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UniProtKB - Q62230 (SN_MOUSE)

Entry version 171 (17 Jun 2020)
Sequence version 2 (21 Sep 2011)
Previous versions | rss
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Protein

Sialoadhesin

Gene

Siglec1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hematopoiesis. May act as a counter-receptor for CLEC10A in lymph node.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei63Sialic acid1 Publication1
Binding sitei116Sialic acid4 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Endocytosis
LigandLectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Protein family/group databases

UniLectin database of carbohydrate-binding proteins

More...UniLectini		Q62230

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sialoadhesin
Alternative name(s):
Sheep erythrocyte receptor
Short name:
SER
Sialic acid-binding Ig-like lectin 1
Short name:
Siglec-1
CD_antigen: CD169
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Siglec1
Synonyms:Sa, Sn
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:99668 Siglec1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 1639ExtracellularSequence analysisAdd BLAST1620
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1640 – 1660HelicalSequence analysisAdd BLAST21
Topological domaini1661 – 1695CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi21W → Q: Loss of sialic acid binding. 1 Publication1
Mutagenesisi116R → A: Loss of sialic acid binding. 1 Publication1
Mutagenesisi116R → L: 10-fold loss in affinity to sialic acid. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Add BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001496920 – 1695SialoadhesinAdd BLAST1676

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 166PROSITE-ProRule annotation
Disulfide bondi41 ↔ 98PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 218PROSITE-ProRule annotation
Disulfide bondi263 ↔ 306PROSITE-ProRule annotation
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi347 ↔ 391PROSITE-ProRule annotation
Disulfide bondi434 ↔ 492PROSITE-ProRule annotation
Glycosylationi500N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi532 ↔ 576PROSITE-ProRule annotation
Glycosylationi583N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi625 ↔ 685PROSITE-ProRule annotation
Glycosylationi693N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi722N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi725 ↔ 770PROSITE-ProRule annotation
Glycosylationi737N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi813 ↔ 872PROSITE-ProRule annotation
Glycosylationi882N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi912 ↔ 956PROSITE-ProRule annotation
Disulfide bondi1001 ↔ 1063PROSITE-ProRule annotation
Glycosylationi1090N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1103 ↔ 1145PROSITE-ProRule annotation
Disulfide bondi1189 ↔ 1237PROSITE-ProRule annotation
Glycosylationi1247N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1277 ↔ 1320PROSITE-ProRule annotation
Disulfide bondi1363 ↔ 1422PROSITE-ProRule annotation
Glycosylationi1460N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1463 ↔ 1509PROSITE-ProRule annotation
Glycosylationi1474N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1552 ↔ 1611PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q62230

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q62230

PRoteomics IDEntifications database

More...PRIDEi		Q62230

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q62230

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q62230

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in lymph node in the subcapsular sinus, interfollicular regions, and T and B-cell boundary (at protein level). Expressed by macrophages in various tissues. Highest expression in spleen and lymph node with lower amounts in lung, liver, bone marrow, heart and skin. No expression in thymus, kidney, brain or small intestine.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CLEC10A.

5 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		203360, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q62230, 3 interactors

Molecular INTeraction database

More...MINTi		Q62230

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000028794

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q62230 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11695
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q62230

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q62230

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 136Ig-like V-typeAdd BLAST117
Domaini153 – 235Ig-like C2-type 1Add BLAST83
Domaini239 – 321Ig-like C2-type 2Add BLAST83
Domaini326 – 406Ig-like C2-type 3Add BLAST81
Domaini416 – 508Ig-like C2-type 4Add BLAST93
Domaini509 – 594Ig-like C2-type 5Add BLAST86
Domaini602 – 701Ig-like C2-type 6Add BLAST100
Domaini704 – 781Ig-like C2-type 7Add BLAST78
Domaini795 – 890Ig-like C2-type 8Add BLAST96
Domaini894 – 973Ig-like C2-type 9Add BLAST80
Domaini980 – 1079Ig-like C2-type 10Add BLAST100
Domaini1081 – 1161Ig-like C2-type 11Add BLAST81
Domaini1172 – 1264Ig-like C2-type 12Add BLAST93
Domaini1245 – 1337Ig-like C2-type 13Add BLAST93
Domaini1342 – 1439Ig-like C2-type 14Add BLAST98
Domaini1442 – 1520Ig-like C2-type 15Add BLAST79
Domaini1534 – 1627Ig-like C2-type 16Add BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni122 – 126Sialic acid binding5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi827 – 829Cell attachment siteSequence analysis3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410KDW5 Eukaryota
ENOG410ZJZH LUCA

