UniProtKB - Q62132 (PTPRR_MOUSE)
Protein
Receptor-type tyrosine-protein phosphatase R
Gene
Ptprr
Organism
Mus musculus (Mouse)
Status
Functioni
Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Isoform gamma may have a role in patterning and cellular proliferation of skeletal elements in the precartilaginous/cartilaginous skeleton.2 Publications
Catalytic activityi
- EC:3.1.3.48PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 553 | SubstrateBy similarity | 1 | |
Active sitei | 587 | Phosphocysteine intermediatePROSITE-ProRule annotation | 1 | |
Binding sitei | 631 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
- protein tyrosine phosphatase activity Source: MGI
GO - Biological processi
- ERBB2 signaling pathway Source: MGI
- in utero embryonic development Source: UniProtKB
- negative regulation of epithelial cell migration Source: MGI
- negative regulation of ERK1 and ERK2 cascade Source: MGI
- protein dephosphorylation Source: MGI
Keywordsi
Molecular function | Hydrolase, Protein phosphatase, Receptor |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor-type tyrosine-protein phosphatase R (EC:3.1.3.48)Short name: R-PTP-R Alternative name(s): Phosphotyrosine phosphatase 13 Protein-tyrosine-phosphatase SL |
Gene namesi | Name:Ptprr Synonyms:Ptp13 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109559 Ptprr |
Subcellular locationi
Isoform Alpha :
Plasma membrane
Isoform Beta :
Other locations
Note: Locates to the areas within the cytoplasm.
Isoform Gamma :
Other locations
Note: Locates to the areas within the cytoplasm.
Cytosol
- cytosol Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cell junction Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 226 | ExtracellularSequence analysisAdd BLAST | 203 | |
Transmembranei | 227 – 247 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 248 – 656 | CytoplasmicSequence analysisAdd BLAST | 409 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 338 | S → A: Loss of phosphorylation by PKA, constitutive MAPK binding. 1 Publication | 1 | |
Mutagenesisi | 338 | S → E: Mimics phosphorylation by PKA, prevents MAPK binding. 1 Publication | 1 | |
Mutagenesisi | 587 | C → S: Loss of phosphatase activity. 1 Publication | 1 | |
Mutagenesisi | 593 | R → M: Loss of phosphatase activity. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000025460 | 24 – 656 | Receptor-type tyrosine-protein phosphatase RAdd BLAST | 633 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 128 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 271 | PhosphoserineCombined sources | 1 | |
Modified residuei | 338 | Phosphoserine; by PKA1 Publication | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q62132 |
PRIDEi | Q62132 |
PTM databases
iPTMneti | Q62132 |
PhosphoSitePlusi | Q62132 |
Expressioni
Tissue specificityi
Expressed in the heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Isoform alpha is expressed throughout the granular layer of the cerebellar but not within the Purkinje cells, also in the villi of the ileum and jejunum and both the villi and crypts of the duodenum. Isoform beta is expressed only in the Purkinje cells. Isoform gamma is expressed throughout the brain, the villi and crypts of the duodenum, jejunum and ileum and expressed at low levels in the proximal colon.4 Publications
Developmental stagei
