UniProtKB - Q62159 (RHOC_MOUSE)
Protein
Rho-related GTP-binding protein RhoC
Gene
Rhoc
Organism
Mus musculus (Mouse)
Status
Functioni
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 12 – 19 | GTPBy similarity | 8 | |
Nucleotide bindingi | 59 – 63 | GTPBy similarity | 5 | |
Nucleotide bindingi | 117 – 120 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: GO_Central
- protein kinase binding Source: GO_Central
GO - Biological processi
- actin cytoskeleton organization Source: GO_Central
- actin filament organization Source: GO_Central
- apical junction assembly Source: UniProtKB
- cell migration Source: GO_Central
- cortical cytoskeleton organization Source: GO_Central
- establishment or maintenance of cell polarity Source: GO_Central
- mitotic cytokinesis Source: UniProtKB
- positive regulation of cell migration Source: MGI
- positive regulation of lipase activity Source: MGI
- positive regulation of protein-containing complex assembly Source: UniProtKB
- positive regulation of stress fiber assembly Source: MGI
- regulation of actin cytoskeleton organization Source: GO_Central
- regulation of cell shape Source: GO_Central
- skeletal muscle satellite cell migration Source: AgBase
- small GTPase mediated signal transduction Source: InterPro
- wound healing, spreading of cells Source: AgBase
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-194840, Rho GTPase cycle R-MMU-416482, G alpha (12/13) signalling events R-MMU-416572, Sema4D induced cell migration and growth-cone collapse R-MMU-5625740, RHO GTPases activate PKNs R-MMU-5625900, RHO GTPases activate CIT R-MMU-5627117, RHO GTPases Activate ROCKs R-MMU-5663220, RHO GTPases Activate Formins |
Names & Taxonomyi
Protein namesi | Recommended name: Rho-related GTP-binding protein RhoCAlternative name(s): Silica-induced gene 61 protein Short name: SIG-61 |
Gene namesi | Name:Rhoc Synonyms:Arhc |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:106028, Rhoc |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Other locations
- Cleavage furrow By similarity
Note: Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.By similarity
Cytoskeleton
- cytoskeleton Source: GO_Central
Cytosol
- cytosol Source: MGI
Nucleus
- nucleus Source: MGI
Plasma Membrane
- cleavage furrow Source: UniProtKB
- plasma membrane Source: MGI
Other locations
- cell cortex Source: GO_Central
- cell projection Source: GO_Central
- cytoplasm Source: GO_Central
- cytoplasmic vesicle Source: GO_Central
- intracellular membrane-bounded organelle Source: GO_Central
- membrane Source: MGI
- neuron projection Source: GO_Central
- stereocilium Source: UniProtKB
- vesicle Source: GO_Central
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000042024 | 1 – 190 | Rho-related GTP-binding protein RhoCAdd BLAST | 190 | |
PropeptideiPRO_0000042025 | 191 – 193 | Removed in mature formBy similarity | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 190 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 190 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Methylation, PrenylationProteomic databases
EPDi | Q62159 |
jPOSTi | Q62159 |
MaxQBi | Q62159 |
PaxDbi | Q62159 |
PeptideAtlasi | Q62159 |
PRIDEi | Q62159 |
TopDownProteomicsi | Q62159 |
PTM databases
iPTMneti | Q62159 |
PhosphoSitePlusi | Q62159 |
SwissPalmi | Q62159 |
Expressioni
Inductioni
Up-regulated in silica-treated macrophages.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000002233, Expressed in decidua and 297 other tissues |
Genevisiblei | Q62159, MM |
Interactioni
Subunit structurei
GO - Molecular functioni
- protein kinase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 198197, 2 interactors |
IntActi | Q62159, 4 interactors |
MINTi | Q62159 |
STRINGi | 10090.ENSMUSP00000002303 |
Miscellaneous databases
RNActi | Q62159, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 34 – 42 | Effector regionSequence analysis | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0393, Eukaryota |
