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Protein

T-cell acute lymphocytic leukemia protein 2 homolog

Gene

Tal2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

  • midbrain development Source: MGI
  • multicellular organism growth Source: MGI
  • post-embryonic development Source: MGI
  • thalamus development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell acute lymphocytic leukemia protein 2 homolog
Short name:
TAL-2
Gene namesi
Name:Tal2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:99540 Tal2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274571 – 108T-cell acute lymphocytic leukemia protein 2 homologAdd BLAST108

Proteomic databases

PaxDbiQ62282
PRIDEiQ62282

PTM databases

iPTMnetiQ62282
PhosphoSitePlusiQ62282

Expressioni

Gene expression databases

BgeeiENSMUSG00000028417 Expressed in 37 organ(s), highest expression level in head
CleanExiMM_TAL2
ExpressionAtlasiQ62282 baseline and differential
GenevisibleiQ62282 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203963, 3 interactors
STRINGi10090.ENSMUSP00000030124

Structurei

3D structure databases

ProteinModelPortaliQ62282
SMRiQ62282
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 54bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000129920
HOVERGENiHBG004515
InParanoidiQ62282
KOiK09068
OMAiHLPGLEN
OrthoDBiEOG091G0ESI
PhylomeDBiQ62282
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q62282-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRKIFTNTR ERWRQQSVNN AFAKLRKLIP THPPDKKLSK NETLRLAMRY
60 70 80 90 100
INFLVKVLGE QSLHQTGVAA QGNILGLFPP KTRLPDEDDR TLLNDYRVPS

PGPSHGAP
Length:108
Mass (Da):12,315
Last modified:November 1, 1996 - v1
Checksum:i11B8A7711520AF13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81077 Genomic DNA Translation: AAA40162.1
AK018448 mRNA Translation: BAB31216.1
CCDSiCCDS18192.1
RefSeqiNP_033343.1, NM_009317.3
UniGeneiMm.56955

Genome annotation databases

EnsembliENSMUST00000030124; ENSMUSP00000030124; ENSMUSG00000028417
GeneIDi21350
KEGGimmu:21350
UCSCiuc008sxg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81077 Genomic DNA Translation: AAA40162.1
AK018448 mRNA Translation: BAB31216.1
CCDSiCCDS18192.1
RefSeqiNP_033343.1, NM_009317.3
UniGeneiMm.56955

3D structure databases

ProteinModelPortaliQ62282
SMRiQ62282
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203963, 3 interactors
STRINGi10090.ENSMUSP00000030124

PTM databases

iPTMnetiQ62282
PhosphoSitePlusiQ62282

Proteomic databases

PaxDbiQ62282
PRIDEiQ62282

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030124; ENSMUSP00000030124; ENSMUSG00000028417
GeneIDi21350
KEGGimmu:21350
UCSCiuc008sxg.1 mouse

Organism-specific databases

CTDi6887
MGIiMGI:99540 Tal2

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000129920
HOVERGENiHBG004515
InParanoidiQ62282
KOiK09068
OMAiHLPGLEN
OrthoDBiEOG091G0ESI
PhylomeDBiQ62282
TreeFamiTF315153

Miscellaneous databases

PROiPR:Q62282
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028417 Expressed in 37 organ(s), highest expression level in head
CleanExiMM_TAL2
ExpressionAtlasiQ62282 baseline and differential
GenevisibleiQ62282 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAL2_MOUSE
AccessioniPrimary (citable) accession number: Q62282
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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