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Entry version 161 (02 Jun 2021)
Sequence version 2 (09 Jan 2007)
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Protein

Sodium channel protein type 9 subunit alpha

Gene

Scn9a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient (PubMed:15123669).

It is a tetrodotoxin-sensitive Na+ channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:15314237).

By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei821Is directly targeted by the spider protoxin-IIBy similarity1
Sitei826Is directly targeted by the spider protoxin-IIBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channel, Voltage-gated channel
Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5576892, Phase 0 - rapid depolarisation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel protein type 9 subunit alphaBy similarity
Alternative name(s):
Peripheral sodium channel 1
Short name:
PN1By similarity
Sodium channel protein type IX subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Scn9aImported
Synonyms:Kiaa41971 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107636, Scn9a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 126CytoplasmicCuratedAdd BLAST126
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei127 – 145Helical; Name=S1 of repeat IBy similarityAdd BLAST19
Topological domaini146 – 152ExtracellularCurated7
Transmembranei153 – 173Helical; Name=S2 of repeat IBy similarityAdd BLAST21
Topological domaini174 – 187CytoplasmicCuratedAdd BLAST14
Transmembranei188 – 205Helical; Name=S3 of repeat IBy similarityAdd BLAST18
Topological domaini206 – 211ExtracellularCurated6
Transmembranei212 – 228Helical; Name=S4 of repeat IBy similarityAdd BLAST17
Topological domaini229 – 247CytoplasmicCuratedAdd BLAST19
Transmembranei248 – 267Helical; Name=S5 of repeat IBy similarityAdd BLAST20
Topological domaini268 – 346ExtracellularCuratedAdd BLAST79
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei347 – 371Pore-formingBy similarityAdd BLAST25
Topological domaini372 – 378ExtracellularCurated7
Transmembranei379 – 399Helical; Name=S6 of repeat IBy similarityAdd BLAST21
Topological domaini400 – 743CytoplasmicCuratedAdd BLAST344
Transmembranei744 – 762Helical; Name=S1 of repeat IIBy similarityAdd BLAST19
Topological domaini763 – 773ExtracellularCuratedAdd BLAST11
Transmembranei774 – 793Helical; Name=S2 of repeat IIBy similarityAdd BLAST20
Topological domaini794 – 807CytoplasmicCuratedAdd BLAST14
Transmembranei808 – 827Helical; Name=S3 of repeat IIBy similarityAdd BLAST20
Topological domaini828 – 829ExtracellularCurated2
Transmembranei830 – 847Helical; Name=S4 of repeat IIBy similarityAdd BLAST18
Topological domaini848 – 863CytoplasmicCuratedAdd BLAST16
Transmembranei864 – 882Helical; Name=S5 of repeat IIBy similarityAdd BLAST19
Topological domaini883 – 911ExtracellularCuratedAdd BLAST29
Intramembranei912 – 932Pore-formingBy similarityAdd BLAST21
Topological domaini933 – 945ExtracellularCuratedAdd BLAST13
Transmembranei946 – 966Helical; Name=S6 of repeat IIBy similarityAdd BLAST21
Topological domaini967 – 1191CytoplasmicCuratedAdd BLAST225
Transmembranei1192 – 1209Helical; Name=S1 of repeat IIIBy similarityAdd BLAST18
Topological domaini1210 – 1222ExtracellularCuratedAdd BLAST13
Transmembranei1223 – 1241Helical; Name=S2 of repeat IIIBy similarityAdd BLAST19
Topological domaini1242 – 1255CytoplasmicCuratedAdd BLAST14
Transmembranei1256 – 1274Helical; Name=S3 of repeat IIIBy similarityAdd BLAST19
Topological domaini1275 – 1282ExtracellularCurated8
Transmembranei1283 – 1301Helical; Name=S4 of repeat IIIBy similarityAdd BLAST19
Topological domaini1302 – 1318CytoplasmicCuratedAdd BLAST17
Transmembranei1319 – 1338Helical; Name=S5 of repeat IIIBy similarityAdd BLAST20
Topological domaini1339 – 1390ExtracellularCuratedAdd BLAST52
Intramembranei1391 – 1412Pore-formingBy similarityAdd BLAST22
Topological domaini1413 – 1429ExtracellularCuratedAdd BLAST17
Transmembranei1430 – 1451Helical; Name=S6 of repeat IIIBy similarityAdd BLAST22
Topological domaini1452 – 1514CytoplasmicCuratedAdd BLAST63
Transmembranei1515 – 1532Helical; Name=S1 of repeat IVBy similarityAdd BLAST18
Topological domaini1533 – 1543ExtracellularCuratedAdd BLAST11
Transmembranei1544 – 1562Helical; Name=S2 of repeat IVBy similarityAdd BLAST19
Topological domaini1563 – 1574CytoplasmicCuratedAdd BLAST12
Transmembranei1575 – 1592Helical; Name=S3 of repeat IVBy similarityAdd BLAST18
Topological domaini1593 – 1605ExtracellularCuratedAdd BLAST13
Transmembranei1606 – 1622Helical; Name=S4 of repeat IVBy similarityAdd BLAST17
Topological domaini1623 – 1641CytoplasmicCuratedAdd BLAST19
Transmembranei1642 – 1659Helical; Name=S5 of repeat IVBy similarityAdd BLAST18
Topological domaini1660 – 1681ExtracellularCuratedAdd BLAST22
Intramembranei1682 – 1704Pore-formingBy similarityAdd BLAST23
Topological domaini1705 – 1734ExtracellularCuratedAdd BLAST30
Transmembranei1735 – 1757Helical; Name=S6 of repeat IVBy similarityAdd BLAST23
Topological domaini1758 – 1984CytoplasmicCuratedAdd BLAST227

