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Protein

Paired amphipathic helix protein Sin3b

Gene

Sin3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression (PubMed:22476904).3 Publications

GO - Molecular functioni

  • chromatin binding Source: MGI
  • transcription corepressor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Names & Taxonomyi

Protein namesi
Recommended name:
Paired amphipathic helix protein Sin3b
Alternative name(s):
Histone deacetylase complex subunit Sin3b
Transcriptional corepressor Sin3b
Gene namesi
Name:Sin3b
Synonyms:Kiaa0700
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:107158 Sin3b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001215401 – 1098Paired amphipathic helix protein Sin3bAdd BLAST1098

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei667PhosphoserineCombined sources1
Modified residuei670PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated by RNF220 that leads to proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ62141
PaxDbiQ62141
PeptideAtlasiQ62141
PRIDEiQ62141

PTM databases

iPTMnetiQ62141
PhosphoSitePlusiQ62141

Expressioni

Gene expression databases

BgeeiENSMUSG00000031622 Expressed in 307 organ(s), highest expression level in placenta
CleanExiMM_SIN3B
ExpressionAtlasiQ62141 baseline and differential
GenevisibleiQ62141 MM

Interactioni

Subunit structurei

Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SUDS3 enhances the interaction with HDAC1 to form a complex. Interacts with CRY1, HCFC1, MAD3, MAD4, MAEL, REST, RNF220 and SETDB1. Interacts with MYT1L (PubMed:28379941). Interacts with C6orf89 (By similarity).By similarity14 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi203257, 17 interactors
ComplexPortaliCPX-3444 SIN3B histone deacetylase complex
CORUMiQ62141
DIPiDIP-470N
IntActiQ62141, 8 interactors
MINTiQ62141
STRINGi10090.ENSMUSP00000004494

Structurei

Secondary structure

11098
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ62141
SMRiQ62141
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ62141

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 100PAH 1PROSITE-ProRule annotationAdd BLAST71
Domaini145 – 230PAH 2PROSITE-ProRule annotationAdd BLAST86
Domaini283 – 360PAH 3PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 299Interaction with CRY11 PublicationAdd BLAST299
Regioni52 – 98Interaction with REST1 PublicationAdd BLAST47
Regioni275 – 499Interaction with NCOR11 PublicationAdd BLAST225
Regioni383 – 550Interaction with SUDS3 and HDAC11 PublicationAdd BLAST168

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4204 Eukaryota
COG5602 LUCA
GeneTreeiENSGT00390000007239
HOGENOMiHOG000230688
HOVERGENiHBG060425
InParanoidiQ62141
OMAiCNVDCRF
OrthoDBiEOG091G03HY
PhylomeDBiQ62141
TreeFamiTF106187

