UniProtKB - Q62210 (BIRC2_MOUSE)
Baculoviral IAP repeat-containing protein 2
Birc2
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication EC:2.3.2.27
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 299 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 302 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 319 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 326 | ZincPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 565 – 600 | RING-typePROSITE-ProRule annotationAdd BLAST | 36 |
GO - Molecular functioni
- chaperone binding Source: MGI
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: GO_Central
- FBXO family protein binding Source: MGI
- identical protein binding Source: MGI
- protein-containing complex binding Source: MGI
- protein N-terminus binding Source: MGI
- transcription coactivator activity Source: UniProtKB
- transferase activity Source: MGI
- ubiquitin binding Source: MGI
- ubiquitin protein ligase activity Source: GO_Central
- ubiquitin-protein transferase activity Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- cellular response to tumor necrosis factor Source: MGI
- inhibition of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
- necroptotic process Source: UniProtKB
- negative regulation of apoptotic process Source: MGI
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
- negative regulation of necroptotic process Source: MGI
- negative regulation of ripoptosome assembly involved in necroptotic process Source: MGI
- placenta development Source: MGI
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- positive regulation of protein K48-linked ubiquitination Source: UniProtKB
- positive regulation of protein K63-linked ubiquitination Source: UniProtKB
- positive regulation of protein monoubiquitination Source: MGI
- positive regulation of protein polyubiquitination Source: MGI
- positive regulation of protein ubiquitination Source: GO_Central
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
- protein polyubiquitination Source: UniProtKB
- regulation of apoptotic process Source: MGI
- regulation of cell cycle Source: UniProtKB
- regulation of necroptotic process Source: MGI
- regulation of NIK/NF-kappaB signaling Source: MGI
- regulation of reactive oxygen species metabolic process Source: MGI
- response to cAMP Source: Ensembl
- response to ethanol Source: Ensembl
- response to hypoxia Source: MGI
Keywordsi
Molecular function | Activator, Transferase |
Biological process | Apoptosis, Transcription, Transcription regulation, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-111465, Apoptotic cleavage of cellular proteins R-MMU-168638, NOD1/2 Signaling Pathway R-MMU-5213460, RIPK1-mediated regulated necrosis R-MMU-5357905, Regulation of TNFR1 signaling R-MMU-5357956, TNFR1-induced NFkappaB signaling pathway R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5675482, Regulation of necroptotic cell death R-MMU-5676594, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-MMU-5689880, Ub-specific processing proteases R-MMU-937041, IKK complex recruitment mediated by RIP1 |
Protein family/group databases
MEROPSi | I32.007 |
Names & Taxonomyi
Protein namesi | Recommended name: Baculoviral IAP repeat-containing protein 2 (EC:2.3.2.271 Publication)Alternative name(s): Cellular inhibitor of apoptosis 1 Short name: C-IAP11 Publication Inhibitor of apoptosis protein 21 Publication Short name: mIAP21 Publication RING-type E3 ubiquitin transferase BIRC2Curated |
Gene namesi | Name:Birc2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1197009, Birc2 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasm By similarity
Note: Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells (By similarity).By similarity
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- CD40 receptor complex Source: BHF-UCL
- cytoplasmic side of plasma membrane Source: BHF-UCL
Other locations
- cytoplasm Source: MGI
- membrane raft Source: MGI
- protein-containing complex Source: MGI
- XY body Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000122348 | 1 – 612 | Baculoviral IAP repeat-containing protein 2Add BLAST | 612 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 143 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 153 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q62210 |
jPOSTi | Q62210 |
MaxQBi | Q62210 |
PaxDbi | Q62210 |
PRIDEi | Q62210 |
PTM databases
iPTMneti | Q62210 |
PhosphoSitePlusi | Q62210 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000057367, Expressed in blood and 309 other tissues |
ExpressionAtlasi | Q62210, baseline and differential |
Genevisiblei | Q62210, MM |
Interactioni
Subunit structurei
Interacts with DIABLO/SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity.
Interacts with CASP9.
Interacts (via BIR domains) with TRAF2; the interaction is required for IKBKE ubiquitination.
Interacts with E2F1, RIPK1, RIPK2, RIPK3, RIPK4, BIRC5/survivin and USP19 (By similarity).
Interacts with HSP90AB1 (By similarity).
