UniProtKB - Q62151 (RAGE_MOUSE)
Advanced glycosylation end product-specific receptor
Ager
Functioni
GO - Molecular functioni
- advanced glycation end-product binding Source: MGI
- amyloid-beta binding Source: MGI
- high mobility group box 1 binding Source: MGI
- identical protein binding Source: MGI
- protein-containing complex binding Source: MGI
- S100 protein binding Source: UniProtKB
- signaling receptor activity Source: MGI
GO - Biological processi
- astrocyte activation Source: MGI
- astrocyte development Source: MGI
- calcium ion homeostasis Source: MGI
- cellular response to amyloid-beta Source: ARUK-UCL
- glucose mediated signaling pathway Source: MGI
- induction of positive chemotaxis Source: MGI
- inflammatory response Source: MGI
- learning or memory Source: MGI
- microglial cell activation Source: ARUK-UCL
- modulation of age-related behavioral decline Source: MGI
- negative regulation of advanced glycation end-product receptor activity Source: MGI
- negative regulation of blood circulation Source: ARUK-UCL
- negative regulation of cell adhesion Source: MGI
- negative regulation of cell migration Source: MGI
- negative regulation of collagen biosynthetic process Source: MGI
- negative regulation of connective tissue replacement involved in inflammatory response wound healing Source: MGI
- negative regulation of endothelial cell migration Source: MGI
- negative regulation of endothelial cell proliferation Source: MGI
- negative regulation of interleukin-10 production Source: MGI
- negative regulation of long-term synaptic depression Source: MGI
- negative regulation of long-term synaptic potentiation Source: ARUK-UCL
- negative regulation of protein phosphorylation Source: MGI
- negative regulation of signaling Source: MGI
- neuron projection development Source: MGI
- positive regulation of activated T cell proliferation Source: MGI
- positive regulation of advanced glycation end-product receptor activity Source: MGI
- positive regulation of apoptotic process Source: MGI
- positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Source: MGI
- positive regulation of autophagy Source: MGI
- positive regulation of cell migration Source: MGI
- positive regulation of chemokine production Source: ARUK-UCL
- positive regulation of dendritic cell differentiation Source: MGI
- positive regulation of endothelial cell apoptotic process Source: MGI
- positive regulation of endothelin production Source: ARUK-UCL
- positive regulation of epithelial to mesenchymal transition Source: MGI
- positive regulation of ERK1 and ERK2 cascade Source: MGI
- positive regulation of fibroblast migration Source: MGI
- positive regulation of fibroblast proliferation Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of heterotypic cell-cell adhesion Source: MGI
- positive regulation of inflammatory response Source: MGI
- positive regulation of interleukin-12 production Source: MGI
- positive regulation of interleukin-1 beta production Source: ARUK-UCL
- positive regulation of interleukin-6 production Source: ARUK-UCL
- positive regulation of JNK cascade Source: MGI
- positive regulation of JUN kinase activity Source: MGI
- positive regulation of monocyte chemotactic protein-1 production Source: MGI
- positive regulation of monocyte extravasation Source: MGI
- positive regulation of neuron apoptotic process Source: MGI
- positive regulation of neuron death Source: MGI
- positive regulation of NF-kappaB transcription factor activity Source: MGI
- positive regulation of NIK/NF-kappaB signaling Source: MGI
- positive regulation of p38MAPK cascade Source: MGI
- positive regulation of phagocytosis, engulfment Source: MGI
- positive regulation of potassium ion transmembrane transporter activity Source: MGI
- positive regulation of protein phosphorylation Source: MGI
- positive regulation of reactive oxygen species metabolic process Source: MGI
