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Protein

Transforming growth factor beta-1-induced transcript 1 protein

Gene

Tgfb1i1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.17 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processDifferentiation, Wnt signaling pathway
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transforming growth factor beta-1-induced transcript 1 protein
Alternative name(s):
Androgen receptor-associated protein of 55 kDa
Hydrogen peroxide-inducible clone 5 protein
Short name:
Hic-5
TGF beta-stimulated clone 5
Short name:
TSC-5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tgfb1i1
Synonyms:Ara55
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:102784 Tgfb1i1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi38Y → F: Reduced phosphorylation. Loss of phosphorylation; when associated with F-60. 1 Publication1
Mutagenesisi60Y → F: Reduced phosphorylation. Loss of phosphorylation; when associated with F-38. 1 Publication1
Mutagenesisi64C → N: Increase in nuclear localization. 1 Publication1
Mutagenesisi91C → S: Increase in nuclear localization. 1 Publication1
Mutagenesisi161L → A: Increase in nuclear localization. 1 Publication1
Mutagenesisi366H → G: Loss of interaction with PTPN12; when associated with G-369. 1 Publication1
Mutagenesisi369C → A: Loss of localization to focal adhesion; when associated with A-372. 2 Publications1
Mutagenesisi369C → G: Loss of interaction with PTPN12; when associated with G-366. 2 Publications1
Mutagenesisi372C → A: Loss of localization to focal adhesion; when associated with A-369. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002915831 – 461Transforming growth factor beta-1-induced transcript 1 proteinAdd BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei33PhosphothreonineBy similarity1
Modified residuei38Phosphotyrosine1 Publication1
Modified residuei60Phosphotyrosine1 Publication1
Modified residuei68PhosphoserineCombined sources1
Modified residuei141PhosphoserineBy similarity1
Modified residuei164PhosphoserineBy similarity1
Modified residuei186PhosphoserineCombined sources1
Modified residuei188PhosphothreonineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei407PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by gonadotropin-releasing hormone-activated SRC.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q62219

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62219

PeptideAtlas

More...
PeptideAtlasi
Q62219

PRoteomics IDEntifications database

More...
PRIDEi
Q62219

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62219

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62219

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Higher expression is detected in lung and spleen. Expression decreases during pregnancy in mammary glands. Expressed in all brain areas, with higher levels in cerebellum, prefrontal cortex and hypothalamus. Expressed in smooth muscle, myoepithelial cells and platelets (at protein level). Preferentially expressed in mesenchymal versus epithelial cells (at protein level).6 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected in the developing heart tube at E8.0 and then in cardiac, skeletal and smooth muscle during early stages of development. Highly expressed in differentiating gut epithelial cells.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during epithelial to mesenchymal transformation. Up-regulated by TGFB1 and hydrogen peroxide.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030782 Expressed in 76 organ(s), highest expression level in fibroblast

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q62219 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q62219 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer. Interacts with CRIP2, HSPB1, ILK, LIMS1, LIMS2, NCK2, NUDT16L1, PAK, PPARG, PTPN12, TCF3, TCF7L2 and VCL. Forms a complex with GIT1 and ARHGEF7. Interacts with AR/androgen receptor in a ligand-dependent manner. Interacts with CSK, LYN, MAPK15, NR3C1, PPARG, PTK2/FAK1, PTK2B/PYK2, SLC6A3, SLC6A4, SMAD3, SRC and talin. Interacts (via LIM zinc-binding domain 2) with CBLC (via RING-type zinc finger); the interaction is direct and enhances CBLC E3 ubiquitin-protein ligase activity.20 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
204158, 7 interactors

Protein interaction database and analysis system

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IntActi
Q62219, 5 interactors

Molecular INTeraction database

More...
MINTi
Q62219

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000068529

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q62219

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q62219

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini226 – 285LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini286 – 343LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST58
Domaini344 – 403LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST60
Domaini404 – 461LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 240Interaction with PTK2B/PYK2By similarityAdd BLAST240
Regioni1 – 200Transcription activationAdd BLAST200
Regioni83 – 136Interaction with PTK2/FAK1Add BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi3 – 15LD motif 1Add BLAST13
Motifi92 – 104LD motif 2Add BLAST13
Motifi157 – 168LD motif 3Add BLAST12
Motifi203 – 215LD motif 4Add BLAST13

