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Protein

Transcription initiation factor TFIID subunit 6

Gene

Taf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 6
Alternative name(s):
Transcription initiation factor TFIID 70 kDa subunit
Short name:
TAF(II)70
Short name:
TAFII-70
Short name:
TAFII70
Transcription initiation factor TFIID 80 kDa subunit
Short name:
TAF(II)80
Short name:
TAFII-80
Short name:
TAFII80
p80
Gene namesi
Name:Taf6
Synonyms:Taf2e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:109129 Taf6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188741 – 678Transcription initiation factor TFIID subunit 6Add BLAST678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei120PhosphothreonineBy similarity1
Cross-linki196Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei248PhosphothreonineBy similarity1
Modified residuei253PhosphotyrosineBy similarity1
Modified residuei264PhosphoserineBy similarity1
Modified residuei524Omega-N-methylarginineCombined sources1
Modified residuei626PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1
Modified residuei636PhosphoserineBy similarity1
Modified residuei653PhosphoserineCombined sources1
Modified residuei660PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ62311
MaxQBiQ62311
PaxDbiQ62311
PeptideAtlasiQ62311
PRIDEiQ62311

PTM databases

iPTMnetiQ62311
PhosphoSitePlusiQ62311

Expressioni

Gene expression databases

BgeeiENSMUSG00000036980 Expressed in 245 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiQ62311 baseline and differential
GenevisibleiQ62311 MM

Interactioni

Subunit structurei

TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP, TAF1/TAFII250, TAF9/TAFII31 AND TAF12/TAFII20. The TAF6/TAFII70-TAF9/TAFII31 heterodimer forms an octamer complex with the TAF4B/TFII105-TAF12/TFIID20 heterodimer. Also interacts with the GTFs, TFIIEalpha/GTF2E1 and TFIIFalpha/GTF2F1. Component of the TFTC-HAT complex. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with TP53/p53.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203959, 3 interactors
ComplexPortaliCPX-916 TFTC histone acetylation complex
CPX-932 General transcription factor complex TFIID
CPX-959 General transcription factor complex TFIID, Taf4b variant
CORUMiQ62311
DIPiDIP-493N
IntActiQ62311, 4 interactors
MINTiQ62311
STRINGi10090.ENSMUSP00000048016

Structurei

3D structure databases

ProteinModelPortaliQ62311
SMRiQ62311
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TAF6 family.Curated

Phylogenomic databases

eggNOGiKOG2549 Eukaryota
COG5095 LUCA
GeneTreeiENSGT00640000091486
HOGENOMiHOG000253001
HOVERGENiHBG012489
InParanoidiQ62311
KOiK03131
OrthoDBiEOG091G05S9
PhylomeDBiQ62311
TreeFamiTF313632