- positive regulation of signaling Source: MGI
- positive regulation of smooth muscle cell migration Source: MGI
- positive regulation of smooth muscle cell proliferation Source: MGI
- positive regulation of tumor necrosis factor production Source: ARUK-UCL
- positive regulation of type B pancreatic cell apoptotic process Source: MGI
- protein localization to membrane Source: MGI
- receptor signaling pathway via JAK-STAT Source: MGI
- regulation of CD4-positive, alpha-beta T cell activation Source: MGI
- regulation of DNA binding Source: MGI
- regulation of inflammatory response Source: UniProtKB
- regulation of long-term synaptic potentiation Source: ARUK-UCL
- regulation of p38MAPK cascade Source: ARUK-UCL
- regulation of spontaneous synaptic transmission Source: MGI
- regulation of T cell mediated cytotoxicity Source: MGI
- response to amyloid-beta Source: ARUK-UCL
- response to hypoxia Source: MGI
- transcytosis Source: ARUK-UCL
- transport across blood-brain barrier Source: MGI
Keywordsi
Biological process | Inflammatory response |
Enzyme and pathway databases
Reactomei | R-MMU-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-MMU-879415, Advanced glycosylation endproduct receptor signaling R-MMU-933542, TRAF6 mediated NF-kB activation |
Names & Taxonomyi
Protein namesi | Recommended name: Advanced glycosylation end product-specific receptorAlternative name(s): Receptor for advanced glycosylation end products |
Gene namesi | Name:Ager Synonyms:Rage |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:893592, Ager |
Subcellular locationi
Other locations
Extracellular region or secreted
- Secreted 1 Publication
Plasma membrane
- Cell membrane 1 Publication; Single-pass membrane protein Sequence analysis
Cytosol
- cytosol Source: MGI
Extracellular region or secreted
- extracellular region Source: MGI
- extracellular space Source: MGI
Nucleus
- fibrillar center Source: MGI
Plasma Membrane
- apical plasma membrane Source: MGI
- basal plasma membrane Source: MGI
- external side of plasma membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- axon Source: MGI
- cell junction Source: MGI
- cell surface Source: MGI
- cytoplasm Source: MGI
- integral component of membrane Source: UniProtKB-KW
- neuronal cell body Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 340 | ExtracellularSequence analysisAdd BLAST | 318 | |
Transmembranei | 341 – 361 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 362 – 402 | CytoplasmicSequence analysisAdd BLAST | 41 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000014924 | 23 – 402 | Advanced glycosylation end product-specific receptorAdd BLAST | 380 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 25 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 38 ↔ 98 | PROSITE-ProRule annotation | ||
Glycosylationi | 80 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 143 ↔ 206 | PROSITE-ProRule annotation | ||
Disulfide bondi | 257 | InterchainPROSITE-ProRule annotation | ||
Disulfide bondi | 299 | InterchainPROSITE-ProRule annotation | ||
Modified residuei | 376 | PhosphoserineCombined sources | 1 | |
Modified residuei | 389 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | Q62151 |
PaxDbi | Q62151 |
PRIDEi | Q62151 |
ProteomicsDBi | 255077 [Q62151-1] 255078 [Q62151-2] 255079 [Q62151-3] 255080 [Q62151-4] 255081 [Q62151-5] 255082 [Q62151-6] 255083 [Q62151-7] 255084 [Q62151-8] 255085 [Q62151-9] 255086 [Q62151-10] 255087 [Q62151-11] 255088 [Q62151-12] 255089 [Q62151-13] |
PTM databases
GlyGeni | Q62151, 2 sites |
iPTMneti | Q62151 |
PhosphoSitePlusi | Q62151 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000015452, Expressed in lung and 195 other tissues |
Interactioni
Subunit structurei
Interacts with S100B, S100A1 and S100A14. Constitutive homodimer; disulfide-linked (By similarity).
Interacts with S100A12 and APP.
