UniProtKB - Q62356 (FSTL1_MOUSE)
Follistatin-related protein 1
Fstl1
Functioni
Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (By similarity).
Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (PubMed:21826198, PubMed:19595790).
Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (PubMed:20054002).
Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (By similarity).
By similarity3 PublicationsGO - Molecular functioni
- calcium ion binding Source: InterPro
- heparin binding Source: UniProtKB-KW
GO - Biological processi
- cell differentiation Source: GO_Central
- endothelial cell differentiation Source: UniProtKB
- endothelial cell migration Source: UniProtKB
- hematopoietic stem cell homeostasis Source: MGI
- negative regulation of apoptotic process Source: UniProtKB
- regulation of BMP signaling pathway Source: GO_Central
Keywordsi
Molecular function | Heparin-binding |
Enzyme and pathway databases
Reactomei | R-MMU-201451, Signaling by BMP R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-8957275, Post-translational protein phosphorylation |
Protein family/group databases
MEROPSi | I01.967 |
Names & Taxonomyi
Protein namesi | Recommended name: Follistatin-related protein 1Alternative name(s): Follistatin-like protein 1 TGF-beta-inducible protein TSC-36 |
Gene namesi | Name:Fstl1 Synonyms:Frp, Fstl, Tsc36 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:102793, Fstl1 |
VEuPathDBi | HostDB:ENSMUSG00000022816 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular space Source: BHF-UCL
Keywords - Cellular componenti
SecretedPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | By similarityAdd BLAST | 18 | |
ChainiPRO_0000010113 | 19 – 306 | Follistatin-related protein 1Add BLAST | 288 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 29 ↔ 40 | Combined sources1 Publication | ||
Disulfide bondi | 34 ↔ 50 | Combined sources1 Publication | ||
Disulfide bondi | 52 ↔ 82 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Disulfide bondi | 56 ↔ 75 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Disulfide bondi | 64 ↔ 96 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Glycosylationi | 142 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 163 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 173 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 178 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3314 |
MaxQBi | Q62356 |
PaxDbi | Q62356 |
PeptideAtlasi | Q62356 |
PRIDEi | Q62356 |
ProteomicsDBi | 267528 |
PTM databases
GlyGeni | Q62356, 3 sites |
iPTMneti | Q62356 |
PhosphoSitePlusi | Q62356 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000022816, Expressed in epithelium of cochlear duct and 351 other tissues |
Genevisiblei | Q62356, MM |
Interactioni
Subunit structurei
Homodimer (PubMed:31351024).
Interacts with SCN10A (By similarity).
Interacts with DIP2A; DIP2A may act as a cell surface receptor for FSTL1 (PubMed:20054002).
Interacts with BMP4 (By similarity).
Interacts with CD14; this interaction promotes TL4-mediated signaling cascade (By similarity).
By similarity2 PublicationsBinary interactionsi
Q62356
With | #Exp. | IntAct |
---|---|---|
DIP2A [Q14689] from Homo sapiens. | 3 | EBI-2564326,EBI-2564275 |
Protein-protein interaction databases
BioGRIDi | 199752, 3 interactors |
DIPi | DIP-56414N |
IntActi | Q62356, 4 interactors |
STRINGi | 10090.ENSMUSP00000110411 |
Miscellaneous databases
RNActi | Q62356, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q62356 |
SMRi | Q62356 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 51 | Follistatin-likeAdd BLAST | 24 | |
Domaini | 46 – 98 | Kazal-likePROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 142 – 176 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 191 – 226 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 231 – 285 | VWFCAdd BLAST | 55 |
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QQAG, Eukaryota |
GeneTreei | ENSGT00940000157784 |
HOGENOMi | CLU_038229_0_0_1 |
InParanoidi | Q62356 |
OMAi | HRIIQWL |
OrthoDBi | 1079836at2759 |
PhylomeDBi | Q62356 |
