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Protein

Tolloid-like protein 1

Gene

Tll1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development, especially heart development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.1 Publication

Cofactori

Zn2+PROSITE-ProRule annotationNote: Binds 1 zinc ion per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi240Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
Active sitei241PROSITE-ProRule annotation1
Metal bindingi244Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
Metal bindingi250Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • collagen binding Source: MGI
  • metalloendopeptidase activity Source: InterPro
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Metalloprotease, Protease
Biological processDifferentiation
LigandCalcium, Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.016

Names & Taxonomyi

Protein namesi
Recommended name:
Tolloid-like protein 1 (EC:3.4.24.-)
Short name:
mTll
Gene namesi
Name:Tll1
Synonyms:Tll
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:106923 Tll1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
PropeptideiPRO_000004602531 – 147By similarityAdd BLAST117
ChainiPRO_0000046026148 – 1013Tolloid-like protein 1Add BLAST866

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi190 ↔ 346PROSITE-ProRule annotation
Disulfide bondi210 ↔ 232PROSITE-ProRule annotation
Disulfide bondi212 ↔ 213PROSITE-ProRule annotation
Disulfide bondi349 ↔ 375By similarity
Glycosylationi359N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi402 ↔ 424By similarity
Disulfide bondi462 ↔ 488By similarity
Disulfide bondi515 ↔ 537By similarity
Disulfide bondi578 ↔ 590By similarity
Disulfide bondi586 ↔ 599By similarity
Disulfide bondi601 ↔ 614By similarity
Disulfide bondi618 ↔ 644By similarity
Glycosylationi626N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi671 ↔ 693By similarity
Disulfide bondi734 ↔ 745By similarity
Disulfide bondi741 ↔ 754By similarity
Disulfide bondi756 ↔ 769By similarity
Disulfide bondi774 ↔ 800By similarity
Disulfide bondi827 ↔ 849By similarity
Disulfide bondi887 ↔ 917By similarity
Disulfide bondi944 ↔ 966By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ62381
PeptideAtlasiQ62381
PRIDEiQ62381

PTM databases

iPTMnetiQ62381
PhosphoSitePlusiQ62381

Expressioni

Tissue specificityi

Highly expressed in brain and kidney and weakly in lung, skeletal muscle. A perceptible level of expression is observed in heart and testis.1 Publication

Developmental stagei

Expressed at detectable level on E7, at increased level on E11, at maximal level on E15. Then, expression decreases from E17. Expressed in the developing neural tube.1 Publication

Gene expression databases

CleanExiMM_TLL1

Interactioni

Protein-protein interaction databases

BioGridi204220, 2 interactors
IntActiQ62381, 3 interactors
STRINGi10090.ENSMUSP00000070560

Structurei

3D structure databases

ProteinModelPortaliQ62381
SMRiQ62381
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini148 – 347Peptidase M12APROSITE-ProRule annotationAdd BLAST200
Domaini349 – 461CUB 1PROSITE-ProRule annotationAdd BLAST113
Domaini462 – 574CUB 2PROSITE-ProRule annotationAdd BLAST113
Domaini574 – 615EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini618 – 730CUB 3PROSITE-ProRule annotationAdd BLAST113
Domaini730 – 770EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini774 – 886CUB 4PROSITE-ProRule annotationAdd BLAST113
Domaini887 – 1003CUB 5PROSITE-ProRule annotationAdd BLAST117

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
HOGENOMiHOG000236339
HOVERGENiHBG004859
InParanoidiQ62381
PhylomeDBiQ62381