Interacts with several death receptors, inclusing FAS, TNFRSF10A and TNFRSF10B (By similarity). Recruited to TNFRSF10B in the absence of receptor stimulation. When TNFRSF10B is stimulated, further recruited to the receptor and cleaved by caspases. Proteolytic fragments remain associated with TNFRSF10B (By similarity).
By similarityGO - Molecular functioni
- chaperone binding Source: MGI
- FBXO family protein binding Source: MGI
- identical protein binding Source: MGI
- protein N-terminus binding Source: MGI
- ubiquitin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 198148, 14 interactors |
CORUMi | Q62210 |
IntActi | Q62210, 3 interactors |
MINTi | Q62210 |
STRINGi | 10090.ENSMUSP00000140049 |
Miscellaneous databases
RNActi | Q62210, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 46 – 113 | BIR 1Add BLAST | 68 | |
Repeati | 177 – 243 | BIR 2Add BLAST | 67 | |
Repeati | 262 – 329 | BIR 3Add BLAST | 68 | |
Domaini | 447 – 537 | CARDPROSITE-ProRule annotationAdd BLAST | 91 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 565 – 600 | RING-typePROSITE-ProRule annotationAdd BLAST | 36 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1101, Eukaryota |
GeneTreei | ENSGT00940000154175 |
HOGENOMi | CLU_016347_1_1_1 |
InParanoidi | Q62210 |
OMAi | FQRLTCV |
OrthoDBi | 1340284at2759 |
PhylomeDBi | Q62210 |
TreeFami | TF105356 |
Family and domain databases
CDDi | cd00022, BIR, 3 hits cd14394, UBA_BIRC2_3, 1 hit |
InterProi | View protein in InterPro IPR001370, BIR_rpt IPR041933, BIRC2/BIRC3_UBA IPR001315, CARD IPR011029, DEATH-like_dom_sf IPR001841, Znf_RING |
Pfami | View protein in Pfam PF00653, BIR, 3 hits PF00619, CARD, 1 hit |
SMARTi | View protein in SMART SM00238, BIR, 3 hits SM00114, CARD, 1 hit SM00184, RING, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS01282, BIR_REPEAT_1, 3 hits PS50143, BIR_REPEAT_2, 3 hits PS50209, CARD, 1 hit PS50089, ZF_RING_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MDKTVSQRLG QGTLHQKLKR IMEKSTILSN WTKESEEKMK FDFSCELYRM
60 70 80 90 100
STYSAFPRGV PVSERSLARA GFYYTGVNDK VKCFCCGLML DNWKQGDSPV
110 120 130 140 150
EKHRQFYPSC SFVQTLLSAS LQSPSKNMSP VKSRFAHSSP LERGGIHSNL
160 170 180 190 200
CSSPLNSRAV EDFSSRMDPC SYAMSTEEAR FLTYSMWPLS FLSPAELARA
210 220 230 240 250
GFYYIGPGDR VACFACGGKL SNWEPKDDAM SEHRRHFPHC PFLENTSETQ
260 270 280 290 300
RFSISNLSMQ THSARLRTFL YWPPSVPVQP EQLASAGFYY VDRNDDVKCF
310 320 330 340 350
CCDGGLRCWE PGDDPWIEHA KWFPRCEFLI RMKGQEFVDE IQARYPHLLE
360 370 380 390 400
QLLSTSDTPG EENADPTETV VHFGPGESSE DVVMMSTPVV KAALEMGFSR
410 420 430 440 450
SLVRQTVQRQ ILATGENYRT VNDIVSVLLN AEDERREEEK ERQTEEMASG
460 470 480 490 500
DLSLIRKNRM ALFQQLTHVL PILDNLLEAS VITKQEHDII RQKTQIPLQA
510 520 530 540 550
RELIDTVLVK GNAAANIFKN SLKEIDSTLY ENLFVEKNMK YIPTEDVSGL
560 570 580 590 600
SLEEQLRRLQ EERTCKVCMD REVSIVFIPC GHLVVCQECA PSLRKCPICR
610
GTIKGTVRTF LS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF6X8Q0 | F6X8Q0_MOUSE | Baculoviral IAP repeat-containing p... | Birc2 | 125 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 380 | E → K in AAC53532 (PubMed:9441758).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L49433 mRNA Translation: AAC42078.1 U88909 mRNA Translation: AAC53532.1 BC145985 mRNA Translation: AAI45986.1 |
CCDSi | CCDS22811.1 |
