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Entry version 185 (07 Oct 2020)
Sequence version 2 (15 Jul 1999)
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Protein

Son of sevenless homolog 1

Gene

Sos1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (By similarity). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (PubMed:10499589, PubMed:11524436).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-112412, SOS-mediated signalling
R-MMU-1250347, SHC1 events in ERBB4 signaling
R-MMU-1433557, Signaling by SCF-KIT
R-MMU-1433559, Regulation of KIT signaling
R-MMU-167044, Signalling to RAS
R-MMU-179812, GRB2 events in EGFR signaling
R-MMU-180336, SHC1 events in EGFR signaling
R-MMU-186763, Downstream signal transduction
R-MMU-193648, NRAGE signals death through JNK
R-MMU-194840, Rho GTPase cycle
R-MMU-1963640, GRB2 events in ERBB2 signaling
R-MMU-210993, Tie2 Signaling
R-MMU-2179392, EGFR Transactivation by Gastrin
R-MMU-2424491, DAP12 signaling
R-MMU-2428933, SHC-related events triggered by IGF1R
R-MMU-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-MMU-2871796, FCERI mediated MAPK activation
R-MMU-2871809, FCERI mediated Ca+2 mobilization
R-MMU-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins
R-MMU-375165, NCAM signaling for neurite out-growth
R-MMU-416482, G alpha (12/13) signalling events
R-MMU-5654688, SHC-mediated cascade:FGFR1
R-MMU-5654693, FRS-mediated FGFR1 signaling
R-MMU-5654699, SHC-mediated cascade:FGFR2
R-MMU-5654700, FRS-mediated FGFR2 signaling
R-MMU-5654704, SHC-mediated cascade:FGFR3
R-MMU-5654706, FRS-mediated FGFR3 signaling
R-MMU-5654712, FRS-mediated FGFR4 signaling
R-MMU-5654719, SHC-mediated cascade:FGFR4
R-MMU-5673001, RAF/MAP kinase cascade
R-MMU-74749, Signal attenuation
R-MMU-74751, Insulin receptor signalling cascade
R-MMU-8851805, MET activates RAS signaling
R-MMU-8853659, RET signaling
R-MMU-8983432, Interleukin-15 signaling
R-MMU-9028731, Activated NTRK2 signals through FRS2 and FRS3
R-MMU-912526, Interleukin receptor SHC signaling
R-MMU-9607240, FLT3 Signaling
R-MMU-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Son of sevenless homolog 1
Short name:
SOS-1
Short name:
mSOS-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sos1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:98354, Sos1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000688951 – 1319Son of sevenless homolog 1Add BLAST1319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1078PhosphoserineCombined sources1
Modified residuei1082PhosphoserineCombined sources1
Modified residuei1120Phosphoserine; by RPS6KA3By similarity1
Modified residuei1147Phosphoserine; by RPS6KA3By similarity1
Modified residuei1164PhosphoserineBy similarity1
Modified residuei1196PhosphoserineBy similarity1
Modified residuei1215PhosphoserineBy similarity1
Modified residuei1261PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-1120 and Ser-1147 by RPS6KA3 create YWHAB and YWHAE binding sites and which contribute to the negative regulation of EGF-induced MAPK1/3 phosphorylation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q62245

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q62245

MaxQB - The MaxQuant DataBase

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MaxQBi
Q62245

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62245

PRoteomics IDEntifications database

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PRIDEi
Q62245

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62245

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62245

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in most embryonic and adult tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024241, Expressed in pineal body and 288 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q62245, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminus) with GRB2 (via SH3 domain).

Forms a complex with phosphorylated MUC1 and GRB2 (via its SH3 domains).

Interacts with phosphorylated LAT2.

Interacts with NCK1 and NCK2 (By similarity).

Part of a complex consisting of ABI1, EPS8 and SOS1 (PubMed:10499589, PubMed:11524436).

Interacts (Ser-1120 and Ser-1147 phosphorylated form) with YWHAB and YWHAE (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
203394, 41 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-413, GTPase Hras - Son of sevenless homolog 1 complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q62245

Database of interacting proteins

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DIPi
DIP-29230N

Protein interaction database and analysis system

More...
IntActi
Q62245, 19 interactors

Molecular INTeraction database

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MINTi
Q62245

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000067786

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q62245, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11319
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q62245

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q62245

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini200 – 390DHPROSITE-ProRule annotationAdd BLAST191
Domaini444 – 548PHPROSITE-ProRule annotationAdd BLAST105
Domaini597 – 741N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST145
Domaini780 – 1019Ras-GEFPROSITE-ProRule annotationAdd BLAST240

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1244 – 1247Poly-Pro4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3417, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155423

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002744_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q62245

KEGG Orthology (KO)

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KOi
K03099

Identification of Orthologs from Complete Genome Data

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OMAi
WFEKCII

Database of Orthologous Groups

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OrthoDBi
576110at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q62245