Family and domain databases

InterProiView protein in InterPro
IPR013194 HDAC_interact_dom
IPR003822 PAH
IPR036600 PAH_sf
IPR039774 Sin3-like
IPR031693 Sin3_C
PANTHERiPTHR12346 PTHR12346, 1 hit
PfamiView protein in Pfam
PF02671 PAH, 3 hits
PF08295 Sin3_corepress, 1 hit
PF16879 Sin3a_C, 1 hit
SMARTiView protein in SMART
SM00761 HDAC_interact, 1 hit
SUPFAMiSSF47762 SSF47762, 3 hits
PROSITEiView protein in PROSITE
PS51477 PAH, 3 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 4 (identifier: Q62141-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHAGSGGSA GRGFGGSRWG RSGSGGHEKL PVHVEDALTY LDQVKIRFGS
60 70 80 90 100
DPATYNGFLE IMKEFKSQSI DTPGVIRRVS QLFHEHPDLI VGFNAFLPLG
110 120 130 140 150
YRIDIPKNGK LNIQSPLSSQ DNSHSHGDCG EDFKQMSYKE DRGQVPLESD
160 170 180 190 200
SVEFNNAISY VNKIKTRFLD HPEIYRSFLE ILHTYQKEQL HTKGRPFRGM
210 220 230 240 250
SEEEVFTEVA NLFRGQEDLL SEFGQFLPEA KRSLFTGNGS CEMNSGQKNE
260 270 280 290 300
EKSLEHNKKR SRPSLLRPVS APAKKKMKLR GTKDLSIAAV GKYGTLQEFS
310 320 330 340 350
FFDKVRRVLK SQEVYENFLR CIALFNQELV SGSELLQLVS PFLGKFPELF
360 370 380 390 400
AQFKSFLGVK ELSFAPPMSD RSGDGISREI DYASCKRIGS SYRALPKTYQ
410 420 430 440 450
QPKCSGRTAI CKEVLNDTWV SFPSWSEDST FVSSKKTPYE EQLHRCEDER
460 470 480 490 500
FELDVVLETN LATIRVLESV QKKLSRMAPE DQEKLRLDDC LGGTSEVIQR
510 520 530 540 550
RAIHRIYGDK APEVIESLKR NPATAVPVVL KRLKAKEEEW REAQQGFNKI
560 570 580 590 600
WREQYEKAYL KSLDHQAVNF KQNDTKALRS KSLLNEIESV YDEHQEQHSE
610 620 630 640 650
GRSAPSSEPH LIFVYEDRQI LEDAAALISY YVKRQPAIQK EDQGTIRQLL
660 670 680 690 700
HRFLPSLFFS QQCPGTSDDS ADERDRDRDS AEPERRRPTD EKPPADASPE
710 720 730 740 750
PPKVLDDVYS LFFANNNWYF FLRLHQTLCA RLLKIYRQAQ KQLLEHRREQ
760 770 780 790 800
EREQLLCEGR REKAADPAME LRLKQPSEVE LEEYYPAFLD MVRSLLEGSI
810 820 830 840 850
DPTQYEDTLR EMFTIHAYIG FTMDKLVQNI ARQLHHLVSD DVCLKVVELY
860 870 880 890 900
LNEQQRGAAG GNLSSRCVRA ARETSYQWKA ERCMADENCF KVMFLQRRGQ
910 920 930 940 950
VIMTIELLDT EEAQTEDPVE VQHLARYVEQ YVGSEGASSS STEGFLLKPV
960 970 980 990 1000
FLQRNLKKFR RWQCEQVRAM RGEAKSSWKR LMGVESACDV DCRFRLGTHK
1010 1020 1030 1040 1050
MVFIVNSEDY MYRRGTLCRA KQVQPLVLLR HHRHFEEWHG RWLEDNVTVA
1060 1070 1080 1090
AAGLVQDWLM GEEEEDMVPC KTLCETAHVH GLPVTRYRVQ YSRRPASP
Note: No experimental confirmation available.
Length:1,098
Mass (Da):126,405
Last modified:June 21, 2005 - v2
Checksum:iA73F6DFC11EBA256
GO
Isoform 1 (identifier: Q62141-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     955-1098: Missing.

Show »
Length:954
Mass (Da):109,393
Checksum:i31F4BE14523EA213
GO
Isoform 2 (identifier: Q62141-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-293: KKMKLRGTKDLSIAAVGKY → VGLQLKCAVVWFGYCTAEE
     294-954: Missing.
     955-1098: Missing.

Show »
Length:293
Mass (Da):32,846
Checksum:i11A75E8F67C818AE
GO
Isoform 3 (identifier: Q62141-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-302: KKMKLRGTKDLSIAAVGKYGTLQEFSFF → VLVHVWVLPAHGRSGVEAQAAGEPEARA
     303-954: Missing.
     955-1098: Missing.

Note: No experimental confirmation available.
Show »
Length:302
Mass (Da):33,637
Checksum:i421131CCD87C88F8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RM25A0A1D5RM25_MOUSE
Paired amphipathic helix protein Si...
Sin3b
207Annotation score:

Sequence cautioni

The sequence BAD32283 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti230A → G in AAC04821 (PubMed:10620510).Curated1
Sequence conflicti233S → P in AAC04821 (PubMed:10620510).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008227275 – 302KKMKL…EFSFF → VLVHVWVLPAHGRSGVEAQA AGEPEARA in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_008225275 – 293KKMKL…AVGKY → VGLQLKCAVVWFGYCTAEE in isoform 2. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_008226294 – 954Missing in isoform 2. 2 PublicationsAdd BLAST661
Alternative sequenceiVSP_008228303 – 954Missing in isoform 3. 1 PublicationAdd BLAST652
Alternative sequenceiVSP_014187955 – 1098Missing in isoform 1, isoform 2 and isoform 3. 3 PublicationsAdd BLAST144

