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UniProtKB - Q62151 (RAGE_MOUSE)

Protein

Advanced glycosylation end product-specific receptor

Gene

Ager

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Can also bind oligonucleotides. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. RAGE-dependent signaling in microglia contributes to neuroinflammation, amyloid accumulation, and impaired learning/memory in a mouse model of Alzheimer disease.4 Publications
Isoform 2: Is able to advanced glycosylation end product (AGE)-induce nuclear factor NF-kappa-B activation.1 Publication
Isoform 10: Down-regulates receptor for advanced glycosylation end products (RAGE)-ligand induced signaling through various MAPK pathways including ERK1/2, p38 and SAPK/JNK. Significantly affects tumor cell properties through decreasing cell migration, invasion, adhesion and proliferation, and increasing cellular apoptosis. Exhibits drastic inhibition on tumorigenesis in vitro.1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processInflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-1810476 RIP-mediated NFkB activation via ZBP1
R-MMU-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-MMU-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-MMU-879415 Advanced glycosylation endproduct receptor signaling
R-MMU-933542 TRAF6 mediated NF-kB activation

Names & Taxonomyi

Protein namesi
Recommended name:
Advanced glycosylation end product-specific receptor
Alternative name(s):
Receptor for advanced glycosylation end products
Gene namesi
Name:Ager
Synonyms:Rage
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:893592 Ager

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 340ExtracellularSequence analysisAdd BLAST318
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Topological domaini362 – 402CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2189161

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001492423 – 402Advanced glycosylation end product-specific receptorAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi38 ↔ 98PROSITE-ProRule annotation
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi143 ↔ 206PROSITE-ProRule annotation
Disulfide bondi257InterchainPROSITE-ProRule annotation
Disulfide bondi299InterchainPROSITE-ProRule annotation
Modified residuei376PhosphoserineCombined sources1
Modified residuei389PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ62151
PaxDbiQ62151
PRIDEiQ62151

PTM databases

iPTMnetiQ62151
PhosphoSitePlusiQ62151

Expressioni

Tissue specificityi

Isoform 1: Expressed at higher levels in the coronary arterioles in type 2 diabetic mice (at protein level). Endothelial cells (PubMed:18539754). Expressed in lung, kidney, brain and heart. Most prevalent isoform with the highest level in heart (PubMed:19164451). Isoform 2: Expressed in brain, lung, kidney and small intestine with the highest level in lung. Expressed in brain, lung, kidney and small intestine with the highest level in small intestine (at protein level). Detected in neurons of the cerebrum, bronchial epithelium, endothelial cells, tubular cells of kidney and epithelial cells of small intestine (at protein level). Expression is increased in the kidney of diabetic wild-type mice (at protein level), but not in the other tissues (PubMed:16503878). Expressed only in kidney. Expression is increased in the kidney of diabetic mice (PubMed:19164451). Isoform 3: Expressed in lung, kidney and heart. The second most prevalent isoform with the highest level in lung. Not expressed in brain (PubMed:19164451). Isoform 4: Expressed at very low level in lung only (PubMed:19164451). Isoform 5: Expressed at very low level in lung only (PubMed:19164451). Isoform 6: Expressed at very low level in lung only (PubMed:19164451). Isoform 7: Expressed at very low level in heart only (PubMed:19164451). Isoform 8: Expressed at very low level in lung only (PubMed:19164451). Isoform 9: Expressed at very low level in heart only (PubMed:19164451). Isoform 10: Expressed in lung, brain, heart and kidney with a very high level in kidney (PubMed:24260107). Isoform 11: Expressed in brain, kidney and heart. Not expressed in lung (PubMed:19164451). Isoform 12: Expressed at very low level in lung and kidney (PubMed:19164451). Isoform 13: Expressed at very low level in lung only (PubMed:19164451).4 Publications

Gene expression databases

BgeeiENSMUSG00000015452 Expressed in 175 organ(s), highest expression level in lung
CleanExiMM_RAGE

