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UniProtKB - Q62151 (RAGE_MOUSE)

Entry version 163 (07 Apr 2021)
Sequence version 2 (17 Feb 2016)
Previous versions | rss
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Protein

Advanced glycosylation end product-specific receptor

Gene

Ager

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Can also bind oligonucleotides. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. RAGE-dependent signaling in microglia contributes to neuroinflammation, amyloid accumulation, and impaired learning/memory in a mouse model of Alzheimer disease.4 Publications
Is able to advanced glycosylation end product (AGE)-induce nuclear factor NF-kappa-B activation.1 Publication
Down-regulates receptor for advanced glycosylation end products (RAGE)-ligand induced signaling through various MAPK pathways including ERK1/2, p38 and SAPK/JNK. Significantly affects tumor cell properties through decreasing cell migration, invasion, adhesion and proliferation, and increasing cellular apoptosis. Exhibits drastic inhibition on tumorigenesis in vitro.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processInflammatory response

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-MMU-879415, Advanced glycosylation endproduct receptor signaling
R-MMU-933542, TRAF6 mediated NF-kB activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Advanced glycosylation end product-specific receptor
Alternative name(s):
Receptor for advanced glycosylation end products
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ager
Synonyms:Rage
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:893592, Ager

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 340ExtracellularSequence analysisAdd BLAST318
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Topological domaini362 – 402CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2189161

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001492423 – 402Advanced glycosylation end product-specific receptorAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi38 ↔ 98PROSITE-ProRule annotation
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi143 ↔ 206PROSITE-ProRule annotation
Disulfide bondi257InterchainPROSITE-ProRule annotation
Disulfide bondi299InterchainPROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei376PhosphoserineCombined sources1
Modified residuei389PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q62151

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q62151

PRoteomics IDEntifications database

More...PRIDEi		Q62151

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		255077 [Q62151-1]
255078 [Q62151-2]
255079 [Q62151-3]
255080 [Q62151-4]
255081 [Q62151-5]
255082 [Q62151-6]
255083 [Q62151-7]
255084 [Q62151-8]
255085 [Q62151-9]
255086 [Q62151-10]
255087 [Q62151-11]
255088 [Q62151-12]
255089 [Q62151-13]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q62151, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q62151

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q62151

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1: Expressed at higher levels in the coronary arterioles in type 2 diabetic mice (at protein level). Endothelial cells (PubMed:18539754). Expressed in lung, kidney, brain and heart. Most prevalent isoform with the highest level in heart (PubMed:19164451). Isoform 2: Expressed in brain, lung, kidney and small intestine with the highest level in lung. Expressed in brain, lung, kidney and small intestine with the highest level in small intestine (at protein level). Detected in neurons of the cerebrum, bronchial epithelium, endothelial cells, tubular cells of kidney and epithelial cells of small intestine (at protein level). Expression is increased in the kidney of diabetic wild-type mice (at protein level), but not in the other tissues (PubMed:16503878). Expressed only in kidney. Expression is increased in the kidney of diabetic mice (PubMed:19164451). Isoform 3: Expressed in lung, kidney and heart. The second most prevalent isoform with the highest level in lung. Not expressed in brain (PubMed:19164451). Isoform 4: Expressed at very low level in lung only (PubMed:19164451). Isoform 5: Expressed at very low level in lung only (PubMed:19164451). Isoform 6: Expressed at very low level in lung only (PubMed:19164451). Isoform 7: Expressed at very low level in heart only (PubMed:19164451). Isoform 8: Expressed at very low level in lung only (PubMed:19164451). Isoform 9: Expressed at very low level in heart only (PubMed:19164451). Isoform 10: Expressed in lung, brain, heart and kidney with a very high level in kidney (PubMed:24260107). Isoform 11: Expressed in brain, kidney and heart. Not expressed in lung (PubMed:19164451). Isoform 12: Expressed at very low level in lung and kidney (PubMed:19164451). Isoform 13: Expressed at very low level in lung only (PubMed:19164451).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000015452, Expressed in lung and 195 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with S100B, S100A1 and S100A14. Constitutive homodimer; disulfide-linked (By similarity).