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12.
The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the paxillin family.Curated

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1703 Eukaryota
ENOG410XRD4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160447

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG001512

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q62219

Database of Orthologous Groups

More...
OrthoDBi
1593918at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q62219

TreeFam database of animal gene trees

More...
TreeFami
TF314113

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017305 Tgfb1i1/Leupaxin/TGFB1I1
IPR001781 Znf_LIM

Pfam protein domain database

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Pfami
View protein in Pfam
PF00412 LIM, 4 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037881 Leupaxin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00132 LIM, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 10 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q62219-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDLDALLSD LETTTSHMSR LGAPKERPPE TLTPPPPYGH QPQTGSGESS
60 70 80 90 100
GTTGDKDHLY STVCKPRSPK PVAPVAPPFS SSSGVLGNGL CELDRLLQEL
110 120 130 140 150
NATQFNITDE IMSQFPSSKM AEGEEKEDQS EDKSSPTVPP SPFPAPSKPS
160 170 180 190 200
ATSATQELDR LMASLSDFRV QNHLPASGPP QPPAASPTRE GCPSPPGQTS
210 220 230 240 250
KGSLDTMLGL LQSDLSRRGV PTQAKGLCGS CNKPIAGQVV TALGRAWHPE
260 270 280 290 300
HFLCSGCSTT LGGSSFFEKD GAPFCPECYF ERFSPRCGFC NQPIRHKMVT
310 320 330 340 350
ALGTHWHPEH FCCVSCGEPF GEEGFHEREG RPYCRRDFLQ LFAPRCQGCQ
360 370 380 390 400
GPILDNYISA LSALWHPDCF VCRECLAPFS GGSFFEHEGR PLCENHFHAQ
410 420 430 440 450
RGSLCATCGL PVTGRCVSAL GRRFHPDHFT CTFCLRPLTK GSFQERASKP
460
YCQPCFLKLF G
Note: Transcripts of the alpha group are more abundantly expressed.
Length:461
Mass (Da):50,101
Last modified:June 26, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6AB15FFF466FEE73
GO
Isoform 2 (identifier: Q62219-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.

Show »
Length:444
Mass (Da):48,228
Checksum:i54E80E09A7CC7C51
GO
Isoform 3 (identifier: Q62219-3) [UniParc]FASTAAdd to basket
Also known as: Alpha-B

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: MEDLDALLSD...PPPPYGHQPQ → MSPCSPFIAP...SASAPPWRTW

Note: Transcripts of the alpha group are more abundantly expressed.
Show »
Length:483
Mass (Da):51,988
Checksum:iFE6D462670C2BFFE
GO
Isoform 4 (identifier: Q62219-4) [UniParc]FASTAAdd to basket
Also known as: Alpha-E

The sequence of this isoform differs from the canonical sequence as follows:
     62-107: Missing.

Note: Transcripts of the alpha group are more abundantly expressed.
Show »
Length:415
Mass (Da):45,266
Checksum:iF6065EA4A754FEF5
GO
Isoform 5 (identifier: Q62219-5) [UniParc]FASTAAdd to basket
Also known as: Beta-G

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.
     60-82: YSTVCKPRSPKPVAPVAPPFSSS → MATSHRQGLENLQEPLGTRIIYT

Show »
Length:402
Mass (Da):44,059
Checksum:iAF3A2DD21C47869E
GO
Isoform 6 (identifier: Q62219-6) [UniParc]FASTAAdd to basket
Also known as: Alpha-C

The sequence of this isoform differs from the canonical sequence as follows:
     61-61: S → R
     62-461: Missing.

