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Protein

Semaphorin-3B

Gene

Sema3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.

GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • neuropilin binding Source: GO_Central
  • semaphorin receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3B
Alternative name(s):
Semaphorin-A
Short name:
Sema A
Gene namesi
Name:Sema3b
Synonyms:Sema, Semaa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107561 Sema3b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003231026 – 748Semaphorin-3BAdd BLAST723

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi102 ↔ 113By similarity
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi131 ↔ 140By similarity
Disulfide bondi268 ↔ 379By similarity
Disulfide bondi292 ↔ 339By similarity
Disulfide bondi515 ↔ 533By similarity
Disulfide bondi643 ↔ 709By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ62177
PaxDbiQ62177
PeptideAtlasiQ62177
PRIDEiQ62177

PTM databases

iPTMnetiQ62177
PhosphoSitePlusiQ62177

Expressioni

Developmental stagei

Expressed from day 10 in the embryo. Low levels found between days 10-12. Expression peaks on day 13 with moderate levels from then until birth.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073152

Structurei

3D structure databases

ProteinModelPortaliQ62177
SMRiQ62177
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 512SemaPROSITE-ProRule annotationAdd BLAST483
Domaini561 – 659Ig-like C2-typeAdd BLAST99

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi698 – 702Poly-Gly5
Compositional biasi723 – 743Arg-rich (basic)Add BLAST21

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
HOGENOMiHOG000039964
HOVERGENiHBG055071
InParanoidiQ62177

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q62177-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRAEAAAMI PGLALLWVAG LGDTAPNLPR LRLSFQELQA RHGVRTFRLE
60 70 80 90 100
RTCCYEALLV DEERGRLFVG AENHVASLSL DNISKRAKKL AWPAPVEWRE
110 120 130 140 150
ECNWAGKDIG TECMNFVKLL HTYNHTHLLA CGTGAFHPTC ALWRWATAGG
160 170 180 190 200
THASTGPEKL EDGKGKTPYD PRHRAASVLV GEELYSGVTA DLMGRDFTIF
210 220 230 240 250
RSLGQNPSLR TEPHDSRWLN EPKFVKVFWI PESENPDDDK IYFFFRESAV
260 270 280 290 300
EAAPAMGRMS VSRVGQICRN DLGGQRSLVN KWTTFLKARL VCSVPGVEGD
310 320 330 340 350
THFDQLQDVF LLSSRDRQTP LLYAVFSTSS GVFQGSAVCV YSMNDVRRAF
360 370 380 390 400
LGPFAHKEGP THQWVSYQGR VPYPRPGMCP SKTFGTFSST KDFPDDVIQF
410 420 430 440 450
ARNHPLMYNP VLPMGGRPLF LQVGAGYTFT QIAADRVAAA DGHYDVLFIG
460 470 480 490 500
TDVGTVLKVI SVPKGSRPNS EGLLLEELQV FEDSAAITSM QISSKRQQLY
510 520 530 540 550
IASRSAVAQI ALHRCTALGR ACAECCLARD PYCAWDGSAC TRFQPTAKRR
560 570 580 590 600
FRRQDIRNGD PSTLCSGDSS HSVLLEKKVL GVESGSAFLE CEPRSLQAHV
610 620 630 640 650
QWTFQGAGEA AHTQVLAEER VERTARGLLL RGLRRQDSGV YLCVAVEQGF
660 670 680 690 700
SQPLRRLVLH VLSAAQAERL ARAEEAAAPA PPGPKLWYRD FLQLVEPGGG
710 720 730 740
GGANSLRMCR PQPGHHSVAA DSRRKGRNRR MHVSELRAER GPRSAAHW
Length:748
Mass (Da):82,700
Last modified:July 27, 2011 - v2
Checksum:iE0B4D127F2E75C9E
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9MMK0M9MMK0_MOUSE
Semaphorin-3B
Sema3b
749Annotation score:
M0QWQ7M0QWQ7_MOUSE
Semaphorin-3B
Sema3b
534Annotation score:
A0A0A6YW56A0A0A6YW56_MOUSE
Semaphorin-3B
Sema3b
172Annotation score:
A0A0A6YWW1A0A0A6YWW1_MOUSE
Semaphorin-3B
Sema3b
147Annotation score:
A0A0A6YWM9A0A0A6YWM9_MOUSE
Semaphorin-3B
Sema3b
137Annotation score:
A0A0A6YXC1A0A0A6YXC1_MOUSE
Semaphorin-3B
Sema3b
48Annotation score:
A0A0G2JDD7A0A0G2JDD7_MOUSE
Semaphorin-3B
Sema3b
10Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8A → V in CAA59982 (PubMed:7748561).Curated1
Sequence conflicti118K → R in CAA59982 (PubMed:7748561).Curated1
Sequence conflicti122T → A in CAA59982 (PubMed:7748561).Curated1
Sequence conflicti132G → R in CAA59982 (PubMed:7748561).Curated1
Sequence conflicti175 – 176AA → PP in CAA59982 (PubMed:7748561).Curated2
Sequence conflicti354 – 355FA → LP in CAA59982 (PubMed:7748561).Curated2
Sequence conflicti401A → G in CAA59982 (PubMed:7748561).Curated1
Sequence conflicti466S → R in CAA59982 (PubMed:7748561).Curated1
Sequence conflicti501I → V in CAA59982 (PubMed:7748561).Curated1
Sequence conflicti505S → A in CAA59982 (PubMed:7748561).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85990 mRNA Translation: CAA59982.1
AL672219 Genomic DNA No translation available.
PIRiI48744
UniGeneiMm.4083

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85990 mRNA Translation: CAA59982.1
AL672219 Genomic DNA No translation available.
PIRiI48744
UniGeneiMm.4083

3D structure databases

ProteinModelPortaliQ62177
SMRiQ62177
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073152

PTM databases

iPTMnetiQ62177
PhosphoSitePlusiQ62177

Proteomic databases

MaxQBiQ62177
PaxDbiQ62177
PeptideAtlasiQ62177
PRIDEiQ62177

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:107561 Sema3b

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
HOGENOMiHOG000039964
HOVERGENiHBG055071
InParanoidiQ62177

Miscellaneous databases

ChiTaRSiSema3b mouse
PROiPR:Q62177
SOURCEiSearch...

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEM3B_MOUSE
AccessioniPrimary (citable) accession number: Q62177
Secondary accession number(s): E9Q9Q1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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