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Entry version 196 (16 Oct 2019)
Sequence version 2 (16 May 2006)
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Protein

Spectrin beta chain, non-erythrocytic 1

Gene

Sptbn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin capping, Actin-binding, Calmodulin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-375165 NCAM signaling for neurite out-growth
R-MMU-445095 Interaction between L1 and Ankyrins
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6807878 COPI-mediated anterograde transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spectrin beta chain, non-erythrocytic 1
Alternative name(s):
Beta-II spectrin
Embryonic liver fodrin
Fodrin beta chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sptbn1
Synonyms:Elf, Spnb-2, Spnb2, Sptb2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:98388 Sptbn1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000734622 – 2363Spectrin beta chain, non-erythrocytic 1Add BLAST2362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylthreonineBy similarity1
Modified residuei36PhosphoserineCombined sources1
Modified residuei90N6-acetyllysineBy similarity1
Modified residuei228PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1
Modified residuei903PhosphoserineCombined sources1
Modified residuei1057PhosphoserineBy similarity1
Modified residuei1076PhosphoserineCombined sources1
Modified residuei1079PhosphoserineCombined sources1
Modified residuei1237PhosphoserineBy similarity1
Modified residuei1388PhosphoserineBy similarity1
Modified residuei1447PhosphoserineBy similarity1
Modified residuei1557PhosphoserineBy similarity1
Modified residuei1805PhosphotyrosineCombined sources1
Modified residuei1815N6-acetyllysineBy similarity1
Modified residuei1913N6-acetyllysineBy similarity1
Modified residuei1989N6-acetyllysineBy similarity1
Modified residuei2102PhosphoserineCombined sources1
Modified residuei2127PhosphoserineCombined sources1
Modified residuei2137PhosphoserineCombined sources1
Modified residuei2146PhosphothreonineCombined sources1
Modified residuei2147PhosphoserineCombined sources1
Modified residuei2158PhosphothreonineCombined sources1
Modified residuei2159PhosphoserineBy similarity1
Modified residuei2160PhosphoserineCombined sources1
Modified residuei2163PhosphoserineCombined sources1
Modified residuei2164PhosphoserineCombined sources1
Modified residuei2168PhosphoserineCombined sources1
Modified residuei2170PhosphothreonineCombined sources1
Modified residuei2183PhosphoserineCombined sources1
Modified residuei2186PhosphothreonineCombined sources1
Modified residuei2194PhosphothreonineCombined sources1
Modified residuei2313PhosphoserineBy similarity1
Modified residuei2318PhosphoserineBy similarity1
Modified residuei2319PhosphothreonineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi2323O-linked (GlcNAc) serine1 Publication1
Modified residuei2327PhosphothreonineBy similarity1
Modified residuei2339PhosphoserineBy similarity1
Modified residuei2340PhosphoserineCombined sources1
Isoform 2 (identifier: Q62261-2)
Modified residuei14PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q62261

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q62261

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62261

PeptideAtlas

More...
PeptideAtlasi
Q62261

PRoteomics IDEntifications database

More...
PRIDEi
Q62261

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62261

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62261

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q62261

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is present in brain, heart, kidney and liver (at protein level).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 2 is expressed in brain, heart and liver throughout embryonic development. Isoform 1 is mainly expressed in neonatal developing ventricular cardiomyocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020315 Expressed in 295 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q62261 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q62261 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ANK2 (PubMed:15262991).

Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Like erythrocyte spectrin, the spectrin-like proteins are capable to form dimers which can further associate to tetramers (By similarity).

