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Protein

Nuclear receptor subfamily 0 group B member 2

Gene

Nr0b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 0 group B member 2
Alternative name(s):
Orphan nuclear receptor SHP
Small heterodimer partner
Gene namesi
Name:Nr0b2
Synonyms:Shp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1346344 Nr0b2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537531 – 260Nuclear receptor subfamily 0 group B member 2Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57Symmetric dimethylarginine; by PRMT51 Publication1

Post-translational modificationi

Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.1 Publication

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ62227
PRIDEiQ62227

PTM databases

iPTMnetiQ62227
PhosphoSitePlusiQ62227

Expressioni

Tissue specificityi

Expressed in islets of Langerhans (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000037583 Expressed in 62 organ(s), highest expression level in head
CleanExiMM_NR0B2
GenevisibleiQ62227 MM

Interactioni

Subunit structurei

Heterodimer; efficient DNA binding requires dimerization with another bHLH protein. Interacts (via N-terminus) with NEUROD1 (via N-terminus an C-terminus). Interacts with ID2. Interacts with NR5A2, PPARA and PPARG. May also interact with HNF4A (By similarity). Interacts with RARA, RXRA, THRB, NR5A1, NR1I3 and EID1.By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204818, 18 interactors
IntActiQ62227, 3 interactors
STRINGi10090.ENSMUSP00000039175

Structurei

Secondary structure

1260
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ62227
SMRiQ62227
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ62227

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 260NR LBDPROSITE-ProRule annotationAdd BLAST245

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00390000015719
HOGENOMiHOG000231151
HOVERGENiHBG008136
InParanoidiQ62227
KOiK08563
OMAiSPKEYAY
OrthoDBiEOG091G0FGK
PhylomeDBiQ62227
TreeFamiTF332386

Family and domain databases

InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PRINTSiPR00398 STRDHORMONER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit

Sequencei

Sequence statusi: Complete.

Q62227-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSGQSGVCP CQGSAGRPTI LYALLSPSPR TRPVAPASHS HCLCQQQRPV
60 70 80 90 100
RLCAPHRTCR EALDVLAKTV AFLRNLPSFC HLPHEDQRRL LECCWGPLFL
110 120 130 140 150
LGLAQDAVTF EVAEAPVPSI LKKILLEEAS SGTQGAQPSD RPQPSLAAVQ
160 170 180 190 200
WLQRCLESFW SLELGPKEYA YLKGTILFNP DVPGLRASCH IAHLQQEAHW
210 220 230 240 250
ALCEVLEPWY PASQGRLARI LLMASTLKNI PGTLLVDLFF RPIMGDVDIT
260
ELLEDMLLLR
Length:260
Mass (Da):28,763
Last modified:November 1, 1996 - v1
Checksum:i7B859325AA73DCA1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti241R → C. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76567 Genomic DNA Translation: AAB59732.1
AY360323 mRNA Translation: AAQ55057.1
AY360324 mRNA Translation: AAQ55058.1
BC019540 mRNA Translation: AAH19540.1
CCDSiCCDS18751.1
RefSeqiNP_035980.1, NM_011850.3
UniGeneiMm.346759

Genome annotation databases

EnsembliENSMUST00000042706; ENSMUSP00000039175; ENSMUSG00000037583
GeneIDi23957
KEGGimmu:23957
UCSCiuc008vcz.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76567 Genomic DNA Translation: AAB59732.1
AY360323 mRNA Translation: AAQ55057.1
AY360324 mRNA Translation: AAQ55058.1
BC019540 mRNA Translation: AAH19540.1
CCDSiCCDS18751.1
RefSeqiNP_035980.1, NM_011850.3
UniGeneiMm.346759

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YMTX-ray1.20B17-30[»]
4NUFX-ray2.80A53-260[»]
ProteinModelPortaliQ62227
SMRiQ62227
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204818, 18 interactors
IntActiQ62227, 3 interactors
STRINGi10090.ENSMUSP00000039175

PTM databases

iPTMnetiQ62227
PhosphoSitePlusiQ62227

Proteomic databases

PaxDbiQ62227
PRIDEiQ62227

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042706; ENSMUSP00000039175; ENSMUSG00000037583
GeneIDi23957
KEGGimmu:23957
UCSCiuc008vcz.1 mouse

Organism-specific databases

CTDi8431
MGIiMGI:1346344 Nr0b2

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00390000015719
HOGENOMiHOG000231151
HOVERGENiHBG008136
InParanoidiQ62227
KOiK08563
OMAiSPKEYAY
OrthoDBiEOG091G0FGK
PhylomeDBiQ62227
TreeFamiTF332386

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway

Miscellaneous databases

EvolutionaryTraceiQ62227
PROiPR:Q62227
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037583 Expressed in 62 organ(s), highest expression level in head
CleanExiMM_NR0B2
GenevisibleiQ62227 MM

Family and domain databases

InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PRINTSiPR00398 STRDHORMONER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNR0B2_MOUSE
AccessioniPrimary (citable) accession number: Q62227
Secondary accession number(s): Q53Z53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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