UniProtKB - Q62276 (MED22_MOUSE)
Mediator of RNA polymerase II transcription subunit 22
Med22
Functioni
GO - Molecular functioni
- transcription coregulator activity Source: InterPro
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: InterPro
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Mediator of RNA polymerase II transcription subunit 22Alternative name(s): Mediator complex subunit 22 Surfeit locus protein 5 Short name: Surf-5 |
Gene namesi | Name:Med22 Synonyms:Surf5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98446, Med22 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- mediator complex Source: MGI
- nucleoplasm Source: Reactome
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000178839 | 1 – 200 | Mediator of RNA polymerase II transcription subunit 22Add BLAST | 200 |
Proteomic databases
PaxDbi | Q62276 |
PRIDEi | Q62276 |
PTM databases
iPTMneti | Q62276 |
PhosphoSitePlusi | Q62276 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000015776, Expressed in prostate gland and 294 other tissues |
ExpressionAtlasi | Q62276, baseline and differential |
Genevisiblei | Q62276, MM |
Interactioni
Subunit structurei
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 203582, 34 interactors |
ComplexPortali | CPX-3264, Core mediator complex |
IntActi | Q62276, 33 interactors |
STRINGi | 10090.ENSMUSP00000015920 |
Miscellaneous databases
RNActi | Q62276, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 93 – 122 | Sequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3304, Eukaryota |
GeneTreei | ENSGT00390000004339 |
HOGENOMi | CLU_117242_0_0_1 |
InParanoidi | Q62276 |
OMAi | TQCEQDT |
OrthoDBi | 1573728at2759 |
PhylomeDBi | Q62276 |
TreeFami | TF323390 |
Family and domain databases
Gene3Di | 1.20.58.1600, 1 hit |
InterProi | View protein in InterPro IPR009332, Med22 IPR038427, MED22_sf |
PANTHERi | PTHR12434, PTHR12434, 1 hit |
Pfami | View protein in Pfam PF06179, Med22, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQQRALPQS KETLLQSYNK RLKDDIKSIM DNFTEIIKTA KIEDETQVSR
60 70 80 90 100
ATQGEQDNYE MHVRAANIVR AGESLMKLVS DLKQFLILND FPSVNEAIDQ
110 120 130 140 150
RNQQLRALQE ECDRKLITLR DEVSIDLYEL EEEYYSSSSS LCEANDLPLC
160 170 180 190 200
EAYWRLDLDA DSADGLSAPL LASPETGAGP LQSAAPVHSH GGGPGPTEHT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2ALA4 | A2ALA4_MOUSE | Mediator complex subunit 22 | Med22 | 168 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028993 | 138 – 140 | SSS → RYK in isoform 2. 2 Publications | 3 | |
Alternative sequenceiVSP_028994 | 141 – 200 | Missing in isoform 2. 2 PublicationsAdd BLAST | 60 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X85169 Genomic DNA Translation: CAA59453.1 AK144744 mRNA Translation: BAE26044.1 AK161053 mRNA Translation: BAE36173.1 AK166250 mRNA Translation: BAE38661.1 AK166474 mRNA Translation: BAE38795.1 AL773563 Genomic DNA No translation available. BC018225 mRNA Translation: AAH18225.1 |
CCDSi | CCDS15813.1 [Q62276-1] CCDS15814.1 [Q62276-2] |
RefSeqi | NP_001029080.1, NM_001033908.1 [Q62276-1] NP_035643.1, NM_011513.2 [Q62276-2] |
Genome annotation databases
Ensembli | ENSMUST00000015920; ENSMUSP00000015920; ENSMUSG00000015776 [Q62276-1] ENSMUST00000102899; ENSMUSP00000099963; ENSMUSG00000015776 [Q62276-2] |
GeneIDi | 20933 |
KEGGi | mmu:20933 |
UCSCi | uc008iwd.1, mouse [Q62276-1] uc008iwe.1, mouse [Q62276-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X85169 Genomic DNA Translation: CAA59453.1 AK144744 mRNA Translation: BAE26044.1 AK161053 mRNA Translation: BAE36173.1 AK166250 mRNA Translation: BAE38661.1 AK166474 mRNA Translation: BAE38795.1 AL773563 Genomic DNA No translation available. BC018225 mRNA Translation: AAH18225.1 |
CCDSi | CCDS15813.1 [Q62276-1] CCDS15814.1 [Q62276-2] |
RefSeqi | NP_001029080.1, NM_001033908.1 [Q62276-1] NP_035643.1, NM_011513.2 [Q62276-2] |
3D structure databases
SMRi | Q62276 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203582, 34 interactors |
ComplexPortali | CPX-3264, Core mediator complex |
IntActi | Q62276, 33 interactors |
STRINGi | 10090.ENSMUSP00000015920 |
PTM databases
iPTMneti | Q62276 |
PhosphoSitePlusi | Q62276 |
Proteomic databases
PaxDbi | Q62276 |
PRIDEi | Q62276 |
Protocols and materials databases
Antibodypediai | 18330, 165 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000015920; ENSMUSP00000015920; ENSMUSG00000015776 [Q62276-1] ENSMUST00000102899; ENSMUSP00000099963; ENSMUSG00000015776 [Q62276-2] |
GeneIDi | 20933 |
KEGGi | mmu:20933 |
UCSCi | uc008iwd.1, mouse [Q62276-1] uc008iwe.1, mouse [Q62276-2] |
Organism-specific databases
CTDi | 6837 |
MGIi | MGI:98446, Med22 |
Phylogenomic databases
eggNOGi | KOG3304, Eukaryota |
GeneTreei | ENSGT00390000004339 |
HOGENOMi | CLU_117242_0_0_1 |
InParanoidi | Q62276 |
OMAi | TQCEQDT |
OrthoDBi | 1573728at2759 |
PhylomeDBi | Q62276 |
TreeFami | TF323390 |
Miscellaneous databases
BioGRID-ORCSi | 20933, 8 hits in 17 CRISPR screens |
ChiTaRSi | Med22, mouse |
PROi | PR:Q62276 |
RNActi | Q62276, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000015776, Expressed in prostate gland and 294 other tissues |
ExpressionAtlasi | Q62276, baseline and differential |
Genevisiblei | Q62276, MM |
Family and domain databases
Gene3Di | 1.20.58.1600, 1 hit |
InterProi | View protein in InterPro IPR009332, Med22 IPR038427, MED22_sf |
PANTHERi | PTHR12434, PTHR12434, 1 hit |
Pfami | View protein in Pfam PF06179, Med22, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MED22_MOUSE | |
Accessioni | Q62276Primary (citable) accession number: Q62276 Secondary accession number(s): A2ALA2, Q3TTZ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families