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Protein

Translin

Gene

Tsn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.1 Publication
Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.1 Publication

GO - Molecular functioni

  • endoribonuclease activity Source: GO_Central
  • identical protein binding Source: MGI
  • mRNA binding Source: MGI
  • protein-containing complex binding Source: MGI
  • RNA binding Source: MGI
  • sequence-specific DNA binding Source: GO_Central
  • single-stranded DNA binding Source: GO_Central

Keywordsi

Molecular functionDNA-binding, Endonuclease, Hydrolase, Nuclease, RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-426486 Small interfering RNA (siRNA) biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translin (EC:3.1.-.-)
Alternative name(s):
Component 3 of promoter of RISC
Short name:
C3PO
Testis/brain RNA-binding protein
Short name:
TB-RBP
Gene namesi
Name:Tsn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:109263 Tsn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916841 – 228TranslinAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei187N6-acetyllysineBy similarity1
Modified residuei190PhosphoserineBy similarity1
Modified residuei199N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ62348
MaxQBiQ62348
PaxDbiQ62348
PRIDEiQ62348

PTM databases

iPTMnetiQ62348
PhosphoSitePlusiQ62348

Expressioni

Gene expression databases

BgeeiENSMUSG00000026374 Expressed in 265 organ(s), highest expression level in respiratory primordium
CleanExiMM_TSN
ExpressionAtlasiQ62348 baseline and differential
GenevisibleiQ62348 MM

Interactioni

Subunit structurei

Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204347, 2 interactors
IntActiQ62348, 1 interactor
MINTiQ62348
STRINGi10090.ENSMUSP00000027623

Structurei

Secondary structure

1228
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ62348
SMRiQ62348
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ62348

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni86 – 90DNA/RNA binding5
Regioni177 – 198Leucine-zipperSequence analysisAdd BLAST22

Sequence similaritiesi

Belongs to the translin family.Curated

Phylogenomic databases

eggNOGiKOG3067 Eukaryota
ENOG410XR87 LUCA
GeneTreeiENSGT00390000014517
HOGENOMiHOG000198374
HOVERGENiHBG000373
InParanoidiQ62348
OMAiARELFCT
OrthoDBiEOG091G0NRN
PhylomeDBiQ62348
TreeFamiTF323690

Family and domain databases

CDDicd14819 Translin, 1 hit
Gene3Di1.20.58.190, 1 hit
1.20.58.200, 1 hit
InterProiView protein in InterPro
IPR033956 Translin
IPR016069 Translin_C
IPR002848 Translin_fam
IPR016068 Translin_N
IPR036081 Translin_sf
PANTHERiPTHR10741 PTHR10741, 1 hit
PTHR10741:SF2 PTHR10741:SF2, 1 hit
PfamiView protein in Pfam
PF01997 Translin, 1 hit
SUPFAMiSSF74784 SSF74784, 1 hit

Sequencei

Sequence statusi: Complete.

Q62348-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVSEIFVEL QGFLAAEQDI REEIRKVVQS LEQTAREILT LLQGVHQGTG
60 70 80 90 100
FQDIPKRCLK AREHFSTVKT HLTSLKTKFP AEQYYRFHEH WRFVLQRLVF
110 120 130 140 150
LAAFVVYLET ETLVTREAVT EILGIEPDRE KGFHLDVEDY LSGVLILASE
160 170 180 190 200
LSRLSVNSVT AGDYSRPLHI STFINELDSG FRLLNLKNDS LRKRYDGLKY
210 220
DVKKVEEVVY DLSIRGFNKE TAAACGEK
Length:228
Mass (Da):26,201
Last modified:November 1, 1996 - v1
Checksum:i39FBB4FCC5AA375C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81464 mRNA Translation: CAA57222.1
Y12568
, Y12569, Y12570, Y12571, Y12572 Genomic DNA Translation: CAA73151.1
BC004615 mRNA Translation: AAH04615.1
CCDSiCCDS35690.1
RefSeqiNP_035780.1, NM_011650.3
UniGeneiMm.426637

Genome annotation databases

EnsembliENSMUST00000027623; ENSMUSP00000027623; ENSMUSG00000026374
GeneIDi22099
KEGGimmu:22099
UCSCiuc007cib.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81464 mRNA Translation: CAA57222.1
Y12568
, Y12569, Y12570, Y12571, Y12572 Genomic DNA Translation: CAA73151.1
BC004615 mRNA Translation: AAH04615.1
CCDSiCCDS35690.1
RefSeqiNP_035780.1, NM_011650.3
UniGeneiMm.426637

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KEYX-ray2.65A/B/C/D1-228[»]
ProteinModelPortaliQ62348
SMRiQ62348
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204347, 2 interactors
IntActiQ62348, 1 interactor
MINTiQ62348
STRINGi10090.ENSMUSP00000027623

PTM databases

iPTMnetiQ62348
PhosphoSitePlusiQ62348

Proteomic databases

EPDiQ62348
MaxQBiQ62348
PaxDbiQ62348
PRIDEiQ62348

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027623; ENSMUSP00000027623; ENSMUSG00000026374
GeneIDi22099
KEGGimmu:22099
UCSCiuc007cib.1 mouse

Organism-specific databases

CTDi7247
MGIiMGI:109263 Tsn

Phylogenomic databases

eggNOGiKOG3067 Eukaryota
ENOG410XR87 LUCA
GeneTreeiENSGT00390000014517
HOGENOMiHOG000198374
HOVERGENiHBG000373
InParanoidiQ62348
OMAiARELFCT
OrthoDBiEOG091G0NRN
PhylomeDBiQ62348
TreeFamiTF323690

Enzyme and pathway databases

ReactomeiR-MMU-426486 Small interfering RNA (siRNA) biogenesis

Miscellaneous databases

EvolutionaryTraceiQ62348
PROiPR:Q62348
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026374 Expressed in 265 organ(s), highest expression level in respiratory primordium
CleanExiMM_TSN
ExpressionAtlasiQ62348 baseline and differential
GenevisibleiQ62348 MM

Family and domain databases

CDDicd14819 Translin, 1 hit
Gene3Di1.20.58.190, 1 hit
1.20.58.200, 1 hit
InterProiView protein in InterPro
IPR033956 Translin
IPR016069 Translin_C
IPR002848 Translin_fam
IPR016068 Translin_N
IPR036081 Translin_sf
PANTHERiPTHR10741 PTHR10741, 1 hit
PTHR10741:SF2 PTHR10741:SF2, 1 hit
PfamiView protein in Pfam
PF01997 Translin, 1 hit
SUPFAMiSSF74784 SSF74784, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSN_MOUSE
AccessioniPrimary (citable) accession number: Q62348
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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