TreeFam database of animal gene trees

More...
TreeFami
TF317296

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00155, RasGEF, 1 hit
cd06224, REM, 1 hit
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.20.10, 1 hit
1.10.840.10, 2 hits
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR009072, Histone-fold
IPR007125, Histone_H2A/H2B/H3
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR019804, Ras_G-nucl-exch_fac_CS
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR23113, PTHR23113, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00125, Histone, 1 hit
PF00169, PH, 1 hit
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47113, SSF47113, 1 hit
SSF48065, SSF48065, 1 hit
SSF48366, SSF48366, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00720, RASGEF, 1 hit
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q62245-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQAQQLPYEF FSEENAPKWR GLLVPALKKV QGQVHPTLES NDDALQYVEE
60 70 80 90 100
LILQLLNMLC QAQPRSASDV EERVQKSFPH PIDKWAIADA QSAIEKRKRR
110 120 130 140 150
NPLSLPAERI HHLLREVLGY KIDHQVSVYI VAVLEYISAD ILKLVGNYVR
160 170 180 190 200
NIRHYEITKQ DIKVAMCADK VLMDMFHQDV EDINILSLTD EEPSTSGEQT
210 220 230 240 250
YYDLVKAFMA EIRQYIRELN LIIKVFREPF VSNSKLFSSN DVENIFSRIV
260 270 280 290 300
DIHELSVKLL GHIEDTVEMT DEGSPHPLVG SCFEDLAEEL AFDPYESYAR
310 320 330 340 350
DILRPGFHGH FLSQLSKPGA ALYLQSIGEG FKEAVQYVLP RLLLAPVYHC
360 370 380 390 400
LHYFELLKQL EEKSEDQEDK ECMKQAITAL LNVQSGMEKI CSKSLAKRRL
410 420 430 440 450
SESACRFYSQ QMKGKQLAIK KMNEIQKNID GWEGKDIGQC CNEFIMEGTL
460 470 480 490 500
TRVGAKHERH IFLFDGLMIC CKSNHGQPRL PGASSAEYRL KEKFFMRKVQ
510 520 530 540 550
INDKDDTSEY KHAFEIILKD GNSVIFSAKS AEEKNNWMAA LISLQYRSTL
560 570 580 590 600
ERMLDVTVLQ EEKEEQMRLP SAEVYRFAEP DSEENILFEE NVQPKAGIPI
610 620 630 640 650
IKAGTVLKLI ERLTYHMYAD PNFVRTFLTT YRSFCRPQEL LSLLIERFEI
660 670 680 690 700
PEPEPTEADR IAIENGDQPL SAELKRFRKE YIQPVQLRVL NVCRHWVEHH
710 720 730 740 750
FYDFERDADL LQRMEEFIGT VRGKAMKKWV ESITKIIQRK KIARDNGPGH
760 770 780 790 800
NITFQSSPPT VEWHISRPGH IETFDLLTLH PIEIARQLTL LESDLYRAVQ
810 820 830 840 850
PSELVGSVWT KEDKEINSPN LLKMIRHTTN LTLWFEKCIV ETENLEERVA
860 870 880 890 900
VVSRIIEILQ VFQELNNFNG VLEVVSAMNS SPVYRLDHTF EQIPSRQKKI
910 920 930 940 950
LEEAHELSED HYKKYLAKLR SINPPCVPFF GIYLTNILKT EEGNPEVLRR
960 970 980 990 1000
HGKELINFSK RRRVAEITGE IQQYQNQPYC LRVEPDIKRF FENLNPMGNS
1010 1020 1030 1040 1050
MEKEFTDYLF NKSLEIEPRH PKPLPRFPKK YSYPLKSPGV RPSNPRPGTM
1060 1070 1080 1090 1100
RHPTPLQQEP RKISYSRIPE SETESTASAP NSPRTPLTPP PASGTSSNTD
1110 1120 1130 1140 1150
VCSVFDSDHS ASPFHSRSAS VSSISLSKGT DEVPVPPPVP PRRRPESAPA
1160 1170 1180 1190 1200
ESSPSKIMSK HLDSPPAIPP RQPTSKAYSP RYSISDRTSI SDPPESPPLL
1210 1220 1230 1240 1250
PPREPVRTPD VFSSSPLHLQ PPPLGKKSDH GNAFFPNSPS PFTPPPPQTP
1260 1270 1280 1290 1300
SPHGTRRHLP SPPLTQEMDL HSIAGPPVPP RQSTSQLIPK LPPKTYKREH
1310
THPSMHRDGP PLLENAHSS
Length:1,319
Mass (Da):150,883
Last modified:July 15, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3286088A5BA0A4A6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z11574 mRNA Translation: CAA77662.1
Z11578 mRNA Translation: CAA77665.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS37704.1

Protein sequence database of the Protein Information Resource

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PIRi
S25715
S25716

NCBI Reference Sequences

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RefSeqi
NP_033257.2, NM_009231.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000068714; ENSMUSP00000067786; ENSMUSG00000024241