By similarity2 PublicationsBinary interactionsi
Q62151
With | #Exp. | IntAct |
---|---|---|
Prkcz [Q02956] | 7 | EBI-6665091,EBI-642057 |
GO - Molecular functioni
- high mobility group box 1 binding Source: MGI
- identical protein binding Source: MGI
- S100 protein binding Source: UniProtKB
Protein-protein interaction databases
IntActi | Q62151, 8 interactors |
MINTi | Q62151 |
STRINGi | 10090.ENSMUSP00000015596 |
Miscellaneous databases
RNActi | Q62151, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 109 | Ig-like V-typeAdd BLAST | 87 | |
Domaini | 123 – 219 | Ig-like C2-type 1Add BLAST | 97 | |
Domaini | 233 – 315 | Ig-like C2-type 2Add BLAST | 83 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SQ8N, Eukaryota |
GeneTreei | ENSGT00890000139566 |
InParanoidi | Q62151 |
OMAi | HWIKDGM |
OrthoDBi | 807961at2759 |
TreeFami | TF337155 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF00047, ig, 1 hit PF13895, Ig_2, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00408, IGc2, 2 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00290, IG_MHC, 1 hit |
s (13)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 13 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPAGTAARAW VLVLALWGAV AGGQNITARI GEPLVLSCKG APKKPPQQLE
60 70 80 90 100
WKLNTGRTEA WKVLSPQGGP WDSVARILPN GSLLLPATGI VDEGTFRCRA
110 120 130 140 150
TNRRGKEVKS NYRVRVYQIP GKPEIVDPAS ELTASVPNKV GTCVSEGSYP
160 170 180 190 200
AGTLSWHLDG KLLIPDGKET LVKEETRRHP ETGLFTLRSE LTVIPTQGGT
210 220 230 240 250
HPTFSCSFSL GLPRRRPLNT APIQLRVREP GPPEGIQLLV EPEGGIVAPG
260 270 280 290 300
GTVTLTCAIS AQPPPQVHWI KDGAPLPLAP SPVLLLPEVG HEDEGTYSCV
310 320 330 340 350
ATHPSHGPQE SPPVSIRVTE TGDEGPAEGS VGESGLGTLA LALGILGGLG
360 370 380 390 400
VVALLVGAIL WRKRQPRREE RKAPESQEDE EERAELNQSE EAEMPENGAG
GP
The sequence of this isoform differs from the canonical sequence as follows:
330-333: SVGE → EGLD
334-402: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
118-138: QIPGKPEIVDPASELTASVPN → RKGPRLSHFAFIKKPSCTPNP
139-402: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
119-137: IPGKPEIVDPASELTASVP → KPAMRGQLKALWVSLGWVR
138-402: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
27-85: TARIGEPLVL...RILPNGSLLL → PALCCSSLRW...ALWVSLGWVR
86-402: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
372-384: KAPESQEDEEERA → PRKARRMRRNVQS
385-402: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
19-77: AVAGGQNITA...GGPWDSVARI → ETLPAPTLPL...PHLSPSTLPQ
78-402: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
30-40: IGEPLVLSCKG → KARRMRRNVQS
41-402: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
31-402: Missing.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 28 – 30 | ARI → TQA in ACK28146 (PubMed:19164451).Curated | 3 | |
Sequence conflicti | 76 | R → Q in AAA40040 (PubMed:9224812).Curated | 1 | |
Sequence conflicti | 76 | R → Q in BAE72665 (PubMed:16503878).Curated | 1 | |
Sequence conflicti | 199 | G → GT in AAA40040 (PubMed:9224812).Curated | 1 | |
Sequence conflicti | 199 | G → GT in BAE72665 (PubMed:16503878).Curated | 1 | |
Sequence conflicti | 292 | E → A in AAA40040 (PubMed:9224812).Curated | 1 | |
Sequence conflicti | 292 | E → A in BAE72665 (PubMed:16503878).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_058075 | 19 – 77 | AVAGG…SVARI → ETLPAPTLPLSSPAPTPPPV PPCPLEIPLNLGTTFQRPSP TLSYTRTPQPHLSPSTLPQ in isoform 11. 1 PublicationAdd BLAST | 59 | |
Alternative sequenceiVSP_058076 | 27 – 85 | TARIG…GSLLL → PALCCSSLRWGTRMRAPIAA WPPTLATDLRKALLSASGSQ KPAMRGQLKALWVSLGWVR in isoform 9. 1 PublicationAdd BLAST | 59 | |
Alternative sequenceiVSP_058077 | 30 – 40 | IGEPLVLSCKG → KARRMRRNVQS in isoform 12. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_058078 | 31 – 402 | Missing in isoform 13. Add BLAST | 372 | |