Isoform gamma is the only family member developmentally expressed. Expressed throughout the brain in 15.5 day embryos and in cranial nerve cells, skeletal tissues such as neural crest-derived face bones, and the periphery of cartilaginous skeletal elements including the rib and vertebrae anlage. On day 17.5, expression was observed throughout the brain, trigeminal ganglion, cranofacial bones, oral-facial structures, cervical vertebrae, axis and the ileum. Expression continued in the vertebral column throughout ossification.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000020151 Expressed in 189 organ(s), highest expression level in embryo |
ExpressionAtlasi | Q62132 baseline and differential |
Genevisiblei | Q62132 MM |
Interactioni
Subunit structurei
Interacts with MAPKs.1 Publication
Binary interactionsi
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
ELMi | Q62132 |
IntActi | Q62132, 5 interactors |
MINTi | Q62132 |
STRINGi | 10090.ENSMUSP00000064392 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1JLN | X-ray | 1.81 | A | 361-655 | [»] | |
ProteinModelPortali | Q62132 | |||||
SMRi | Q62132 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q62132 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 392 – 646 | Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST | 255 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 587 – 593 | Substrate bindingBy similarity | 7 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0789 Eukaryota COG5599 LUCA |
GeneTreei | ENSGT00940000157212 |
HOGENOMi | HOG000294188 |
HOVERGENi | HBG001594 |
InParanoidi | Q62132 |
KOi | K04458 |
OrthoDBi | 411281at2759 |
PhylomeDBi | Q62132 |
TreeFami | TF331016 |
Family and domain databases
Gene3Di | 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR008356 Tyr_Pase_KIM-con IPR016334 Tyr_Pase_rcpt_R/non-rcpt_5 IPR000387 TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00102 Y_phosphatase, 1 hit |
PIRSFi | PIRSF001997 PTPRR, 1 hit |
PRINTSi | PR01778 KIMPTPASE PR00700 PRTYPHPHTASE |
SMARTi | View protein in SMART SM00194 PTPc, 1 hit SM00404 PTPc_motif, 1 hit |
SUPFAMi | SSF52799 SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50055 TYR_PHOSPHATASE_PTP, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform Alpha (identifier: Q62132-1) [UniParc]FASTAAdd to basket
Also known as: PTPBR7
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MRRAVGFPAL CLLLNLHAAG CFSRNNDHFL AIRQKKSWKP VFIYDHSQDI
60 70 80 90 100
KKSLDIAQEA YKHNYHSPSE VQISKHHQII NSAFPRPAYD PSLNLLAESD
110 120 130 140 150
QDLEIENLPI PAANVIVVTL QMDITKLNIT LLRIFRQGVA AALGLLPQQV
160 170 180 190 200
HINRLIEKKN QVELFVSPGN RKPGETQALQ AEEVLRSLNV DGLHQSLPQF
210 220 230 240 250
GITDVAPEKN VLQGQHEADK IWSKEGFYAV VIFLSIFIII VTCLMIIYRL
260 270 280 290 300
KERLQLSLRQ DKEKNQEIHL SPIARQQAQS EAKTTHSMVQ PDQAPKVLNV
310 320 330 340 350
VVDPQGQCTP EIRNSTSTSV CPSPFRMKPI GLQERRGSNV SLTLDMSSLG
360 370 380 390 400
SVEPFVAVST PREKVAMEYL QSASRVLTRS QLRDVVASSH LLQSEFMEIP
410 420 430 440 450
MNFVDPKEID IPRHGTKNRY KTILPNPLSR VCLRPKNITD SLSTYINANY
460 470 480 490 500
IRGYSGKEKA FIATQGPMIN TVNDFWQMVW QEDSPVIVMI TKLKEKNEKC
510 520 530 540 550
VLYWPEKRGI YGKVEVLVTG VTECDNYTIR NLVLKQGSHT QHVKHYWYTS
560 570 580 590 600
WPDHKTPDSA QPLLQLMLDV EEDRLASEGR GPVVVHCSAG IGRTGCFIAT
610 620 630 640 650
SIGCQQLKEE GVVDALSIVC QLRVDRGGMV QTSEQYEFVH HALCLFESRL
SPETVE
Isoform Beta (identifier: Q62132-2) [UniParc]FASTAAdd to basket
Also known as: PTP-SL
The sequence of this isoform differs from the canonical sequence as follows:
1-107: Missing.
108-121: LPIPAANVIVVTLQ → MHRNTRSVSTPTLQ
Isoform Gamma (identifier: Q62132-3) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-244: Missing.
