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Protein

Semaphorin-3C

Gene

Sema3c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance.3 Publications

GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • neuropilin binding Source: GO_Central
  • semaphorin receptor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3C
Alternative name(s):
Semaphorin-E
Short name:
Sema E
Gene namesi
Name:Sema3c
Synonyms:Semae, SemE
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107557 Sema3c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Perinatal lethality. Mice display severe defects in cardiovascular development, including aortic arch malformations and septation defects in the cardiac outflow tract.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003231221 – 751Semaphorin-3CAdd BLAST731

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 112By similarity
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi130 ↔ 139By similarity
Glycosylationi252N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi266 ↔ 378By similarity
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi290 ↔ 338By similarity
Glycosylationi465N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi514 ↔ 532By similarity
Glycosylationi585N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi586N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi643 ↔ 709By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ62181
PaxDbiQ62181
PeptideAtlasiQ62181
PRIDEiQ62181

PTM databases

iPTMnetiQ62181
PhosphoSitePlusiQ62181

Expressioni

Developmental stagei

Expressed from day 10 in the embryo. Maximum expression between days 10-12 with moderate levels from day 13 until birth.

Gene expression databases

BgeeiENSMUSG00000028780 Expressed in 314 organ(s), highest expression level in lung
ExpressionAtlasiQ62181 baseline and differential
GenevisibleiQ62181 MM

Interactioni

Subunit structurei

Interacts with PLXND1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030568

Structurei

3D structure databases

ProteinModelPortaliQ62181
SMRiQ62181
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 511SemaPROSITE-ProRule annotationAdd BLAST484
Domaini571 – 655Ig-like C2-typeAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi714 – 717Poly-Gln4
Compositional biasi724 – 745Arg/Lys-rich (basic)Add BLAST22

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000039964
HOVERGENiHBG055071
InParanoidiQ62181
KOiK06840
OMAiWPASAIK
OrthoDBiEOG091G01W0
TreeFamiTF352628

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q62181-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFRAICVLV GVFICSICVR GSSQPQARVY LTFDELRETK TSEYFSLSHQ
60 70 80 90 100
QLDYRILLMD EDQDRIYVGS KDHILSLNIN NISQEPLSVF WPASTIKVEE
110 120 130 140 150
CKMAGKDPTH GCGNFVRVIQ TFNRTHLYVC GSGAFSPVCT YLNRGRRSED
160 170 180 190 200
QVFMIDSKCE SGKGRCSFNP NVNTVSVMIN EELFSGMYID FMGTDAAIFR
210 220 230 240 250
SLTKRNAVRT DQHNSKWLSE PMFVDAHVIP DGTDPNDAKV YFFFKERLTD
260 270 280 290 300
NNRSTKQIHS MIARICPNDT GGQRSLVNKW TTFLKARLVC SVTDEDGPET
310 320 330 340 350
HFDELEDVFL LETDNPRTTL VYGIFTTSSS VFKGSAVCVY HLSDIQTVFN
360 370 380 390 400
GPFAHKEGPN HQLISYQGRI PYPRPGTCPG GAFTPNMRTT KDFPDDVVTF
410 420 430 440 450
IRNHPLMYNS IYPIHRRPLI VRIGTDYKYT KIAVDRVNAA DGRYHVLFLG
460 470 480 490 500
TDRGTVQKVV VLPTNSSASG ELILEELEVF KNHVPITTMK ISSKKQQLYV
510 520 530 540 550
SSNEGVSQVS LHRCHIYGTA CADCCLARDP YCAWDGHSCS RFYPTGKRRS
560 570 580 590 600
RRQDVRHGNP LTQCRGFNLK AYRNAAEIVQ YGVRNNSTFL ECAPKSPQAS
610 620 630 640 650
IKWLLQKDKD RRKEVKLNER IIATSQGLLI RSVQDSDQGL YHCIATENSF
660 670 680 690 700
KQTIAKINFK VLDSEMVAVV TDKWSPWTWA GSVRALPFHP KDILGAFSHS
710 720 730 740 750
EMQLINQYCK DTRQQQQLGE EPQKMRGDYG KLKALINSRK SRNRRNQLPE

S
Length:751
Mass (Da):85,289
Last modified:July 27, 2011 - v2
Checksum:i32537E9D664123EE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q0Z0E9Q0Z0_MOUSE
Semaphorin-3C
Sema3c
226Annotation score:
E9PXL2E9PXL2_MOUSE
Semaphorin-3C
Sema3c
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti206 – 208NAV → MQL in CAA59986 (PubMed:7748561).Curated3
Sequence conflicti412Y → S in CAA59986 (PubMed:7748561).Curated1
Sequence conflicti490K → E in CAA59986 (PubMed:7748561).Curated1
Sequence conflicti615V → G in CAA59986 (PubMed:7748561).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85994 mRNA Translation: CAA59986.1
CH466586 Genomic DNA Translation: EDL03234.1
BC066852 mRNA Translation: AAH66852.1
CCDSiCCDS19099.1
PIRiI48748
RefSeqiNP_038685.3, NM_013657.5
UniGeneiMm.5071

Genome annotation databases

EnsembliENSMUST00000030568; ENSMUSP00000030568; ENSMUSG00000028780
GeneIDi20348
KEGGimmu:20348
UCSCiuc008wnl.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85994 mRNA Translation: CAA59986.1
CH466586 Genomic DNA Translation: EDL03234.1
BC066852 mRNA Translation: AAH66852.1
CCDSiCCDS19099.1
PIRiI48748
RefSeqiNP_038685.3, NM_013657.5
UniGeneiMm.5071

3D structure databases

ProteinModelPortaliQ62181
SMRiQ62181
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030568

PTM databases

iPTMnetiQ62181
PhosphoSitePlusiQ62181

Proteomic databases

MaxQBiQ62181
PaxDbiQ62181
PeptideAtlasiQ62181
PRIDEiQ62181

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030568; ENSMUSP00000030568; ENSMUSG00000028780
GeneIDi20348
KEGGimmu:20348
UCSCiuc008wnl.1 mouse

Organism-specific databases

CTDi10512
MGIiMGI:107557 Sema3c

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000039964
HOVERGENiHBG055071
InParanoidiQ62181
KOiK06840
OMAiWPASAIK
OrthoDBiEOG091G01W0
TreeFamiTF352628

Miscellaneous databases

PROiPR:Q62181
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028780 Expressed in 314 organ(s), highest expression level in lung
ExpressionAtlasiQ62181 baseline and differential
GenevisibleiQ62181 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEM3C_MOUSE
AccessioniPrimary (citable) accession number: Q62181
Secondary accession number(s): Q6NXW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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