Interacts with CAMSAP1 (By similarity).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
203461, 36 interactors

Database of interacting proteins

More...
DIPi
DIP-31558N

Protein interaction database and analysis system

More...
IntActi
Q62261, 36 interactors

Molecular INTeraction database

More...
MINTi
Q62261

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099902

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12363
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q62261

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q62261

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 158Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST105
Domaini173 – 278Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST106
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati303 – 411Spectrin 1Sequence analysisAdd BLAST109
Repeati423 – 525Spectrin 2Sequence analysisAdd BLAST103
Repeati530 – 636Spectrin 3Sequence analysisAdd BLAST107
Repeati639 – 742Spectrin 4Sequence analysisAdd BLAST104
Repeati745 – 847Spectrin 5Sequence analysisAdd BLAST103
Repeati850 – 952Spectrin 6Sequence analysisAdd BLAST103
Repeati957 – 1060Spectrin 7Sequence analysisAdd BLAST104
Repeati1063 – 1166Spectrin 8Sequence analysisAdd BLAST104
Repeati1170 – 1259Spectrin 9Sequence analysisAdd BLAST90
Repeati1276 – 1376Spectrin 10Sequence analysisAdd BLAST101
Repeati1381 – 1482Spectrin 11Sequence analysisAdd BLAST102
Repeati1486 – 1590Spectrin 12Sequence analysisAdd BLAST105
Repeati1592 – 1696Spectrin 13Sequence analysisAdd BLAST105
Repeati1698 – 1801Spectrin 14Sequence analysisAdd BLAST104
Repeati1805 – 1907Spectrin 15Sequence analysisAdd BLAST103
Repeati1914 – 2014Spectrin 16Sequence analysisAdd BLAST101
Repeati2018 – 2097Spectrin 17Sequence analysisAdd BLAST80
Domaini2196 – 2306PHPROSITE-ProRule annotationAdd BLAST111

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 275Actin-bindingAdd BLAST274
Regioni1563 – 2093Interaction with ANK2By similarityAdd BLAST531
Regioni2148 – 2176Mediates interaction with CAMSAP1By similarityAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the spectrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0035 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154864

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007281

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q62261

KEGG Orthology (KO)

More...
KOi
K06115

Identification of Orthologs from Complete Genome Data

More...
OMAi
FMLNREV

Database of Orthologous Groups

More...
OrthoDBi
543832at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q62261

TreeFam database of animal gene trees

More...
TreeFami
TF313446

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF15410 PH_9, 1 hit
PF00435 Spectrin, 17 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002297 Spectrin_beta_subunit, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00683 SPECTRINPH

