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Protein

Transferrin receptor protein 1

Gene

Tfrc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Upon stimulation, positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processEndocytosis

Enzyme and pathway databases

ReactomeiR-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis
R-MMU-917977 Transferrin endocytosis and recycling

Protein family/group databases

MEROPSiM28.972

Names & Taxonomyi

Protein namesi
Recommended name:
Transferrin receptor protein 1
Short name:
TR
Short name:
TfR
Short name:
TfR1
Short name:
Trfr
Alternative name(s):
CD_antigen: CD71
Gene namesi
Name:Tfrc
Synonyms:Trfr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:98822 Tfrc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 67CytoplasmicSequence analysisAdd BLAST67
Transmembranei68 – 88Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini89 – 763ExtracellularSequence analysisAdd BLAST675

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi20Y → H: Negatively regulates of T and B cell proliferation upon activation. Significantly increases cell surface expression on T and B cells. Impairs internalization. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001741331 – 763Transferrin receptor protein 1Add BLAST763

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Modified residuei19PhosphoserineCombined sources1
Modified residuei20PhosphotyrosineCombined sources1
Modified residuei21PhosphothreonineBy similarity1
Modified residuei24PhosphoserineBy similarity1
Lipidationi67S-palmitoyl cysteineBy similarity1
Disulfide bondi89InterchainBy similarity
Disulfide bondi98InterchainBy similarity
Glycosylationi104O-linked (GalNAc...) threonineBy similarity1
Glycosylationi253N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi319N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi725N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi730N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

N- and O-glycosylated, phosphorylated and palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ62351
MaxQBiQ62351
PaxDbiQ62351
PRIDEiQ62351

PTM databases

iPTMnetiQ62351
PhosphoSitePlusiQ62351
SwissPalmiQ62351

Expressioni

Gene expression databases

BgeeiENSMUSG00000022797 Expressed in 297 organ(s), highest expression level in placenta labyrinth
CleanExiMM_TFRC
ExpressionAtlasiQ62351 baseline and differential
GenevisibleiQ62351 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Binds one transferrin molecule per subunit. Interacts with SH3BP4 (By similarity). Interacts with STEAP3; facilitates TFRC endocytosis in erythroid precursor cells (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204314, 6 interactors
IntActiQ62351, 12 interactors
MINTiQ62351
STRINGi10090.ENSMUSP00000023486

Structurei

3D structure databases

ProteinModelPortaliQ62351
SMRiQ62351
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini225 – 315PAAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 67Mediates interaction with SH3BP4By similarityAdd BLAST67
Regioni572 – 763Ligand-bindingBy similarityAdd BLAST192

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi20 – 23Endocytosis signal4
Motifi58 – 61Stop-transfer sequence4
Motifi649 – 651Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the peptidase M28 family. M28B subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2195 Eukaryota
COG2234 LUCA
GeneTreeiENSGT00550000074421
HOGENOMiHOG000124067
HOVERGENiHBG023177
InParanoidiQ62351
KOiK06503
OMAiIMKVEYH
OrthoDBiEOG091G02ZM
PhylomeDBiQ62351
TreeFamiTF312981