Interacts with S100A12 and APP.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q62151, 8 interactors

Molecular INTeraction database

More...MINTi		Q62151

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000015596

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q62151, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q62151

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 109Ig-like V-typeAdd BLAST87
Domaini123 – 219Ig-like C2-type 1Add BLAST97
Domaini233 – 315Ig-like C2-type 2Add BLAST83

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SQ8N, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00890000139566

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q62151

Identification of Orthologs from Complete Genome Data

More...OMAi		HWIKDGM

Database of Orthologous Groups

More...OrthoDBi		807961at2759

TreeFam database of animal gene trees

More...TreeFami		TF337155

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013162, CD80_C2-set
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013151, Immunoglobulin

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08205, C2-set_2, 1 hit
PF00047, ig, 1 hit
PF13895, Ig_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 2 hits
SM00408, IGc2, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 3 hits
PS00290, IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (13)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 13 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q62151-1) [UniParc]FASTAAdd to basket
Also known as: mRAGE1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPAGTAARAW VLVLALWGAV AGGQNITARI GEPLVLSCKG APKKPPQQLE 
        60         70         80         90        100
WKLNTGRTEA WKVLSPQGGP WDSVARILPN GSLLLPATGI VDEGTFRCRA 
       110        120        130        140        150
TNRRGKEVKS NYRVRVYQIP GKPEIVDPAS ELTASVPNKV GTCVSEGSYP 
       160        170        180        190        200
AGTLSWHLDG KLLIPDGKET LVKEETRRHP ETGLFTLRSE LTVIPTQGGT 
       210        220        230        240        250
HPTFSCSFSL GLPRRRPLNT APIQLRVREP GPPEGIQLLV EPEGGIVAPG 
       260        270        280        290        300
GTVTLTCAIS AQPPPQVHWI KDGAPLPLAP SPVLLLPEVG HEDEGTYSCV 
       310        320        330        340        350
ATHPSHGPQE SPPVSIRVTE TGDEGPAEGS VGESGLGTLA LALGILGGLG 
       360        370        380        390        400
VVALLVGAIL WRKRQPRREE RKAPESQEDE EERAELNQSE EAEMPENGAG 

GP
Length:402
Mass (Da):42,654
Last modified:February 17, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDBFDC50A6C8CB902
GO
Isoform 2 (identifier: Q62151-2) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v11 Publication, mRAGE_v31 Publication, endogenous secretory receptor for AGE (esRAGE)1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     330-333: SVGE → EGLD
     334-402: Missing.

Show »
Length:333
Mass (Da):35,362
Checksum:i7AC9E992F2DDF3F3
GO
Isoform 3 (identifier: Q62151-3) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v41 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     320-328: Missing.

Show »
Length:393
Mass (Da):41,768
Checksum:iDB2B868448D060AA
GO
Isoform 4 (identifier: Q62151-4) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v151 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     54-62: Missing.
     320-328: Missing.

Show »
Length:384
Mass (Da):40,724
Checksum:iAB3C4E0FB1DF2B78
GO
Isoform 5 (identifier: Q62151-5) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v141 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     188-382: Missing.

Show »
Length:207
Mass (Da):22,225
Checksum:iE404D4E72999C51F
GO
Isoform 6 (identifier: Q62151-6) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v101 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     153-153: T → G
     154-402: Missing.

