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Protein

Son of sevenless homolog 1

Gene

Sos1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (By similarity). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (PubMed:10499589, PubMed:11524436).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

  • B cell homeostasis Source: MGI
  • blood vessel morphogenesis Source: MGI
  • cardiac atrium morphogenesis Source: MGI
  • epidermal growth factor receptor signaling pathway Source: MGI
  • eyelid development in camera-type eye Source: MGI
  • hair follicle development Source: MGI
  • heart morphogenesis Source: MGI
  • heart trabecula morphogenesis Source: MGI
  • lymphocyte homeostasis Source: MGI
  • midbrain morphogenesis Source: MGI
  • multicellular organism growth Source: MGI
  • neurotrophin TRK receptor signaling pathway Source: MGI
  • pericardium morphogenesis Source: MGI
  • positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
  • positive regulation of Ras protein signal transduction Source: ParkinsonsUK-UCL
  • positive regulation of small GTPase mediated signal transduction Source: MGI
  • Ras protein signal transduction Source: MGI
  • regulation of pro-B cell differentiation Source: MGI
  • regulation of Rho protein signal transduction Source: InterPro
  • regulation of T cell differentiation in thymus Source: MGI
  • regulation of T cell proliferation Source: MGI
  • roof of mouth development Source: MGI
  • small GTPase mediated signal transduction Source: MGI
  • vitellogenesis Source: MGI

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-MMU-112412 SOS-mediated signalling
R-MMU-1250347 SHC1 events in ERBB4 signaling
R-MMU-1433557 Signaling by SCF-KIT
R-MMU-1433559 Regulation of KIT signaling
R-MMU-167044 Signalling to RAS
R-MMU-179812 GRB2 events in EGFR signaling
R-MMU-180336 SHC1 events in EGFR signaling
R-MMU-186763 Downstream signal transduction
R-MMU-193648 NRAGE signals death through JNK
R-MMU-194840 Rho GTPase cycle
R-MMU-1963640 GRB2 events in ERBB2 signaling
R-MMU-210993 Tie2 Signaling
R-MMU-2179392 EGFR Transactivation by Gastrin
R-MMU-2424491 DAP12 signaling
R-MMU-2428933 SHC-related events triggered by IGF1R
R-MMU-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-MMU-2871796 FCERI mediated MAPK activation
R-MMU-2871809 FCERI mediated Ca+2 mobilization
R-MMU-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-MMU-375165 NCAM signaling for neurite out-growth
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-5654688 SHC-mediated cascade:FGFR1
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654699 SHC-mediated cascade:FGFR2
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654704 SHC-mediated cascade:FGFR3
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654719 SHC-mediated cascade:FGFR4
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-74749 Signal attenuation
R-MMU-74751 Insulin receptor signalling cascade
R-MMU-8851805 MET activates RAS signaling
R-MMU-8853659 RET signaling
R-MMU-8983432 Interleukin-15 signaling
R-MMU-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-MMU-912526 Interleukin receptor SHC signaling
R-MMU-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Names & Taxonomyi

Protein namesi
Recommended name:
Son of sevenless homolog 1
Short name:
SOS-1
Short name:
mSOS-1
Gene namesi
Name:Sos1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:98354 Sos1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688951 – 1319Son of sevenless homolog 1Add BLAST1319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1078PhosphoserineCombined sources1
Modified residuei1082PhosphoserineCombined sources1
Modified residuei1120Phosphoserine; by RPS6KA3By similarity1
Modified residuei1147Phosphoserine; by RPS6KA3By similarity1
Modified residuei1164PhosphoserineBy similarity1
Modified residuei1196PhosphoserineBy similarity1
Modified residuei1215PhosphoserineBy similarity1
Modified residuei1261PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Ser-1120 and Ser-1147 by RPS6KA3 create YWHAB and YWHAE binding sites and which contribute to the negative regulation of EGF-induced MAPK1/3 phosphorylation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ62245
MaxQBiQ62245
PaxDbiQ62245
PRIDEiQ62245

PTM databases

iPTMnetiQ62245
PhosphoSitePlusiQ62245

Expressioni

Tissue specificityi

Expressed in most embryonic and adult tissues.

Gene expression databases

BgeeiENSMUSG00000024241
CleanExiMM_SOS1
GenevisibleiQ62245 MM

Interactioni

Subunit structurei

Interacts (via C-terminus) with GRB2 (via SH3 domain). Forms a complex with phosphorylated MUC1 and GRB2 (via its SH3 domains). Interacts with phosphorylated LAT2. Interacts with NCK1 and NCK2 (By similarity). Part of a complex consisting of ABI1, EPS8 and SOS1 (PubMed:10499589, PubMed:11524436). Interacts (Ser-1120 and Ser-1147 phosphorylated form) with YWHAB and YWHAE (By similarity).By similarity2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203394, 8 interactors
ComplexPortaliCPX-413 GTPase Hras - Son of sevenless homolog 1 complex
CORUMiQ62245
DIPiDIP-29230N
IntActiQ62245, 18 interactors
MINTiQ62245
STRINGi10090.ENSMUSP00000067786

Structurei

Secondary structure

11319
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni416 – 418Combined sources3
Helixi419 – 427Combined sources9
Beta strandi437 – 441Combined sources5
Turni443 – 445Combined sources3
Beta strandi446 – 454Combined sources9
Beta strandi459 – 463Combined sources5
Beta strandi465 – 471Combined sources7
Beta strandi481 – 484Combined sources4
Beta strandi490 – 495Combined sources6
Beta strandi500 – 502Combined sources3
Beta strandi514 – 517Combined sources4
Beta strandi519 – 521Combined sources3
Beta strandi523 – 527Combined sources5
Beta strandi529 – 531Combined sources3
Helixi532 – 545Combined sources14