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3414411

DrugCentral

More...
DrugCentrali
Q62205

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
584

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000485031 – 1984Sodium channel protein type 9 subunit alphaAdd BLAST1984

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi275 ↔ 324By similarity
Disulfide bondi894Interchain; with SCN2B or SCN4BBy similarity
Disulfide bondi894Interchain; with the conotoxin GVIIJ (when the channel is not linked to SCN2B or SCN4B; the bond to SCN2B or SCN4B protects the channel from the inhibition by toxin)By similarity
Disulfide bondi896 ↔ 902By similarity
Disulfide bondi934 ↔ 943By similarity
Disulfide bondi1348 ↔ 1368By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1488Phosphoserine; by PKCBy similarity1
Disulfide bondi1713 ↔ 1728By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4.1 Publication
Phosphorylation at Ser-1488 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q62205

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62205

PRoteomics IDEntifications database

More...
PRIDEi
Q62205

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
256751

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62205

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62205

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed strongly in sciatic nerves, with moderate levels in kidney (PubMed:31647222). Not detected in liver, brain and muscle (PubMed:31647222).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000075316, Expressed in olfactory epithelium and 126 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q62205, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q62205, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The sodium channel complex consists of a large, channel-forming alpha subunit (SCN9A) regulated by one or more beta subunits (SCN1B, SCN2B, SCN3B and SCN4B) (By similarity). SCN1B and SCN3B are non-covalently associated with SCN2A. SCN2B and SCN4B are disulfide-linked to SCN2A (By similarity).

Interacts with NEDD4 and NEDD4L.

Interacts with the conotoxin GVIIJ (By similarity).

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
203104, 14 interactors

Protein interaction database and analysis system

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IntActi
Q62205, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000097642

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q62205

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q62205, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q62205

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati112 – 410ICuratedAdd BLAST299
Repeati725 – 988IICuratedAdd BLAST264
Repeati1178 – 1486IIICuratedAdd BLAST309
Repeati1495 – 1793IVCuratedAdd BLAST299
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1887 – 1916IQAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 55DisorderedSequence analysisAdd BLAST30
Regioni458 – 540DisorderedSequence analysisAdd BLAST83
Regioni574 – 609DisorderedSequence analysisAdd BLAST36
Regioni1015 – 1039DisorderedSequence analysisAdd BLAST25
Regioni1089 – 1145DisorderedSequence analysisAdd BLAST57
Regioni1933 – 1984DisorderedSequence analysisAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili402 – 449Sequence analysisAdd BLAST48
Coiled coili684 – 708Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi26 – 51Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi485 – 528Basic and acidic residuesSequence analysisAdd BLAST44
Compositional biasi574 – 599Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi1015 – 1031Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi1108 – 1123Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1933 – 1959Polar residuesSequence analysisAdd BLAST27
Compositional biasi1961 – 1984Basic and acidic residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.Curated

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2301, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161368

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q62205

Database of Orthologous Groups

More...
OrthoDBi
56920at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q62205

