10090.ENSMUSP00000002121

PTM databases

iPTMnetiQ62383
PhosphoSitePlusiQ62383

Proteomic databases

EPDiQ62383
jPOSTiQ62383
MaxQBiQ62383
PaxDbiQ62383
PeptideAtlasiQ62383
PRIDEiQ62383

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
3242, 142 antibodies

Genome annotation databases

EnsembliENSMUST00000002121; ENSMUSP00000002121; ENSMUSG00000002052
GeneIDi20926
KEGGimmu:20926
UCSCiuc007kip.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
20926
MGIiMGI:107726, Supt6

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG1856, Eukaryota
GeneTreeiENSGT00510000047446
HOGENOMiCLU_001680_4_0_1
InParanoidiQ62383
KOiK11292
OMAiNTSPHSM
OrthoDBi56990at2759
PhylomeDBiQ62383
TreeFamiTF105956

Enzyme and pathway databases

ReactomeiR-MMU-112382, Formation of RNA Pol II elongation complex
R-MMU-674695, RNA Polymerase II Pre-transcription Events
R-MMU-75955, RNA Polymerase II Transcription Elongation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
20926, 7 hits in 23 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Supt6, mouse

Protein Ontology

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PROi
PR:Q62383
RNActiQ62383, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000002052, Expressed in midbrain and 317 other tissues
GenevisibleiQ62383, MM

Family and domain databases

CDDicd09928, SH2_Cterm_SPT6_like, 1 hit
cd09918, SH2_Nterm_SPT6_like, 1 hit
Gene3Di3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR041692, HHH_9
IPR012340, NA-bd_OB-fold
IPR012337, RNaseH-like_sf
IPR010994, RuvA_2-like
IPR022967, S1_dom
IPR003029, S1_domain
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR028083, Spt6_acidic_N_dom
IPR032706, Spt6_HHH
IPR028088, Spt6_HTH_DNA-bd_dom
IPR035420, Spt6_SH2
IPR035018, Spt6_SH2_C
IPR035019, Spt6_SH2_N
IPR028231, Spt6_YqgF
IPR017072, TF_Spt6
IPR006641, YqgF/RNaseH-like_dom
PANTHERiPTHR10145, PTHR10145, 1 hit
PfamiView protein in Pfam
PF14635, HHH_7, 1 hit
PF17674, HHH_9, 1 hit
PF14641, HTH_44, 1 hit
PF00575, S1, 1 hit
PF14633, SH2_2, 1 hit
PF14632, SPT6_acidic, 1 hit
PF14639, YqgF, 1 hit
PIRSFiPIRSF036947, Spt6, 1 hit
SMARTiView protein in SMART
SM00316, S1, 1 hit
SM00252, SH2, 1 hit
SM00732, YqgFc, 1 hit
SUPFAMiSSF47781, SSF47781, 2 hits
SSF50249, SSF50249, 1 hit
SSF53098, SSF53098, 1 hit
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50126, S1, 1 hit
PS50001, SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPT6H_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62383
Secondary accession number(s): Q5SYM0
, Q6GQS3, Q6ZQI0, Q8BQY6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: August 12, 2020
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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