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Entry version 168 (16 Oct 2019)
Sequence version 2 (21 Sep 2011)
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Protein

Sialoadhesin

Gene

Siglec1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hematopoiesis. May act as a counter-receptor for CLEC10A in lymph node.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei63Sialic acid1 Publication1
Binding sitei116Sialic acid4 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Endocytosis
LigandLectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Protein family/group databases

UniLectin database of carbohydrate-binding proteins

More...
UniLectini
Q62230

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sialoadhesin
Alternative name(s):
Sheep erythrocyte receptor
Short name:
SER
Sialic acid-binding Ig-like lectin 1
Short name:
Siglec-1
CD_antigen: CD169
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Siglec1
Synonyms:Sa, Sn
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:99668 Siglec1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 1639ExtracellularSequence analysisAdd BLAST1620
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1640 – 1660HelicalSequence analysisAdd BLAST21
Topological domaini1661 – 1695CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi21W → Q: Loss of sialic acid binding. 1 Publication1
Mutagenesisi116R → A: Loss of sialic acid binding. 1 Publication1
Mutagenesisi116R → L: 10-fold loss in affinity to sialic acid. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Add BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001496920 – 1695SialoadhesinAdd BLAST1676

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 166PROSITE-ProRule annotation
Disulfide bondi41 ↔ 98PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160 ↔ 218PROSITE-ProRule annotation
Disulfide bondi263 ↔ 306PROSITE-ProRule annotation
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi347 ↔ 391PROSITE-ProRule annotation
Disulfide bondi434 ↔ 492PROSITE-ProRule annotation
Glycosylationi500N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi532 ↔ 576PROSITE-ProRule annotation
Glycosylationi583N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi625 ↔ 685PROSITE-ProRule annotation
Glycosylationi693N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi722N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi725 ↔ 770PROSITE-ProRule annotation
Glycosylationi737N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi813 ↔ 872PROSITE-ProRule annotation
Glycosylationi882N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi912 ↔ 956PROSITE-ProRule annotation
Disulfide bondi1001 ↔ 1063PROSITE-ProRule annotation
Glycosylationi1090N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1103 ↔ 1145PROSITE-ProRule annotation
Disulfide bondi1189 ↔ 1237PROSITE-ProRule annotation
Glycosylationi1247N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1277 ↔ 1320PROSITE-ProRule annotation
Disulfide bondi1363 ↔ 1422PROSITE-ProRule annotation
Glycosylationi1460N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1463 ↔ 1509PROSITE-ProRule annotation
Glycosylationi1474N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1552 ↔ 1611PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q62230

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62230

PRoteomics IDEntifications database

More...
PRIDEi
Q62230

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62230

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62230

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in lymph node in the subcapsular sinus, interfollicular regions, and T and B-cell boundary (at protein level). Expressed by macrophages in various tissues. Highest expression in spleen and lymph node with lower amounts in lung, liver, bone marrow, heart and skin. No expression in thymus, kidney, brain or small intestine.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CLEC10A.

5 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
203360, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q62230, 3 interactors

Molecular INTeraction database

More...
MINTi
Q62230

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000028794

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11695
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q62230

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q62230

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 136Ig-like V-typeAdd BLAST117
Domaini153 – 235Ig-like C2-type 1Add BLAST83
Domaini239 – 321Ig-like C2-type 2Add BLAST83
Domaini326 – 406Ig-like C2-type 3Add BLAST81
Domaini416 – 508Ig-like C2-type 4Add BLAST93
Domaini509 – 594Ig-like C2-type 5Add BLAST86
Domaini602 – 701Ig-like C2-type 6Add BLAST100
Domaini704 – 781Ig-like C2-type 7Add BLAST78
Domaini795 – 890Ig-like C2-type 8Add BLAST96
Domaini894 – 973Ig-like C2-type 9Add BLAST80
Domaini980 – 1079Ig-like C2-type 10Add BLAST100
Domaini1081 – 1161Ig-like C2-type 11Add BLAST81
Domaini1172 – 1264Ig-like C2-type 12Add BLAST93
Domaini1245 – 1337Ig-like C2-type 13Add BLAST93
Domaini1342 – 1439Ig-like C2-type 14Add BLAST98
Domaini1442 – 1520Ig-like C2-type 15Add BLAST79
Domaini1534 – 1627Ig-like C2-type 16Add BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni122 – 126Sialic acid binding5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi827 – 829Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KDW5 Eukaryota
ENOG410ZJZH LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154365

