Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 195 (29 Sep 2021)
Sequence version 3 (27 Jul 2011)
Previous versions | rss
Add a publicationFeedback
Protein

Macrophage-stimulating protein receptor

Gene

Mst1r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Miscellaneous

Interaction with FSFFV envelope-like membrane glycoprotein gp55 results in constitutive tyrosine phosphorylation and activation of isoform sf-Stk.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1091ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1185Proton acceptorPROSITE-ProRule annotation1
Binding sitei1189ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1065 – 1073ATPPROSITE-ProRule annotation9
Nucleotide bindingi1138 – 1141ATPPROSITE-ProRule annotation4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processHost-virus interaction, Immunity, Innate immunity
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.10.1, 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8852405, Signaling by MST1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Macrophage-stimulating protein receptor (EC:2.7.10.1)
Short name:
MSP receptor
Alternative name(s):
Stem cell-derived tyrosine kinase
p185-Ron
CD_antigen: CD136
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mst1r
Synonyms:Ron, Stk
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:99614, Mst1r

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000032584

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 960ExtracellularSequence analysisAdd BLAST936
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei961 – 981HelicalSequence analysisAdd BLAST21
Topological domaini982 – 1378CytoplasmicSequence analysisAdd BLAST397

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show increased inflammation in an IFN-gamma-mediated delayed-type hypersensitivity reaction and increased susceptibility to lipopolysaccharide-induced endotoxic shock.1 Publication

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1795170

DrugCentral

More...
DrugCentrali
Q62190

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002445524 – 1378Macrophage-stimulating protein receptorAdd BLAST1355
ChainiPRO_000002445625 – 305Macrophage-stimulating protein receptor alpha chainSequence analysisAdd BLAST281
ChainiPRO_0000024457311 – 1378Macrophage-stimulating protein receptor beta chainSequence analysisAdd BLAST1068

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi102 ↔ 105PROSITE-ProRule annotation
Disulfide bondi108 ↔ 163PROSITE-ProRule annotation
Disulfide bondi136 ↔ 144PROSITE-ProRule annotation
Disulfide bondi175 ↔ 178PROSITE-ProRule annotation
Disulfide bondi301 ↔ 368PROSITE-ProRule annotation
Disulfide bondi386 ↔ 409PROSITE-ProRule annotation
Disulfide bondi387 ↔ 424PROSITE-ProRule annotation
Glycosylationi391N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi460N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi490N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi529 ↔ 547PROSITE-ProRule annotation
Disulfide bondi535 ↔ 569PROSITE-ProRule annotation
Disulfide bondi538 ↔ 554PROSITE-ProRule annotation
Disulfide bondi550 ↔ 560PROSITE-ProRule annotation
Glycosylationi656N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi722N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi845N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi901N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1215Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei1216Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei1330Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei1337Phosphotyrosine; by autocatalysisBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytic processing yields the two subunits.By similarity
Autophosphorylated in response to ligand binding on Tyr-1215 and Tyr-1216 in the kinase domain leading to further phosphorylation of Tyr-1330 and Tyr-1337 in the C-terminal multifunctional docking site.By similarity
Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q62190

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62190

PRoteomics IDEntifications database

More...
PRIDEi
Q62190

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
260829 [Q62190-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q62190, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62190

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62190

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver, skin, lung, brain, testis and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032584, Expressed in stomach and 155 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q62190, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q62190, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha chain and a beta chain which are disulfide linked. Binds PLXNB1. Associates with and is negatively regulated by HYAL2.

Interacts when phosphorylated with downstream effectors including PIK3R1, PCLG1, GRB2 and GAB1.

Interacts with integrin beta1/ITGB1 in a ligand-independent fashion. Isoform sf-Stk forms covalent heterodimers with friend spleen focus-forming virus (FSFFV) gp55.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
202955, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q62190, 2 interactors

Molecular INTeraction database

More...
MINTi
Q62190

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000035203

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q62190

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q62190, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q62190

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 524SemaPROSITE-ProRule annotationAdd BLAST492
Domaini571 – 673IPT/TIG 1Add BLAST103
Domaini686 – 769IPT/TIG 2Add BLAST84
Domaini772 – 864IPT/TIG 3Add BLAST93
Domaini1059 – 1322Protein kinasePROSITE-ProRule annotationAdd BLAST264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1002 – 1026DisorderedSequence analysisAdd BLAST25
Regioni1347 – 1378DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1353 – 1367Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1095, Eukaryota
KOG3610, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157842

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005158_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q62190

Identification of Orthologs from Complete Genome Data

More...
OMAi
CWRCLRA

Database of Orthologous Groups

More...
OrthoDBi
408584at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q62190