TreeFam database of animal gene trees

More...
TreeFami
TF323985

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13433, Na_channel_gate, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821, Ion_trans_dom
IPR000048, IQ_motif_EF-hand-BS
IPR001696, Na_channel_asu
IPR044564, Na_chnl_inactivation_gate
IPR010526, Na_trans_assoc
IPR024583, Na_trans_cytopl
IPR028803, SCN9A
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037, PTHR10037, 1 hit
PTHR10037:SF221, PTHR10037:SF221, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520, Ion_trans, 4 hits
PF06512, Na_trans_assoc, 1 hit
PF11933, Na_trans_cytopl, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00170, NACHANNEL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015, IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q62205-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMLPPPGPQ SFVHFTKQSL ALIEQRISEE KAKGHKDEKK DDEEEGPKPS
60 70 80 90 100
SDLEAGKQLP FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF
110 120 130 140 150
NATPALYMLS PFSPLRRISI KILVHSLFSM LIMCTILTNC IFMTMSNPPD
160 170 180 190 200
WTKNVEYTFT GIYTFESLIK ILARGFCVGE FTFLRDPWNW LDFVVIVFAY
210 220 230 240 250
LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ SVKKLSDVMI
260 270 280 290 300
LTVFCLSVFA LIGLQLFMGN LKHKCFRKDL EQNETLESIM STAESEEELK
310 320 330 340 350
RYFYYLEGSK DALLCGFSTD SGQCPEGYEC VTAGRNPDYG YTSFDTFGWA
360 370 380 390 400
FLALFRLMTQ DYWENLYQQT LRAAGKTYMI FFVVVIFLGS FYLINLILAV
410 420 430 440 450
VAMAYEEQNQ ANIEEAKQKE LEFQQMLDRL KKEQEEAEAI AAAAAEYTSL
460 470 480 490 500
GRSRIMGLSE SSSETSRLSS KSAKERRNRR KKKKQKLSSG EEKGDDEKLS
510 520 530 540 550
KSGSEESIRK KSFHLGVEGH HRAREKRLST PNQSPLSIRG SLFSARRSSR
560 570 580 590 600
TSLFSFKGRG RDLGSETEFA DDEHSIFGDN ESRRGSLFVP HRPRERRSSN
610 620 630 640 650
ISQASRSPPV LPVNGKMHSA VDCNGVVSLV DGPSALMLPN GQLLPEVIID
660 670 680 690 700
KATSDDSGTT NQMRKKRLSS SYFLSEDMLN DPHLRQRAMS RASILTNTVE
710 720 730 740 750
ELEESRQKCP PWWYRFAHTF LIWNCSPYWI KFKKFIYFIV MDPFVDLAIT
760 770 780 790 800
ICIVLNTLFM AMEHHPMTDE FKNVLAVGNL VFTGIFAAEM VLKLIAMDPY
810 820 830 840 850
EYFQVGWNIF DSLIVTLSLV ELFLADVEGL SVLRSFRLLR VFKLAKSWPT
860 870 880 890 900
LNMLIKIIGN SVGALGNLTL VLAIIVFIFA VVGMQLFGKS YKECVCKINE
910 920 930 940 950
NCKLPRWHMN DFFHSFLIVF RVLCGEWIET MWDCMEVAGQ TMCLIVYMMV
960 970 980 990 1000
MVIGNLVVLN LFLALLLSSF SSDNLTAIEE DTDANNLQIA VARIKRGINY
1010 1020 1030 1040 1050
VKQTLREFIL KSFSKKPKGS KDTKRTADPN NKRENYISNR TLAEISKDHN
1060 1070 1080 1090 1100
FLKEKDKISG FSSSLDKSFM DENDYQSFIH NPSLTVTVPI APGESDLENM
1110 1120 1130 1140 1150
NTEELSSDSD SDYSKERRNR SSSSECSTVD NPLPGEEEAE AEPINADEPE
1160 1170 1180 1190 1200
ACFTDGCVRR FPCCQVNIDS GKGKVWWTIR KTCYRIVEHS WFESFIVLMI
1210 1220 1230 1240 1250
LLSSGALAFE DIYIEKKKTI KIILEYADKI FTYIFILEML LKWVAYGYKT
1260 1270 1280 1290 1300
YFTNAWCWLD FLIVDVSLVT LVANTLGYSD LGPIKSLRTL RALRPLRALS
1310 1320 1330 1340 1350
RFEGMRVVVN ALIGAIPSIM NVLLVCLIFW LIFSIMGVNL FAGKFYECVN
1360 1370 1380 1390 1400
TTDGSRFSVS QVANRSECFA LMNVSGNVRW KNLKVNFDNV GLGYLSLLQV
1410 1420 1430 1440 1450
ATFKGWMDIM YAAVDSVNVN AQPIYEYNLY MYIYFVIFII FGSFFTLNLF
1460 1470 1480 1490 1500
IGVIIDNFNQ QKKKLGGQDI FMTEEQKKYY NAMKKLGSKK PQKPIPRPGN
1510 1520 1530 1540 1550
KFQGCIFDLV TNQAFDITIM VLICLNMVTM MVEKEGQTDY MSFVLYWINV
1560 1570 1580 1590 1600
VFIILFTGEC VLKLISLRHY YFTVGWNIFD FVVVILSIVG MFLAEMIEKY
1610 1620 1630 1640 1650
FVSPTLFRVI RLARIGRILR LIKGAKGIRT LLFALMMSLP ALFNIGLLLF
1660 1670 1680 1690 1700
LVMFIYAIFG MSNFAYVKKE AGINDMFNFE TFGNSMICLF QITTSAGWDG
1710 1720 1730 1740 1750
LLAPILNSAP PDCDPKKVHP GSSVEGDCGN PSVGIFYFVS YIIISFLVVV
1760 1770 1780 1790 1800
NMYIAVILEN FSVATEESTE PLSEDDFEMF YEVWEKFDPD ATQFIEFCKL
1810 1820 1830 1840 1850
SDFAAALDPP LLIAKPNKVQ LIAMDLPMVS GDRIHCLDIL FAFTKRVLGE
1860 1870 1880 1890 1900
SGEMDSLRSQ MEERFMSANP SKVSYEPITT TLKRKQEDVS ATIIQRAYRR
1910 1920 1930 1940 1950
YRLRQNVKNI SSIYIKDGDR DDDLPNKEDI VFDNVNENSS PEKTDATAST
1960 1970 1980
ISPPSYDSVT KPDQEKYETD KTEKEDKEKD ESRK
Length:1,984
Mass (Da):225,813
Last modified:January 9, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51A8DBA38EC7EF38
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PW82E9PW82_MOUSE
Sodium channel protein
Scn9a
1,973Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AYL0B1AYL0_MOUSE
Sodium channel protein
Scn9a
1,973Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VPQ7F8VPQ7_MOUSE
Sodium channel protein
Scn9a
1,975Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL928623 Genomic DNA No translation available.
AL928726 Genomic DNA No translation available.
L42338 mRNA Translation: AAA67106.1
AK220540 mRNA Translation: BAD90315.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS71063.1