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q62230

KEGG Orthology (KO)

More...
KOi
K06548

Database of Orthologous Groups

More...
OrthoDBi
54136at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 17 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR013151 Immunoglobulin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08205 C2-set_2, 1 hit
PF07679 I-set, 3 hits
PF00047 ig, 1 hit
PF13895 Ig_2, 6 hits
PF07686 V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 16 hits
SM00408 IGc2, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q62230-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCVLFSLLLL ASVFSLGQTT WGVSSPKNVQ GLSGSCLLIP CIFSYPADVP
60 70 80 90 100
VSNGITAIWY YDYSGKRQVV IHSGDPKLVD KRFRGRAELM GNMDHKVCNL
110 120 130 140 150
LLKDLKPEDS GTYNFRFEIS DSNRWLDVKG TTVTVTTDPS PPTITIPEEL
160 170 180 190 200
REGMERNFNC STPYLCLQEK QVSLQWRGQD PTHSVTSSFQ SLEPTGVYHQ
210 220 230 240 250
TTLHMALSWQ DHGRTLLCQF SLGAHSSRKE VYLQVPHAPK GVEILLSSSG
260 270 280 290 300
RNILPGDPVT LTCRVNSSYP AVSAVQWARD GVNLGVTGHV LRLFSAAWND
310 320 330 340 350
SGAYTCQATN DMGSLVSSPL SLHVFMAEVK MNPAGPVLEN ETVTLLCSTP
360 370 380 390 400
KEAPQELRYS WYKNHILLED AHASTLHLPA VTRADTGFYF CEVQNAQGSE
410 420 430 440 450
RSSPLSVVVR YPPLTPDLTT FLETQAGLVG ILHCSVVSEP LATVVLSHGG
460 470 480 490 500
LTLASNSGEN DFNPRFRISS APNSLRLEIR DLQPADSGEY TCLAVNSLGN
510 520 530 540 550
STSSLDFYAN VARLLINPSA EVVEGQAVTL SCRSGLSPAP DTRFSWYLNG
560 570 580 590 600
ALLLEGSSSS LLLPAASSTD AGSYYCRTQA GPNTSGPSLP TVLTVFYPPR
610 620 630 640 650
KPTFTARLDL DTSGVGDGRR GILLCHVDSD PPAQLRLLHK GHVVATSLPS
660 670 680 690 700
RCGSCSQRTK VSRTSNSLHV EIQKPVLEDE GVYLCEASNT LGNSSAAASF
710 720 730 740 750
NAKATVLVIT PSNTLREGTE ANLTCNVNQE VAVSPANFSW FRNGVLWTQG
760 770 780 790 800
SLETVRLQPV ARTDAAVYAC RLLTEDGAQL SAPVVLSVLY APDPPKLSAL
810 820 830 840 850
LDVGQGHMAV FICTVDSYPL AHLSLFRGDH LLATNLEPQR PSHGRIQAKA
860 870 880 890 900
TANSLQLEVR ELGLVDSGNY HCEATNILGS ANSSLFFQVR GAWVQVSPSP
910 920 930 940 950
ELREGQAVVL SCQVPTGVSE GTSYSWYQDG RPLQESTSST LRIAAISLRQ
960 970 980 990 1000
AGAYHCQAQA PDTAIASLAA PVSLHVSYTP RHVTLSALLS TDPERLGHLV
1010 1020 1030 1040 1050
CSVQSDPPAQ LQLFHRNRLV ASTLQGADEL AGSNPRLHVT VLPNELRLQI
1060 1070 1080 1090 1100
HFPELEDDGT YTCEASNTLG QASAAADFDA QAVRVTVWPN ATVQEGQQVN
1110 1120 1130 1140 1150
LTCLVWSTHQ DSLSYTWYKG GQQLLGARSI TLPSVKVLDA TSYRCGVGLP
1160 1170 1180 1190 1200
GHAPHLSRPV TLDVLHAPRN LRLTYLLETQ GRQLALVLCT VDSRPPAQLT
1210 1220 1230 1240 1250
LSHGDQLVAS STEASVPNTL RLELQDPRPS NEGLYSCSAH SPLGKANTSL
1260 1270 1280 1290 1300
ELLLEGVRVK MNPSGSVPEG EPVTVTCEDP AALSSALYAW FHNGHWLQEG
1310 1320 1330 1340 1350
PASSLQFLVT TRAHAGAYFC QVHDTQGTRS SRPASLQILY APRDAVLSSF
1360 1370 1380 1390 1400
RDSRTRLMVV IQCTVDSEPP AEMVLSHNGK VLAASHERHS SASGIGHIQV
1410 1420 1430 1440 1450
ARNALRLQVQ DVTLGDGNTY VCTAQNTLGS ISTTQRLLTE TDIRVTAEPG
1460 1470 1480 1490 1500
LDVPEGTALN LSCLLPGGSG PTGNSSFTWF WNRHRLHSAP VPTLSFTPVV
1510 1520 1530 1540 1550
RAQAGLYHCR ADLPTGATTS APVMLRVLYP PKTPTLIVFV EPQGGHQGIL
1560 1570 1580 1590 1600
DCRVDSEPLA ILTLHRGSQL VASNQLHDAP TKPHIRVTAP PNALRVDIEE
1610 1620 1630 1640 1650
LGPSNQGEYV CTASNTLGSA SASAYFGTRA LHQLQLFQRL LWVLGFLAGF
1660 1670 1680 1690
LCLLLGLVAY HTWRKKSSTK LNEDENSAEM ATKKNTIQEE VVAAL
Length:1,695
Mass (Da):182,979
Last modified:September 21, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF704F68C40E113A
GO
Isoform 2 (identifier: Q62230-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-340: MAEVKMNPAGPVLEN → SESWMRLRGPVSGKH
     341-1695: Missing.