Database of genes from NCBI RefSeq genomes

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GeneIDi
20662

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:20662

UCSC genome browser

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UCSCi
uc008drg.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11574 mRNA Translation: CAA77662.1
Z11578 mRNA Translation: CAA77665.1
CCDSiCCDS37704.1
PIRiS25715
S25716
RefSeqiNP_033257.2, NM_009231.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B07X-ray2.50C1135-1144[»]
1GBQNMR-B1135-1144[»]
1PMSNMR-A414-548[»]
2GBQNMR-B1135-1144[»]
3GBQNMR-B1135-1144[»]
4GBQNMR-B1135-1144[»]
SMRiQ62245
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi203394, 41 interactors
ComplexPortaliCPX-413, GTPase Hras - Son of sevenless homolog 1 complex
CORUMiQ62245
DIPiDIP-29230N
IntActiQ62245, 19 interactors
MINTiQ62245
STRINGi10090.ENSMUSP00000067786

PTM databases

iPTMnetiQ62245
PhosphoSitePlusiQ62245

Proteomic databases

EPDiQ62245
jPOSTiQ62245
MaxQBiQ62245
PaxDbiQ62245
PRIDEiQ62245

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2769, 229 antibodies

The DNASU plasmid repository

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DNASUi
20662

Genome annotation databases

EnsembliENSMUST00000068714; ENSMUSP00000067786; ENSMUSG00000024241
GeneIDi20662
KEGGimmu:20662
UCSCiuc008drg.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6654
MGIiMGI:98354, Sos1

Phylogenomic databases

eggNOGiKOG3417, Eukaryota
GeneTreeiENSGT00940000155423
HOGENOMiCLU_002744_0_0_1
InParanoidiQ62245
KOiK03099
OMAiWFEKCII
OrthoDBi576110at2759
PhylomeDBiQ62245
TreeFamiTF317296

Enzyme and pathway databases

ReactomeiR-MMU-112412, SOS-mediated signalling
R-MMU-1250347, SHC1 events in ERBB4 signaling
R-MMU-1433557, Signaling by SCF-KIT
R-MMU-1433559, Regulation of KIT signaling
R-MMU-167044, Signalling to RAS
R-MMU-179812, GRB2 events in EGFR signaling
R-MMU-180336, SHC1 events in EGFR signaling
R-MMU-186763, Downstream signal transduction
R-MMU-193648, NRAGE signals death through JNK
R-MMU-194840, Rho GTPase cycle
R-MMU-1963640, GRB2 events in ERBB2 signaling
R-MMU-210993, Tie2 Signaling
R-MMU-2179392, EGFR Transactivation by Gastrin
R-MMU-2424491, DAP12 signaling
R-MMU-2428933, SHC-related events triggered by IGF1R
R-MMU-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-MMU-2871796, FCERI mediated MAPK activation
R-MMU-2871809, FCERI mediated Ca+2 mobilization
R-MMU-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins
R-MMU-375165, NCAM signaling for neurite out-growth
R-MMU-416482, G alpha (12/13) signalling events
R-MMU-5654688, SHC-mediated cascade:FGFR1
R-MMU-5654693, FRS-mediated FGFR1 signaling
R-MMU-5654699, SHC-mediated cascade:FGFR2
R-MMU-5654700, FRS-mediated FGFR2 signaling
R-MMU-5654704, SHC-mediated cascade:FGFR3
R-MMU-5654706, FRS-mediated FGFR3 signaling
R-MMU-5654712, FRS-mediated FGFR4 signaling
R-MMU-5654719, SHC-mediated cascade:FGFR4
R-MMU-5673001, RAF/MAP kinase cascade
R-MMU-74749, Signal attenuation
R-MMU-74751, Insulin receptor signalling cascade
R-MMU-8851805, MET activates RAS signaling
R-MMU-8853659, RET signaling
R-MMU-8983432, Interleukin-15 signaling
R-MMU-9028731, Activated NTRK2 signals through FRS2 and FRS3
R-MMU-912526, Interleukin receptor SHC signaling
R-MMU-9607240, FLT3 Signaling
R-MMU-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
20662, 4 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Sos1, mouse
EvolutionaryTraceiQ62245

Protein Ontology

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PROi
PR:Q62245
RNActiQ62245, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024241, Expressed in pineal body and 288 other tissues
GenevisibleiQ62245, MM

Family and domain databases

CDDicd00155, RasGEF, 1 hit
cd06224, REM, 1 hit
cd00160, RhoGEF, 1 hit
Gene3Di1.10.20.10, 1 hit
1.10.840.10, 2 hits
1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR009072, Histone-fold
IPR007125, Histone_H2A/H2B/H3
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR019804, Ras_G-nucl-exch_fac_CS
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf
PANTHERiPTHR23113, PTHR23113, 1 hit
PfamiView protein in Pfam
PF00125, Histone, 1 hit
PF00169, PH, 1 hit
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF47113, SSF47113, 1 hit
SSF48065, SSF48065, 1 hit
SSF48366, SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00720, RASGEF, 1 hit
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSOS1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62245
Secondary accession number(s): Q62244
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: October 7, 2020
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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