Show »
Length:153
Mass (Da):16,201
Checksum:i565D39235B4282B3
GO
Isoform 7 (identifier: Q62151-7) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v71 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     118-138: QIPGKPEIVDPASELTASVPN → RKGPRLSHFAFIKKPSCTPNP
     139-402: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.1 Publication
Show »
Length:138
Mass (Da):15,027
Checksum:i007981C1151AA802
GO
Isoform 8 (identifier: Q62151-8) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v111 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     119-137: IPGKPEIVDPASELTASVP → KPAMRGQLKALWVSLGWVR
     138-402: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.1 Publication
Show »
Length:137
Mass (Da):14,970
Checksum:iF137773B18869E4E
GO
Isoform 9 (identifier: Q62151-9) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v91 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     27-85: TARIGEPLVL...RILPNGSLLL → PALCCSSLRW...ALWVSLGWVR
     86-402: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.1 Publication
Show »
Length:85
Mass (Da):9,010
Checksum:i2F781505A35E6E69
GO
Isoform 10 (identifier: Q62151-10) [UniParc]FASTAAdd to basket
Also known as: RAGE deletion of intracellular domain1 Publication, RAGEdeltaICD1 Publication, mRAGE_v201 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     372-384: KAPESQEDEEERA → PRKARRMRRNVQS
     385-402: Missing.

Show »
Length:384
Mass (Da):40,950
Checksum:iEBC66DBB542FEE24
GO
Isoform 11 (identifier: Q62151-11) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v21 Publication, mRAGE_v51 Publication, mRAGE_v61 Publication, mRAGE_v81 Publication, mRAGE_v161 Publication, mRAGE_v171 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     19-77: AVAGGQNITA...GGPWDSVARI → ETLPAPTLPL...PHLSPSTLPQ
     78-402: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.1 Publication
Show »
Length:77
Mass (Da):8,113
Checksum:iD56C8B05BECF7981
GO
Isoform 12 (identifier: Q62151-12) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v131 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     30-40: IGEPLVLSCKG → KARRMRRNVQS
     41-402: Missing.

Show »
Length:40
Mass (Da):4,306
Checksum:i9669BDD4B4668380
GO
Isoform 13 (identifier: Q62151-13) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v121 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     31-402: Missing.

Show »
Length:30
Mass (Da):3,036
Checksum:i97EE921F1AAD78B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28 – 30ARI → TQA in ACK28146 (PubMed:19164451).Curated3
Sequence conflicti76R → Q in AAA40040 (PubMed:9224812).Curated1
Sequence conflicti76R → Q in BAE72665 (PubMed:16503878).Curated1
Sequence conflicti199G → GT in AAA40040 (PubMed:9224812).Curated1
Sequence conflicti199G → GT in BAE72665 (PubMed:16503878).Curated1
Sequence conflicti292E → A in AAA40040 (PubMed:9224812).Curated1