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q62261-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTTVATDYD NIEIQQQYSD VNNRWDVDDW DNENSSARLF ERSRIKALAD
60 70 80 90 100
EREAVQKKTF TKWVNSHLAR VSCRITDLYT DLRDGRMLIK LLEVLSGERL
110 120 130 140 150
PKPTKGRMRI HCLENVDKAL QFLKEQRVHL ENMGSHDIVD GNHRLTLGLI
160 170 180 190 200
WTIILRFQIQ DISVETEDNK EKKSAKDALL LWCQMKTAGY PNVNIHNFTT
210 220 230 240 250
SWRDGMAFNA LIHKHRPDLI DFDKLKKSNA HYNLQNAFNL AEQHLGLTKL
260 270 280 290 300
LDPEDISVDH PDEKSIITYV VTYYHYFSKM KALAVEGKRI GKVLDNAIET
310 320 330 340 350
EKMIEKYESL ASDLLEWIEQ TIIILNNRKF ANSLVGVQQQ LQAFNTYRTV
360 370 380 390 400
EKPPKFTEKG NLEVLLFTIQ SKMRANNQKV YMPREGKLIS DINKAWERLE
410 420 430 440 450
KAEHERELAL RNELIRQEKL EQLARRFDRK AAMRETWLSE NQRLVSQDNF
460 470 480 490 500
GFDLPAVEAA TKKHEAIETD IAAYEERVQA VVAVARELEA ENYHDIKRIT
510 520 530 540 550
ARKDNVIRLW EYLLELLRAR RQRLEMNLGL QKIFQEMLYI MDWMDEMKVL
560 570 580 590 600
LLSQDYGKHL LGVEDLLQKH ALVEADIAIQ AERVRGVNAS AQKFATDGEG
610 620 630 640 650
YKPCDPQVIR DRVAHMEFCY QELCQLAAER RARLEESRRL WKFFWEMAEE
660 670 680 690 700
EGWIREKEKI LSSDDYGKDL TSVMRLLSKH RAFEDEMSGR SGHFEQAIKE
710 720 730 740 750
GEDMIAEEHF GSEKIRERII YIREQWANLE QLSAIRKKRL EEASLLHQFQ
760 770 780 790 800
ADADDIDAWM LDILKIVSSN DVGHDEYSTQ SLVKKHKDVA EEITNYRPTI
810 820 830 840 850
DTLHEQASAL PQAHAESPDV KGRLAGIEER CKEMAELTRL RKQALQDTLA
860 870 880 890 900
LYKMFSEADA CELWIDEKEQ WLNNMQIPEK LEDLEVIQHR FESLEPEMNN
910 920 930 940 950
QASRVAVVNQ IARQLMHNGH PSEKEIRAQQ DKLNTRWSQF RELVDRKKDA
960 970 980 990 1000
LLSALSIQNY HLECNETKSW IREKTKVIES TQDLGNDLAG VMALQRKLTG
1010 1020 1030 1040 1050
MERDLVAIEA KLSDLQKEAE KLESEHPDQA QAILSRLAEI SDVWEEMKTT
1060 1070 1080 1090 1100
LKNREASLGE ASKLQQFLRD LDDFQSWLSR TQTAIASEDM PNTLTEAEKL
1110 1120 1130 1140 1150
LTQHENIKNE IDNYEEDYQK MRDMGEMVTQ GQTDAQYMFL RQRLQALDTG
1160 1170 1180 1190 1200
WNELHKMWEN RQNLLSQSHA YQQFLRDTKQ AEAFLNNQEY VLAHTEMPTT
1210 1220 1230 1240 1250
LEGAEAAIKK QEDFMTTMDA NEEKINAVVE TGRRLVSDGN INSDRIQEKV
1260 1270 1280 1290 1300
DSIDDRHRKN REAASELLMR LKDNRDLQKF LQDCQELSLW INEKMLTAQD
1310 1320 1330 1340 1350
MSYDEARNLH SKWLKHQAFM AELASNKEWL DKIEKEGMQL ISEKPETEAV
1360 1370 1380 1390 1400
VKEKLTGLHK MWEVLESTTQ TKAQRLFDAN KAELFTQSCA DLDKWLHGLE
1410 1420 1430 1440 1450
SQIQSDDYGK DLTSVNILLK KQQMLENQME VRKKEIEELQ SQAQALSQEG
1460 1470 1480 1490 1500
KSTDEVDSKR LTVQTKFMEL LEPLSERKHN LLASKEIHQF NRDVEDEILW
1510 1520 1530 1540 1550
VGERMPLATS TDHGHNLQTV QLLIKKNQTL QKEIQGHQPR IDDIFERSQN
1560 1570 1580 1590 1600
IITDSSSLNA EAIRQRLADL KQLWGLLIEE TEKRHRRLEE AHKAQQYYFD
1610 1620 1630 1640 1650
AAEAEAWMSE QELYMMSEEK AKDEQSAVSM LKKHQILEQA VEDYAETVHQ
1660 1670 1680 1690 1700
LSKTSRALVA DSHPESERIS MRQSKVDKLY AGLKDLAEER RGKLDERHRL
1710 1720 1730 1740 1750
FQLNREVDDL EQWIAEREVV AGSHELGQDY EHVTMLQERF REFARDTGNI
1760 1770 1780 1790 1800
GQERVDTVNN MADELINSGH SDAATIAEWK DGLNEAWADL LELIDTRTQI
1810 1820 1830 1840 1850
LAASYELHKF YHDAKEIFGR IQDKHKKLPE ELGRDQNTVE TLQRMHTTFE
1860 1870 1880 1890 1900
HDIQALGTQV RQLQEDAARL QAAYAGDKAD DIQKRENEVL EAWKSLLDAC
1910 1920 1930 1940 1950
EGRRVRLVDT GDKFRFFSMV RDLMLWMEDV IRQIEAQEKP RDVSSVELLM
1960 1970 1980 1990 2000
NNHQGIKAEI DARNDSFTAC IELGKSLLAR KHYASEEIKE KLLQLTEKRK
2010 2020 2030 2040 2050
EMIDKWEDRW EWLRLILEVH QFSRDASVAE AWLLGQEPYL SSREIGQSVD
2060 2070 2080 2090 2100
EVEKLIKRHE AFEKSAATWD ERFSALERLT TLELLEVRRQ QEEEERKRRP
2110 2120 2130 2140 2150
PSPDPNTKVS EEAESQQWDT SKGDQVSQNG LPAEQGSPRM AGTMETSEMV
2160 2170 2180 2190 2200
NGAAEQRTSS KESSPVPSPT LDRKAKSALP AQSAATLPAR TLETPAAQME
2210 2220 2230 2240 2250
GFLNRKHEWE AHNKKASSRS WHNVYCVINN QEMGFYKDAK SAASGIPYHS
2260 2270 2280 2290 2300
EVPVSLKEAI CEVALDYKKK KHVFKLRLSD GNEYLFQAKD DEEMNTWIQA
2310 2320 2330 2340 2350
ISSAISSDKH DTSASTQSTP ASSRAQTLPT SVVTITSESS PGKREKDKEK
2360
DKEKRFSLFG KKK
Length:2,363
Mass (Da):274,223
Last modified:May 16, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i221362054E64BB8C
GO
Isoform 2 (identifier: Q62261-2) [UniParc]FASTAAdd to basket
Also known as: Elf3

