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Protein

Semaphorin-4B

Gene

Sema4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.

GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • neuropilin binding Source: GO_Central
  • semaphorin receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4B
Alternative name(s):
Semaphorin-C
Short name:
Sema C
Gene namesi
Name:Sema4b
Synonyms:Kiaa1745, Semac, SemC
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107559 Sema4b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 703ExtracellularSequence analysisAdd BLAST673
Transmembranei704 – 724HelicalSequence analysisAdd BLAST21
Topological domaini725 – 823CytoplasmicSequence analysisAdd BLAST99

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000004216231 – 823Semaphorin-4BAdd BLAST793

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi107 ↔ 118PROSITE-ProRule annotation
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi136 ↔ 145PROSITE-ProRule annotation
Disulfide bondi273 ↔ 386PROSITE-ProRule annotation
Disulfide bondi297 ↔ 346PROSITE-ProRule annotation
Glycosylationi397N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi512N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi513 ↔ 530PROSITE-ProRule annotation
Glycosylationi567N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi596 ↔ 642PROSITE-ProRule annotation
Glycosylationi615N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi680N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei779PhosphoserineBy similarity1
Modified residuei780PhosphoserineCombined sources1
Modified residuei804PhosphoserineCombined sources1
Modified residuei816PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ62179
MaxQBiQ62179
PaxDbiQ62179
PeptideAtlasiQ62179
PRIDEiQ62179

PTM databases

iPTMnetiQ62179
PhosphoSitePlusiQ62179

Expressioni

Developmental stagei

Expressed from day 10 in the embryo. Low levels found between days 10-12. Expression peaks on day 13 with moderate levels from then until birth.

Gene expression databases

BgeeiENSMUSG00000030539 Expressed in 248 organ(s), highest expression level in cumulus cell
GenevisibleiQ62179 MM

Interactioni

Subunit structurei

Interacts with GIPC PDZ domain.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ62179, 2 interactors
MINTiQ62179
STRINGi10090.ENSMUSP00000032754

Structurei

3D structure databases

ProteinModelPortaliQ62179
SMRiQ62179
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 510SemaPROSITE-ProRule annotationAdd BLAST477
Domaini512 – 582PSIAdd BLAST71
Domaini589 – 649Ig-like C2-typeAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi744 – 767Pro-richAdd BLAST24

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000116087
HOVERGENiHBG061165
InParanoidiQ62179
KOiK06521
OMAiCQNYIKI
OrthoDBiEOG091G01W0
PhylomeDBiQ62179
TreeFamiTF352903

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62179-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRASRSAVL RRALLLLLLL LLLRTTTTRA LGPRISVPLG SEERLIRKFE
60 70 80 90 100
AENISNYTAL LLSQDGKTLY VGAREALFAL NSNLSFLPGG EYQELLWSAD
110 120 130 140 150
ADRKQQCSFK GKDPKRDCQN YIKILLPLNS SHLLTCGTAA FSPLCAYIHI
160 170 180 190 200
ASFTLAQDEA GNVILEDGKG RCPFDPNFKS TALVVDGELY TGTVSSFQGN
210 220 230 240 250
DPAISRSQSS RPTKTESSLN WLQDPAFVAS AYVPESLGSP IGDDDKIYFF
260 270 280 290 300
FSETGQEFEF FENTIVSRVA RVCKGDEGGE RVLQQRWTSF LKAQLLCSRP
310 320 330 340 350
DDGFPFNVLQ DVFTLNPNPQ DWRKTLFYGV FTSQWHRGTT EGSAICVFTM
360 370 380 390 400
NDVQKAFDGL YKKVNRETQQ WYTETHQVPT PRPGACITNS ARERKINSSL
410 420 430 440 450
QLPDRVLNFL KDHFLMDGQV RSRLLLLQPR ARYQRVAVHR VPGLHSTYDV
460 470 480 490 500
LFLGTGDGRL HKAVTLSSRV HIIEELQIFP QGQPVQNLLL DSHGGLLYAS
510 520 530 540 550
SHSGVVQVPV ANCSLYPTCG DCLLARDPYC AWTGSACRLA SLYQPDLASR
560 570 580 590 600
PWTQDIEGAS VKELCKNSSY KARFLVPGKP CKQVQIQPNT VNTLACPLLS
610 620 630 640 650
NLATRLWVHN GAPVNASASC RVLPTGDLLL VGSQQGLGVF QCWSIEEGFQ
660 670 680 690 700
QLVASYCPEV MEEGVMDQKN QRDGTPVIIN TSRVSAPAGG RASWGADKSY
710 720 730 740 750
WNEFLVMCTL FVFAMVLLFL FFLYRHRDGM KLFLKQGECA SVHPKTRPIV
760 770 780 790 800
LPPETRPLNG VGPPSTPLDH RGYQALSDSS PGPRVFTESE KRPLSIQDSF
810 820
VEVSPVCPRP RVRLGSEIRD SVV
Length:823
Mass (Da):91,392
Last modified:September 27, 2005 - v2
Checksum:i051589B4DFAE9883
GO