Sequence conflicti292E → A in BAE72665 (PubMed:16503878).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05807519 – 77AVAGG…SVARI → ETLPAPTLPLSSPAPTPPPV PPCPLEIPLNLGTTFQRPSP TLSYTRTPQPHLSPSTLPQ in isoform 11. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_05807627 – 85TARIG…GSLLL → PALCCSSLRWGTRMRAPIAA WPPTLATDLRKALLSASGSQ KPAMRGQLKALWVSLGWVR in isoform 9. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_05807730 – 40IGEPLVLSCKG → KARRMRRNVQS in isoform 12. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_05807831 – 402Missing in isoform 13. Add BLAST372
Alternative sequenceiVSP_05807941 – 402Missing in isoform 12. 1 PublicationAdd BLAST362
Alternative sequenceiVSP_05808054 – 62Missing in isoform 4. 1 Publication9
Alternative sequenceiVSP_05808178 – 402Missing in isoform 11. 1 PublicationAdd BLAST325
Alternative sequenceiVSP_05808286 – 402Missing in isoform 9. 1 PublicationAdd BLAST317
Alternative sequenceiVSP_058083118 – 138QIPGK…ASVPN → RKGPRLSHFAFIKKPSCTPN P in isoform 7. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_058084119 – 137IPGKP…TASVP → KPAMRGQLKALWVSLGWVR in isoform 8. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_058085138 – 402Missing in isoform 8. 1 PublicationAdd BLAST265
Alternative sequenceiVSP_058086139 – 402Missing in isoform 7. 1 PublicationAdd BLAST264
Alternative sequenceiVSP_058087153T → G in isoform 6. 1 Publication1
Alternative sequenceiVSP_058088154 – 402Missing in isoform 6. 1 PublicationAdd BLAST249
Alternative sequenceiVSP_058089188 – 382Missing in isoform 5. 1 PublicationAdd BLAST195
Alternative sequenceiVSP_058090320 – 328Missing in isoform 3 and isoform 4. 1 Publication9
Alternative sequenceiVSP_058091330 – 333SVGE → EGLD in isoform 2. 2 Publications4
Alternative sequenceiVSP_058092334 – 402Missing in isoform 2. 2 PublicationsAdd BLAST69
Alternative sequenceiVSP_058093372 – 384KAPES…EEERA → PRKARRMRRNVQS in isoform 10. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_058094385 – 402Missing in isoform 10. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L33412 mRNA Translation: AAA40040.1
AB207883 mRNA Translation: BAE72665.1
EU520325 mRNA Translation: ACD35949.1
EU570240 mRNA Translation: ACE63492.1
EU570241 mRNA Translation: ACE63493.1
EU570242 mRNA Translation: ACE63494.1
EU570243 mRNA Translation: ACE63495.1
EU570244 mRNA Translation: ACE63496.1
EU570245 mRNA Translation: ACE63497.1
EU570246 mRNA Translation: ACE63498.1
EU570247 mRNA Translation: ACE63499.1
EU906857 mRNA Translation: ACK28143.1
EU906858 mRNA Translation: ACK28144.1
EU906859 mRNA Translation: ACK28145.1
EU906860 mRNA Translation: ACK28146.1
EU906861 mRNA Translation: ACK28147.1
EU906862 mRNA Translation: ACK28148.1
EU906863 mRNA Translation: ACK28149.1
EU906864 mRNA Translation: ACK28150.1
EU906865 mRNA Translation: ACK28151.1
KC692918 mRNA Translation: AHB30242.1
AF030001 Genomic DNA Translation: AAB82007.1
CT009767 Genomic DNA No translation available.
CH466666 Genomic DNA Translation: EDL26799.1
CH466666 Genomic DNA Translation: EDL26800.1
BC061182 mRNA Translation: AAH61182.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS28649.1 [Q62151-1]
CCDS70795.1 [Q62151-3]
CCDS70796.1 [Q62151-4]