Family and domain databases

CDDicd00041 CUB, 5 hits
cd04281 ZnMc_BMP1_TLD, 1 hit
Gene3Di2.60.120.290, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR015446 BMP_1/tolloid-like
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
IPR035914 Sperma_CUB_dom_sf
IPR034036 ZnMP_TLD/BMP1
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PF00431 CUB, 5 hits
PIRSFiPIRSF001199 BMP_1/tolloid-like, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00042 CUB, 5 hits
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF49854 SSF49854, 5 hits
PROSITEiView protein in PROSITE
PS51864 ASTACIN, 1 hit
PS01180 CUB, 5 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 2 hits
PS00142 ZINC_PROTEASE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q62381-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLQALSPRM LLWLVVSGIV FSRVLWVCAG LDYDYTFDGN EEDKTEPIDY
60 70 80 90 100
KDPCKAAVFW GDIALDDEDL NIFQIDRTID LTQSPFGKLG HITGGFGDHG
110 120 130 140 150
MPKKRGALYQ LIERIRRIGS GLEQNNTMKG KAPPKLSEQS EKNRVPRAAT
160 170 180 190 200
SRTERIWPGG VIPYVIGGNF TGSQRAMFKQ AMRHWEKHTC VTFTERSDEE
210 220 230 240 250
SYIVFTYRPC GCCSYVGRRG NGPQAISIGK NCDKFGIVVH ELGHVIGFWH
260 270 280 290 300
EHTRPDRDNH VTIIRENIQP GQEYNFLKME PGEVNSLGER YDFDSIMHYA
310 320 330 340 350
RNTFSRGMFL DTILPSRDDN GIRPAIGQRT RLSKGDIAQA RKLYRCPACG
360 370 380 390 400
ETLQESSGNL SSPGFPNGYP SYTHCIWRVS VTPGEKIVLN FTTMDLYKSS
410 420 430 440 450
LCWYDYIEVR DGYWRKSPLL GRFCGDKVAG VLTSTDSRMW IEFRSSSNWV
460 470 480 490 500
GKGFAAVYEA ICGGEIRKNE GQIQSPNYPD DYRPMKECVW KIMVSEGYHV
510 520 530 540 550
GLTFQAFEIE RHDSCAYDHL EVRDGASENS PLIGRFCGYD KPEDIRSTSN
560 570 580 590 600
TLWMKFVSDG TVNKAGFAAN FFKEEDECAK PDRGGCEQRC LNTLGSYQCA
610 620 630 640 650
CEPGYELGPD RRSCEAACGG LLTKLNGTIT TPGWPKEYPP NKNCVWQVIA
660 670 680 690 700
PSQYRISVKF EFFELEGNEV CKYDYVEIWS GPSSESKLHG KFCGADIPEV
710 720 730 740 750
MTSHFNNMRI EFKSDNTVSK KGFKAHFFSD KDECSKDNGG CQHECVNTMG
760 770 780 790 800
SYTCQCRNGF VLHENKHDCK EAECEQKIHS PSGLITSPNW PDKYPSRKEC
810 820 830 840 850
TWVISAIPGH RITLAFNEFE VEQHQECAYD HLEIFDGETE KSPILGRLCG
860 870 880 890 900
SKIPDPLMAT GNEMFIRFIS DASVQRKGFQ ATHSTECGGR LKAESKPRDL
910 920 930 940 950
YSHAQFGDNN YPGQLDCEWL LVSERGSRLE LSFQTFEVEE EADCGYDYVE
960 970 980 990 1000
VFDGLSSKAV GLGRFCGSGP PEEIYSIGDV ALIHFHTDDT INKKGFYIRY
1010
KSIRYPETMH AKN
Length:1,013
Mass (Da):114,533
Last modified:November 1, 1996 - v1
Checksum:iB388914642BDD078
GO
Isoform 2 (identifier: Q62381-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-390: IVLN → VVDT
     391-1013: Missing.

Note: No experimental confirmation available.
Show »
Length:390
Mass (Da):43,967
Checksum:i31193DE9826893E8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X9F5G3X9F5_MOUSE
Metalloendopeptidase
Tll1 mCG_22897
1,013Annotation score:
A0A1B0GRW8A0A1B0GRW8_MOUSE
Tolloid-like protein 1
Tll1
8Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti682P → L in BAE23891 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017199387 – 390IVLN → VVDT in isoform 2. 1 Publication4
Alternative sequenceiVSP_017200391 – 1013Missing in isoform 2. 1 PublicationAdd BLAST623

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34042 mRNA Translation: AAC52654.1
AK080919 mRNA Translation: BAC38078.1
AK139103 mRNA Translation: BAE23891.1
CCDSiCCDS40352.1 [Q62381-1]
UniGeneiMm.418367
Mm.438712

Genome annotation databases

UCSCiuc009luu.1 mouse [Q62381-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34042 mRNA Translation: AAC52654.1
AK080919 mRNA Translation: BAC38078.1
AK139103 mRNA Translation: BAE23891.1
CCDSiCCDS40352.1 [Q62381-1]
UniGeneiMm.418367
Mm.438712

3D structure databases

ProteinModelPortaliQ62381
SMRiQ62381
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204220, 2 interactors
IntActiQ62381, 3 interactors
STRINGi10090.ENSMUSP00000070560

Protein family/group databases

MEROPSiM12.016

PTM databases

iPTMnetiQ62381
PhosphoSitePlusiQ62381

Proteomic databases

PaxDbiQ62381
PeptideAtlasiQ62381
PRIDEiQ62381

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc009luu.1 mouse [Q62381-2]

Organism-specific databases

MGIiMGI:106923 Tll1

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
HOGENOMiHOG000236339
HOVERGENiHBG004859
InParanoidiQ62381
PhylomeDBiQ62381

Miscellaneous databases

ChiTaRSiTll1 mouse
PROiPR:Q62381
SOURCEiSearch...

Gene expression databases

CleanExiMM_TLL1

Family and domain databases

CDDicd00041 CUB, 5 hits
cd04281 ZnMc_BMP1_TLD, 1 hit
Gene3Di2.60.120.290, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR015446 BMP_1/tolloid-like
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024079 MetalloPept_cat_dom_sf
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
IPR035914 Sperma_CUB_dom_sf
IPR034036 ZnMP_TLD/BMP1
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PF00431 CUB, 5 hits
PIRSFiPIRSF001199 BMP_1/tolloid-like, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00042 CUB, 5 hits
SM00181 EGF, 2 hits
SM00179 EGF_CA, 2 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF49854 SSF49854, 5 hits
PROSITEiView protein in PROSITE
PS51864 ASTACIN, 1 hit
PS01180 CUB, 5 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 2 hits
PS00142 ZINC_PROTEASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTLL1_MOUSE
AccessioniPrimary (citable) accession number: Q62381
Secondary accession number(s): Q3UTT9, Q8BNP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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