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Protein

Cornifin-A

Gene

Sprr1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. May participate widely in the construction of cell envelopes in cornifying epithelia characterized by either increased thickness or a requirement for extreme flexibility.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processKeratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Cornifin-A
Alternative name(s):
Small proline-rich protein 1A
Short name:
SPR1 A
Short name:
SPR1A
Gene namesi
Name:Sprr1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106660 Sprr1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499981 – 144Cornifin-AAdd BLAST144

Proteomic databases

MaxQBiQ62266
PaxDbiQ62266
PeptideAtlasiQ62266
PRIDEiQ62266

PTM databases

iPTMnetiQ62266
PhosphoSitePlusiQ62266

Expressioni

Tissue specificityi

Expressed in fetal periderm, hair follicles and in the thickened epidermis of the lip and footpad. Also present in the epithelia of various tissues such as the penis, vagina, forestomach, tongue and esophagus.1 Publication

Developmental stagei

First detected in fetal skin around day 16 and expression continues throughout newborn and adult stages.1 Publication

Gene expression databases

BgeeiENSMUSG00000050359 Expressed in 163 organ(s), highest expression level in skin of back
CleanExiMM_SPRR1A
GenevisibleiQ62266 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053751

Structurei

3D structure databases

ProteinModelPortaliQ62266
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati27 – 3418
Repeati35 – 4228
Repeati43 – 4937
Repeati50 – 5748
Repeati58 – 6558
Repeati66 – 7368
Repeati74 – 8178
Repeati82 – 8988
Repeati90 – 9798
Repeati98 – 105108
Repeati106 – 113118
Repeati114 – 121128
Repeati122 – 129138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni27 – 12913 X 8 AA approximate tandem repeatsAdd BLAST103

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JH2M Eukaryota
ENOG410XUVY LUCA
GeneTreeiENSGT00730000111065
HOGENOMiHOG000059526
HOVERGENiHBG079213
InParanoidiQ62266
OMAiPVVPEPC
OrthoDBiEOG091G0QRS
PhylomeDBiQ62266
TreeFamiTF338205

Family and domain databases

InterProiView protein in InterPro
IPR026075 SPRR/LCE
PANTHERiPTHR23263 PTHR23263, 3 hits

Sequencei

Sequence statusi: Complete.

Q62266-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSHQQKQPC TVPPQLHQQQ VKQPCQPPPQ EPCAPKTKDP CHPVPEPCNP
60 70 80 90 100
KGPEPCHPKA PEPCHPKAPE PCNPKVPEPC QPKVPEPCQP KVPEPCNPKV
110 120 130 140
PEPCQPKAPE PCHPKAPEPC HPVVPEPCPS TVTPSPYQQK TKQK
Length:144
Mass (Da):15,765
Last modified:November 1, 1996 - v1
Checksum:iA7D591678E5823AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91824 mRNA Translation: CAA62933.1
AF057156 Genomic DNA Translation: AAD10126.1
AK144782 mRNA Translation: BAE26064.1
CH466656 Genomic DNA Translation: EDL00695.1
BC027534 mRNA Translation: AAH27534.1
CCDSiCCDS17559.1
RefSeqiNP_033290.1, NM_009264.2
UniGeneiMm.331191

Genome annotation databases

EnsembliENSMUST00000054599; ENSMUSP00000053751; ENSMUSG00000050359
GeneIDi20753
KEGGimmu:20753
UCSCiuc008qed.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91824 mRNA Translation: CAA62933.1
AF057156 Genomic DNA Translation: AAD10126.1
AK144782 mRNA Translation: BAE26064.1
CH466656 Genomic DNA Translation: EDL00695.1
BC027534 mRNA Translation: AAH27534.1
CCDSiCCDS17559.1
RefSeqiNP_033290.1, NM_009264.2
UniGeneiMm.331191

3D structure databases

ProteinModelPortaliQ62266
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053751

PTM databases

iPTMnetiQ62266
PhosphoSitePlusiQ62266

Proteomic databases

MaxQBiQ62266
PaxDbiQ62266
PeptideAtlasiQ62266
PRIDEiQ62266

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054599; ENSMUSP00000053751; ENSMUSG00000050359
GeneIDi20753
KEGGimmu:20753
UCSCiuc008qed.1 mouse

Organism-specific databases

CTDi6698
MGIiMGI:106660 Sprr1a

Phylogenomic databases

eggNOGiENOG410JH2M Eukaryota
ENOG410XUVY LUCA
GeneTreeiENSGT00730000111065
HOGENOMiHOG000059526
HOVERGENiHBG079213
InParanoidiQ62266
OMAiPVVPEPC
OrthoDBiEOG091G0QRS
PhylomeDBiQ62266
TreeFamiTF338205

Miscellaneous databases

ChiTaRSiSprr1a mouse
PROiPR:Q62266
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050359 Expressed in 163 organ(s), highest expression level in skin of back
CleanExiMM_SPRR1A
GenevisibleiQ62266 MM

Family and domain databases

InterProiView protein in InterPro
IPR026075 SPRR/LCE
PANTHERiPTHR23263 PTHR23263, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSPR1A_MOUSE
AccessioniPrimary (citable) accession number: Q62266
Secondary accession number(s): Q3UMN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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