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: MTTTVATDYD...FERSRIKALA → MELQRTSSIS...QLEGRFKQLQ
     2140-2246: MAGTMETSEM...KDAKSAASGI → VSYRSQTYQNYKNFNSRRTASDHSWSGM
     2247-2363: Missing.

Show »
Length:2,154
Mass (Da):251,156
Checksum:i5128A840C3FD28AC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQG2A0A0A0MQG2_MOUSE
Spectrin beta chain, non-erythrocyt...
Sptbn1
2,092Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti252D → A in BAE41221 (PubMed:16141072).Curated1
Sequence conflicti309S → T in AAD01616 (PubMed:9927192).Curated1
Sequence conflicti368T → A in AAD01616 (PubMed:9927192).Curated1
Sequence conflicti737K → I in AAC42040 (PubMed:8479293).Curated1
Sequence conflicti796Y → C in AAD01616 (PubMed:9927192).Curated1
Sequence conflicti846Q → R in AAC42040 (PubMed:8479293).Curated1
Sequence conflicti970W → C in AAD01616 (PubMed:9927192).Curated1
Sequence conflicti996R → C in AAD01616 (PubMed:9927192).Curated1
Sequence conflicti1401 – 1403SQI → KPGF in AAC42040 (PubMed:8479293).Curated3
Sequence conflicti1414 – 1455SVNIL…KSTDE → QSQYSSEKGNRRRRIRWKFG RKRSRNCRPSPGSSRGRAQM R in AAC42040 (PubMed:8479293).CuratedAdd BLAST42
Sequence conflicti1508A → R in AAC42040 (PubMed:8479293).Curated1
Sequence conflicti1619 – 1624EKAKDE → KRPRMK in AAC42040 (PubMed:8479293).Curated6
Sequence conflicti1898D → G in AAC42040 (PubMed:8479293).Curated1
Sequence conflicti2171L → S in AAC42040 (PubMed:8479293).Curated1
Sequence conflicti2345 – 2346EK → AE in AAC42040 (PubMed:8479293).Curated2
Sequence conflicti2356 – 2358FSL → STV in AAC42040 (PubMed:8479293).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0260571 – 49MTTTV…IKALA → MELQRTSSISGPLSPAYTGQ VPYNYNQLEGRFKQLQ in isoform 2. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_0260582140 – 2246MAGTM…AASGI → VSYRSQTYQNYKNFNSRRTA SDHSWSGM in isoform 2. 2 PublicationsAdd BLAST107
Alternative sequenceiVSP_0260592247 – 2363Missing in isoform 2. 2 PublicationsAdd BLAST117