Protein sequence database of the Protein Information Resource

More...PIRi		T09062

NCBI Reference Sequences

More...RefSeqi		NP_001258351.1, NM_001271422.1 [Q62151-3]
NP_001258352.1, NM_001271423.1 [Q62151-4]
NP_031451.2, NM_007425.3 [Q62151-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000015596; ENSMUSP00000015596; ENSMUSG00000015452 [Q62151-1]
ENSMUST00000173992; ENSMUSP00000134579; ENSMUSG00000015452 [Q62151-4]
ENSMUST00000174069; ENSMUSP00000133391; ENSMUSG00000015452 [Q62151-2]
ENSMUST00000174496; ENSMUSP00000134401; ENSMUSG00000015452 [Q62151-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11596

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:11596

UCSC genome browser

More...UCSCi		uc008ccw.3, mouse
uc008ccx.2, mouse
uc012aqe.2, mouse
uc012aqf.2, mouse
uc012aqg.2, mouse
uc033hcv.1, mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33412 mRNA Translation: AAA40040.1
AB207883 mRNA Translation: BAE72665.1
EU520325 mRNA Translation: ACD35949.1
EU570240 mRNA Translation: ACE63492.1
EU570241 mRNA Translation: ACE63493.1
EU570242 mRNA Translation: ACE63494.1
EU570243 mRNA Translation: ACE63495.1
EU570244 mRNA Translation: ACE63496.1
EU570245 mRNA Translation: ACE63497.1
EU570246 mRNA Translation: ACE63498.1
EU570247 mRNA Translation: ACE63499.1
EU906857 mRNA Translation: ACK28143.1
EU906858 mRNA Translation: ACK28144.1
EU906859 mRNA Translation: ACK28145.1
EU906860 mRNA Translation: ACK28146.1
EU906861 mRNA Translation: ACK28147.1
EU906862 mRNA Translation: ACK28148.1
EU906863 mRNA Translation: ACK28149.1
EU906864 mRNA Translation: ACK28150.1
EU906865 mRNA Translation: ACK28151.1
KC692918 mRNA Translation: AHB30242.1
AF030001 Genomic DNA Translation: AAB82007.1
CT009767 Genomic DNA No translation available.
CH466666 Genomic DNA Translation: EDL26799.1
CH466666 Genomic DNA Translation: EDL26800.1
BC061182 mRNA Translation: AAH61182.1
CCDSiCCDS28649.1 [Q62151-1]
CCDS70795.1 [Q62151-3]
CCDS70796.1 [Q62151-4]
PIRiT09062
RefSeqiNP_001258351.1, NM_001271422.1 [Q62151-3]
NP_001258352.1, NM_001271423.1 [Q62151-4]
NP_031451.2, NM_007425.3 [Q62151-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IM8X-ray3.50A23-230[»]
SMRiQ62151
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ62151, 8 interactors
MINTiQ62151
STRINGi10090.ENSMUSP00000015596

Chemistry databases

ChEMBLiCHEMBL2189161

PTM databases

GlyGeniQ62151, 2 sites
iPTMnetiQ62151
PhosphoSitePlusiQ62151

Proteomic databases

MaxQBiQ62151
PaxDbiQ62151
PRIDEiQ62151
ProteomicsDBi255077 [Q62151-1]
255078 [Q62151-2]
255079 [Q62151-3]
255080 [Q62151-4]
255081 [Q62151-5]
255082 [Q62151-6]
255083 [Q62151-7]
255084 [Q62151-8]
255085 [Q62151-9]
255086 [Q62151-10]
255087 [Q62151-11]
255088 [Q62151-12]
255089 [Q62151-13]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q62151, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28483, 849 antibodies

Genome annotation databases

EnsembliENSMUST00000015596; ENSMUSP00000015596; ENSMUSG00000015452 [Q62151-1]
ENSMUST00000173992; ENSMUSP00000134579; ENSMUSG00000015452 [Q62151-4]
ENSMUST00000174069; ENSMUSP00000133391; ENSMUSG00000015452 [Q62151-2]
ENSMUST00000174496; ENSMUSP00000134401; ENSMUSG00000015452 [Q62151-3]
GeneIDi11596
KEGGimmu:11596
UCSCiuc008ccw.3, mouse
uc008ccx.2, mouse
uc012aqe.2, mouse
uc012aqf.2, mouse
uc012aqg.2, mouse
uc033hcv.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		177
MGIiMGI:893592, Ager

Phylogenomic databases

eggNOGiENOG502SQ8N, Eukaryota
GeneTreeiENSGT00890000139566
InParanoidiQ62151
OMAiHWIKDGM
OrthoDBi807961at2759
TreeFamiTF337155

Enzyme and pathway databases

ReactomeiR-MMU-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-MMU-879415, Advanced glycosylation endproduct receptor signaling
R-MMU-933542, TRAF6 mediated NF-kB activation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11596, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Mok, mouse

Protein Ontology

More...PROi		PR:Q62151
RNActiQ62151, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000015452, Expressed in lung and 195 other tissues

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162, CD80_C2-set
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013151, Immunoglobulin
PfamiView protein in Pfam
PF08205, C2-set_2, 1 hit
PF00047, ig, 1 hit
PF13895, Ig_2, 1 hit
SMARTiView protein in SMART
SM00409, IG, 2 hits
SM00408, IGc2, 2 hits
SUPFAMiSSF48726, SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 3 hits
PS00290, IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAGE_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62151
Secondary accession number(s): C5H3H4
, C5H3H5, C5H3H7, C5H3I0, C5H7W3, C5H7W4, C5H7W5, C5H7W6, C5H7W7, C5H7W8, C5H7W9, O35444, Q2PGG1, V5R4Y0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 17, 2016
Last modified: April 7, 2021
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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