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38622 mRNA Translation: AAA69774.1
AF038848 mRNA Translation: AAC04821.1
AK173005 mRNA Translation: BAD32283.1 Different initiation.
BC020049 mRNA Translation: AAH20049.1
BC021160 mRNA Translation: AAH21160.1
CCDSiCCDS52598.1 [Q62141-2]
CCDS52599.1 [Q62141-4]
PIRiI61714
RefSeqiNP_001106719.1, NM_001113248.2 [Q62141-2]
NP_033214.2, NM_009188.4 [Q62141-4]
UniGeneiMm.2137

Genome annotation databases

EnsembliENSMUST00000004494; ENSMUSP00000004494; ENSMUSG00000031622 [Q62141-4]
ENSMUST00000109950; ENSMUSP00000105576; ENSMUSG00000031622 [Q62141-2]
ENSMUST00000212095; ENSMUSP00000148407; ENSMUSG00000031622 [Q62141-3]
GeneIDi20467
KEGGimmu:20467
UCSCiuc009mgp.3 mouse [Q62141-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38622 mRNA Translation: AAA69774.1
AF038848 mRNA Translation: AAC04821.1
AK173005 mRNA Translation: BAD32283.1 Different initiation.
BC020049 mRNA Translation: AAH20049.1
BC021160 mRNA Translation: AAH21160.1
CCDSiCCDS52598.1 [Q62141-2]
CCDS52599.1 [Q62141-4]
PIRiI61714
RefSeqiNP_001106719.1, NM_001113248.2 [Q62141-2]
NP_033214.2, NM_009188.4 [Q62141-4]
UniGeneiMm.2137

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E91NMR-A148-232[»]
1PD7NMR-A148-232[»]
2CR7NMR-A32-98[»]
2CZYNMR-A31-107[»]
2F05NMR-A148-252[»]
5Y95NMR-A32-98[»]
ProteinModelPortaliQ62141
SMRiQ62141
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203257, 17 interactors
ComplexPortaliCPX-3444 SIN3B histone deacetylase complex
CORUMiQ62141
DIPiDIP-470N
IntActiQ62141, 8 interactors
MINTiQ62141
STRINGi10090.ENSMUSP00000004494

PTM databases

iPTMnetiQ62141
PhosphoSitePlusiQ62141

Proteomic databases

MaxQBiQ62141
PaxDbiQ62141
PeptideAtlasiQ62141
PRIDEiQ62141

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004494; ENSMUSP00000004494; ENSMUSG00000031622 [Q62141-4]
ENSMUST00000109950; ENSMUSP00000105576; ENSMUSG00000031622 [Q62141-2]
ENSMUST00000212095; ENSMUSP00000148407; ENSMUSG00000031622 [Q62141-3]
GeneIDi20467
KEGGimmu:20467
UCSCiuc009mgp.3 mouse [Q62141-4]

Organism-specific databases

CTDi23309
MGIiMGI:107158 Sin3b
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4204 Eukaryota
COG5602 LUCA
GeneTreeiENSGT00390000007239
HOGENOMiHOG000230688
HOVERGENiHBG060425
InParanoidiQ62141
OMAiCNVDCRF
OrthoDBiEOG091G03HY
PhylomeDBiQ62141
TreeFamiTF106187

Enzyme and pathway databases

ReactomeiR-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Miscellaneous databases

ChiTaRSiSin3b mouse
EvolutionaryTraceiQ62141
PROiPR:Q62141
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031622 Expressed in 307 organ(s), highest expression level in placenta
CleanExiMM_SIN3B
ExpressionAtlasiQ62141 baseline and differential
GenevisibleiQ62141 MM

Family and domain databases

InterProiView protein in InterPro
IPR013194 HDAC_interact_dom
IPR003822 PAH
IPR036600 PAH_sf
IPR039774 Sin3-like
IPR031693 Sin3_C
PANTHERiPTHR12346 PTHR12346, 1 hit
PfamiView protein in Pfam
PF02671 PAH, 3 hits
PF08295 Sin3_corepress, 1 hit
PF16879 Sin3a_C, 1 hit
SMARTiView protein in SMART
SM00761 HDAC_interact, 1 hit
SUPFAMiSSF47762 SSF47762, 3 hits
PROSITEiView protein in PROSITE
PS51477 PAH, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSIN3B_MOUSE
AccessioniPrimary (citable) accession number: Q62141
Secondary accession number(s): O54976
, Q6A013, Q8VCB8, Q8VDZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 21, 2005
Last modified: November 7, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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