3D structure databases

ProteinModelPortaliQ62245
SMRiQ62245
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ62245

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini200 – 390DHPROSITE-ProRule annotationAdd BLAST191
Domaini444 – 548PHPROSITE-ProRule annotationAdd BLAST105
Domaini597 – 741N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST145
Domaini780 – 1019Ras-GEFPROSITE-ProRule annotationAdd BLAST240

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1244 – 1247Poly-Pro4

Phylogenomic databases

eggNOGiKOG3417 Eukaryota
ENOG410XR96 LUCA
GeneTreeiENSGT00910000143985
HOGENOMiHOG000013040
HOVERGENiHBG017831
InParanoidiQ62245
KOiK03099
OMAiMENGDQP
OrthoDBiEOG091G04UL
PhylomeDBiQ62245
TreeFamiTF317296

Family and domain databases

CDDicd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
cd00160 RhoGEF, 1 hit
Gene3Di1.10.20.10, 1 hit
1.10.840.10, 2 hits
1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000651 Ras-like_Gua-exchang_fac_N
IPR019804 Ras_G-nucl-exch_fac_CS
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF00169 PH, 1 hit
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SM00325 RhoGEF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
SSF48065 SSF48065, 1 hit
SSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00720 RASGEF, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q62245-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES NDDALQYVEE
60 70 80 90 100
LILQLLNMLC QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR
110 120 130 140 150
NPLSLPAERI HHLLREVLGY KIDHQVSVYI VAVLEYISAD ILKLVGNYVR
160 170 180 190 200
NIRHYEITKQ DIKVAMCADK VLMDMFHQDV EDINILSLTD EEPSTSGEQT
210 220 230 240 250
YYDLVKAFMA EIRQYIRELN LIIKVFREPF VSNSKLFSSN DVENIFSRIV
260 270 280 290 300
DIHELSVKLL GHIEDTVEMT DEGSPHPLVG SCFEDLAEEL AFDPYESYAR
310 320 330 340 350
DILRPGFHGH FLSQLSKPGA ALYLQSIGEG FKEAVQYVLP RLLLAPVYHC
360 370 380 390 400
LHYFELLKQL EEKSEDQEDK ECMKQAITAL LNVQSGMEKI CSKSLAKRRL
410 420 430 440 450
SESACRFYSQ QMKGKQLAIK KMNEIQKNID GWEGKDIGQC CNEFIMEGTL
460 470 480 490 500
TRVGAKHERH IFLFDGLMIC CKSNHGQPRL PGASSAEYRL KEKFFMRKVQ
510 520 530 540 550
INDKDDTSEY KHAFEIILKD GNSVIFSAKS AEEKNNWMAA LISLQYRSTL
560 570 580 590 600
ERMLDVTVLQ EEKEEQMRLP SAEVYRFAEP DSEENILFEE NVQPKAGIPI
610 620 630 640 650
IKAGTVLKLI ERLTYHMYAD PNFVRTFLTT YRSFCRPQEL LSLLIERFEI
660 670 680 690 700
PEPEPTEADR IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH
710 720 730 740 750
FYDFERDADL LQRMEEFIGT VRGKAMKKWV ESITKIIQRK KIARDNGPGH
760 770 780 790 800
NITFQSSPPT VEWHISRPGH IETFDLLTLH PIEIARQLTL LESDLYRAVQ
810 820 830 840 850
PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV ETENLEERVA
860 870 880 890 900
VVSRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI
910 920 930 940 950
LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLRR
960 970 980 990 1000
HGKELINFSK RRRVAEITGE IQQYQNQPYC LRVEPDIKRF FENLNPMGNS
1010 1020 1030 1040 1050
MEKEFTDYLF NKSLEIEPRH PKPLPRFPKK YSYPLKSPGV RPSNPRPGTM
1060 1070 1080 1090 1100
RHPTPLQQEP RKISYSRIPE SETESTASAP NSPRTPLTPP PASGTSSNTD
1110 1120 1130 1140 1150
VCSVFDSDHS ASPFHSRSAS VSSISLSKGT DEVPVPPPVP PRRRPESAPA
1160 1170 1180 1190 1200
ESSPSKIMSK HLDSPPAIPP RQPTSKAYSP RYSISDRTSI SDPPESPPLL
1210 1220 1230 1240 1250
PPREPVRTPD VFSSSPLHLQ PPPLGKKSDH GNAFFPNSPS PFTPPPPQTP
1260 1270 1280 1290 1300
SPHGTRRHLP SPPLTQEMDL HSIAGPPVPP RQSTSQLIPK LPPKTYKREH
1310
THPSMHRDGP PLLENAHSS
Length:1,319
Mass (Da):150,883
Last modified:July 15, 1999 - v2
Checksum:i3286088A5BA0A4A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11574 mRNA Translation: CAA77662.1
Z11578 mRNA Translation: CAA77665.1
CCDSiCCDS37704.1
PIRiS25715
S25716
RefSeqiNP_033257.2, NM_009231.2
UniGeneiMm.360004
Mm.60975

Genome annotation databases

EnsembliENSMUST00000068714; ENSMUSP00000067786; ENSMUSG00000024241
GeneIDi20662
KEGGimmu:20662
UCSCiuc008drg.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSOS1_MOUSE
AccessioniPrimary (citable) accession number: Q62245
Secondary accession number(s): Q62244
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: June 20, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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