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q62230

KEGG Orthology (KO)

More...KOi		K06548

Database of Orthologous Groups

More...OrthoDBi		54136at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 17 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR013151 Immunoglobulin

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08205 C2-set_2, 1 hit
PF07679 I-set, 3 hits
PF00047 ig, 1 hit
PF13895 Ig_2, 6 hits
PF07686 V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409 IG, 16 hits
SM00408 IGc2, 15 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726 SSF48726, 12 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835 IG_LIKE, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q62230-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCVLFSLLLL ASVFSLGQTT WGVSSPKNVQ GLSGSCLLIP CIFSYPADVP 
        60         70         80         90        100
VSNGITAIWY YDYSGKRQVV IHSGDPKLVD KRFRGRAELM GNMDHKVCNL 
       110        120        130        140        150
LLKDLKPEDS GTYNFRFEIS DSNRWLDVKG TTVTVTTDPS PPTITIPEEL 
       160        170        180        190        200
REGMERNFNC STPYLCLQEK QVSLQWRGQD PTHSVTSSFQ SLEPTGVYHQ 
       210        220        230        240        250
TTLHMALSWQ DHGRTLLCQF SLGAHSSRKE VYLQVPHAPK GVEILLSSSG 
       260        270        280        290        300
RNILPGDPVT LTCRVNSSYP AVSAVQWARD GVNLGVTGHV LRLFSAAWND 
       310        320        330        340        350
SGAYTCQATN DMGSLVSSPL SLHVFMAEVK MNPAGPVLEN ETVTLLCSTP 
       360        370        380        390        400
KEAPQELRYS WYKNHILLED AHASTLHLPA VTRADTGFYF CEVQNAQGSE 
       410        420        430        440        450
RSSPLSVVVR YPPLTPDLTT FLETQAGLVG ILHCSVVSEP LATVVLSHGG 
       460        470        480        490        500
LTLASNSGEN DFNPRFRISS APNSLRLEIR DLQPADSGEY TCLAVNSLGN 
       510        520        530        540        550
STSSLDFYAN VARLLINPSA EVVEGQAVTL SCRSGLSPAP DTRFSWYLNG 
       560        570        580        590        600
ALLLEGSSSS LLLPAASSTD AGSYYCRTQA GPNTSGPSLP TVLTVFYPPR 
       610        620        630        640        650
KPTFTARLDL DTSGVGDGRR GILLCHVDSD PPAQLRLLHK GHVVATSLPS 
       660        670        680        690        700
RCGSCSQRTK VSRTSNSLHV EIQKPVLEDE GVYLCEASNT LGNSSAAASF 
       710        720        730        740        750
NAKATVLVIT PSNTLREGTE ANLTCNVNQE VAVSPANFSW FRNGVLWTQG 