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Length:340
Mass (Da):37,511
Checksum:i26F3E85E35BC02E9
GO
Isoform 3 (identifier: Q62230-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1529-1599: YPPKTPTLIV...PPNALRVDIE → CEYEPISALC...LLPFWDEYRR
     1600-1695: Missing.

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Length:1,599
Mass (Da):172,769
Checksum:i7FC111F331066F0C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X8X6G3X8X6_MOUSE
Sialic acid binding Ig-like lectin ...
Siglec1 mCG_18494
1,701Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9KUZ2H9KUZ2_MOUSE
Sialoadhesin
Siglec1
346Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9KUZ3H9KUZ3_MOUSE
Sialic acid binding Ig-like lectin ...
Siglec1 mCG_18494
1,605Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA85268 differs from that shown. Reason: Frameshift.Curated
The sequence CAA85290 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti159N → F in AAB95641 (PubMed:9383289).Curated1
Sequence conflicti197V → S in CAA85268 (PubMed:7925291).Curated1
Sequence conflicti197V → S in CAA85290 (PubMed:7925291).Curated1
Sequence conflicti197V → S in AAB95641 (PubMed:9383289).Curated1
Sequence conflicti590P → Q AA sequence (PubMed:7925291).Curated1
Sequence conflicti727V → G in CAA85268 (PubMed:7925291).Curated1
Sequence conflicti727V → G in CAA85290 (PubMed:7925291).Curated1
Sequence conflicti727V → G in AAB95641 (PubMed:9383289).Curated1
Sequence conflicti759 – 760PV → LL in CAA85268 (PubMed:7925291).Curated2
Sequence conflicti759 – 760PV → LL in CAA85290 (PubMed:7925291).Curated2
Sequence conflicti759 – 760PV → LL in AAB95641 (PubMed:9383289).Curated2
Sequence conflicti1050 – 1052IHF → FLV AA sequence (PubMed:7925291).Curated3
Sequence conflicti1055 – 1056LE → VQ AA sequence (PubMed:7925291).Curated2
Sequence conflicti1062T → Q AA sequence (PubMed:7925291).Curated1
Sequence conflicti1066S → Q AA sequence (PubMed:7925291).Curated1
Sequence conflicti1426N → H in CAA85268 (PubMed:7925291).Curated1
Sequence conflicti1426N → H in CAA85290 (PubMed:7925291).Curated1
Sequence conflicti1426N → H in AAB95641 (PubMed:9383289).Curated1
Sequence conflicti1453V → W in CAA85268 (PubMed:7925291).Curated1
Sequence conflicti1453V → W in CAA85290 (PubMed:7925291).Curated1
Sequence conflicti1453V → W in AAB95641 (PubMed:9383289).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002573326 – 340MAEVK…PVLEN → SESWMRLRGPVSGKH in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_002574341 – 1695Missing in isoform 2. 1 PublicationAdd BLAST1355
Alternative sequenceiVSP_0025751529 – 1599YPPKT…RVDIE → CEYEPISALCLSLHLTGPYQ AFSSAQSKGFIGKGLRTLAS SLAGCMWFVSMLGYPALKWR ILLPFWDEYRR in isoform 3. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_0025761600 – 1695Missing in isoform 3. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z36293 mRNA Translation: CAA85290.1 Frameshift.
Z36233 mRNA Translation: CAA85268.1 Frameshift.
Z36234 mRNA Translation: CAA85269.1
U92842
, U92833, U92834, U92836, U92837, U92838, U92839, U92840, U92841 Genomic DNA Translation: AAB95641.1
AL831736 Genomic DNA No translation available.
AL833771 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