Family and domain databases

CDDicd02128 PA_TfR, 1 hit
Gene3Di1.20.930.40, 1 hit
InterProiView protein in InterPro
IPR003137 PA_domain
IPR007484 Peptidase_M28
IPR039373 Peptidase_M28B
IPR029513 TfR
IPR007365 TFR-like_dimer_dom
IPR036757 TFR-like_dimer_dom_sf
IPR037324 TfR1/2_PA
PANTHERiPTHR10404 PTHR10404, 1 hit
PTHR10404:SF26 PTHR10404:SF26, 1 hit
PfamiView protein in Pfam
PF02225 PA, 1 hit
PF04389 Peptidase_M28, 1 hit
PF04253 TFR_dimer, 1 hit
SUPFAMiSSF47672 SSF47672, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q62351-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMDQARSAFS NLFGGEPLSY TRFSLARQVD GDNSHVEMKL AADEEENADN
60 70 80 90 100
NMKASVRKPK RFNGRLCFAA IALVIFFLIG FMSGYLGYCK RVEQKEECVK
110 120 130 140 150
LAETEETDKS ETMETEDVPT SSRLYWADLK TLLSEKLNSI EFADTIKQLS
160 170 180 190 200
QNTYTPREAG SQKDESLAYY IENQFHEFKF SKVWRDEHYV KIQVKSSIGQ
210 220 230 240 250
NMVTIVQSNG NLDPVESPEG YVAFSKPTEV SGKLVHANFG TKKDFEELSY
260 270 280 290 300
SVNGSLVIVR AGEITFAEKV ANAQSFNAIG VLIYMDKNKF PVVEADLALF
310 320 330 340 350
GHAHLGTGDP YTPGFPSFNH TQFPPSQSSG LPNIPVQTIS RAAAEKLFGK
360 370 380 390 400
MEGSCPARWN IDSSCKLELS QNQNVKLIVK NVLKERRILN IFGVIKGYEE
410 420 430 440 450
PDRYVVVGAQ RDALGAGVAA KSSVGTGLLL KLAQVFSDMI SKDGFRPSRS
460 470 480 490 500
IIFASWTAGD FGAVGATEWL EGYLSSLHLK AFTYINLDKV VLGTSNFKVS
510 520 530 540 550
ASPLLYTLMG KIMQDVKHPV DGKSLYRDSN WISKVEKLSF DNAAYPFLAY
560 570 580 590 600
SGIPAVSFCF CEDADYPYLG TRLDTYEALT QKVPQLNQMV RTAAEVAGQL
610 620 630 640 650
IIKLTHDVEL NLDYEMYNSK LLSFMKDLNQ FKTDIRDMGL SLQWLYSARG
660 670 680 690 700
DYFRATSRLT TDFHNAEKTN RFVMREINDR IMKVEYHFLS PYVSPRESPF
710 720 730 740 750
RHIFWGSGSH TLSALVENLK LRQKNITAFN ETLFRNQLAL ATWTIQGVAN
760
ALSGDIWNID NEF
Length:763
Mass (Da):85,731
Last modified:November 1, 1996 - v1
Checksum:i832A148CC26CE489
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8C872Q8C872_MOUSE
Transferrin receptor protein 1
Tfrc mCG_129940
515Annotation score:
D3YZB9D3YZB9_MOUSE
Transferrin receptor protein 1
Tfrc
12Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25 – 26LA → AL in AAA37616 (PubMed:2984291).Curated2
Sequence conflicti743W → H AA sequence (PubMed:6092468).Curated1
Sequence conflicti757W → I AA sequence (PubMed:6092468).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57349 mRNA Translation: CAA40624.1
BC054522 mRNA Translation: AAH54522.1
M29618 mRNA Translation: AAA37616.1
CCDSiCCDS28123.1
PIRiS29548
RefSeqiNP_035768.1, NM_011638.4
XP_006522062.1, XM_006521999.3
UniGeneiMm.28683

Genome annotation databases

EnsembliENSMUST00000023486; ENSMUSP00000023486; ENSMUSG00000022797
GeneIDi22042
KEGGimmu:22042
UCSCiuc007yza.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57349 mRNA Translation: CAA40624.1
BC054522 mRNA Translation: AAH54522.1
M29618 mRNA Translation: AAA37616.1
CCDSiCCDS28123.1
PIRiS29548
RefSeqiNP_035768.1, NM_011638.4
XP_006522062.1, XM_006521999.3
UniGeneiMm.28683

3D structure databases

ProteinModelPortaliQ62351
SMRiQ62351
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204314, 6 interactors
IntActiQ62351, 12 interactors
MINTiQ62351
STRINGi10090.ENSMUSP00000023486

Protein family/group databases

MEROPSiM28.972

PTM databases

iPTMnetiQ62351
PhosphoSitePlusiQ62351
SwissPalmiQ62351

Proteomic databases

EPDiQ62351
MaxQBiQ62351
PaxDbiQ62351
PRIDEiQ62351

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023486; ENSMUSP00000023486; ENSMUSG00000022797
GeneIDi22042
KEGGimmu:22042
UCSCiuc007yza.2 mouse

Organism-specific databases

CTDi7037
MGIiMGI:98822 Tfrc

Phylogenomic databases

eggNOGiKOG2195 Eukaryota
COG2234 LUCA
GeneTreeiENSGT00550000074421
HOGENOMiHOG000124067
HOVERGENiHBG023177
InParanoidiQ62351
KOiK06503
OMAiIMKVEYH
OrthoDBiEOG091G02ZM
PhylomeDBiQ62351
TreeFamiTF312981

Enzyme and pathway databases

ReactomeiR-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis
R-MMU-917977 Transferrin endocytosis and recycling

Miscellaneous databases

ChiTaRSiTfrc mouse
PROiPR:Q62351
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022797 Expressed in 297 organ(s), highest expression level in placenta labyrinth
CleanExiMM_TFRC
ExpressionAtlasiQ62351 baseline and differential
GenevisibleiQ62351 MM

Family and domain databases

CDDicd02128 PA_TfR, 1 hit
Gene3Di1.20.930.40, 1 hit
InterProiView protein in InterPro
IPR003137 PA_domain
IPR007484 Peptidase_M28
IPR039373 Peptidase_M28B
IPR029513 TfR
IPR007365 TFR-like_dimer_dom
IPR036757 TFR-like_dimer_dom_sf
IPR037324 TfR1/2_PA
PANTHERiPTHR10404 PTHR10404, 1 hit
PTHR10404:SF26 PTHR10404:SF26, 1 hit
PfamiView protein in Pfam
PF02225 PA, 1 hit
PF04389 Peptidase_M28, 1 hit
PF04253 TFR_dimer, 1 hit
SUPFAMiSSF47672 SSF47672, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTFR1_MOUSE
AccessioniPrimary (citable) accession number: Q62351
Secondary accession number(s): Q61560
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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