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Protein

Sperm surface protein Sp17

Gene

Spa17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).By similarity

GO - Molecular functioni

  • calmodulin binding Source: GO_Central

GO - Biological processi

  • binding of sperm to zona pellucida Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm surface protein Sp17
Alternative name(s):
Sperm autoantigenic protein 17
Gene namesi
Name:Spa17
Synonyms:Sp17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1333778 Spa17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001813441 – 149Sperm surface protein Sp17Add BLAST149

Proteomic databases

MaxQBiQ62252
PaxDbiQ62252
PRIDEiQ62252

2D gel databases

REPRODUCTION-2DPAGEiQ62252

PTM databases

iPTMnetiQ62252
PhosphoSitePlusiQ62252

Expressioni

Tissue specificityi

Testis- and sperm-specific.

Gene expression databases

BgeeiENSMUSG00000001948 Expressed in 204 organ(s), highest expression level in testis
CleanExiMM_SPA17
ExpressionAtlasiQ62252 baseline and differential
GenevisibleiQ62252 MM

Interactioni

Subunit structurei

Homodimer. May interact with ROPN1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002013

Structurei

3D structure databases

ProteinModelPortaliQ62252
SMRiQ62252
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 141IQPROSITE-ProRule annotationAdd BLAST30

Phylogenomic databases

eggNOGiENOG410IX7J Eukaryota
ENOG410XXA6 LUCA
GeneTreeiENSGT00440000039164
HOGENOMiHOG000059525
HOVERGENiHBG003879
InParanoidiQ62252
OrthoDBiEOG091G18VB
PhylomeDBiQ62252
TreeFamiTF332959

Family and domain databases

InterProiView protein in InterPro
IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
IPR000048 IQ_motif_EF-hand-BS
IPR012105 Sp17
PANTHERiPTHR10699:SF16 PTHR10699:SF16, 1 hit
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF02197 RIIa, 1 hit
PIRSFiPIRSF016533 Sp17, 1 hit
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00394 RIIa, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q62252-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIPFSNTHY RIPQGFGNLL EGLTREILRE QPDNIPAFAA AYFENLLEKR
60 70 80 90 100
EKTSFDPAEW GAKVEDRFYN NHAFKEQEQV EKCEQELAKS SGREETPVTP
110 120 130 140
FEESTEEERE QEEAAALKIQ SLFRGHVARE EVKKMKSDKN ENLKEEADN
Length:149
Mass (Da):17,296
Last modified:November 1, 1996 - v1
Checksum:iC7E05D111D6AF0DC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SU87A0A1L1SU87_MOUSE
Sperm surface protein Sp17
Spa17
130Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46299 mRNA Translation: CAA86455.1
BC059727 mRNA Translation: AAH59727.1
CCDSiCCDS22982.1
PIRiS49527
RefSeqiNP_001311474.1, NM_001324545.1
NP_035579.1, NM_011449.2
UniGeneiMm.196345
Mm.8637

Genome annotation databases

EnsembliENSMUST00000002013; ENSMUSP00000002013; ENSMUSG00000001948
GeneIDi20686
KEGGimmu:20686
UCSCiuc009ovd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46299 mRNA Translation: CAA86455.1
BC059727 mRNA Translation: AAH59727.1
CCDSiCCDS22982.1
PIRiS49527
RefSeqiNP_001311474.1, NM_001324545.1
NP_035579.1, NM_011449.2
UniGeneiMm.196345
Mm.8637

3D structure databases

ProteinModelPortaliQ62252
SMRiQ62252
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002013

PTM databases

iPTMnetiQ62252
PhosphoSitePlusiQ62252

2D gel databases

REPRODUCTION-2DPAGEiQ62252

Proteomic databases

MaxQBiQ62252
PaxDbiQ62252
PRIDEiQ62252

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002013; ENSMUSP00000002013; ENSMUSG00000001948
GeneIDi20686
KEGGimmu:20686
UCSCiuc009ovd.2 mouse

Organism-specific databases

CTDi53340
MGIiMGI:1333778 Spa17

Phylogenomic databases

eggNOGiENOG410IX7J Eukaryota
ENOG410XXA6 LUCA
GeneTreeiENSGT00440000039164
HOGENOMiHOG000059525
HOVERGENiHBG003879
InParanoidiQ62252
OrthoDBiEOG091G18VB
PhylomeDBiQ62252
TreeFamiTF332959

Miscellaneous databases

ChiTaRSiSpa17 mouse
PROiPR:Q62252
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001948 Expressed in 204 organ(s), highest expression level in testis
CleanExiMM_SPA17
ExpressionAtlasiQ62252 baseline and differential
GenevisibleiQ62252 MM

Family and domain databases

InterProiView protein in InterPro
IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
IPR000048 IQ_motif_EF-hand-BS
IPR012105 Sp17
PANTHERiPTHR10699:SF16 PTHR10699:SF16, 1 hit
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF02197 RIIa, 1 hit
PIRSFiPIRSF016533 Sp17, 1 hit
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00394 RIIa, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSP17_MOUSE
AccessioniPrimary (citable) accession number: Q62252
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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