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Protein

Paired amphipathic helix protein Sin3b

Gene

Sin3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression (PubMed:22476904).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chromatin binding Source: MGI
  • transcription corepressor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Paired amphipathic helix protein Sin3b
Alternative name(s):
Histone deacetylase complex subunit Sin3b
Transcriptional corepressor Sin3b
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sin3b
Synonyms:Kiaa0700
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107158 Sin3b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001215401 – 1098Paired amphipathic helix protein Sin3bAdd BLAST1098

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei667PhosphoserineCombined sources1
Modified residuei670PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by RNF220 that leads to proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q62141

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q62141

PeptideAtlas

More...
PeptideAtlasi
Q62141

PRoteomics IDEntifications database

More...
PRIDEi
Q62141

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q62141

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q62141

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031622 Expressed in 307 organ(s), highest expression level in placenta

CleanEx database of gene expression profiles

More...
CleanExi
MM_SIN3B

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q62141 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q62141 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SUDS3 enhances the interaction with HDAC1 to form a complex. Interacts with CRY1, HCFC1, MAD3, MAD4, MAEL, REST, RNF220 and SETDB1. Interacts with MYT1L (PubMed:28379941). Interacts with C6orf89 (By similarity).By similarity14 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
203257, 17 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3444 SIN3B histone deacetylase complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q62141

Database of interacting proteins

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DIPi
DIP-470N

Protein interaction database and analysis system

More...
IntActi
Q62141, 8 interactors

Molecular INTeraction database

More...
MINTi
Q62141

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000004494

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11098
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q62141

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q62141

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q62141

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 100PAH 1PROSITE-ProRule annotationAdd BLAST71
Domaini145 – 230PAH 2PROSITE-ProRule annotationAdd BLAST86
Domaini283 – 360PAH 3PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 299Interaction with CRY11 PublicationAdd BLAST299
Regioni52 – 98Interaction with REST1 PublicationAdd BLAST47
Regioni275 – 499Interaction with NCOR11 PublicationAdd BLAST225
Regioni383 – 550Interaction with SUDS3 and HDAC11 PublicationAdd BLAST168

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4204 Eukaryota
COG5602 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159560

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230688

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG060425

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q62141

Identification of Orthologs from Complete Genome Data

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OMAi
CNVDCRF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03HY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q62141

TreeFam database of animal gene trees

More...
TreeFami
TF106187

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013194 HDAC_interact_dom
IPR003822 PAH
IPR036600 PAH_sf
IPR039774 Sin3-like
IPR031693 Sin3_C