TreeFami | TF106409 |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom IPR003645, Fol_N IPR015369, Follistatin/Osteonectin_EGF IPR002350, Kazal_dom IPR036058, Kazal_dom_sf |
Pfami | View protein in Pfam PF09289, FOLN, 1 hit PF07648, Kazal_2, 1 hit |
SMARTi | View protein in SMART SM00274, FOLN, 1 hit SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 2 hits PS51465, KAZAL_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MWKRWLALSL VTIALVHGEE EPRSKSKICA NVFCGAGREC AVTEKGEPTC
60 70 80 90 100
LCIEQCKPHK RPVCGSNGKT YLNHCELHRD ACLTGSKIQV DYDGHCKEKK
110 120 130 140 150
SASPSASPVV CYQANRDELR RRLIQWLEAE IIPDGWFSKG SNYSEILDKY
160 170 180 190 200
FKSFDNGDSH LDSSEFLKFV EQNETAINIT TYADQENNKL LRSLCVDALI
210 220 230 240 250
ELSDENADWK LSFQEFLKCL NPSFNPPEKK CALEDETYAD GAETEVDCNR
260 270 280 290 300
CVCSCGHWVC TAMTCDGKNQ KGVQTHTEEE KTGYVQELQK HQGTAEKTKK
VNTKEI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 235 | D → V in AAC37633 (PubMed:7901004).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M91380 mRNA Translation: AAC37633.1 AK049440 mRNA Translation: BAC33751.1 AK147117 mRNA Translation: BAE27689.1 CH466521 Genomic DNA Translation: EDK97964.1 BC028921 mRNA Translation: AAH28921.1 BC006185 mRNA No translation available. |
CCDSi | CCDS37339.1 |
PIRi | S38251 |
RefSeqi | NP_032073.2, NM_008047.5 |
Genome annotation databases
Ensembli | ENSMUST00000114763; ENSMUSP00000110411; ENSMUSG00000022816 |
GeneIDi | 14314 |
KEGGi | mmu:14314 |
UCSCi | uc007zej.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M91380 mRNA Translation: AAC37633.1 AK049440 mRNA Translation: BAC33751.1 AK147117 mRNA Translation: BAE27689.1 CH466521 Genomic DNA Translation: EDK97964.1 BC028921 mRNA Translation: AAH28921.1 BC006185 mRNA No translation available. |
CCDSi | CCDS37339.1 |
PIRi | S38251 |
RefSeqi | NP_032073.2, NM_008047.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6JZA | X-ray | 2.30 | A | 20-98 | [»] | |
AlphaFoldDBi | Q62356 | |||||
SMRi | Q62356 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 199752, 3 interactors |
DIPi | DIP-56414N |
IntActi | Q62356, 4 interactors |
STRINGi | 10090.ENSMUSP00000110411 |
Protein family/group databases
MEROPSi | I01.967 |
PTM databases
GlyGeni | Q62356, 3 sites |
iPTMneti | Q62356 |
PhosphoSitePlusi | Q62356 |
Proteomic databases
CPTACi | non-CPTAC-3314 |
MaxQBi | Q62356 |
PaxDbi | Q62356 |
PeptideAtlasi | Q62356 |
PRIDEi | Q62356 |
ProteomicsDBi | 267528 |
Protocols and materials databases
Antibodypediai | 32794, 437 antibodies from 32 providers |
DNASUi | 14314 |
Genome annotation databases
Ensembli | ENSMUST00000114763; ENSMUSP00000110411; ENSMUSG00000022816 |
GeneIDi | 14314 |
KEGGi | mmu:14314 |
UCSCi | uc007zej.1, mouse |
Organism-specific databases
CTDi | 11167 |
MGIi | MGI:102793, Fstl1 |
VEuPathDBi | HostDB:ENSMUSG00000022816 |
Phylogenomic databases
eggNOGi | ENOG502QQAG, Eukaryota |
GeneTreei | ENSGT00940000157784 |
HOGENOMi | CLU_038229_0_0_1 |
InParanoidi | Q62356 |
OMAi | HRIIQWL |
OrthoDBi | 1079836at2759 |
PhylomeDBi | Q62356 |
TreeFami | TF106409 |
Enzyme and pathway databases
Reactomei | R-MMU-201451, Signaling by BMP R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
BioGRID-ORCSi | 14314, 0 hits in 71 CRISPR screens |
ChiTaRSi | Fstl1, mouse |
PROi | PR:Q62356 |
RNActi | Q62356, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022816, Expressed in epithelium of cochlear duct and 351 other tissues |
Genevisiblei | Q62356, MM |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom IPR003645, Fol_N IPR015369, Follistatin/Osteonectin_EGF IPR002350, Kazal_dom IPR036058, Kazal_dom_sf |
Pfami | View protein in Pfam PF09289, FOLN, 1 hit PF07648, Kazal_2, 1 hit |
SMARTi | View protein in SMART SM00274, FOLN, 1 hit SM00280, KAZAL, 1 hit |
SUPFAMi | SSF100895, SSF100895, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 2 hits PS51465, KAZAL_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FSTL1_MOUSE | |
Accessioni | Q62356Primary (citable) accession number: Q62356 Secondary accession number(s): Q6GTX2, Q99JI9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 175 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references