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UniProtKB - Q62132 (PTPRR_MOUSE)

Protein

Receptor-type tyrosine-protein phosphatase R

Gene

Ptprr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Isoform gamma may have a role in patterning and cellular proliferation of skeletal elements in the precartilaginous/cartilaginous skeleton.2 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei553SubstrateBy similarity1
Active sitei587Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei631SubstrateBy similarity1

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • protein tyrosine phosphatase activity Source: MGI
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase R (EC:3.1.3.48)
Short name:
R-PTP-R
Alternative name(s):
Phosphotyrosine phosphatase 13
Protein-tyrosine-phosphatase SL
Gene namesi
Name:Ptprr
Synonyms:Ptp13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:109559 Ptprr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 226ExtracellularSequence analysisAdd BLAST203
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Topological domaini248 – 656CytoplasmicSequence analysisAdd BLAST409

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi338S → A: Loss of phosphorylation by PKA, constitutive MAPK binding. 1 Publication1
Mutagenesisi338S → E: Mimics phosphorylation by PKA, prevents MAPK binding. 1 Publication1
Mutagenesisi587C → S: Loss of phosphatase activity. 1 Publication1
Mutagenesisi593R → M: Loss of phosphatase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002546024 – 656Receptor-type tyrosine-protein phosphatase RAdd BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei271PhosphoserineCombined sources1
Modified residuei338Phosphoserine; by PKA1 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ62132
PRIDEiQ62132

PTM databases

iPTMnetiQ62132
PhosphoSitePlusiQ62132

Expressioni

Tissue specificityi

Expressed in the heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Isoform alpha is expressed throughout the granular layer of the cerebellar but not within the Purkinje cells, also in the villi of the ileum and jejunum and both the villi and crypts of the duodenum. Isoform beta is expressed only in the Purkinje cells. Isoform gamma is expressed throughout the brain, the villi and crypts of the duodenum, jejunum and ileum and expressed at low levels in the proximal colon.4 Publications

Developmental stagei

Isoform gamma is the only family member developmentally expressed. Expressed throughout the brain in 15.5 day embryos and in cranial nerve cells, skeletal tissues such as neural crest-derived face bones, and the periphery of cartilaginous skeletal elements including the rib and vertebrae anlage. On day 17.5, expression was observed throughout the brain, trigeminal ganglion, cranofacial bones, oral-facial structures, cervical vertebrae, axis and the ileum. Expression continued in the vertebral column throughout ossification.1 Publication

Gene expression databases

BgeeiENSMUSG00000020151 Expressed in 189 organ(s), highest expression level in embryo
CleanExiMM_PTPRR
ExpressionAtlasiQ62132 baseline and differential
GenevisibleiQ62132 MM

Interactioni

Subunit structurei

Interacts with MAPKs.1 Publication

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

ELMiQ62132
IntActiQ62132, 5 interactors
MINTiQ62132
STRINGi10090.ENSMUSP00000064392

Structurei

Secondary structure

1656
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ62132
SMRiQ62132
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ62132

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini392 – 646Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST255

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni587 – 593Substrate bindingBy similarity7

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00920000148980
HOGENOMiHOG000294188
HOVERGENiHBG001594
InParanoidiQ62132
KOiK04458
OrthoDBiEOG091G0HLB
PhylomeDBiQ62132
TreeFamiTF331016

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR008356 Tyr_Pase_KIM-con
IPR016334 Tyr_Pase_rcpt_R/non-rcpt_5
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF001997 PTPRR, 1 hit
PRINTSiPR01778 KIMPTPASE
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Alpha (identifier: Q62132-1) [UniParc]FASTAAdd to basket
Also known as: PTPBR7

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRAVGFPAL CLLLNLHAAG CFSRNNDHFL AIRQKKSWKP VFIYDHSQDI 
        60         70         80         90        100
KKSLDIAQEA YKHNYHSPSE VQISKHHQII NSAFPRPAYD PSLNLLAESD 
       110        120        130        140        150
QDLEIENLPI PAANVIVVTL QMDITKLNIT LLRIFRQGVA AALGLLPQQV 
       160        170        180        190        200
HINRLIEKKN QVELFVSPGN RKPGETQALQ AEEVLRSLNV DGLHQSLPQF 
       210        220        230        240        250
GITDVAPEKN VLQGQHEADK IWSKEGFYAV VIFLSIFIII VTCLMIIYRL 
       260        270        280        290        300
KERLQLSLRQ DKEKNQEIHL SPIARQQAQS EAKTTHSMVQ PDQAPKVLNV 
       310        320        330        340        350
VVDPQGQCTP EIRNSTSTSV CPSPFRMKPI GLQERRGSNV SLTLDMSSLG 
       360        370        380        390        400
SVEPFVAVST PREKVAMEYL QSASRVLTRS QLRDVVASSH LLQSEFMEIP 
       410        420        430        440        450
MNFVDPKEID IPRHGTKNRY KTILPNPLSR VCLRPKNITD SLSTYINANY 
       460        470        480        490        500
IRGYSGKEKA FIATQGPMIN TVNDFWQMVW QEDSPVIVMI TKLKEKNEKC 
       510        520        530        540        550
VLYWPEKRGI YGKVEVLVTG VTECDNYTIR NLVLKQGSHT QHVKHYWYTS 
       560        570        580        590        600
WPDHKTPDSA QPLLQLMLDV EEDRLASEGR GPVVVHCSAG IGRTGCFIAT 
       610        620        630        640        650
SIGCQQLKEE GVVDALSIVC QLRVDRGGMV QTSEQYEFVH HALCLFESRL 

SPETVE
Length:656
Mass (Da):74,036
Last modified:November 1, 1996 - v1
Checksum:i31FA82F582992720
GO
Isoform Beta (identifier: Q62132-2) [UniParc]FASTAAdd to basket
Also known as: PTP-SL

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.
     108-121: LPIPAANVIVVTLQ → MHRNTRSVSTPTLQ

Show »
Length:549
Mass (Da):61,921
Checksum:iC82AB43DF4C4FD7A
GO
Isoform Gamma (identifier: Q62132-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-244: Missing.

