UniProtKB - Q62148 (AL1A2_MOUSE)
Protein
Retinal dehydrogenase 2
Gene
Aldh1a2
Organism
Mus musculus (Mouse)
Status
Functioni
Converts retinaldehyde to retinoic acid (PubMed:8797830). Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal (By similarity). Lacks activity with benzaldehyde, acetaldehyde and octanal (PubMed:8797830). Displays complete lack of activity with citral (By similarity).By similarity1 Publication
Catalytic activityi
- EC:1.2.1.361 Publication
: retinol metabolism Pathwayi
This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 187 | Transition state stabilizerBy similarity | 1 | |
Active sitei | 286 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Active sitei | 320 | NucleophilePROSITE-ProRule annotation | 1 | |
Binding sitei | 417 | NADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 184 – 186 | NADBy similarity | 3 | |
Nucleotide bindingi | 210 – 213 | NADBy similarity | 4 | |
Nucleotide bindingi | 264 – 266 | NADBy similarity | 3 | |
Nucleotide bindingi | 366 – 370 | NADBy similarity | 5 |
GO - Molecular functioni
- 3-chloroallyl aldehyde dehydrogenase activity Source: MGI
- aldehyde dehydrogenase (NAD+) activity Source: GO_Central
- retinal binding Source: MGI
- retinal dehydrogenase activity Source: MGI
GO - Biological processi
- 9-cis-retinoic acid biosynthetic process Source: MGI
- anterior/posterior pattern specification Source: MGI
- blood vessel development Source: MGI
- camera-type eye development Source: MGI
- cardiac muscle tissue development Source: MGI
- cellular response to retinoic acid Source: UniProtKB
- determination of bilateral symmetry Source: MGI
- embryonic camera-type eye development Source: MGI
- embryonic digestive tract development Source: MGI
- embryonic forelimb morphogenesis Source: MGI
- embryonic limb morphogenesis Source: MGI
- face development Source: MGI
- forebrain development Source: MGI
- heart development Source: DFLAT
- heart looping Source: DFLAT
- heart morphogenesis Source: MGI
- hindbrain development Source: MGI
- kidney development Source: Ensembl
- liver development Source: Ensembl
- lung development Source: MGI
- midgut development Source: Ensembl
- morphogenesis of embryonic epithelium Source: MGI
- negative regulation of cell population proliferation Source: MGI
- neural crest cell development Source: MGI
- neural tube development Source: MGI
- neuron differentiation Source: MGI
- pancreas development Source: MGI
- pituitary gland development Source: Ensembl
- positive regulation of apoptotic process Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of gene expression Source: MGI
- protein homotetramerization Source: UniProtKB
- proximal/distal pattern formation Source: MGI
- regulation of endothelial cell proliferation Source: MGI
- response to cytokine Source: MGI
- response to estradiol Source: Ensembl
- response to vitamin A Source: Ensembl
- retinal metabolic process Source: MGI
- retinoic acid biosynthetic process Source: MGI
- retinoic acid metabolic process Source: MGI
- retinoic acid receptor signaling pathway Source: MGI
- retinoic acid receptor signaling pathway involved in somitogenesis Source: MGI
- retinoid metabolic process Source: DFLAT
- retinol metabolic process Source: UniProtKB-UniPathway
- ureter maturation Source: MGI
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
BRENDAi | 1.2.1.36, 3474 |
Reactomei | R-MMU-5365859, RA biosynthesis pathway |
UniPathwayi | UPA00912 |
Names & Taxonomyi
Protein namesi | Recommended name: Retinal dehydrogenase 2 (EC:1.2.1.361 Publication)Short name: RALDH 21 Publication Short name: RalDH21 Publication Alternative name(s): Aldehyde dehydrogenase family 1 member A2 Retinaldehyde-specific dehydrogenase type 2 Short name: RALDH(II) |
Gene namesi | Name:Aldh1a2 Synonyms:Aldh1a7, Raldh21 Publication |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107928, Aldh1a2 |
Subcellular locationi
Other locations
Cytosol
- cytosol Source: MGI
Other locations
- cytoplasm Source: MGI
- perinuclear region of cytoplasm Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056423 | 1 – 518 | Retinal dehydrogenase 2Add BLAST | 518 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 168 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 351 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q62148 |
jPOSTi | Q62148 |
MaxQBi | Q62148 |
PaxDbi | Q62148 |
PeptideAtlasi | Q62148 |
PRIDEi | Q62148 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00122212 Q62148 |
PTM databases
iPTMneti | Q62148 |
PhosphoSitePlusi | Q62148 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000013584, Expressed in uterine cervix and 353 other tissues |
Genevisiblei | Q62148, MM |
Interactioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
BioGRIDi | 202578, 1 interactor |
IntActi | Q62148, 1 interactor |
MINTi | Q62148 |
STRINGi | 10090.ENSMUSP00000034723 |
Miscellaneous databases
RNActi | Q62148, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | KOG2450, Eukaryota |
GeneTreei | ENSGT00940000158898 |
HOGENOMi | CLU_005391_0_1_1 |
InParanoidi | Q62148 |
OMAi | ERWSPAC |
OrthoDBi | 153834at2759 |
PhylomeDBi | Q62148 |
TreeFami | TF300455 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
i Sequence
Sequence statusi: Complete.