Interactioni

Subunit structurei

Interacts with S100B, S100A1 and S100A14. Constitutive homodimer; disulfide-linked (By similarity). Interacts with S100A12 and APP.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PrkczQ029567EBI-6665091,EBI-642057

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActiQ62151, 8 interactors
MINTiQ62151
STRINGi10090.ENSMUSP00000015596

Structurei

3D structure databases

ProteinModelPortaliQ62151
SMRiQ62151
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 109Ig-like V-typeAdd BLAST87
Domaini123 – 219Ig-like C2-type 1Add BLAST97
Domaini233 – 315Ig-like C2-type 2Add BLAST83

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVT2 Eukaryota
ENOG4111C4I LUCA
GeneTreeiENSGT00890000139566
HOGENOMiHOG000232122
HOVERGENiHBG004350
InParanoidiQ62151
KOiK19722
OMAiPNKVGTC
OrthoDBiEOG091G0BCY
TreeFamiTF337155

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF00047 ig, 1 hit
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 1 hit

Sequences (13)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 13 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q62151-1) [UniParc]FASTAAdd to basket
Also known as: mRAGE1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPAGTAARAW VLVLALWGAV AGGQNITARI GEPLVLSCKG APKKPPQQLE 
        60         70         80         90        100
WKLNTGRTEA WKVLSPQGGP WDSVARILPN GSLLLPATGI VDEGTFRCRA 
       110        120        130        140        150
TNRRGKEVKS NYRVRVYQIP GKPEIVDPAS ELTASVPNKV GTCVSEGSYP 
       160        170        180        190        200
AGTLSWHLDG KLLIPDGKET LVKEETRRHP ETGLFTLRSE LTVIPTQGGT 
       210        220        230        240        250
HPTFSCSFSL GLPRRRPLNT APIQLRVREP GPPEGIQLLV EPEGGIVAPG 
       260        270        280        290        300
GTVTLTCAIS AQPPPQVHWI KDGAPLPLAP SPVLLLPEVG HEDEGTYSCV 
       310        320        330        340        350
ATHPSHGPQE SPPVSIRVTE TGDEGPAEGS VGESGLGTLA LALGILGGLG 
       360        370        380        390        400
VVALLVGAIL WRKRQPRREE RKAPESQEDE EERAELNQSE EAEMPENGAG 

GP
Length:402
Mass (Da):42,654
Last modified:February 17, 2016 - v2
Checksum:iDBFDC50A6C8CB902
GO
Isoform 2 (identifier: Q62151-2) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v11 Publication, mRAGE_v31 Publication, endogenous secretory receptor for AGE (esRAGE)1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     330-333: SVGE → EGLD
     334-402: Missing.

Show »
Length:333
Mass (Da):35,362
Checksum:i7AC9E992F2DDF3F3
GO
Isoform 3 (identifier: Q62151-3) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v41 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     320-328: Missing.

Show »
Length:393
Mass (Da):41,768
Checksum:iDB2B868448D060AA
GO
Isoform 4 (identifier: Q62151-4) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v151 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     54-62: Missing.
     320-328: Missing.

Show »
Length:384
Mass (Da):40,724
Checksum:iAB3C4E0FB1DF2B78
GO
Isoform 5 (identifier: Q62151-5) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v141 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     188-382: Missing.

Show »
Length:207
Mass (Da):22,225
Checksum:iE404D4E72999C51F
GO
Isoform 6 (identifier: Q62151-6) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v101 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     153-153: T → G
     154-402: Missing.

