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Protein

Synaptonemal complex protein 1

Gene

Sycp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:16717126). Required for normal assembly of the central element of the synaptonemal complexes (PubMed:15937223). Required for normal centromere pairing during meiosis (PubMed:22761579). Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility (PubMed:15937223).3 Publications

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • chiasma assembly Source: MGI
  • lateral element assembly Source: MGI
  • meiotic DNA repair synthesis Source: MGI
  • reciprocal meiotic recombination Source: UniProtKB
  • regulation of protein localization Source: MGI
  • spermatogenesis Source: MGI
  • sperm chromatin condensation Source: MGI
  • synapsis Source: UniProtKB
  • synaptonemal complex assembly Source: HGNC

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Meiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptonemal complex protein 1
Short name:
SCP-1
Gene namesi
Name:Sycp1
Synonyms:Scp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:105931 Sycp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice appear generally healthy, but display complete sterility, due to defective meiosis during germ cell development. Ovaries and testes from mutant mice have strongly reduced weight relative to wild-type. Ovaries display an absence of growing follicles and oocytes. Testes show a complete lack of spermatids and spermatozoa. Synaptonemal complexes from mutant spermatocytes form normal axial elements, but lack the central element; chromosomes do not synapse properly, cross-overs are rare, and DNA repair after meiotic double-strand breaks is impaired.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000723641 – 993Synaptonemal complex protein 1Add BLAST993

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei820PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ62209
PRIDEiQ62209

PTM databases

iPTMnetiQ62209
PhosphoSitePlusiQ62209

Expressioni

Tissue specificityi

Detected in testis (PubMed:15937223). Detected in spermatocytes (at protein level) (PubMed:22761579).2 Publications

Gene expression databases

BgeeiENSMUSG00000027855 Expressed in 45 organ(s), highest expression level in testis
CleanExiMM_SYCP1
ExpressionAtlasiQ62209 baseline and differential
GenevisibleiQ62209 MM

Interactioni

Subunit structurei

Homodimer (By similarity). Component of synaptonemal complexes (PubMed:15937223, PubMed:16717126, PubMed:22761579). Found in a complex with SYCE1 and SYCE2. Interacts with SYCE1 and SYCE2 (PubMed:15944401).By similarity4 Publications

Protein-protein interaction databases

BioGridi203596, 2 interactors
CORUMiQ62209
IntActiQ62209, 1 interactor
MINTiQ62209
STRINGi10090.ENSMUSP00000029448

Structurei

3D structure databases

ProteinModelPortaliQ62209
SMRiQ62209
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili104 – 815Sequence analysisAdd BLAST712

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi114 – 117Nuclear localization signalSequence analysis4
Motifi697 – 700Nuclear localization signalSequence analysis4
Motifi898 – 901Nuclear localization signalSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 97Asp/Glu-rich (acidic)Add BLAST86
Compositional biasi978 – 986Arg/Lys-rich (basic)9

Domaini

Consists of a predicted coiled coil region of 700 AA residues, flanked by N- and C-terminal globular domains. The C-terminal domain may have DNA-binding capacity.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH3F Eukaryota
ENOG410XZPD LUCA
GeneTreeiENSGT00390000003368
HOGENOMiHOG000154467
HOVERGENiHBG059062
InParanoidiQ62209
KOiK19533
OMAiETRQVYM
OrthoDBiEOG091G0116
TreeFamiTF331737

Family and domain databases

InterProiView protein in InterPro
IPR008827 SYCP1
IPR024835 SYCP1/2
PANTHERiPTHR15607 PTHR15607, 1 hit
PfamiView protein in Pfam
PF05483 SCP-1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q62209-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKQKPFTLF VPPRLSSSQV SAVKPQTAGG DSNYFKTANK CTEGDFGVPF
60 70 80 90 100
TMSSRENIDK DPAFQKLSIL PMLEQVANSG SCHYQEGVND SDFENSEPMS
110 120 130 140 150
RLYSKLYKEA EKIKKWKVSI ESELKQKENK LQENRKIIEA QRKAIQELQF
160 170 180 190 200
ENEKVSLKLE EEIQENKDLI KENNATIHWC NLLKETCARS AEKTNKYEYE
210 220 230 240 250
REETRQVYVD LNSNIEKMIL AFEELRVQAE NARLEMHFKL KEDHEKIQHL
260 270 280 290 300
EEEYQKEVNN KENQVSELLI QSAEKENKMK DLTFLLEESR DKANQLEEKT
310 320 330 340 350
KLQDENLKEL SEKKDHLTSE LEDIKMSMQR SMSTQKALEE DLQIATKTIS
360 370 380 390 400
QLTEVKEAQM EELNKAKTTH SFVVTELKAT TCTLEELLRT EQQRLEKNED
410 420 430 440 450
QLKLITVELQ KKSNELEEMT KFKNNKEVEL EELKNILAED QKLLDEKKQV
460 470 480 490 500
EKLAEELQEK EQELTFLLET REKEVHDLQE QVTVTKTSEQ HYLKQVEEMK
510 520 530 540 550
TELEKEKLKN TELTASCDML LLENKKFVQE ASDMALELKK HQEDIINCKK
560 570 580 590 600
QEERLLKQIE NLEEKEMHLR DELESVRKEF IQQGDEVKCK LDKSEENARS
610 620 630 640 650
IECEVLKKEK QMKILESKCN NLKKQVENKS KNIEELHQEN KTLKKKSSAE
660 670 680 690 700
IKQLNAYEIK VSKLELELES TKQRFEEMTN NYQKEIENKK ISEGKLLGEV
710 720 730 740 750
EKAKATVDEA VKLQKEIDLR CQHKIAEMVA LMEKHKHQYD KIVEERDSEL
760 770 780 790 800
GLYKNREQEQ SSAKIALETE LSNIRNELVS LKKQLEIEKE EKEKLKMAKE
810 820 830 840 850
NTAILKDKKD KKIQASLLES PEATSWKFDS KTTPSQNISR LSSSMDSGKS
860 870 880 890 900
KDNRDNLRAS AKSILPTTVT KEYTVKTPTK KSIYQRENKY IPTGGSNKKR
910 920 930 940 950
KTAFEFDVNS DSSETADLLS LVSEEDVSNR LYDNNPPDSH LLVKTPKQTP
960 970 980 990
LSLSTPASFM KFGSLKKMRE DRWTTIAKID RKRRLKEAEK LFS
Length:993
Mass (Da):115,935
Last modified:July 27, 2011 - v2
Checksum:iFF4930F279FBC251
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGA9A0A0G2JGA9_MOUSE
Synaptonemal complex protein 1
Sycp1
182Annotation score:

Sequence cautioni

The sequence AAA64514 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38A → V in AAC53335 (PubMed:7548215).Curated1
Sequence conflicti38A → V in CAA86262 (PubMed:7548215).Curated1
Sequence conflicti38A → V in AAA64514 (Ref. 2) Curated1
Sequence conflicti38A → V in AAI37968 (PubMed:15489334).Curated1
Sequence conflicti527F → L in AAA64514 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38118 mRNA Translation: CAA86262.1
L41069 mRNA Translation: AAA64514.1 Different initiation.
AH006782 Genomic DNA Translation: AAC53335.1
AC122219 Genomic DNA No translation available.
AC134871 Genomic DNA No translation available.
BC137967 mRNA Translation: AAI37968.1
D88539 mRNA Translation: BAA13639.1
CCDSiCCDS38567.1
PIRiS49461
RefSeqiNP_035646.2, NM_011516.2
UniGeneiMm.243849

Genome annotation databases

EnsembliENSMUST00000029448; ENSMUSP00000029448; ENSMUSG00000027855
ENSMUST00000196988; ENSMUSP00000143651; ENSMUSG00000027855
GeneIDi20957
KEGGimmu:20957
UCSCiuc008qrz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38118 mRNA Translation: CAA86262.1
L41069 mRNA Translation: AAA64514.1 Different initiation.
AH006782 Genomic DNA Translation: AAC53335.1
AC122219 Genomic DNA No translation available.
AC134871 Genomic DNA No translation available.
BC137967 mRNA Translation: AAI37968.1
D88539 mRNA Translation: BAA13639.1
CCDSiCCDS38567.1
PIRiS49461
RefSeqiNP_035646.2, NM_011516.2
UniGeneiMm.243849

3D structure databases

ProteinModelPortaliQ62209
SMRiQ62209
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203596, 2 interactors
CORUMiQ62209
IntActiQ62209, 1 interactor
MINTiQ62209
STRINGi10090.ENSMUSP00000029448

PTM databases

iPTMnetiQ62209
PhosphoSitePlusiQ62209

Proteomic databases

PaxDbiQ62209
PRIDEiQ62209

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029448; ENSMUSP00000029448; ENSMUSG00000027855
ENSMUST00000196988; ENSMUSP00000143651; ENSMUSG00000027855
GeneIDi20957
KEGGimmu:20957
UCSCiuc008qrz.2 mouse

Organism-specific databases

CTDi6847
MGIiMGI:105931 Sycp1

Phylogenomic databases

eggNOGiENOG410IH3F Eukaryota
ENOG410XZPD LUCA
GeneTreeiENSGT00390000003368
HOGENOMiHOG000154467
HOVERGENiHBG059062
InParanoidiQ62209
KOiK19533
OMAiETRQVYM
OrthoDBiEOG091G0116
TreeFamiTF331737

Miscellaneous databases

ChiTaRSiDlk1 mouse
PROiPR:Q62209
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027855 Expressed in 45 organ(s), highest expression level in testis
CleanExiMM_SYCP1
ExpressionAtlasiQ62209 baseline and differential
GenevisibleiQ62209 MM

Family and domain databases

InterProiView protein in InterPro
IPR008827 SYCP1
IPR024835 SYCP1/2
PANTHERiPTHR15607 PTHR15607, 1 hit
PfamiView protein in Pfam
PF05483 SCP-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYCP1_MOUSE
AccessioniPrimary (citable) accession number: Q62209
Secondary accession number(s): B2RQK2
, E9QP17, O09205, P70192, Q62329
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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