Alternative sequenceiVSP_058079 | 41 – 402 | Missing in isoform 12. 1 PublicationAdd BLAST | 362 | |
Alternative sequenceiVSP_058080 | 54 – 62 | Missing in isoform 4. 1 Publication | 9 | |
Alternative sequenceiVSP_058081 | 78 – 402 | Missing in isoform 11. 1 PublicationAdd BLAST | 325 | |
Alternative sequenceiVSP_058082 | 86 – 402 | Missing in isoform 9. 1 PublicationAdd BLAST | 317 | |
Alternative sequenceiVSP_058083 | 118 – 138 | QIPGK…ASVPN → RKGPRLSHFAFIKKPSCTPN P in isoform 7. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_058084 | 119 – 137 | IPGKP…TASVP → KPAMRGQLKALWVSLGWVR in isoform 8. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_058085 | 138 – 402 | Missing in isoform 8. 1 PublicationAdd BLAST | 265 | |
Alternative sequenceiVSP_058086 | 139 – 402 | Missing in isoform 7. 1 PublicationAdd BLAST | 264 | |
Alternative sequenceiVSP_058087 | 153 | T → G in isoform 6. 1 Publication | 1 | |
Alternative sequenceiVSP_058088 | 154 – 402 | Missing in isoform 6. 1 PublicationAdd BLAST | 249 | |
Alternative sequenceiVSP_058089 | 188 – 382 | Missing in isoform 5. 1 PublicationAdd BLAST | 195 | |
Alternative sequenceiVSP_058090 | 320 – 328 | Missing in isoform 3 and isoform 4. 1 Publication | 9 | |
Alternative sequenceiVSP_058091 | 330 – 333 | SVGE → EGLD in isoform 2. 2 Publications | 4 | |
Alternative sequenceiVSP_058092 | 334 – 402 | Missing in isoform 2. 2 PublicationsAdd BLAST | 69 | |
Alternative sequenceiVSP_058093 | 372 – 384 | KAPES…EEERA → PRKARRMRRNVQS in isoform 10. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_058094 | 385 – 402 | Missing in isoform 10. 1 PublicationAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L33412 mRNA Translation: AAA40040.1 AB207883 mRNA Translation: BAE72665.1 EU520325 mRNA Translation: ACD35949.1 EU570240 mRNA Translation: ACE63492.1 EU570241 mRNA Translation: ACE63493.1 EU570242 mRNA Translation: ACE63494.1 EU570243 mRNA Translation: ACE63495.1 EU570244 mRNA Translation: ACE63496.1 EU570245 mRNA Translation: ACE63497.1 EU570246 mRNA Translation: ACE63498.1 EU570247 mRNA Translation: ACE63499.1 EU906857 mRNA Translation: ACK28143.1 EU906858 mRNA Translation: ACK28144.1 EU906859 mRNA Translation: ACK28145.1 EU906860 mRNA Translation: ACK28146.1 EU906861 mRNA Translation: ACK28147.1 EU906862 mRNA Translation: ACK28148.1 EU906863 mRNA Translation: ACK28149.1 EU906864 mRNA Translation: ACK28150.1 EU906865 mRNA Translation: ACK28151.1 KC692918 mRNA Translation: AHB30242.1 AF030001 Genomic DNA Translation: AAB82007.1 CT009767 Genomic DNA No translation available. CH466666 Genomic DNA Translation: EDL26799.1 CH466666 Genomic DNA Translation: EDL26800.1 BC061182 mRNA Translation: AAH61182.1 |
CCDSi | CCDS28649.1 [Q62151-1] CCDS70795.1 [Q62151-3] CCDS70796.1 [Q62151-4] |
PIRi | T09062 |
RefSeqi | NP_001258351.1, NM_001271422.1 [Q62151-3] NP_001258352.1, NM_001271423.1 [Q62151-4] NP_031451.2, NM_007425.3 [Q62151-1] |
Genome annotation databases
Ensembli | ENSMUST00000015596; ENSMUSP00000015596; ENSMUSG00000015452 [Q62151-1] ENSMUST00000173992; ENSMUSP00000134579; ENSMUSG00000015452 [Q62151-4] ENSMUST00000174069; ENSMUSP00000133391; ENSMUSG00000015452 [Q62151-2] ENSMUST00000174496; ENSMUSP00000134401; ENSMUSG00000015452 [Q62151-3] |
GeneIDi | 11596 |
KEGGi | mmu:11596 |