Show »
Length:153
Mass (Da):16,201
Checksum:i565D39235B4282B3
GO
Isoform 7 (identifier: Q62151-7) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v71 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     118-138: QIPGKPEIVDPASELTASVPN → RKGPRLSHFAFIKKPSCTPNP
     139-402: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.1 Publication
Show »
Length:138
Mass (Da):15,027
Checksum:i007981C1151AA802
GO
Isoform 8 (identifier: Q62151-8) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v111 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     119-137: IPGKPEIVDPASELTASVP → KPAMRGQLKALWVSLGWVR
     138-402: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.1 Publication
Show »
Length:137
Mass (Da):14,970
Checksum:iF137773B18869E4E
GO
Isoform 9 (identifier: Q62151-9) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v91 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     27-85: TARIGEPLVL...RILPNGSLLL → PALCCSSLRW...ALWVSLGWVR
     86-402: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.1 Publication
Show »
Length:85
Mass (Da):9,010
Checksum:i2F781505A35E6E69
GO
Isoform 10 (identifier: Q62151-10) [UniParc]FASTAAdd to basket
Also known as: RAGE deletion of intracellular domain1 Publication, RAGEdeltaICD1 Publication, mRAGE_v201 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     372-384: KAPESQEDEEERA → PRKARRMRRNVQS
     385-402: Missing.

Show »
Length:384
Mass (Da):40,950
Checksum:iEBC66DBB542FEE24
GO
Isoform 11 (identifier: Q62151-11) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v21 Publication, mRAGE_v51 Publication, mRAGE_v61 Publication, mRAGE_v81 Publication, mRAGE_v161 Publication, mRAGE_v171 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     19-77: AVAGGQNITA...GGPWDSVARI → ETLPAPTLPL...PHLSPSTLPQ
     78-402: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.1 Publication
Show »
Length:77
Mass (Da):8,113
Checksum:iD56C8B05BECF7981
GO
Isoform 12 (identifier: Q62151-12) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v131 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     30-40: IGEPLVLSCKG → KARRMRRNVQS
     41-402: Missing.

Show »
Length:40
Mass (Da):4,306
Checksum:i9669BDD4B4668380
GO
Isoform 13 (identifier: Q62151-13) [UniParc]FASTAAdd to basket
Also known as: mRAGE_v121 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     31-402: Missing.