Q62148-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSSEIAMPG EVKADPAALM ASLQLLPSPT PNLEIKYTKI FINNEWQNSE
60 70 80 90 100
SGRVFPVCNP ATGEQVCEVQ EADKVDIDKA VQAARLAFSL GSVWRRMDAS
110 120 130 140 150
ERGRLLDKLA DLVERDRATL ATMESLNGGK PFLQAFYIDL QGVIKTLRYY
160 170 180 190 200
AGWADKIHGM TIPVDGDYFT FTRHEPIGVC GQIIPWNFPL LMFTWKIAPA
210 220 230 240 250
LCCGNTVVIK PAEQTPLSAL YMGALIKEAG FPPGVVNILP GYGPTAGAAI
260 270 280 290 300
ASHIGIDKIA FTGSTEVGKL IQEAAGRSNL KRVTLELGGK SPNIIFADAD
310 320 330 340 350
LDYAVEQAHQ GVFFNQGQCC TAGSRIFVEE SIYEEFVKRS VERAKRRIVG
360 370 380 390 400
SPFDPTTEQG PQIDKKQYNK VLELIQSGVA EGAKLECGGK GLGRKGFFIE
410 420 430 440 450
PTVFSNVTDD MRIAKEEIFG PVQEILRFKT MDEVIERANN SDFGLVAAVF
460 470 480 490 500
TNDINKALMV SSAMQAGTVW INCYNALNAQ SPFGGFKMSG NGREMGEFGL
510
REYSEVKTVT VKIPQKNS
Sequence cautioni
The sequence BAC37332 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA67666 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99273 mRNA Translation: CAA67666.1 Different initiation. BC075704 mRNA Translation: AAH75704.1 AK078553 mRNA Translation: BAC37332.1 Different initiation. |
CCDSi | CCDS52852.1 |
PIRi | S74224 |
RefSeqi | NP_033048.2, NM_009022.4 |
Genome annotation databases
Ensembli | ENSMUST00000034723; ENSMUSP00000034723; ENSMUSG00000013584 |
GeneIDi | 19378 |
KEGGi | mmu:19378 |
UCSCi | uc009qox.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99273 mRNA Translation: CAA67666.1 Different initiation. BC075704 mRNA Translation: AAH75704.1 AK078553 mRNA Translation: BAC37332.1 Different initiation. |
CCDSi | CCDS52852.1 |
PIRi | S74224 |
RefSeqi | NP_033048.2, NM_009022.4 |
3D structure databases
SMRi | Q62148 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 202578, 1 interactor |
IntActi | Q62148, 1 interactor |
MINTi | Q62148 |
STRINGi | 10090.ENSMUSP00000034723 |
PTM databases
iPTMneti | Q62148 |
PhosphoSitePlusi | Q62148 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00122212 Q62148 |
Proteomic databases
EPDi | Q62148 |
jPOSTi | Q62148 |
MaxQBi | Q62148 |
PaxDbi | Q62148 |
PeptideAtlasi | Q62148 |
PRIDEi | Q62148 |
Protocols and materials databases
Antibodypediai | 2127, 342 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000034723; ENSMUSP00000034723; ENSMUSG00000013584 |
GeneIDi | 19378 |
KEGGi | mmu:19378 |
UCSCi | uc009qox.2, mouse |
Organism-specific databases
CTDi | 8854 |
MGIi | MGI:107928, Aldh1a2 |
Phylogenomic databases
eggNOGi | KOG2450, Eukaryota |
GeneTreei | ENSGT00940000158898 |
HOGENOMi | CLU_005391_0_1_1 |
InParanoidi | Q62148 |
OMAi | ERWSPAC |
OrthoDBi | 153834at2759 |
PhylomeDBi | Q62148 |
TreeFami | TF300455 |
Enzyme and pathway databases
UniPathwayi | UPA00912 |
BRENDAi | 1.2.1.36, 3474 |
Reactomei | R-MMU-5365859, RA biosynthesis pathway |
Miscellaneous databases
BioGRID-ORCSi | 19378, 1 hit in 17 CRISPR screens |
ChiTaRSi | Aldh1a2, mouse |
PROi | PR:Q62148 |
RNActi | Q62148, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000013584, Expressed in uterine cervix and 353 other tissues |
Genevisiblei | Q62148, MM |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AL1A2_MOUSE | |
Accessioni | Q62148Primary (citable) accession number: Q62148 Secondary accession number(s): Q6DI79 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | March 7, 2006 | |
Last modified: | December 2, 2020 | |
This is version 167 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families