Sequence cautioni

The sequence BAD32527 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171R → H in CAA59984 (PubMed:7748561).Curated1
Sequence conflicti232 – 233YV → TS in CAA59984 (PubMed:7748561).Curated2
Sequence conflicti246K → R in AAY82464 (Ref. 1) Curated1
Sequence conflicti327 – 328FY → SI in CAA59984 (PubMed:7748561).Curated2
Sequence conflicti544Q → K in AAY82464 (Ref. 1) Curated1
Sequence conflicti692A → D in CAA59984 (PubMed:7748561).Curated1
Sequence conflicti722F → L in AAY82464 (Ref. 1) Curated1
Sequence conflicti760G → C in AAY82464 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ073331 mRNA Translation: AAY82464.1
AK173249 mRNA Translation: BAD32527.1 Different initiation.
X85992 mRNA Translation: CAA59984.1
CCDSiCCDS21391.1
PIRiI48746
RefSeqiNP_038687.2, NM_013659.4
XP_011249132.1, XM_011250830.2
UniGeneiMm.275909

Genome annotation databases

EnsembliENSMUST00000032754; ENSMUSP00000032754; ENSMUSG00000030539
ENSMUST00000205822; ENSMUSP00000145622; ENSMUSG00000030539
GeneIDi20352
KEGGimmu:20352
UCSCiuc009hzo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ073331 mRNA Translation: AAY82464.1
AK173249 mRNA Translation: BAD32527.1 Different initiation.
X85992 mRNA Translation: CAA59984.1
CCDSiCCDS21391.1
PIRiI48746
RefSeqiNP_038687.2, NM_013659.4
XP_011249132.1, XM_011250830.2
UniGeneiMm.275909

3D structure databases

ProteinModelPortaliQ62179
SMRiQ62179
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62179, 2 interactors
MINTiQ62179
STRINGi10090.ENSMUSP00000032754

PTM databases

iPTMnetiQ62179
PhosphoSitePlusiQ62179

Proteomic databases

EPDiQ62179
MaxQBiQ62179
PaxDbiQ62179
PeptideAtlasiQ62179
PRIDEiQ62179

Protocols and materials databases

DNASUi20352
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032754; ENSMUSP00000032754; ENSMUSG00000030539
ENSMUST00000205822; ENSMUSP00000145622; ENSMUSG00000030539
GeneIDi20352
KEGGimmu:20352
UCSCiuc009hzo.1 mouse

Organism-specific databases

CTDi10509
MGIiMGI:107559 Sema4b
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000116087
HOVERGENiHBG061165
InParanoidiQ62179
KOiK06521
OMAiCQNYIKI
OrthoDBiEOG091G01W0
PhylomeDBiQ62179
TreeFamiTF352903

Miscellaneous databases

PROiPR:Q62179
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030539 Expressed in 248 organ(s), highest expression level in cumulus cell
GenevisibleiQ62179 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEM4B_MOUSE
AccessioniPrimary (citable) accession number: Q62179
Secondary accession number(s): Q4PKI6, Q69ZB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 27, 2005
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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