Show »
Length:30
Mass (Da):3,036
Checksum:i97EE921F1AAD78B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28 – 30ARI → TQA in ACK28146 (PubMed:19164451).Curated3
Sequence conflicti76R → Q in AAA40040 (PubMed:9224812).Curated1
Sequence conflicti76R → Q in BAE72665 (PubMed:16503878).Curated1
Sequence conflicti199G → GT in AAA40040 (PubMed:9224812).Curated1
Sequence conflicti199G → GT in BAE72665 (PubMed:16503878).Curated1
Sequence conflicti292E → A in AAA40040 (PubMed:9224812).Curated1
Sequence conflicti292E → A in BAE72665 (PubMed:16503878).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05807519 – 77AVAGG…SVARI → ETLPAPTLPLSSPAPTPPPV PPCPLEIPLNLGTTFQRPSP TLSYTRTPQPHLSPSTLPQ in isoform 11. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_05807627 – 85TARIG…GSLLL → PALCCSSLRWGTRMRAPIAA WPPTLATDLRKALLSASGSQ KPAMRGQLKALWVSLGWVR in isoform 9. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_05807730 – 40IGEPLVLSCKG → KARRMRRNVQS in isoform 12. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_05807831 – 402Missing in isoform 13. Add BLAST372
Alternative sequenceiVSP_05807941 – 402Missing in isoform 12. 1 PublicationAdd BLAST362
Alternative sequenceiVSP_05808054 – 62Missing in isoform 4. 1 Publication9
Alternative sequenceiVSP_05808178 – 402Missing in isoform 11. 1 PublicationAdd BLAST325
Alternative sequenceiVSP_05808286 – 402Missing in isoform 9. 1 PublicationAdd BLAST317
Alternative sequenceiVSP_058083118 – 138QIPGK…ASVPN → RKGPRLSHFAFIKKPSCTPN P in isoform 7. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_058084119 – 137IPGKP…TASVP → KPAMRGQLKALWVSLGWVR in isoform 8. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_058085138 – 402Missing in isoform 8. 1 PublicationAdd BLAST265
Alternative sequenceiVSP_058086139 – 402Missing in isoform 7. 1 PublicationAdd BLAST264
Alternative sequenceiVSP_058087153T → G in isoform 6. 1 Publication1
Alternative sequenceiVSP_058088154 – 402Missing in isoform 6. 1 PublicationAdd BLAST249
Alternative sequenceiVSP_058089188 – 382Missing in isoform 5. 1 PublicationAdd BLAST195
Alternative sequenceiVSP_058090320 – 328Missing in isoform 3 and isoform 4. 1 Publication9
Alternative sequenceiVSP_058091330 – 333SVGE → EGLD in isoform 2. 2 Publications4
Alternative sequenceiVSP_058092334 – 402Missing in isoform 2. 2 PublicationsAdd BLAST69
Alternative sequenceiVSP_058093372 – 384KAPES…EEERA → PRKARRMRRNVQS in isoform 10. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_058094385 – 402Missing in isoform 10. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33412 mRNA Translation: AAA40040.1
AB207883 mRNA Translation: BAE72665.1
EU520325 mRNA Translation: ACD35949.1
EU570240 mRNA Translation: ACE63492.1
EU570241 mRNA Translation: ACE63493.1
EU570242 mRNA Translation: ACE63494.1
EU570243 mRNA Translation: ACE63495.1
EU570244 mRNA Translation: ACE63496.1
EU570245 mRNA Translation: ACE63497.1
EU570246 mRNA Translation: ACE63498.1
EU570247 mRNA Translation: ACE63499.1
EU906857 mRNA Translation: ACK28143.1
EU906858 mRNA Translation: ACK28144.1
EU906859 mRNA Translation: ACK28145.1
EU906860 mRNA Translation: ACK28146.1
EU906861 mRNA Translation: ACK28147.1
EU906862 mRNA Translation: ACK28148.1
EU906863 mRNA Translation: ACK28149.1
EU906864 mRNA Translation: ACK28150.1
EU906865 mRNA Translation: ACK28151.1
KC692918 mRNA Translation: AHB30242.1
AF030001 Genomic DNA Translation: AAB82007.1
CT009767 Genomic DNA No translation available.
CH466666 Genomic DNA Translation: EDL26799.1
CH466666 Genomic DNA Translation: EDL26800.1
BC061182 mRNA Translation: AAH61182.1
CCDSiCCDS28649.1 [Q62151-1]
CCDS70795.1 [Q62151-3]
CCDS70796.1 [Q62151-4]
PIRiT09062
RefSeqiNP_001258351.1, NM_001271422.1 [Q62151-3]
NP_001258352.1, NM_001271423.1 [Q62151-4]
NP_031451.2, NM_007425.3 [Q62151-1]
UniGeneiMm.3383

Genome annotation databases

EnsembliENSMUST00000015596; ENSMUSP00000015596; ENSMUSG00000015452 [Q62151-1]
ENSMUST00000173992; ENSMUSP00000134579; ENSMUSG00000015452 [Q62151-4]
ENSMUST00000174069; ENSMUSP00000133391; ENSMUSG00000015452 [Q62151-2]
ENSMUST00000174496; ENSMUSP00000134401; ENSMUSG00000015452 [Q62151-3]
GeneIDi11596
KEGGimmu:11596
UCSCiuc008ccw.3 mouse
uc008ccx.2 mouse
uc012aqe.2 mouse
uc012aqf.2 mouse
uc012aqg.2 mouse
uc033hcv.1 mouse