TreeFam database of animal gene trees

More...
TreeFami
TF317402

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11279, Sema_RON, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR016201, PSI
IPR039413, RON_Sema
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
IPR016244, Tyr_kinase_HGF/MSP_rcpt
IPR015943, WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07714, PK_Tyr_Ser-Thr, 1 hit
PF01403, Sema, 1 hit
PF01833, TIG, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000617, TyrPK_HGF-R, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109, TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429, IPT, 4 hits
SM00423, PSI, 1 hit
SM00630, Sema, 1 hit
SM00219, TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101912, SSF101912, 1 hit
SSF56112, SSF56112, 1 hit
SSF81296, SSF81296, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS51004, SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform RON (identifier: Q62190-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLPLPLLQS SLLLMLLLRL SAASTNLNWQ CPRIPYAASR DFSVKYVVPS
60 70 80 90 100
FSAGGRVQAT AAYEDSTNSA VFVATRNHLH VLGPDLQFIE NLTTGPIGNP
110 120 130 140 150
GCQTCASCGP GPHGPPKDTD TLVLVMEPGL PALVSCGSTL QGRCFLHELE
160 170 180 190 200
PRGKALHLAA PACLFSANNN KPEACTDCVA SPLGTRVTVV EQGHASYFYV
210 220 230 240 250
ASSLDPELAA SFSPRSVSIR RLKSDTSGFQ PGFPSLSVLP KYLASYLIKY
260 270 280 290 300
VYSFHSGDFV YFLTVQPISV TSPPSALHTR LVRLNAVEPE IGDYRELVLD
310 320 330 340 350
CHFAPKRRRR GAPEGTQPYP VLQAAHSAPV DAKLAVELSI SEGQEVLFGV
360 370 380 390 400
FVTVKDGGSG MGPNSVVCAF PIYHLNILIE EGVEYCCHSS NSSSLLSRGL
410 420 430 440 450
DFFQTPSFCP NPPGGEASGP SSRCHYFPLM VHASFTRVDL FNGLLGSVKV
460 470 480 490 500
TALHVTRLGN VTVAHMGTVD GRVLQVEIAR SLNYLLYVSN FSLGSSGQPV
510 520 530 540 550
HRDVSRLGND LLFASGDQVF KVPIQGPGCR HFLTCWRCLR AQRFMGCGWC
560 570 580 590 600
GDRCDRQKEC PGSWQQDHCP PEISEFYPHS GPLRGTTRLT LCGSNFYLRP
610 620 630 640 650
DDVVPEGTHQ ITVGQSPCRL LPKDSSSPRP GSLKEFIQEL ECELEPLVTQ
660 670 680 690 700
AVGTTNISLV ITNMPAGKHF RVEGISVQEG FSFVEPVLTS IKPDFGPRAG
710 720 730 740 750
GTYLTLEGQS LSVGTSRAVL VNGTQCRLEQ VNEEQILCVT PPGAGTARVP
760 770 780 790 800
LHLQIGGAEV PGSWTFHYKE DPIVLDISPK CGYSGSHIMI HGQHLTSAWH
810 820 830 840 850
FTLSFHDGQS TVESRCAGQF VEQQQRRCRL PEYVVRNPQG WATGNLSVWG
860 870 880 890 900
DGAAGFTLPG FRFLPPPSPL RAGLVELKPE EHSVKVEYVG LGAVADCVTV
910 920 930 940 950
NMTVGGEVCQ HELRGDVVIC PLPPSLQLGK DGVPLQVCVD GGCHILSQVV
960 970 980 990 1000
RSSPGRASQR ILLIALLVLI LLVAVLAVAL IFNSRRRKKQ LGAHSLSPTT
1010 1020 1030 1040 1050
LSDINDTASG APNHEESSES RDGTSVPLLR TESIRLQDLD RMLLAEVKDV
1060 1070 1080 1090 1100
LIPHEQVVIH TDQVIGKGHF GVVYHGEYTD GAQNQTHCAI KSLSRITEVQ
1110 1120 1130 1140 1150
EVEAFLREGL LMRGLHHPNI LALIGIMLPP EGLPRVLLPY MRHGDLLHFI
1160 1170 1180 1190 1200
RSPQRNPTVK DLVSFGLQVA CGMEYLAEQK FVHRDLAARN CMLDESFTVK
1210 1220 1230 1240 1250
VADFGLARGV LDKEYYSVRQ HRHARLPVKW MALESLQTYR FTTKSDVWSF
1260 1270 1280 1290 1300
GVLLWELLTR GAPPYPHIDP FDLSHFLAQG RRLPQPEYCP DSLYHVMLRC
1310 1320 1330 1340 1350
WEADPAARPT FRALVLEVKQ VVASLLGDHY VQLTAAYVNV GPRAVDDGSV
1360 1370
PPEQVQPSPQ HCRSTSKPRP LSEPPLPT
Length:1,378
Mass (Da):150,519
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5899D3A17F95F76D
GO
Isoform sf-Stk (identifier: Q62190-2)
Sequence is not available
Note: Lacks part of the extracellular domain, oligomerizes and is constitutively activated. This isoform confers host susceptibility to Friend disease.Curated
Length:
Mass (Da):