NCBI Reference Sequences

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RefSeqi
NP_001277603.1, NM_001290674.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000100064; ENSMUSP00000097642; ENSMUSG00000075316
ENSMUST00000164384; ENSMUSP00000126528; ENSMUSG00000075316

Database of genes from NCBI RefSeq genomes

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GeneIDi
20274

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:20274

UCSC genome browser

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UCSCi
uc008jxe.4, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928623 Genomic DNA No translation available.
AL928726 Genomic DNA No translation available.
L42338 mRNA Translation: AAA67106.1
AK220540 mRNA Translation: BAD90315.1
CCDSiCCDS71063.1
RefSeqiNP_001277603.1, NM_001290674.1

3D structure databases

SMRiQ62205
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi203104, 14 interactors
IntActiQ62205, 1 interactor
STRINGi10090.ENSMUSP00000097642

Chemistry databases

BindingDBiQ62205
ChEMBLiCHEMBL3414411
DrugCentraliQ62205
GuidetoPHARMACOLOGYi584

PTM databases

iPTMnetiQ62205
PhosphoSitePlusiQ62205

Proteomic databases

MaxQBiQ62205
PaxDbiQ62205
PRIDEiQ62205
ProteomicsDBi256751

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q62205, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33781, 507 antibodies

The DNASU plasmid repository

More...
DNASUi
20274

Genome annotation databases

EnsembliENSMUST00000100064; ENSMUSP00000097642; ENSMUSG00000075316
ENSMUST00000164384; ENSMUSP00000126528; ENSMUSG00000075316
GeneIDi20274
KEGGimmu:20274
UCSCiuc008jxe.4, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6335
MGIiMGI:107636, Scn9a

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG2301, Eukaryota
GeneTreeiENSGT00940000161368
InParanoidiQ62205
OrthoDBi56920at2759
PhylomeDBiQ62205
TreeFamiTF323985

Enzyme and pathway databases

ReactomeiR-MMU-5576892, Phase 0 - rapid depolarisation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
20274, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Scn9a, mouse

Protein Ontology

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PROi
PR:Q62205
RNActiQ62205, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000075316, Expressed in olfactory epithelium and 126 other tissues
ExpressionAtlasiQ62205, baseline and differential
GenevisibleiQ62205, MM

Family and domain databases

CDDicd13433, Na_channel_gate, 1 hit
Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821, Ion_trans_dom
IPR000048, IQ_motif_EF-hand-BS
IPR001696, Na_channel_asu
IPR044564, Na_chnl_inactivation_gate
IPR010526, Na_trans_assoc
IPR024583, Na_trans_cytopl
IPR028803, SCN9A
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR10037, PTHR10037, 1 hit
PTHR10037:SF221, PTHR10037:SF221, 1 hit
PfamiView protein in Pfam
PF00520, Ion_trans, 4 hits
PF06512, Na_trans_assoc, 1 hit
PF11933, Na_trans_cytopl, 1 hit
PRINTSiPR00170, NACHANNEL
SMARTiView protein in SMART
SM00015, IQ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCN9A_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62205
Secondary accession number(s): A2ASI7, Q5DTI0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 9, 2007
Last modified: June 2, 2021
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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