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33412 mRNA Translation: AAA40040.1
AB207883 mRNA Translation: BAE72665.1
EU520325 mRNA Translation: ACD35949.1
EU570240 mRNA Translation: ACE63492.1
EU570241 mRNA Translation: ACE63493.1
EU570242 mRNA Translation: ACE63494.1
EU570243 mRNA Translation: ACE63495.1
EU570244 mRNA Translation: ACE63496.1
EU570245 mRNA Translation: ACE63497.1
EU570246 mRNA Translation: ACE63498.1
EU570247 mRNA Translation: ACE63499.1
EU906857 mRNA Translation: ACK28143.1
EU906858 mRNA Translation: ACK28144.1
EU906859 mRNA Translation: ACK28145.1
EU906860 mRNA Translation: ACK28146.1
EU906861 mRNA Translation: ACK28147.1
EU906862 mRNA Translation: ACK28148.1
EU906863 mRNA Translation: ACK28149.1
EU906864 mRNA Translation: ACK28150.1
EU906865 mRNA Translation: ACK28151.1
KC692918 mRNA Translation: AHB30242.1
AF030001 Genomic DNA Translation: AAB82007.1
CT009767 Genomic DNA No translation available.
CH466666 Genomic DNA Translation: EDL26799.1
CH466666 Genomic DNA Translation: EDL26800.1
BC061182 mRNA Translation: AAH61182.1
CCDSiCCDS28649.1 [Q62151-1]
CCDS70795.1 [Q62151-3]
CCDS70796.1 [Q62151-4]
PIRiT09062
RefSeqiNP_001258351.1, NM_001271422.1 [Q62151-3]
NP_001258352.1, NM_001271423.1 [Q62151-4]
NP_031451.2, NM_007425.3 [Q62151-1]
UniGeneiMm.3383

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IM8X-ray3.50A23-230[»]
ProteinModelPortaliQ62151
SMRiQ62151
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62151, 8 interactors
MINTiQ62151
STRINGi10090.ENSMUSP00000015596

Chemistry databases

ChEMBLiCHEMBL2189161

PTM databases

iPTMnetiQ62151
PhosphoSitePlusiQ62151

Proteomic databases

MaxQBiQ62151
PaxDbiQ62151
PRIDEiQ62151

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015596; ENSMUSP00000015596; ENSMUSG00000015452 [Q62151-1]
ENSMUST00000173992; ENSMUSP00000134579; ENSMUSG00000015452 [Q62151-4]
ENSMUST00000174069; ENSMUSP00000133391; ENSMUSG00000015452 [Q62151-2]
ENSMUST00000174496; ENSMUSP00000134401; ENSMUSG00000015452 [Q62151-3]
GeneIDi11596
KEGGimmu:11596
UCSCiuc008ccw.3 mouse
uc008ccx.2 mouse
uc012aqe.2 mouse
uc012aqf.2 mouse
uc012aqg.2 mouse
uc033hcv.1 mouse

Organism-specific databases

CTDi177
MGIiMGI:893592 Ager

Phylogenomic databases

eggNOGiENOG410IVT2 Eukaryota
ENOG4111C4I LUCA
GeneTreeiENSGT00890000139566
HOGENOMiHOG000232122
HOVERGENiHBG004350
InParanoidiQ62151
KOiK19722
OMAiPNKVGTC
OrthoDBiEOG091G0BCY
TreeFamiTF337155

Enzyme and pathway databases

ReactomeiR-MMU-1810476 RIP-mediated NFkB activation via ZBP1
R-MMU-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-MMU-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-MMU-879415 Advanced glycosylation endproduct receptor signaling
R-MMU-933542 TRAF6 mediated NF-kB activation

Miscellaneous databases

PROiPR:Q62151
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015452 Expressed in 175 organ(s), highest expression level in lung
CleanExiMM_RAGE

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF00047 ig, 1 hit
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAGE_MOUSE
AccessioniPrimary (citable) accession number: Q62151
Secondary accession number(s): C5H3H4
, C5H3H5, C5H3H7, C5H3I0, C5H7W3, C5H7W4, C5H7W5, C5H7W6, C5H7W7, C5H7W8, C5H7W9, O35444, Q2PGG1, V5R4Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 17, 2016
Last modified: September 12, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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