Note: Transcripts of the alpha group are more abundantly expressed. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:61
Mass (Da):6,605
Checksum:iE45E004C4EFCFAC7
GO
Isoform 7 (identifier: Q62219-7) [UniParc]FASTAAdd to basket
Also known as: Beta-B, Beta-D

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Show »
Length:350
Mass (Da):38,289
Checksum:i3AFEE18DB06963F9
GO
Isoform 8 (identifier: Q62219-8) [UniParc]FASTAAdd to basket
Also known as: Beta-C

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.
     61-61: S → R
     62-461: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:44
Mass (Da):4,732
Checksum:iFDEBBC62BE006A91
GO
Isoform 9 (identifier: Q62219-9) [UniParc]FASTAAdd to basket
Also known as: Beta-E, Beta-F

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
     63-138: VCKPRSPKPV...QSEDKSSPTV → MPPSSTLQMK...SEVIHGVLHN

Show »
Length:399
Mass (Da):43,798
Checksum:iDD062C34B5C62F81
GO
Isoform 10 (identifier: Q62219-10) [UniParc]FASTAAdd to basket
Also known as: Alpha-D

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.
     111-148: IMSQFPSSKM...PPSPFPAPSK → MPPSSTLQMK...NLKTRAHPLS

Note: Transcripts of the alpha group are more abundantly expressed.
Show »
Length:351
Mass (Da):38,669
Checksum:i79F2BFB888438DDC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q1D5E9Q1D5_MOUSE
Transforming growth factor beta-1-i...
Tgfb1i1
422Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PYQ1E9PYQ1_MOUSE
Transforming growth factor beta-1-i...
Tgfb1i1
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q1V4E9Q1V4_MOUSE
Transforming growth factor beta-1-i...
Tgfb1i1
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH02049 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAZ82195 differs from that shown. Reason: Frameshift at position 28.Curated
The sequence AAZ82200 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAE33707 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE34493 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0261841 – 111Missing in isoform 7. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_0261851 – 110Missing in isoform 10. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_0261881 – 62Missing in isoform 9. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_0261891 – 59Missing in isoform 5. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_0261901 – 43MEDLD…GHQPQ → MSPCSPFIAPPPPTVSQRVP ASIHGHGPASNSLTSPPSPS SAPTGHGPRPTLPKLSASAP PWRTW in isoform 3. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_0261911 – 17Missing in isoform 2 and isoform 8. 3 PublicationsAdd BLAST17
Alternative sequenceiVSP_02619260 – 82YSTVC…PFSSS → MATSHRQGLENLQEPLGTRI IYT in isoform 5. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_03981361S → R in isoform 6 and isoform 8. 2 Publications1
Alternative sequenceiVSP_03981462 – 461Missing in isoform 6 and isoform 8. 2 PublicationsAdd BLAST400
Alternative sequenceiVSP_02619362 – 107Missing in isoform 4. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_02619463 – 138VCKPR…SSPTV → MPPSSTLQMKSCLSSHLVKW LKGKRRRTNLKTRAHPLCEF GRVGRAGKRMMGPACLTYQR GVRLAGSEVIHGVLHN in isoform 9. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_026197111 – 148IMSQF…PAPSK → MPPSSTLQMKSCLSSHLVKW LKGKRRRTNLKTRAHPLS in isoform 10. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L22482 mRNA Translation: AAA62226.1
AF083064 Genomic DNA Translation: AAD51090.1
DQ143891 mRNA Translation: AAZ82195.1 Frameshift.
DQ143892 mRNA Translation: AAZ82196.1
DQ143893 mRNA Translation: AAZ82197.1
DQ143894 mRNA Translation: AAZ82198.1
DQ143895 mRNA Translation: AAZ82199.1
DQ143896 mRNA Translation: AAZ82200.1 Sequence problems.
DQ143897 mRNA Translation: AAZ82201.1
DQ143898 mRNA Translation: AAZ82202.1
DQ143899 mRNA Translation: AAZ82203.1
DQ143900 mRNA Translation: AAZ82204.1
AK156423 mRNA Translation: BAE33707.1 Different initiation.
AK158409 mRNA Translation: BAE34493.1 Sequence problems.
BC002049 mRNA Translation: AAH02049.1 Different initiation.
BC056362 mRNA Translation: AAH56362.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS21893.2 [Q62219-1]
CCDS80812.1 [Q62219-7]

Protein sequence database of the Protein Information Resource

More...
PIRi
A55071

NCBI Reference Sequences

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RefSeqi
NP_001276479.1, NM_001289550.1 [Q62219-1]
NP_001276481.1, NM_001289552.1
NP_001276482.1, NM_001289553.1 [Q62219-7]
XP_006507630.1, XM_006507567.2 [Q62219-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.3248