Show »
Length:412
Mass (Da):46,585
Checksum:iC51B5F816CB8C874
GO

Sequence cautioni

The sequence CAA82958 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0051611 – 244Missing in isoform Gamma. 1 PublicationAdd BLAST244
Alternative sequenceiVSP_0051591 – 107Missing in isoform Beta. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_005160108 – 121LPIPA…VVTLQ → MHRNTRSVSTPTLQ in isoform Beta. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31898 mRNA Translation: BAA06696.1
Z30313 mRNA Translation: CAA82957.1
Z30313 mRNA Translation: CAA82958.1 Different initiation.
AF129509 mRNA Translation: AAD29673.1
AF041866 mRNA Translation: AAD09171.1
CCDSiCCDS24182.1 [Q62132-1]
CCDS48693.1 [Q62132-3]
CCDS56750.1 [Q62132-2]
PIRiA55574
RefSeqiNP_001155309.1, NM_001161837.1 [Q62132-2]
NP_001155310.1, NM_001161838.1 [Q62132-3]
NP_001155311.1, NM_001161839.1 [Q62132-3]
NP_001155312.1, NM_001161840.1 [Q62132-3]
NP_035347.1, NM_011217.2 [Q62132-1]
UniGeneiMm.336316

Genome annotation databases

EnsembliENSMUST00000063470; ENSMUSP00000064392; ENSMUSG00000020151 [Q62132-1]
ENSMUST00000105271; ENSMUSP00000100907; ENSMUSG00000020151 [Q62132-2]
ENSMUST00000128399; ENSMUSP00000114455; ENSMUSG00000020151 [Q62132-3]
ENSMUST00000148731; ENSMUSP00000120965; ENSMUSG00000020151 [Q62132-3]
ENSMUST00000155606; ENSMUSP00000122259; ENSMUSG00000020151 [Q62132-3]
GeneIDi19279
KEGGimmu:19279
UCSCiuc007hbp.2 mouse [Q62132-1]
uc007hbr.2 mouse [Q62132-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31898 mRNA Translation: BAA06696.1
Z30313 mRNA Translation: CAA82957.1
Z30313 mRNA Translation: CAA82958.1 Different initiation.
AF129509 mRNA Translation: AAD29673.1
AF041866 mRNA Translation: AAD09171.1
CCDSiCCDS24182.1 [Q62132-1]
CCDS48693.1 [Q62132-3]
CCDS56750.1 [Q62132-2]
PIRiA55574
RefSeqiNP_001155309.1, NM_001161837.1 [Q62132-2]
NP_001155310.1, NM_001161838.1 [Q62132-3]
NP_001155311.1, NM_001161839.1 [Q62132-3]
NP_001155312.1, NM_001161840.1 [Q62132-3]
NP_035347.1, NM_011217.2 [Q62132-1]
UniGeneiMm.336316

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JLNX-ray1.81A361-655[»]
ProteinModelPortaliQ62132
SMRiQ62132
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiQ62132
IntActiQ62132, 5 interactors
MINTiQ62132
STRINGi10090.ENSMUSP00000064392

PTM databases

iPTMnetiQ62132
PhosphoSitePlusiQ62132

Proteomic databases

PaxDbiQ62132
PRIDEiQ62132

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063470; ENSMUSP00000064392; ENSMUSG00000020151 [Q62132-1]
ENSMUST00000105271; ENSMUSP00000100907; ENSMUSG00000020151 [Q62132-2]
ENSMUST00000128399; ENSMUSP00000114455; ENSMUSG00000020151 [Q62132-3]
ENSMUST00000148731; ENSMUSP00000120965; ENSMUSG00000020151 [Q62132-3]
ENSMUST00000155606; ENSMUSP00000122259; ENSMUSG00000020151 [Q62132-3]
GeneIDi19279
KEGGimmu:19279
UCSCiuc007hbp.2 mouse [Q62132-1]
uc007hbr.2 mouse [Q62132-2]

Organism-specific databases

CTDi5801
MGIiMGI:109559 Ptprr

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00920000148980
HOGENOMiHOG000294188
HOVERGENiHBG001594
InParanoidiQ62132
KOiK04458
OrthoDBiEOG091G0HLB
PhylomeDBiQ62132
TreeFamiTF331016

Miscellaneous databases

EvolutionaryTraceiQ62132
PROiPR:Q62132
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020151 Expressed in 189 organ(s), highest expression level in embryo
CleanExiMM_PTPRR
ExpressionAtlasiQ62132 baseline and differential
GenevisibleiQ62132 MM

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR008356 Tyr_Pase_KIM-con
IPR016334 Tyr_Pase_rcpt_R/non-rcpt_5
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF001997 PTPRR, 1 hit
PRINTSiPR01778 KIMPTPASE
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRR_MOUSE
AccessioniPrimary (citable) accession number: Q62132
Secondary accession number(s): Q64491, Q64492, Q9QUH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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