GeneTreei | ENSGT00950000182945 |
InParanoidi | Q62159 |
OMAi | APEVNHY |
OrthoDBi | 1166960at2759 |
PhylomeDBi | Q62159 |
TreeFami | TF300837 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR003578, Small_GTPase_Rho |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51420, RHO, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q62159-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG
60 70 80 90 100
KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT
110 120 130 140 150
PEVKHFCPNV PIILVGNKKD LRQDEHTRRE LAKMKQEPVR SEEGRDMANR
160 170 180 190
ISAFGYLECS AKTKEGVREV FEMATRAGLQ VRKNKRRRGC PIL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BL56 | H3BL56_MOUSE | Rho-related GTP-binding protein Rho... | Rhoc | 149 | Annotation score: | ||
A0A0G2JEP8 | A0A0G2JEP8_MOUSE | Rho-related GTP-binding protein Rho... | Rhoc | 118 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 102 | E → Q in CAA56682 (PubMed:7868905).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80638 mRNA Translation: CAA56682.1 AK011599 mRNA Translation: BAB27724.1 AK152802 mRNA Translation: BAE31507.1 AK160650 mRNA Translation: BAE35941.1 BC004627 mRNA Translation: AAH04627.1 |
CCDSi | CCDS17704.1 |
RefSeqi | NP_001278788.1, NM_001291859.1 NP_031510.2, NM_007484.2 |
Genome annotation databases
Ensembli | ENSMUST00000002303; ENSMUSP00000002303; ENSMUSG00000002233 ENSMUST00000106787; ENSMUSP00000102399; ENSMUSG00000002233 ENSMUST00000196817; ENSMUSP00000142697; ENSMUSG00000002233 |
GeneIDi | 11853 |
KEGGi | mmu:11853 |
UCSCi | uc008qul.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80638 mRNA Translation: CAA56682.1 AK011599 mRNA Translation: BAB27724.1 AK152802 mRNA Translation: BAE31507.1 AK160650 mRNA Translation: BAE35941.1 BC004627 mRNA Translation: AAH04627.1 |
CCDSi | CCDS17704.1 |
RefSeqi | NP_001278788.1, NM_001291859.1 NP_031510.2, NM_007484.2 |
3D structure databases
SMRi | Q62159 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198197, 2 interactors |
IntActi | Q62159, 4 interactors |
MINTi | Q62159 |
STRINGi | 10090.ENSMUSP00000002303 |
PTM databases
iPTMneti | Q62159 |
PhosphoSitePlusi | Q62159 |
SwissPalmi | Q62159 |
Proteomic databases
EPDi | Q62159 |
jPOSTi | Q62159 |
MaxQBi | Q62159 |
PaxDbi | Q62159 |
PeptideAtlasi | Q62159 |
PRIDEi | Q62159 |
TopDownProteomicsi | Q62159 |
Genome annotation databases
Ensembli | ENSMUST00000002303; ENSMUSP00000002303; ENSMUSG00000002233 ENSMUST00000106787; ENSMUSP00000102399; ENSMUSG00000002233 ENSMUST00000196817; ENSMUSP00000142697; ENSMUSG00000002233 |
GeneIDi | 11853 |
KEGGi | mmu:11853 |
UCSCi | uc008qul.2, mouse |
Organism-specific databases
CTDi | 389 |
MGIi | MGI:106028, Rhoc |
Phylogenomic databases
eggNOGi | KOG0393, Eukaryota |
GeneTreei | ENSGT00950000182945 |
InParanoidi | Q62159 |
OMAi | APEVNHY |
OrthoDBi | 1166960at2759 |
PhylomeDBi | Q62159 |
TreeFami | TF300837 |
Enzyme and pathway databases
Reactomei | R-MMU-194840, Rho GTPase cycle R-MMU-416482, G alpha (12/13) signalling events R-MMU-416572, Sema4D induced cell migration and growth-cone collapse R-MMU-5625740, RHO GTPases activate PKNs R-MMU-5625900, RHO GTPases activate CIT R-MMU-5627117, RHO GTPases Activate ROCKs R-MMU-5663220, RHO GTPases Activate Formins |
Miscellaneous databases
BioGRID-ORCSi | 11853, 2 hits in 17 CRISPR screens |
PROi | PR:Q62159 |
RNActi | Q62159, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000002233, Expressed in decidua and 297 other tissues |
Genevisiblei | Q62159, MM |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR003578, Small_GTPase_Rho |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51420, RHO, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RHOC_MOUSE | |
Accessioni | Q62159Primary (citable) accession number: Q62159 Secondary accession number(s): Q3TUN0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | April 13, 2004 | |
Last modified: | December 2, 2020 | |
This is version 188 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families