UCSCi | uc008ccw.3, mouse uc008ccx.2, mouse uc012aqe.2, mouse uc012aqf.2, mouse uc012aqg.2, mouse uc033hcv.1, mouse |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L33412 mRNA Translation: AAA40040.1 AB207883 mRNA Translation: BAE72665.1 EU520325 mRNA Translation: ACD35949.1 EU570240 mRNA Translation: ACE63492.1 EU570241 mRNA Translation: ACE63493.1 EU570242 mRNA Translation: ACE63494.1 EU570243 mRNA Translation: ACE63495.1 EU570244 mRNA Translation: ACE63496.1 EU570245 mRNA Translation: ACE63497.1 EU570246 mRNA Translation: ACE63498.1 EU570247 mRNA Translation: ACE63499.1 EU906857 mRNA Translation: ACK28143.1 EU906858 mRNA Translation: ACK28144.1 EU906859 mRNA Translation: ACK28145.1 EU906860 mRNA Translation: ACK28146.1 EU906861 mRNA Translation: ACK28147.1 EU906862 mRNA Translation: ACK28148.1 EU906863 mRNA Translation: ACK28149.1 EU906864 mRNA Translation: ACK28150.1 EU906865 mRNA Translation: ACK28151.1 KC692918 mRNA Translation: AHB30242.1 AF030001 Genomic DNA Translation: AAB82007.1 CT009767 Genomic DNA No translation available. CH466666 Genomic DNA Translation: EDL26799.1 CH466666 Genomic DNA Translation: EDL26800.1 BC061182 mRNA Translation: AAH61182.1 |
CCDSi | CCDS28649.1 [Q62151-1] CCDS70795.1 [Q62151-3] CCDS70796.1 [Q62151-4] |
PIRi | T09062 |
RefSeqi | NP_001258351.1, NM_001271422.1 [Q62151-3] NP_001258352.1, NM_001271423.1 [Q62151-4] NP_031451.2, NM_007425.3 [Q62151-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4IM8 | X-ray | 3.50 | A | 23-230 | [»] | |
SMRi | Q62151 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | Q62151, 8 interactors |
MINTi | Q62151 |
STRINGi | 10090.ENSMUSP00000015596 |
Chemistry databases
ChEMBLi | CHEMBL2189161 |
PTM databases
GlyGeni | Q62151, 2 sites |
iPTMneti | Q62151 |
PhosphoSitePlusi | Q62151 |
Proteomic databases
MaxQBi | Q62151 |
PaxDbi | Q62151 |
PRIDEi | Q62151 |
ProteomicsDBi | 255077 [Q62151-1] 255078 [Q62151-2] 255079 [Q62151-3] 255080 [Q62151-4] 255081 [Q62151-5] 255082 [Q62151-6] 255083 [Q62151-7] 255084 [Q62151-8] 255085 [Q62151-9] 255086 [Q62151-10] 255087 [Q62151-11] 255088 [Q62151-12] 255089 [Q62151-13] |
Protocols and materials databases
ABCDi | Q62151, 1 sequenced antibody |
Antibodypediai | 28483, 849 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000015596; ENSMUSP00000015596; ENSMUSG00000015452 [Q62151-1] ENSMUST00000173992; ENSMUSP00000134579; ENSMUSG00000015452 [Q62151-4] ENSMUST00000174069; ENSMUSP00000133391; ENSMUSG00000015452 [Q62151-2] ENSMUST00000174496; ENSMUSP00000134401; ENSMUSG00000015452 [Q62151-3] |
GeneIDi | 11596 |
KEGGi | mmu:11596 |
UCSCi | uc008ccw.3, mouse uc008ccx.2, mouse uc012aqe.2, mouse uc012aqf.2, mouse uc012aqg.2, mouse uc033hcv.1, mouse |
Organism-specific databases
CTDi | 177 |
MGIi | MGI:893592, Ager |
Phylogenomic databases
eggNOGi | ENOG502SQ8N, Eukaryota |
GeneTreei | ENSGT00890000139566 |
InParanoidi | Q62151 |
OMAi | HWIKDGM |
OrthoDBi | 807961at2759 |
TreeFami | TF337155 |
Enzyme and pathway databases
Reactomei | R-MMU-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-MMU-879415, Advanced glycosylation endproduct receptor signaling R-MMU-933542, TRAF6 mediated NF-kB activation |
Miscellaneous databases
BioGRID-ORCSi | 11596, 0 hits in 52 CRISPR screens |
ChiTaRSi | Mok, mouse |
PROi | PR:Q62151 |
RNActi | Q62151, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000015452, Expressed in lung and 195 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013151, Immunoglobulin |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF00047, ig, 1 hit PF13895, Ig_2, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00408, IGc2, 2 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RAGE_MOUSE | |
Accessioni | Q62151Primary (citable) accession number: Q62151 Secondary accession number(s): C5H3H4 V5R4Y0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 17, 2016 | |
Last modified: | April 7, 2021 | |
This is version 163 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references