       760        770        780        790        800
SLETVRLQPV ARTDAAVYAC RLLTEDGAQL SAPVVLSVLY APDPPKLSAL 
       810        820        830        840        850
LDVGQGHMAV FICTVDSYPL AHLSLFRGDH LLATNLEPQR PSHGRIQAKA 
       860        870        880        890        900
TANSLQLEVR ELGLVDSGNY HCEATNILGS ANSSLFFQVR GAWVQVSPSP 
       910        920        930        940        950
ELREGQAVVL SCQVPTGVSE GTSYSWYQDG RPLQESTSST LRIAAISLRQ 
       960        970        980        990       1000
AGAYHCQAQA PDTAIASLAA PVSLHVSYTP RHVTLSALLS TDPERLGHLV 
      1010       1020       1030       1040       1050
CSVQSDPPAQ LQLFHRNRLV ASTLQGADEL AGSNPRLHVT VLPNELRLQI 
      1060       1070       1080       1090       1100
HFPELEDDGT YTCEASNTLG QASAAADFDA QAVRVTVWPN ATVQEGQQVN 
      1110       1120       1130       1140       1150
LTCLVWSTHQ DSLSYTWYKG GQQLLGARSI TLPSVKVLDA TSYRCGVGLP 
      1160       1170       1180       1190       1200
GHAPHLSRPV TLDVLHAPRN LRLTYLLETQ GRQLALVLCT VDSRPPAQLT 
      1210       1220       1230       1240       1250
LSHGDQLVAS STEASVPNTL RLELQDPRPS NEGLYSCSAH SPLGKANTSL 
      1260       1270       1280       1290       1300
ELLLEGVRVK MNPSGSVPEG EPVTVTCEDP AALSSALYAW FHNGHWLQEG 
      1310       1320       1330       1340       1350
PASSLQFLVT TRAHAGAYFC QVHDTQGTRS SRPASLQILY APRDAVLSSF 
      1360       1370       1380       1390       1400
RDSRTRLMVV IQCTVDSEPP AEMVLSHNGK VLAASHERHS SASGIGHIQV 
      1410       1420       1430       1440       1450
ARNALRLQVQ DVTLGDGNTY VCTAQNTLGS ISTTQRLLTE TDIRVTAEPG 
      1460       1470       1480       1490       1500
LDVPEGTALN LSCLLPGGSG PTGNSSFTWF WNRHRLHSAP VPTLSFTPVV 
      1510       1520       1530       1540       1550
RAQAGLYHCR ADLPTGATTS APVMLRVLYP PKTPTLIVFV EPQGGHQGIL 
      1560       1570       1580       1590       1600
DCRVDSEPLA ILTLHRGSQL VASNQLHDAP TKPHIRVTAP PNALRVDIEE 
      1610       1620       1630       1640       1650
LGPSNQGEYV CTASNTLGSA SASAYFGTRA LHQLQLFQRL LWVLGFLAGF 
      1660       1670       1680       1690 
LCLLLGLVAY HTWRKKSSTK LNEDENSAEM ATKKNTIQEE VVAAL
Length:1,695
Mass (Da):182,979
Last modified:September 21, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF704F68C40E113A
GO
Isoform 2 (identifier: Q62230-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-340: MAEVKMNPAGPVLEN → SESWMRLRGPVSGKH
     341-1695: Missing.