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YXY9A0A0A6YXY9_MOUSE
Macrophage-stimulating protein rece...
Mst1r
442Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti713 – 714VG → IA in CAA52754 (PubMed:8193352).Curated2
Sequence conflicti719V → A in CAA52754 (PubMed:8193352).Curated1
Sequence conflicti1148H → R in CAA52754 (PubMed:8193352).Curated1
Sequence conflicti1148H → R in AAC39953 (PubMed:9467940).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X74736 mRNA Translation: CAA52754.1
U65949 Genomic DNA Translation: AAC39953.1
AL731808 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23509.1 [Q62190-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
I48751

NCBI Reference Sequences

More...
RefSeqi
NP_033100.2, NM_009074.2 [Q62190-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000035203; ENSMUSP00000035203; ENSMUSG00000032584 [Q62190-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
19882

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:19882

UCSC genome browser

More...
UCSCi
uc009rni.1, mouse [Q62190-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74736 mRNA Translation: CAA52754.1
U65949 Genomic DNA Translation: AAC39953.1
AL731808 Genomic DNA No translation available.
CCDSiCCDS23509.1 [Q62190-1]
PIRiI48751
RefSeqiNP_033100.2, NM_009074.2 [Q62190-1]

3D structure databases

SMRiQ62190
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi202955, 11 interactors
IntActiQ62190, 2 interactors
MINTiQ62190
STRINGi10090.ENSMUSP00000035203

Chemistry databases

BindingDBiQ62190
ChEMBLiCHEMBL1795170
DrugCentraliQ62190

PTM databases

GlyGeniQ62190, 8 sites
iPTMnetiQ62190
PhosphoSitePlusiQ62190

Proteomic databases

jPOSTiQ62190
PaxDbiQ62190
PRIDEiQ62190
ProteomicsDBi260829 [Q62190-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2092, 969 antibodies

The DNASU plasmid repository

More...
DNASUi
19882

Genome annotation databases

EnsembliENSMUST00000035203; ENSMUSP00000035203; ENSMUSG00000032584 [Q62190-1]
GeneIDi19882
KEGGimmu:19882
UCSCiuc009rni.1, mouse [Q62190-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4486
MGIiMGI:99614, Mst1r
VEuPathDBiHostDB:ENSMUSG00000032584

Phylogenomic databases

eggNOGiKOG1095, Eukaryota
KOG3610, Eukaryota
GeneTreeiENSGT00940000157842
HOGENOMiCLU_005158_0_0_1
InParanoidiQ62190
OMAiCWRCLRA
OrthoDBi408584at2759
PhylomeDBiQ62190
TreeFamiTF317402

Enzyme and pathway databases

BRENDAi2.7.10.1, 3474
ReactomeiR-MMU-8852405, Signaling by MST1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
19882, 2 hits in 62 CRISPR screens

Protein Ontology

More...
PROi
PR:Q62190
RNActiQ62190, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032584, Expressed in stomach and 155 other tissues
ExpressionAtlasiQ62190, baseline and differential
GenevisibleiQ62190, MM

Family and domain databases

CDDicd11279, Sema_RON, 1 hit
Gene3Di2.130.10.10, 1 hit
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR016201, PSI
IPR039413, RON_Sema
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
IPR016244, Tyr_kinase_HGF/MSP_rcpt
IPR015943, WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF07714, PK_Tyr_Ser-Thr, 1 hit
PF01403, Sema, 1 hit
PF01833, TIG, 2 hits
PIRSFiPIRSF000617, TyrPK_HGF-R, 1 hit
PRINTSiPR00109, TYRKINASE
SMARTiView protein in SMART
SM00429, IPT, 4 hits
SM00423, PSI, 1 hit
SM00630, Sema, 1 hit
SM00219, TyrKc, 1 hit
SUPFAMiSSF101912, SSF101912, 1 hit
SSF56112, SSF56112, 1 hit
SSF81296, SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS51004, SEMA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRON_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62190
Secondary accession number(s): E9QMZ4, Q62555
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: September 29, 2021
This is version 195 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again