RefSeqi | NP_001278432.1, NM_001291503.1 NP_031491.2, NM_007465.3 XP_017168599.1, XM_017313110.1 |
Genome annotation databases
Ensembli | ENSMUST00000074246; ENSMUSP00000091422; ENSMUSG00000057367 ENSMUST00000190341; ENSMUSP00000140049; ENSMUSG00000057367 |
GeneIDi | 11797 |
KEGGi | mmu:11797 |
UCSCi | uc009ocz.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L49433 mRNA Translation: AAC42078.1 U88909 mRNA Translation: AAC53532.1 BC145985 mRNA Translation: AAI45986.1 |
CCDSi | CCDS22811.1 |
RefSeqi | NP_001278432.1, NM_001291503.1 NP_031491.2, NM_007465.3 XP_017168599.1, XM_017313110.1 |
3D structure databases
SMRi | Q62210 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198148, 14 interactors |
CORUMi | Q62210 |
IntActi | Q62210, 3 interactors |
MINTi | Q62210 |
STRINGi | 10090.ENSMUSP00000140049 |
Protein family/group databases
MEROPSi | I32.007 |
PTM databases
iPTMneti | Q62210 |
PhosphoSitePlusi | Q62210 |
Proteomic databases
EPDi | Q62210 |
jPOSTi | Q62210 |
MaxQBi | Q62210 |
PaxDbi | Q62210 |
PRIDEi | Q62210 |
Protocols and materials databases
Antibodypediai | 1043, 464 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000074246; ENSMUSP00000091422; ENSMUSG00000057367 ENSMUST00000190341; ENSMUSP00000140049; ENSMUSG00000057367 |
GeneIDi | 11797 |
KEGGi | mmu:11797 |
UCSCi | uc009ocz.2, mouse |
Organism-specific databases
CTDi | 329 |
MGIi | MGI:1197009, Birc2 |
Phylogenomic databases
eggNOGi | KOG1101, Eukaryota |
GeneTreei | ENSGT00940000154175 |
HOGENOMi | CLU_016347_1_1_1 |
InParanoidi | Q62210 |
OMAi | FQRLTCV |
OrthoDBi | 1340284at2759 |
PhylomeDBi | Q62210 |
TreeFami | TF105356 |
Enzyme and pathway databases
Reactomei | R-MMU-111465, Apoptotic cleavage of cellular proteins R-MMU-168638, NOD1/2 Signaling Pathway R-MMU-5213460, RIPK1-mediated regulated necrosis R-MMU-5357905, Regulation of TNFR1 signaling R-MMU-5357956, TNFR1-induced NFkappaB signaling pathway R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5675482, Regulation of necroptotic cell death R-MMU-5676594, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-MMU-5689880, Ub-specific processing proteases R-MMU-937041, IKK complex recruitment mediated by RIP1 |
Miscellaneous databases
BioGRID-ORCSi | 11797, 4 hits in 21 CRISPR screens |
ChiTaRSi | Birc2, mouse |
PROi | PR:Q62210 |
RNActi | Q62210, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000057367, Expressed in blood and 309 other tissues |
ExpressionAtlasi | Q62210, baseline and differential |
Genevisiblei | Q62210, MM |
Family and domain databases
CDDi | cd00022, BIR, 3 hits cd14394, UBA_BIRC2_3, 1 hit |
InterProi | View protein in InterPro IPR001370, BIR_rpt IPR041933, BIRC2/BIRC3_UBA IPR001315, CARD IPR011029, DEATH-like_dom_sf IPR001841, Znf_RING |
Pfami | View protein in Pfam PF00653, BIR, 3 hits PF00619, CARD, 1 hit |
SMARTi | View protein in SMART SM00238, BIR, 3 hits SM00114, CARD, 1 hit SM00184, RING, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS01282, BIR_REPEAT_1, 3 hits PS50143, BIR_REPEAT_2, 3 hits PS50209, CARD, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BIRC2_MOUSE | |
Accessioni | Q62210Primary (citable) accession number: Q62210 Secondary accession number(s): A6H6S7, O08864 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families