The PANTHER Classification System

More...
PANTHERi
PTHR12346 PTHR12346, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02671 PAH, 3 hits
PF08295 Sin3_corepress, 1 hit
PF16879 Sin3a_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00761 HDAC_interact, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47762 SSF47762, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51477 PAH, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 4 (identifier: Q62141-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHAGSGGSA GRGFGGSRWG RSGSGGHEKL PVHVEDALTY LDQVKIRFGS
60 70 80 90 100
DPATYNGFLE IMKEFKSQSI DTPGVIRRVS QLFHEHPDLI VGFNAFLPLG
110 120 130 140 150
YRIDIPKNGK LNIQSPLSSQ DNSHSHGDCG EDFKQMSYKE DRGQVPLESD
160 170 180 190 200
SVEFNNAISY VNKIKTRFLD HPEIYRSFLE ILHTYQKEQL HTKGRPFRGM
210 220 230 240 250
SEEEVFTEVA NLFRGQEDLL SEFGQFLPEA KRSLFTGNGS CEMNSGQKNE
260 270 280 290 300
EKSLEHNKKR SRPSLLRPVS APAKKKMKLR GTKDLSIAAV GKYGTLQEFS
310 320 330 340 350
FFDKVRRVLK SQEVYENFLR CIALFNQELV SGSELLQLVS PFLGKFPELF
360 370 380 390 400
AQFKSFLGVK ELSFAPPMSD RSGDGISREI DYASCKRIGS SYRALPKTYQ
410 420 430 440 450
QPKCSGRTAI CKEVLNDTWV SFPSWSEDST FVSSKKTPYE EQLHRCEDER
460 470 480 490 500
FELDVVLETN LATIRVLESV QKKLSRMAPE DQEKLRLDDC LGGTSEVIQR
510 520 530 540 550
RAIHRIYGDK APEVIESLKR NPATAVPVVL KRLKAKEEEW REAQQGFNKI
560 570 580 590 600
WREQYEKAYL KSLDHQAVNF KQNDTKALRS KSLLNEIESV YDEHQEQHSE
610 620 630 640 650
GRSAPSSEPH LIFVYEDRQI LEDAAALISY YVKRQPAIQK EDQGTIRQLL
660 670 680 690 700
HRFLPSLFFS QQCPGTSDDS ADERDRDRDS AEPERRRPTD EKPPADASPE
710 720 730 740 750
PPKVLDDVYS LFFANNNWYF FLRLHQTLCA RLLKIYRQAQ KQLLEHRREQ
760 770 780 790 800
EREQLLCEGR REKAADPAME LRLKQPSEVE LEEYYPAFLD MVRSLLEGSI
810 820 830 840 850
DPTQYEDTLR EMFTIHAYIG FTMDKLVQNI ARQLHHLVSD DVCLKVVELY
860 870 880 890 900
LNEQQRGAAG GNLSSRCVRA ARETSYQWKA ERCMADENCF KVMFLQRRGQ
910 920 930 940 950
VIMTIELLDT EEAQTEDPVE VQHLARYVEQ YVGSEGASSS STEGFLLKPV
960 970 980 990 1000
FLQRNLKKFR RWQCEQVRAM RGEAKSSWKR LMGVESACDV DCRFRLGTHK
1010 1020 1030 1040 1050
MVFIVNSEDY MYRRGTLCRA KQVQPLVLLR HHRHFEEWHG RWLEDNVTVA
1060 1070 1080 1090
AAGLVQDWLM GEEEEDMVPC KTLCETAHVH GLPVTRYRVQ YSRRPASP
Note: No experimental confirmation available.
Length:1,098
Mass (Da):126,405
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA73F6DFC11EBA256
GO
Isoform 1 (identifier: Q62141-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     955-1098: Missing.

Show »
Length:954
Mass (Da):109,393
Checksum:i31F4BE14523EA213
GO
Isoform 2 (identifier: Q62141-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-293: KKMKLRGTKDLSIAAVGKY → VGLQLKCAVVWFGYCTAEE
     294-954: Missing.
     955-1098: Missing.

Show »
Length:293
Mass (Da):32,846
Checksum:i11A75E8F67C818AE
GO
Isoform 3 (identifier: Q62141-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     275-302: KKMKLRGTKDLSIAAVGKYGTLQEFSFF → VLVHVWVLPAHGRSGVEAQAAGEPEARA
     303-954: Missing.
     955-1098: Missing.

Note: No experimental confirmation available.
Show »
Length:302
Mass (Da):33,637
Checksum:i421131CCD87C88F8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RM25A0A1D5RM25_MOUSE
Paired amphipathic helix protein Si...
Sin3b
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32283 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti230A → G in AAC04821 (PubMed:10620510).Curated1
Sequence conflicti233S → P in AAC04821 (PubMed:10620510).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008227275 – 302KKMKL…EFSFF → VLVHVWVLPAHGRSGVEAQA AGEPEARA in isoform 3. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_008225275 – 293KKMKL…AVGKY → VGLQLKCAVVWFGYCTAEE in isoform 2. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_008226294 – 954Missing in isoform 2. 2 PublicationsAdd BLAST661
Alternative sequenceiVSP_008228303 – 954Missing in isoform 3. 1 PublicationAdd BLAST652
Alternative sequenceiVSP_014187955 – 1098Missing in isoform 1, isoform 2 and isoform 3. 3 PublicationsAdd BLAST144

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L38622 mRNA Translation: AAA69774.1
AF038848 mRNA Translation: AAC04821.1
AK173005 mRNA Translation: BAD32283.1 Different initiation.
BC020049 mRNA Translation: AAH20049.1
BC021160 mRNA Translation: AAH21160.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS52598.1 [Q62141-2]
CCDS52599.1 [Q62141-4]