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M74773 mRNA Translation: AAC42040.1
AF017112 mRNA Translation: AAD01616.1
AL672225 Genomic DNA No translation available.
AL731792 Genomic DNA No translation available.
AK169544 mRNA Translation: BAE41221.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24506.1 [Q62261-2]
CCDS36123.1 [Q62261-1]

NCBI Reference Sequences

More...
RefSeqi
NP_033286.2, NM_009260.2 [Q62261-2]
NP_787030.2, NM_175836.2 [Q62261-1]
XP_006514662.1, XM_006514599.3 [Q62261-1]
XP_006514663.1, XM_006514600.3 [Q62261-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000006629; ENSMUSP00000006629; ENSMUSG00000020315 [Q62261-1]
ENSMUST00000011877; ENSMUSP00000011877; ENSMUSG00000020315 [Q62261-1]
ENSMUST00000102838; ENSMUSP00000099902; ENSMUSG00000020315 [Q62261-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20742

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:20742

UCSC genome browser

More...
UCSCi
uc007ihs.1 mouse [Q62261-1]
uc007iht.1 mouse [Q62261-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74773 mRNA Translation: AAC42040.1
AF017112 mRNA Translation: AAD01616.1
AL672225 Genomic DNA No translation available.
AL731792 Genomic DNA No translation available.
AK169544 mRNA Translation: BAE41221.1
CCDSiCCDS24506.1 [Q62261-2]
CCDS36123.1 [Q62261-1]
RefSeqiNP_033286.2, NM_009260.2 [Q62261-2]
NP_787030.2, NM_175836.2 [Q62261-1]
XP_006514662.1, XM_006514599.3 [Q62261-1]
XP_006514663.1, XM_006514600.3 [Q62261-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BTNX-ray2.00A2199-2304[»]
1MPHNMR-A2199-2304[»]
SMRiQ62261
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi203461, 36 interactors
DIPiDIP-31558N
IntActiQ62261, 36 interactors
MINTiQ62261
STRINGi10090.ENSMUSP00000099902

PTM databases

iPTMnetiQ62261
PhosphoSitePlusiQ62261
SwissPalmiQ62261

Proteomic databases

EPDiQ62261
jPOSTiQ62261
PaxDbiQ62261
PeptideAtlasiQ62261
PRIDEiQ62261

Genome annotation databases

EnsembliENSMUST00000006629; ENSMUSP00000006629; ENSMUSG00000020315 [Q62261-1]
ENSMUST00000011877; ENSMUSP00000011877; ENSMUSG00000020315 [Q62261-1]
ENSMUST00000102838; ENSMUSP00000099902; ENSMUSG00000020315 [Q62261-2]
GeneIDi20742
KEGGimmu:20742
UCSCiuc007ihs.1 mouse [Q62261-1]
uc007iht.1 mouse [Q62261-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6711
MGIiMGI:98388 Sptbn1

Phylogenomic databases

eggNOGiKOG0035 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000154864
HOGENOMiHOG000007281
InParanoidiQ62261
KOiK06115
OMAiFMLNREV
OrthoDBi543832at2759
PhylomeDBiQ62261
TreeFamiTF313446

Enzyme and pathway databases

ReactomeiR-MMU-375165 NCAM signaling for neurite out-growth
R-MMU-445095 Interaction between L1 and Ankyrins
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6807878 COPI-mediated anterograde transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sptbn1 mouse
EvolutionaryTraceiQ62261

Protein Ontology

More...
PROi
PR:Q62261

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020315 Expressed in 295 organ(s), highest expression level in lung
ExpressionAtlasiQ62261 baseline and differential
GenevisibleiQ62261 MM

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
IPR016343 Spectrin_bsu
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF15410 PH_9, 1 hit
PF00435 Spectrin, 17 hits
PIRSFiPIRSF002297 Spectrin_beta_subunit, 1 hit
PRINTSiPR00683 SPECTRINPH
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00233 PH, 1 hit
SM00150 SPEC, 17 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPTB2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62261
Secondary accession number(s): A2AFU1
, Q3TEM7, Q5SQL8, Q5SQL9, Q9QWJ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 16, 2006
Last modified: October 16, 2019
This is version 196 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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