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR009072 Histone-fold
IPR037796 TAF6
IPR011442 TAF6_C
IPR004823 TAF_TATA-bd
PANTHERiPTHR10221 PTHR10221, 1 hit
PfamiView protein in Pfam
PF02969 TAF, 1 hit
PF07571 TAF6_C, 1 hit
SMARTiView protein in SMART
SM00803 TAF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
SSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q62311-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEEKKLKLS NTVLPSESMK VVAESMGIAQ IQEETCQLLT DEVSYRIKEI
60 70 80 90 100
AQDALKFMHM GKRQKLTTSD IDYALKLKNV EPLYGFHAQE FIPFRFASGG
110 120 130 140 150
GRELYFYEEK EVDLSDIINT PLPRVPLDVC LKAHWLSIEG CQPAIPENPP
160 170 180 190 200
PAPKEQQKAE ATEPLKSAKP GQEEDGPLKG KGQGAAAADG KGKEKKAPPL
210 220 230 240 250
LEGAPFRLKP RSIHELSVEQ QLYYKEITEA CVGSCEAKRA EALQSIATDP
260 270 280 290 300
GLYQMLPRFS TFISEGVRVN VVQNNLALLI YLMRMVKALM DNPTLYLEKY
310 320 330 340 350
VHELIPAVMT CIVSRQLCLR PDVDNHWALR DFAARLVAQI CKHFSTTTNN
360 370 380 390 400
IQSRITKTFT KSWVDEKTPW TTRYGSIAGL AELGHDVIKT LILPRLQQEG
410 420 430 440 450
ERIRSVLDGP VLSNIDRIGA DHVQSLLLKH CAPVLAKLRP PPDNQDAYRG
460 470 480 490 500
EFGSLGPLLC SHVVKARAQA ALQAQQVNRT TLTITQPRPT LTLSQAPQPG
510 520 530 540 550
PRTPGLLKVP GSIALPVQTL VSARAAAPPQ PSPPPTKFIV MSSSSSASST
560 570 580 590 600
QQVLSLSTSA PGSGSTTTSP VTTTVPSVQP IVKLVSTATT APPSTAPAGS
610 620 630 640 650
GSVQKYIVVS LPPTGEGKGG PPSHPSPVPP SSSSPSPLGG STLCGGKQEA
660 670
GDSPPPAPGT PKANGSQPTG PGSPQPAL
Length:678
Mass (Da):72,673
Last modified:November 1, 1996 - v1
Checksum:i2F454DA3A29B410D
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z0T0D3Z0T0_MOUSE
Transcription initiation factor TFI...
Taf6
636Annotation score:
S4R1R2S4R1R2_MOUSE
Transcription initiation factor TFI...
Taf6
114Annotation score:
D3Z5H6D3Z5H6_MOUSE
Transcription initiation factor TFI...
Taf6
214Annotation score:
D3Z4X5D3Z4X5_MOUSE
Transcription initiation factor TFI...
Taf6
55Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49439 mRNA Translation: BAA08417.1
BC058583 mRNA Translation: AAH58583.1
CCDSiCCDS19795.1
PIRiJC4245
RefSeqiNP_033341.1, NM_009315.3
XP_017176274.1, XM_017320785.1
XP_017176275.1, XM_017320786.1
UniGeneiMm.248517

Genome annotation databases

EnsembliENSMUST00000048698; ENSMUSP00000048016; ENSMUSG00000036980
ENSMUST00000110936; ENSMUSP00000106561; ENSMUSG00000036980
GeneIDi21343
KEGGimmu:21343
UCSCiuc009aew.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49439 mRNA Translation: BAA08417.1
BC058583 mRNA Translation: AAH58583.1
CCDSiCCDS19795.1
PIRiJC4245
RefSeqiNP_033341.1, NM_009315.3
XP_017176274.1, XM_017320785.1
XP_017176275.1, XM_017320786.1
UniGeneiMm.248517

3D structure databases

ProteinModelPortaliQ62311
SMRiQ62311
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203959, 3 interactors
ComplexPortaliCPX-916 TFTC histone acetylation complex
CPX-932 General transcription factor complex TFIID
CPX-959 General transcription factor complex TFIID, Taf4b variant
CORUMiQ62311
DIPiDIP-493N
IntActiQ62311, 4 interactors
MINTiQ62311
STRINGi10090.ENSMUSP00000048016

PTM databases

iPTMnetiQ62311
PhosphoSitePlusiQ62311

Proteomic databases

EPDiQ62311
MaxQBiQ62311
PaxDbiQ62311
PeptideAtlasiQ62311
PRIDEiQ62311

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048698; ENSMUSP00000048016; ENSMUSG00000036980
ENSMUST00000110936; ENSMUSP00000106561; ENSMUSG00000036980
GeneIDi21343
KEGGimmu:21343
UCSCiuc009aew.1 mouse

Organism-specific databases

CTDi6878
MGIiMGI:109129 Taf6

Phylogenomic databases

eggNOGiKOG2549 Eukaryota
COG5095 LUCA
GeneTreeiENSGT00640000091486
HOGENOMiHOG000253001
HOVERGENiHBG012489
InParanoidiQ62311
KOiK03131
OrthoDBiEOG091G05S9
PhylomeDBiQ62311
TreeFamiTF313632

Enzyme and pathway databases

ReactomeiR-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

PROiPR:Q62311
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036980 Expressed in 245 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiQ62311 baseline and differential
GenevisibleiQ62311 MM

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR009072 Histone-fold
IPR037796 TAF6
IPR011442 TAF6_C
IPR004823 TAF_TATA-bd
PANTHERiPTHR10221 PTHR10221, 1 hit
PfamiView protein in Pfam
PF02969 TAF, 1 hit
PF07571 TAF6_C, 1 hit
SMARTiView protein in SMART
SM00803 TAF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
SSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAF6_MOUSE
AccessioniPrimary (citable) accession number: Q62311
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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