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PIRi
S50065

NCBI Reference Sequences

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RefSeqi
NP_035556.3, NM_011426.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
20612

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:20612

UCSC genome browser

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UCSCi
uc008mkp.1 mouse [Q62230-3]
uc008mkq.1 mouse [Q62230-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36293 mRNA Translation: CAA85290.1 Frameshift.
Z36233 mRNA Translation: CAA85268.1 Frameshift.
Z36234 mRNA Translation: CAA85269.1
U92842
, U92833, U92834, U92836, U92837, U92838, U92839, U92840, U92841 Genomic DNA Translation: AAB95641.1
AL831736 Genomic DNA No translation available.
AL833771 Genomic DNA No translation available.
PIRiS50065
RefSeqiNP_035556.3, NM_011426.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OD7X-ray3.00A20-138[»]
1OD9X-ray2.10A20-138[»]
1ODAX-ray3.31A20-138[»]
1QFOX-ray1.85A/B/C20-138[»]
1QFPX-ray2.80A20-138[»]
1URLX-ray2.40A20-137[»]
2BVEX-ray2.20A/B20-138[»]
SMRiQ62230
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi203360, 2 interactors
IntActiQ62230, 3 interactors
MINTiQ62230
STRINGi10090.ENSMUSP00000028794

Protein family/group databases

UniLectiniQ62230

PTM databases

iPTMnetiQ62230
PhosphoSitePlusiQ62230

Proteomic databases

jPOSTiQ62230
PaxDbiQ62230
PRIDEiQ62230

Genome annotation databases

GeneIDi20612
KEGGimmu:20612
UCSCiuc008mkp.1 mouse [Q62230-3]
uc008mkq.1 mouse [Q62230-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6614
MGIiMGI:99668 Siglec1

Phylogenomic databases

eggNOGiENOG410KDW5 Eukaryota
ENOG410ZJZH LUCA
HOGENOMiHOG000154365
InParanoidiQ62230
KOiK06548
OrthoDBi54136at2759

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

EvolutionaryTraceiQ62230

Protein Ontology

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PROi
PR:Q62230

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

Gene3Di2.60.40.10, 17 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07679 I-set, 3 hits
PF00047 ig, 1 hit
PF13895 Ig_2, 6 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 16 hits
SM00408 IGc2, 15 hits
SUPFAMiSSF48726 SSF48726, 12 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 14 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSN_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62230
Secondary accession number(s): D3YVZ3
, D3YVZ4, O55216, Q62228, Q62229
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 21, 2011
Last modified: October 16, 2019
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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