Show »
Length:340
Mass (Da):37,511
Checksum:i26F3E85E35BC02E9
GO
Isoform 3 (identifier: Q62230-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1529-1599: YPPKTPTLIV...PPNALRVDIE → CEYEPISALC...LLPFWDEYRR
     1600-1695: Missing.

Show »
Length:1,599
Mass (Da):172,769
Checksum:i7FC111F331066F0C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KUZ2H9KUZ2_MOUSE
Sialoadhesin
Siglec1
346Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3X8X6G3X8X6_MOUSE
Sialoadhesin
Siglec1
1,701Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9KUZ3H9KUZ3_MOUSE
Sialoadhesin
Siglec1
1,605Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA85268 differs from that shown. Reason: Frameshift.Curated
The sequence CAA85290 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti159N → F in AAB95641 (PubMed:9383289).Curated1
Sequence conflicti197V → S in CAA85268 (PubMed:7925291).Curated1
Sequence conflicti197V → S in CAA85290 (PubMed:7925291).Curated1
Sequence conflicti197V → S in AAB95641 (PubMed:9383289).Curated1
Sequence conflicti590P → Q AA sequence (PubMed:7925291).Curated1
Sequence conflicti727V → G in CAA85268 (PubMed:7925291).Curated1
Sequence conflicti727V → G in CAA85290 (PubMed:7925291).Curated1
Sequence conflicti727V → G in AAB95641 (PubMed:9383289).Curated1
Sequence conflicti759 – 760PV → LL in CAA85268 (PubMed:7925291).Curated2
Sequence conflicti759 – 760PV → LL in CAA85290 (PubMed:7925291).Curated2
Sequence conflicti759 – 760PV → LL in AAB95641 (PubMed:9383289).Curated2
Sequence conflicti1050 – 1052IHF → FLV AA sequence (PubMed:7925291).Curated3
Sequence conflicti1055 – 1056LE → VQ AA sequence (PubMed:7925291).Curated2
Sequence conflicti1062T → Q AA sequence (PubMed:7925291).Curated1
Sequence conflicti1066S → Q AA sequence (PubMed:7925291).Curated1
Sequence conflicti1426N → H in CAA85268 (PubMed:7925291).Curated1
Sequence conflicti1426N → H in CAA85290 (PubMed:7925291).Curated1
Sequence conflicti1426N → H in AAB95641 (PubMed:9383289).Curated1
Sequence conflicti1453V → W in CAA85268 (PubMed:7925291).Curated1
Sequence conflicti1453V → W in CAA85290 (PubMed:7925291).Curated1
Sequence conflicti1453V → W in AAB95641 (PubMed:9383289).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002573326 – 340MAEVK…PVLEN → SESWMRLRGPVSGKH in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_002574341 – 1695Missing in isoform 2. 1 PublicationAdd BLAST1355
Alternative sequenceiVSP_0025751529 – 1599YPPKT…RVDIE → CEYEPISALCLSLHLTGPYQ AFSSAQSKGFIGKGLRTLAS SLAGCMWFVSMLGYPALKWR ILLPFWDEYRR in isoform 3. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_0025761600 – 1695Missing in isoform 3. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z36293 mRNA Translation: CAA85290.1 Frameshift.
Z36233 mRNA Translation: CAA85268.1 Frameshift.
Z36234 mRNA Translation: CAA85269.1
U92842 U92841 Genomic DNA Translation: AAB95641.1
AL831736 Genomic DNA No translation available.
AL833771 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

More...PIRi		S50065

NCBI Reference Sequences

More...RefSeqi		NP_035556.3, NM_011426.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		20612

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:20612

UCSC genome browser

More...UCSCi		uc008mkp.1 mouse [Q62230-3]
uc008mkq.1 mouse [Q62230-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36293 mRNA Translation: CAA85290.1 Frameshift.
Z36233 mRNA Translation: CAA85268.1 Frameshift.
Z36234 mRNA Translation: CAA85269.1
U92842 U92841 Genomic DNA Translation: AAB95641.1
AL831736 Genomic DNA No translation available.
AL833771 Genomic DNA No translation available.
PIRiS50065
RefSeqiNP_035556.3, NM_011426.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OD7X-ray3.00A20-138[»]
1OD9X-ray2.10A20-138[»]
1ODAX-ray3.31A20-138[»]
1QFOX-ray1.85A/B/C20-138[»]
1QFPX-ray2.80A20-138[»]
1URLX-ray2.40A20-137[»]
2BVEX-ray2.20A/B20-138[»]
SMRiQ62230
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi203360, 2 interactors
IntActiQ62230, 3 interactors
MINTiQ62230
STRINGi10090.ENSMUSP00000028794

Protein family/group databases

UniLectiniQ62230

PTM databases

iPTMnetiQ62230
PhosphoSitePlusiQ62230

Proteomic databases

jPOSTiQ62230
PaxDbiQ62230
PRIDEiQ62230

Genome annotation databases

GeneIDi20612
KEGGimmu:20612
UCSCiuc008mkp.1 mouse [Q62230-3]
uc008mkq.1 mouse [Q62230-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6614
MGIiMGI:99668 Siglec1

Phylogenomic databases

eggNOGiENOG410KDW5 Eukaryota
ENOG410ZJZH LUCA
InParanoidiQ62230
KOiK06548
OrthoDBi54136at2759

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		20612 0 hits in 12 CRISPR screens
EvolutionaryTraceiQ62230

Protein Ontology

More...PROi		PR:Q62230
RNActiQ62230 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Family and domain databases

Gene3Di2.60.40.10, 17 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07679 I-set, 3 hits
PF00047 ig, 1 hit
PF13895 Ig_2, 6 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 16 hits
SM00408 IGc2, 15 hits
SUPFAMiSSF48726 SSF48726, 12 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 14 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSN_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62230
Secondary accession number(s): D3YVZ3
, D3YVZ4, O55216, Q62228, Q62229
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 21, 2011
Last modified: June 17, 2020
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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