Sequence cautioni
The sequence CAA82958 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005161 | 1 – 244 | Missing in isoform Gamma. 1 PublicationAdd BLAST | 244 | |
Alternative sequenceiVSP_005159 | 1 – 107 | Missing in isoform Beta. 1 PublicationAdd BLAST | 107 | |
Alternative sequenceiVSP_005160 | 108 – 121 | LPIPA…VVTLQ → MHRNTRSVSTPTLQ in isoform Beta. 1 PublicationAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D31898 mRNA Translation: BAA06696.1 Z30313 mRNA Translation: CAA82957.1 Z30313 mRNA Translation: CAA82958.1 Different initiation. AF129509 mRNA Translation: AAD29673.1 AF041866 mRNA Translation: AAD09171.1 |
CCDSi | CCDS24182.1 [Q62132-1] CCDS48693.1 [Q62132-3] CCDS56750.1 [Q62132-2] |
PIRi | A55574 |
RefSeqi | NP_001155309.1, NM_001161837.1 [Q62132-2] NP_001155310.1, NM_001161838.1 [Q62132-3] NP_001155311.1, NM_001161839.1 [Q62132-3] NP_001155312.1, NM_001161840.1 [Q62132-3] NP_035347.1, NM_011217.2 [Q62132-1] |
UniGenei | Mm.336316 |
Genome annotation databases
Ensembli | ENSMUST00000063470; ENSMUSP00000064392; ENSMUSG00000020151 [Q62132-1] ENSMUST00000105271; ENSMUSP00000100907; ENSMUSG00000020151 [Q62132-2] ENSMUST00000128399; ENSMUSP00000114455; ENSMUSG00000020151 [Q62132-3] ENSMUST00000148731; ENSMUSP00000120965; ENSMUSG00000020151 [Q62132-3] ENSMUST00000155606; ENSMUSP00000122259; ENSMUSG00000020151 [Q62132-3] |
GeneIDi | 19279 |
KEGGi | mmu:19279 |
UCSCi | uc007hbp.2 mouse [Q62132-1] uc007hbr.2 mouse [Q62132-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D31898 mRNA Translation: BAA06696.1 Z30313 mRNA Translation: CAA82957.1 Z30313 mRNA Translation: CAA82958.1 Different initiation. AF129509 mRNA Translation: AAD29673.1 AF041866 mRNA Translation: AAD09171.1 |
CCDSi | CCDS24182.1 [Q62132-1] CCDS48693.1 [Q62132-3] CCDS56750.1 [Q62132-2] |
PIRi | A55574 |
RefSeqi | NP_001155309.1, NM_001161837.1 [Q62132-2] NP_001155310.1, NM_001161838.1 [Q62132-3] NP_001155311.1, NM_001161839.1 [Q62132-3] NP_001155312.1, NM_001161840.1 [Q62132-3] NP_035347.1, NM_011217.2 [Q62132-1] |
UniGenei | Mm.336316 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1JLN | X-ray | 1.81 | A | 361-655 | [»] | |
ProteinModelPortali | Q62132 | |||||
SMRi | Q62132 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
ELMi | Q62132 |
IntActi | Q62132, 5 interactors |
MINTi | Q62132 |
STRINGi | 10090.ENSMUSP00000064392 |
PTM databases
iPTMneti | Q62132 |
PhosphoSitePlusi | Q62132 |
Proteomic databases
PaxDbi | Q62132 |
PRIDEi | Q62132 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Organism-specific databases
CTDi | 5801 |
MGIi | MGI:109559 Ptprr |
Phylogenomic databases
eggNOGi | KOG0789 Eukaryota COG5599 LUCA |
GeneTreei | ENSGT00940000157212 |
HOGENOMi | HOG000294188 |
HOVERGENi | HBG001594 |
InParanoidi | Q62132 |
KOi | K04458 |
OrthoDBi | 411281at2759 |
PhylomeDBi | Q62132 |
TreeFami | TF331016 |
Miscellaneous databases
EvolutionaryTracei | Q62132 |
PROi | PR:Q62132 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020151 Expressed in 189 organ(s), highest expression level in embryo |
ExpressionAtlasi | Q62132 baseline and differential |
Genevisiblei | Q62132 MM |
Family and domain databases
Gene3Di | 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR008356 Tyr_Pase_KIM-con IPR016334 Tyr_Pase_rcpt_R/non-rcpt_5 IPR000387 TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00102 Y_phosphatase, 1 hit |
PIRSFi | PIRSF001997 PTPRR, 1 hit |
PRINTSi | PR01778 KIMPTPASE PR00700 PRTYPHPHTASE |
SMARTi | View protein in SMART SM00194 PTPc, 1 hit SM00404 PTPc_motif, 1 hit |
SUPFAMi | SSF52799 SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50055 TYR_PHOSPHATASE_PTP, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | PTPRR_MOUSE | |
Accessioni | Q62132Primary (citable) accession number: Q62132 Secondary accession number(s): Q64491, Q64492, Q9QUH9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 15, 2002 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 13, 2019 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot