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Protein

Testican-1

Gene

Spock1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPSiI31.006

Names & Taxonomyi

Protein namesi
Recommended name:
Testican-1
Alternative name(s):
Protein SPOCK
Gene namesi
Name:Spock1
Synonyms:Spock, Ticn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:105371 Spock1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002670022 – 442Testican-1Add BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 100By similarity
Disulfide bondi94 ↔ 110By similarity
Disulfide bondi139 ↔ 169By similarity
Disulfide bondi142 ↔ 162By similarity
Disulfide bondi151 ↔ 183By similarity
Disulfide bondi316 ↔ 340By similarity
Disulfide bondi351 ↔ 358By similarity
Disulfide bondi360 ↔ 379By similarity
Glycosylationi386O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi391O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1

Post-translational modificationi

Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.

Keywords - PTMi

Disulfide bond, Glycoprotein, Heparan sulfate, Proteoglycan

Proteomic databases

MaxQBiQ62288
PaxDbiQ62288
PeptideAtlasiQ62288
PRIDEiQ62288

PTM databases

PhosphoSitePlusiQ62288

Expressioni

Tissue specificityi

Predominantly expressed in the postsynaptic area of pyramidal neurons.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128840

Structurei

3D structure databases

ProteinModelPortaliQ62288
SMRiQ62288
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 185Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini313 – 379Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST67

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3555 Eukaryota
ENOG410Y6A8 LUCA
HOGENOMiHOG000293295
HOVERGENiHBG026595
InParanoidiQ62288

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR019577 SPARC/Testican_Ca-bd-dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PF00086 Thyroglobulin_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q62288-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAIAVLAAA AAAWCFLQVD SRHLDALAGG AALNNANFLD NDQWLSTVSQ
60 70 80 90 100
YDRDKYWNRF RDGIQDDYFR NWNPNKPFDQ ALDPSKDPCL KVKCSPHKVC
110 120 130 140 150
VTQDYQTALC VSRKHLLPRQ KKGNVAHKHW LGPSNLVKCK PCPVAQSAMV
160 170 180 190 200
CGSDGHTYTS KCKLEFHACS TGKSLNSLCD GPCPCLPEPE PLKPKAEKSA
210 220 230 240 250
CTDKELRNLA SRLKDWFGAL HEDANRVIKP TSSDPAQGRF DTSILPICKD
260 270 280 290 300
SLGWMFNKLD MNYDLLLDHS EINAIYLDKY EPCIKPLFNS CDSFKDGKLS
310 320 330 340 350
NNEWCYCFQK PAGLPCQNEM NRIQKLSKGK SLLGAFIPRC NEEGYYKATQ
360 370 380 390 400
CHGSTGQCWC VDKYGNELAG SRKQGTVSCE EEQETSGDFG SGGSVVLLDD
410 420 430 440
LEDERELGPK DKEGKLRVRT RAVREDDEDE DDDKEDEVGY IW
Length:442
Mass (Da):49,551
Last modified:July 27, 2011 - v2
Checksum:iCEEE011B799E5154
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6DIC9Q6DIC9_MOUSE
Sparc/osteonectin, cwcv and kazal-l...
Spock1
442Annotation score:
Q8BKQ3Q8BKQ3_MOUSE
Testican-1
Spock1
439Annotation score:
Q8BM07Q8BM07_MOUSE
Testican-1
Spock1
364Annotation score:
A0A087WPP6A0A087WPP6_MOUSE
Testican-1
Spock1
367Annotation score:
A0A286YCI6A0A286YCI6_MOUSE
Testican-1
Spock1
343Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63 – 65GIQ → EVE in CAA63448 (PubMed:8626787).Curated3
Sequence conflicti235P → G in CAA63448 (PubMed:8626787).Curated1
Sequence conflicti406 – 407EL → DV in CAA63448 (PubMed:8626787).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92864 mRNA Translation: CAA63448.1
AC142258 Genomic DNA No translation available.
AC154210 Genomic DNA No translation available.
AC154748 Genomic DNA No translation available.
CT010428 Genomic DNA No translation available.
CCDSiCCDS79195.1
UniGeneiMm.379020

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92864 mRNA Translation: CAA63448.1
AC142258 Genomic DNA No translation available.
AC154210 Genomic DNA No translation available.
AC154748 Genomic DNA No translation available.
CT010428 Genomic DNA No translation available.
CCDSiCCDS79195.1
UniGeneiMm.379020

3D structure databases

ProteinModelPortaliQ62288
SMRiQ62288
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128840

Protein family/group databases

MEROPSiI31.006

PTM databases

PhosphoSitePlusiQ62288

Proteomic databases

MaxQBiQ62288
PaxDbiQ62288
PeptideAtlasiQ62288
PRIDEiQ62288

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:105371 Spock1

Phylogenomic databases

eggNOGiKOG3555 Eukaryota
ENOG410Y6A8 LUCA
HOGENOMiHOG000293295
HOVERGENiHBG026595
InParanoidiQ62288

Miscellaneous databases

PROiPR:Q62288
SOURCEiSearch...

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR019577 SPARC/Testican_Ca-bd-dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PF00086 Thyroglobulin_1, 1 hit
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTICN1_MOUSE
AccessioniPrimary (citable) accession number: Q62288
Secondary accession number(s): E9PYW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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