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Protein

Rho GDP-dissociation inhibitor 3

Gene

Arhgdig

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.

GO - Molecular functioni

  • GDP-dissociation inhibitor activity Source: MGI
  • GTPase activator activity Source: UniProtKB-KW
  • GTPase regulator activity Source: MGI
  • Rac GTPase binding Source: GO_Central
  • Rho GDP-dissociation inhibitor activity Source: GO_Central

GO - Biological processi

  • blastocyst hatching Source: MGI
  • regulation of protein localization Source: MGI
  • Rho protein signal transduction Source: GO_Central

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GDP-dissociation inhibitor 3
Short name:
Rho GDI 3
Alternative name(s):
Rho-GDI gamma
Rho-GDI2
Gene namesi
Name:Arhgdig
Synonyms:Gdi5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:108430 Arhgdig

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190191 – 225Rho GDP-dissociation inhibitor 3Add BLAST225

Proteomic databases

PaxDbiQ62160
PRIDEiQ62160

PTM databases

iPTMnetiQ62160
PhosphoSitePlusiQ62160

Expressioni

Tissue specificityi

Detected only in brain, lung, kidney and testis.

Gene expression databases

BgeeiENSMUSG00000073433 Expressed in 236 organ(s), highest expression level in pancreas
CleanExiMM_ARHGDIG
ExpressionAtlasiQ62160 baseline and differential
GenevisibleiQ62160 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025019

Structurei

3D structure databases

ProteinModelPortaliQ62160
SMRiQ62160
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rho GDI family.Curated

Phylogenomic databases

eggNOGiKOG3205 Eukaryota
ENOG4111K44 LUCA
GeneTreeiENSGT00390000006233
HOGENOMiHOG000175765
HOVERGENiHBG000206
InParanoidiQ62160
KOiK12462
OMAiSYPPKKE
OrthoDBiEOG091G0MBU
PhylomeDBiQ62160
TreeFamiTF105387

Family and domain databases

Gene3Di2.70.50.30, 1 hit
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR000406 Rho_GDI
IPR024792 RhoGDI_dom_sf
PANTHERiPTHR10980 PTHR10980, 1 hit
PfamiView protein in Pfam
PF02115 Rho_GDI, 1 hit
PRINTSiPR00492 RHOGDI
SUPFAMiSSF81296 SSF81296, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q62160-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGLDACELG EQLLELLRLA LCARVLLADK DGESTPSDEV LDEIVPEYQA
60 70 80 90 100
PGKKSMLAIW QLDPGDVSLV KYKQALLGPL PPIMDPSLPN VQVTRLTLLT
110 120 130 140 150
EQAPGPIIMD LTGDLDALKN QVFVLKEGIE YKVKITFKVN KEIVSGLKCL
160 170 180 190 200
HHTYRRGLRV DKAIFMVGSY GPRAQEYEFV TSVEEAPRGA LARGLYVVRS
210 220
LFTDDDRLNH LSWEWHLHVC QDWKD
Length:225
Mass (Da):25,296
Last modified:November 1, 1997 - v1
Checksum:iBBCA9B71AC9AAED8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z6W0D3Z6W0_MOUSE
Rho GDP-dissociation inhibitor 3
Arhgdig
197Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42463 mRNA Translation: AAC37704.1
U73198 mRNA Translation: AAB18196.1
BC002032 mRNA Translation: AAH02032.1
CCDSiCCDS28548.1
RefSeqiNP_032139.1, NM_008113.3
UniGeneiMm.1383

Genome annotation databases

EnsembliENSMUST00000025019; ENSMUSP00000025019; ENSMUSG00000073433
ENSMUST00000176961; ENSMUSP00000135717; ENSMUSG00000073433
GeneIDi14570
KEGGimmu:14570
UCSCiuc008bdp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42463 mRNA Translation: AAC37704.1
U73198 mRNA Translation: AAB18196.1
BC002032 mRNA Translation: AAH02032.1
CCDSiCCDS28548.1
RefSeqiNP_032139.1, NM_008113.3
UniGeneiMm.1383

3D structure databases

ProteinModelPortaliQ62160
SMRiQ62160
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025019

PTM databases

iPTMnetiQ62160
PhosphoSitePlusiQ62160

Proteomic databases

PaxDbiQ62160
PRIDEiQ62160

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025019; ENSMUSP00000025019; ENSMUSG00000073433
ENSMUST00000176961; ENSMUSP00000135717; ENSMUSG00000073433
GeneIDi14570
KEGGimmu:14570
UCSCiuc008bdp.1 mouse

Organism-specific databases

CTDi398
MGIiMGI:108430 Arhgdig

Phylogenomic databases

eggNOGiKOG3205 Eukaryota
ENOG4111K44 LUCA
GeneTreeiENSGT00390000006233
HOGENOMiHOG000175765
HOVERGENiHBG000206
InParanoidiQ62160
KOiK12462
OMAiSYPPKKE
OrthoDBiEOG091G0MBU
PhylomeDBiQ62160
TreeFamiTF105387

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Miscellaneous databases

PROiPR:Q62160
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073433 Expressed in 236 organ(s), highest expression level in pancreas
CleanExiMM_ARHGDIG
ExpressionAtlasiQ62160 baseline and differential
GenevisibleiQ62160 MM

Family and domain databases

Gene3Di2.70.50.30, 1 hit
InterProiView protein in InterPro
IPR014756 Ig_E-set
IPR000406 Rho_GDI
IPR024792 RhoGDI_dom_sf
PANTHERiPTHR10980 PTHR10980, 1 hit
PfamiView protein in Pfam
PF02115 Rho_GDI, 1 hit
PRINTSiPR00492 RHOGDI
SUPFAMiSSF81296 SSF81296, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGDIR3_MOUSE
AccessioniPrimary (citable) accession number: Q62160
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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