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Protein

Thyroid hormone-inducible hepatic protein

Gene

Thrsp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB (By similarity).By similarity2 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • lipid metabolic process Source: UniProtKB-KW
  • regulation of lipid biosynthetic process Source: UniProtKB
  • regulation of triglyceride biosynthetic process Source: UniProtKB
  • response to bacterium Source: MGI

Keywordsi

Biological processLipid biosynthesis, Lipid metabolism, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-200425 Import of palmitoyl-CoA into the mitochondrial matrix

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone-inducible hepatic protein
Alternative name(s):
Spot 14 protein
Short name:
S14
Short name:
SPOT14
Gene namesi
Name:Thrsp
Synonyms:S14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:109126 Thrsp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Decreased lipid synthesis in the lactating mammary gland. Milk has reduced triglyceride content, causing reduced weight gain in nursing pups. Adults exhibit reduced body fat content. No effect on lipid synthesis in liver. No effect on the expression of thyroid hormone-induced lipogenic genes.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001237741 – 150Thyroid hormone-inducible hepatic proteinAdd BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ62264
PaxDbiQ62264
PRIDEiQ62264

PTM databases

iPTMnetiQ62264
PhosphoSitePlusiQ62264
SwissPalmiQ62264

Expressioni

Tissue specificityi

Mainly expressed in tissues that synthesize triglycerides.1 Publication

Gene expression databases

BgeeiENSMUSG00000035686 Expressed in 260 organ(s), highest expression level in inguinal mammary gland
ExpressionAtlasiQ62264 baseline and differential
GenevisibleiQ62264 MM

Interactioni

Subunit structurei

Homodimer. Heterodimer with MID1IP1. Interacts with THRB and PLAGL1 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-59527N
IntActiQ62264, 2 interactors
STRINGi10090.ENSMUSP00000042988

Structurei

Secondary structure

1150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ62264
SMRiQ62264
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ62264

Family & Domainsi

Sequence similaritiesi

Belongs to the SPOT14 family.Curated

Phylogenomic databases

eggNOGiENOG410J34G Eukaryota
ENOG410YT7Q LUCA
GeneTreeiENSGT00500000044890
HOGENOMiHOG000001157
HOVERGENiHBG002528
InParanoidiQ62264
OMAiTVMDRYS
OrthoDBiEOG091G0Z4G
PhylomeDBiQ62264
TreeFamiTF326826

Family and domain databases

InterProiView protein in InterPro
IPR009786 Spot_14
PANTHERiPTHR14315 PTHR14315, 1 hit
PfamiView protein in Pfam
PF07084 Spot_14, 1 hit

Sequencei

Sequence statusi: Complete.

Q62264-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQVLTKRYPK NCLLTVMDRY SAVVRNMEQV VMIPSLLRDV QLSGPGGSVQ
60 70 80 90 100
DGAPDLYTYF TMLKSICVEV DHGLLPREEW QAKVAGNETS EAENDAAETE
110 120 130 140 150
EAEEDRISEE LDLEAQFHLH FCSLHHILTH LTRKAQEVTR KYQEMTGQVL
Length:150
Mass (Da):17,093
Last modified:November 1, 1997 - v1
Checksum:iC0CAACD39DBF8E31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95279 Genomic DNA Translation: CAA64600.1
BC009165 mRNA Translation: AAH09165.1
CCDSiCCDS21458.1
RefSeqiNP_033407.1, NM_009381.3
UniGeneiMm.28585

Genome annotation databases

EnsembliENSMUST00000043077; ENSMUSP00000042988; ENSMUSG00000035686
GeneIDi21835
KEGGimmu:21835
UCSCiuc009ije.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95279 Genomic DNA Translation: CAA64600.1
BC009165 mRNA Translation: AAH09165.1
CCDSiCCDS21458.1
RefSeqiNP_033407.1, NM_009381.3
UniGeneiMm.28585

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ONTX-ray2.65A1-150[»]
ProteinModelPortaliQ62264
SMRiQ62264
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59527N
IntActiQ62264, 2 interactors
STRINGi10090.ENSMUSP00000042988

PTM databases

iPTMnetiQ62264
PhosphoSitePlusiQ62264
SwissPalmiQ62264

Proteomic databases

MaxQBiQ62264
PaxDbiQ62264
PRIDEiQ62264

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043077; ENSMUSP00000042988; ENSMUSG00000035686
GeneIDi21835
KEGGimmu:21835
UCSCiuc009ije.1 mouse

Organism-specific databases

CTDi7069
MGIiMGI:109126 Thrsp

Phylogenomic databases

eggNOGiENOG410J34G Eukaryota
ENOG410YT7Q LUCA
GeneTreeiENSGT00500000044890
HOGENOMiHOG000001157
HOVERGENiHBG002528
InParanoidiQ62264
OMAiTVMDRYS
OrthoDBiEOG091G0Z4G
PhylomeDBiQ62264
TreeFamiTF326826

Enzyme and pathway databases

ReactomeiR-MMU-200425 Import of palmitoyl-CoA into the mitochondrial matrix

Miscellaneous databases

EvolutionaryTraceiQ62264
PROiPR:Q62264
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035686 Expressed in 260 organ(s), highest expression level in inguinal mammary gland
ExpressionAtlasiQ62264 baseline and differential
GenevisibleiQ62264 MM

Family and domain databases

InterProiView protein in InterPro
IPR009786 Spot_14
PANTHERiPTHR14315 PTHR14315, 1 hit
PfamiView protein in Pfam
PF07084 Spot_14, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTHRSP_MOUSE
AccessioniPrimary (citable) accession number: Q62264
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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