Protein sequence database of the Protein Information Resource

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PIRi
I61714

NCBI Reference Sequences

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RefSeqi
NP_001106719.1, NM_001113248.2 [Q62141-2]
NP_033214.2, NM_009188.4 [Q62141-4]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.2137

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000004494; ENSMUSP00000004494; ENSMUSG00000031622 [Q62141-4]
ENSMUST00000109950; ENSMUSP00000105576; ENSMUSG00000031622 [Q62141-2]
ENSMUST00000212095; ENSMUSP00000148407; ENSMUSG00000031622 [Q62141-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
20467

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:20467

UCSC genome browser

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UCSCi
uc009mgp.3 mouse [Q62141-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38622 mRNA Translation: AAA69774.1
AF038848 mRNA Translation: AAC04821.1
AK173005 mRNA Translation: BAD32283.1 Different initiation.
BC020049 mRNA Translation: AAH20049.1
BC021160 mRNA Translation: AAH21160.1
CCDSiCCDS52598.1 [Q62141-2]
CCDS52599.1 [Q62141-4]
PIRiI61714
RefSeqiNP_001106719.1, NM_001113248.2 [Q62141-2]
NP_033214.2, NM_009188.4 [Q62141-4]
UniGeneiMm.2137

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E91NMR-A148-232[»]
1PD7NMR-A148-232[»]
2CR7NMR-A32-98[»]
2CZYNMR-A31-107[»]
2F05NMR-A148-252[»]
5Y95NMR-A32-98[»]
ProteinModelPortaliQ62141
SMRiQ62141
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203257, 17 interactors
ComplexPortaliCPX-3444 SIN3B histone deacetylase complex
CORUMiQ62141
DIPiDIP-470N
IntActiQ62141, 8 interactors
MINTiQ62141
STRINGi10090.ENSMUSP00000004494

PTM databases

iPTMnetiQ62141
PhosphoSitePlusiQ62141

Proteomic databases

MaxQBiQ62141
PaxDbiQ62141
PeptideAtlasiQ62141
PRIDEiQ62141

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004494; ENSMUSP00000004494; ENSMUSG00000031622 [Q62141-4]
ENSMUST00000109950; ENSMUSP00000105576; ENSMUSG00000031622 [Q62141-2]
ENSMUST00000212095; ENSMUSP00000148407; ENSMUSG00000031622 [Q62141-3]
GeneIDi20467
KEGGimmu:20467
UCSCiuc009mgp.3 mouse [Q62141-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23309
MGIiMGI:107158 Sin3b

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG4204 Eukaryota
COG5602 LUCA
GeneTreeiENSGT00940000159560
HOGENOMiHOG000230688
HOVERGENiHBG060425
InParanoidiQ62141
OMAiCNVDCRF
OrthoDBiEOG091G03HY
PhylomeDBiQ62141
TreeFamiTF106187

Enzyme and pathway databases

ReactomeiR-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Sin3b mouse
EvolutionaryTraceiQ62141

Protein Ontology

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PROi
PR:Q62141

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000031622 Expressed in 307 organ(s), highest expression level in placenta
CleanExiMM_SIN3B
ExpressionAtlasiQ62141 baseline and differential
GenevisibleiQ62141 MM

Family and domain databases

InterProiView protein in InterPro
IPR013194 HDAC_interact_dom
IPR003822 PAH
IPR036600 PAH_sf
IPR039774 Sin3-like
IPR031693 Sin3_C
PANTHERiPTHR12346 PTHR12346, 1 hit
PfamiView protein in Pfam
PF02671 PAH, 3 hits
PF08295 Sin3_corepress, 1 hit
PF16879 Sin3a_C, 1 hit
SMARTiView protein in SMART
SM00761 HDAC_interact, 1 hit
SUPFAMiSSF47762 SSF47762, 3 hits
PROSITEiView protein in PROSITE
PS51477 PAH, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIN3B_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q62141
Secondary accession number(s): O54976
, Q6A013, Q8VCB8, Q8VDZ5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 21, 2005
Last modified: December 5, 2018
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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