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000070656; ENSMUSP00000068529; ENSMUSG00000030782 [Q62219-2]
ENSMUST00000163609; ENSMUSP00000133134; ENSMUSG00000030782 [Q62219-7]
ENSMUST00000164710; ENSMUSP00000130964; ENSMUSG00000030782 [Q62219-3]
ENSMUST00000167965; ENSMUSP00000132100; ENSMUSG00000030782 [Q62219-1]
ENSMUST00000169919; ENSMUSP00000131705; ENSMUSG00000030782 [Q62219-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
21804

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:21804

UCSC genome browser

More...
UCSCi
uc009jyl.3 mouse [Q62219-1]
uc009jyo.2 mouse [Q62219-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22482 mRNA Translation: AAA62226.1
AF083064 Genomic DNA Translation: AAD51090.1
DQ143891 mRNA Translation: AAZ82195.1 Frameshift.
DQ143892 mRNA Translation: AAZ82196.1
DQ143893 mRNA Translation: AAZ82197.1
DQ143894 mRNA Translation: AAZ82198.1
DQ143895 mRNA Translation: AAZ82199.1
DQ143896 mRNA Translation: AAZ82200.1 Sequence problems.
DQ143897 mRNA Translation: AAZ82201.1
DQ143898 mRNA Translation: AAZ82202.1
DQ143899 mRNA Translation: AAZ82203.1
DQ143900 mRNA Translation: AAZ82204.1
AK156423 mRNA Translation: BAE33707.1 Different initiation.
AK158409 mRNA Translation: BAE34493.1 Sequence problems.
BC002049 mRNA Translation: AAH02049.1 Different initiation.
BC056362 mRNA Translation: AAH56362.1
CCDSiCCDS21893.2 [Q62219-1]
CCDS80812.1 [Q62219-7]
PIRiA55071
RefSeqiNP_001276479.1, NM_001289550.1 [Q62219-1]
NP_001276481.1, NM_001289552.1
NP_001276482.1, NM_001289553.1 [Q62219-7]
XP_006507630.1, XM_006507567.2 [Q62219-3]
UniGeneiMm.3248

3D structure databases

ProteinModelPortaliQ62219
SMRiQ62219
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204158, 7 interactors
IntActiQ62219, 5 interactors
MINTiQ62219
STRINGi10090.ENSMUSP00000068529

PTM databases

iPTMnetiQ62219
PhosphoSitePlusiQ62219

Proteomic databases

jPOSTiQ62219
PaxDbiQ62219
PeptideAtlasiQ62219
PRIDEiQ62219

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070656; ENSMUSP00000068529; ENSMUSG00000030782 [Q62219-2]
ENSMUST00000163609; ENSMUSP00000133134; ENSMUSG00000030782 [Q62219-7]
ENSMUST00000164710; ENSMUSP00000130964; ENSMUSG00000030782 [Q62219-3]
ENSMUST00000167965; ENSMUSP00000132100; ENSMUSG00000030782 [Q62219-1]
ENSMUST00000169919; ENSMUSP00000131705; ENSMUSG00000030782 [Q62219-6]
GeneIDi21804
KEGGimmu:21804
UCSCiuc009jyl.3 mouse [Q62219-1]
uc009jyo.2 mouse [Q62219-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7041
MGIiMGI:102784 Tgfb1i1

Phylogenomic databases

eggNOGiKOG1703 Eukaryota
ENOG410XRD4 LUCA
GeneTreeiENSGT00940000160447
HOVERGENiHBG001512
InParanoidiQ62219
OrthoDBi1593918at2759
PhylomeDBiQ62219
TreeFamiTF314113

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q62219

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030782 Expressed in 76 organ(s), highest expression level in fibroblast
ExpressionAtlasiQ62219 baseline and differential
GenevisibleiQ62219 MM

Family and domain databases

InterProiView protein in InterPro
IPR017305 Tgfb1i1/Leupaxin/TGFB1I1
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 4 hits
PIRSFiPIRSF037881 Leupaxin, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 4 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTGFI1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62219
Secondary accession number(s): Q3YBY7
, Q3YBY8, Q3YBZ0, Q3YBZ1, Q3YBZ3, Q3YBZ4, Q3YBZ5, Q3YBZ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: January 16, 2019
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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