UniProtKB - Q62283 (TSN7_MOUSE)
Protein
Tetraspanin-7
Gene
Tspan7
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in cell proliferation and cell motility.
Enzyme and pathway databases
Reactomei | R-MMU-416993, Trafficking of GluR2-containing AMPA receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Tetraspanin-7Short name: Tspan-7 Alternative name(s): Cell surface glycoprotein A15 PE31 TALLA homolog Transmembrane 4 superfamily member 2 CD_antigen: CD231 |
Gene namesi | Name:Tspan7 Synonyms:Mxs1, Tm4sf2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1298407, Tspan7 |
Subcellular locationi
Other locations
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 16 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 17 – 40 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 41 – 56 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 57 – 75 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 76 – 86 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 87 – 112 | HelicalSequence analysisAdd BLAST | 26 | |
Topological domaini | 113 – 213 | ExtracellularSequence analysisAdd BLAST | 101 | |
Transmembranei | 214 – 234 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 235 – 249 | CytoplasmicSequence analysisAdd BLAST | 15 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219249 | 1 – 249 | Tetraspanin-7Add BLAST | 249 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 54 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 155 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 158 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 177 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 188 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q62283 |
MaxQBi | Q62283 |
PaxDbi | Q62283 |
PeptideAtlasi | Q62283 |
PRIDEi | Q62283 |
PTM databases
GlyGeni | Q62283, 5 sites |
PhosphoSitePlusi | Q62283 |
SwissPalmi | Q62283 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000058254, Expressed in cerebellum and 322 other tissues |
ExpressionAtlasi | Q62283, baseline and differential |
Genevisiblei | Q62283, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 204231, 1 interactor |
STRINGi | 10090.ENSMUSP00000075692 |
Miscellaneous databases
RNActi | Q62283, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the tetraspanin (TM4SF) family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3882, Eukaryota |
GeneTreei | ENSGT00940000156153 |
HOGENOMi | CLU_055524_3_0_1 |
InParanoidi | Q62283 |
OMAi | KNDERSH |
OrthoDBi | 1145558at2759 |
PhylomeDBi | Q62283 |
TreeFami | TF352891 |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin IPR018503, Tetraspanin_CS IPR008952, Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PIRSFi | PIRSF002419, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
SUPFAMi | SSF48652, SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421, TM4_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q62283-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASRRMETKP VITCLKTLLI IYSFVFWITG VILLAVGVWG KLTLGTYISL
60 70 80 90 100
IAENSTNAPY VLIGTGTTIV VFGLFGCFAT CRGSPWMLKL YAMFLSLVFL
110 120 130 140 150
AELVAGISGF VFRHEIKDTF LRTYTDAMQN YNGNDERSRA VDHVQRSLSC
160 170 180 190 200
CGVQNYTNWS SSPYFLDHGI PPSCCMNETD CNPLDLHNLT VAATKVNQKG
210 220 230 240
CYDLVTSFME TNMGIIAGVA FGIAFSQLIG MLLACCLSRF ITANQYEMV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ3UHG5 | Q3UHG5_MOUSE | Tetraspanin | Tspan7 | 230 | Annotation score: |
Sequence cautioni
The sequence AAC34579 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA05493 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 146 | R → P in AAC34579 (PubMed:10617319).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26483 mRNA Translation: BAA05493.1 Different initiation. AF052492 mRNA Translation: AAC34579.1 Different initiation. AK004776 mRNA Translation: BAB23554.1 |
CCDSi | CCDS30016.1 |
RefSeqi | NP_062608.2, NM_019634.2 |
Genome annotation databases
Ensembli | ENSMUST00000076354; ENSMUSP00000075692; ENSMUSG00000058254 |
GeneIDi | 21912 |
KEGGi | mmu:21912 |
UCSCi | uc009sqm.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26483 mRNA Translation: BAA05493.1 Different initiation. AF052492 mRNA Translation: AAC34579.1 Different initiation. AK004776 mRNA Translation: BAB23554.1 |
CCDSi | CCDS30016.1 |
RefSeqi | NP_062608.2, NM_019634.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 204231, 1 interactor |
STRINGi | 10090.ENSMUSP00000075692 |
PTM databases
GlyGeni | Q62283, 5 sites |
PhosphoSitePlusi | Q62283 |
SwissPalmi | Q62283 |
Proteomic databases
jPOSTi | Q62283 |
MaxQBi | Q62283 |
PaxDbi | Q62283 |
PeptideAtlasi | Q62283 |
PRIDEi | Q62283 |
Protocols and materials databases
Antibodypediai | 530, 275 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000076354; ENSMUSP00000075692; ENSMUSG00000058254 |
GeneIDi | 21912 |
KEGGi | mmu:21912 |
UCSCi | uc009sqm.1, mouse |
Organism-specific databases
CTDi | 7102 |
MGIi | MGI:1298407, Tspan7 |
Phylogenomic databases
eggNOGi | KOG3882, Eukaryota |
GeneTreei | ENSGT00940000156153 |
HOGENOMi | CLU_055524_3_0_1 |
InParanoidi | Q62283 |
OMAi | KNDERSH |
OrthoDBi | 1145558at2759 |
PhylomeDBi | Q62283 |
TreeFami | TF352891 |
Enzyme and pathway databases
Reactomei | R-MMU-416993, Trafficking of GluR2-containing AMPA receptors |
Miscellaneous databases
BioGRID-ORCSi | 21912, 1 hit in 18 CRISPR screens |
ChiTaRSi | Tspan7, mouse |
PROi | PR:Q62283 |
RNActi | Q62283, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000058254, Expressed in cerebellum and 322 other tissues |
ExpressionAtlasi | Q62283, baseline and differential |
Genevisiblei | Q62283, MM |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin IPR018503, Tetraspanin_CS IPR008952, Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PIRSFi | PIRSF002419, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
SUPFAMi | SSF48652, SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421, TM4_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TSN7_MOUSE | |
Accessioni | Q62283Primary (citable) accession number: Q62283 Secondary accession number(s): O88429, Q9DBS3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 16, 2001 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families