UniProtKB - Q62120 (JAK2_MOUSE)
Tyrosine-protein kinase JAK2
Jak2
Functioni
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.
9 PublicationsCatalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]PROSITE-ProRule annotation2 PublicationsEC:2.7.10.2PROSITE-ProRule annotation2 Publications
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 882 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 976 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 855 – 863 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- acetylcholine receptor binding Source: MGI
- ATP binding Source: UniProtKB-KW
- growth hormone receptor binding Source: BHF-UCL
- heme binding Source: UniProtKB
- histone binding Source: UniProtKB
- histone kinase activity (H3-Y41 specific) Source: UniProtKB
- identical protein binding Source: MGI
- insulin receptor substrate binding Source: MGI
- interleukin-12 receptor binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: Reactome
- peptide hormone receptor binding Source: MGI
- phosphatidylinositol 3-kinase binding Source: MGI
- protein C-terminus binding Source: MGI
- protein kinase binding Source: BHF-UCL
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: UniProtKB
- SH2 domain binding Source: MGI
- signaling receptor binding Source: MGI
- type 1 angiotensin receptor binding Source: MGI
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: BHF-UCL
- activation of Janus kinase activity Source: UniProtKB
- adaptive immune response Source: UniProtKB-KW
- axon regeneration Source: BHF-UCL
- cell differentiation Source: MGI
- cellular response to dexamethasone stimulus Source: MGI
- cellular response to interleukin-3 Source: MGI
- cellular response to lipopolysaccharide Source: MGI
- chromatin organization Source: UniProtKB-KW
- collagen-activated signaling pathway Source: MGI
- cytokine-mediated signaling pathway Source: UniProtKB
- enzyme linked receptor protein signaling pathway Source: MGI
- erythrocyte differentiation Source: UniProtKB
- extrinsic apoptotic signaling pathway Source: MGI
- G protein-coupled receptor signaling pathway Source: BHF-UCL
- granulocyte-macrophage colony-stimulating factor signaling pathway Source: Ensembl
- growth hormone receptor signaling pathway Source: BHF-UCL
- growth hormone receptor signaling pathway via JAK-STAT Source: BHF-UCL
- histone H3-Y41 phosphorylation Source: UniProtKB
- hormone-mediated signaling pathway Source: BHF-UCL
- interferon-gamma-mediated signaling pathway Source: BHF-UCL
- interleukin-12-mediated signaling pathway Source: BHF-UCL
- intracellular signal transduction Source: MGI
- intrinsic apoptotic signaling pathway in response to oxidative stress Source: BHF-UCL
- mammary gland epithelium development Source: MGI
- microglial cell activation Source: ARUK-UCL
- mineralocorticoid receptor signaling pathway Source: BHF-UCL
- modulation of chemical synaptic transmission Source: MGI
- myeloid cell differentiation Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of cardiac muscle cell apoptotic process Source: MGI
- negative regulation of cell-cell adhesion Source: BHF-UCL
- negative regulation of cell death Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of DNA binding Source: MGI
- negative regulation of heart contraction Source: BHF-UCL
- negative regulation of neuron apoptotic process Source: MGI
- peptidyl-tyrosine phosphorylation Source: MGI
- platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
- positive regulation of apoptotic process Source: MGI
- positive regulation of apoptotic signaling pathway Source: MGI
- positive regulation of cell activation Source: BHF-UCL
- positive regulation of cell differentiation Source: BHF-UCL
- positive regulation of cell migration Source: BHF-UCL
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of cell-substrate adhesion Source: BHF-UCL
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
- positive regulation of DNA binding Source: BHF-UCL
- positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
- positive regulation of epithelial cell apoptotic process Source: MGI
- positive regulation of growth factor dependent skeletal muscle satellite cell proliferation Source: MGI
- positive regulation of growth hormone receptor signaling pathway Source: BHF-UCL
- positive regulation of inflammatory response Source: BHF-UCL
- positive regulation of insulin secretion Source: BHF-UCL
- positive regulation of interferon-gamma production Source: Ensembl
- positive regulation of interleukin-1 beta production Source: ARUK-UCL
- positive regulation of MAPK cascade Source: MGI
- positive regulation of MHC class II biosynthetic process Source: ARUK-UCL
- positive regulation of natural killer cell proliferation Source: Ensembl
- positive regulation of nitric oxide biosynthetic process Source: BHF-UCL
- positive regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
- positive regulation of NK T cell proliferation Source: Ensembl
- positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
- positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
- positive regulation of phosphoprotein phosphatase activity Source: BHF-UCL
- positive regulation of platelet activation Source: MGI
- positive regulation of platelet aggregation Source: MGI
- positive regulation of protein import into nucleus Source: MGI
- positive regulation of signaling receptor activity Source: ARUK-UCL
- positive regulation of SMAD protein signal transduction Source: MGI
- positive regulation of T cell proliferation Source: ComplexPortal
- positive regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of tumor necrosis factor production Source: BHF-UCL
- positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
- positive regulation of vascular associated smooth muscle cell proliferation Source: MGI
- post-embryonic hemopoiesis Source: CACAO
- postsynapse to nucleus signaling pathway Source: MGI
- programmed cell death induced by symbiont Source: MGI
- protein autophosphorylation Source: UniProtKB
- receptor signaling pathway via JAK-STAT Source: MGI
- regulation of apoptotic process Source: GO_Central
- regulation of inflammatory response Source: BHF-UCL
- regulation of nitric oxide biosynthetic process Source: MGI
- response to amine Source: Ensembl
- response to antibiotic Source: MGI
- response to granulocyte macrophage colony-stimulating factor Source: BHF-UCL
- response to hydroperoxide Source: BHF-UCL
- response to interleukin-12 Source: BHF-UCL
- response to lipopolysaccharide Source: BHF-UCL
- response to oxidative stress Source: BHF-UCL
- response to tumor necrosis factor Source: BHF-UCL
- signal transduction Source: UniProtKB
- tumor necrosis factor-mediated signaling pathway Source: BHF-UCL
- tyrosine phosphorylation of STAT protein Source: MGI
Keywordsi
Molecular function | Chromatin regulator, Kinase, Transferase, Tyrosine-protein kinase |
Biological process | Adaptive immunity, Immunity, Innate immunity |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 3474 |
Reactomei | R-MMU-1059683, Interleukin-6 signaling R-MMU-110056, MAPK3 (ERK1) activation R-MMU-112411, MAPK1 (ERK2) activation R-MMU-1170546, Prolactin receptor signaling R-MMU-1433557, Signaling by SCF-KIT R-MMU-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling R-MMU-5673000, RAF activation R-MMU-5673001, RAF/MAP kinase cascade R-MMU-6785807, Interleukin-4 and Interleukin-13 signaling R-MMU-6788467, IL-6-type cytokine receptor ligand interactions R-MMU-69231, Cyclin D associated events in G1 R-MMU-877300, Interferon gamma signaling R-MMU-877312, Regulation of IFNG signaling R-MMU-8854691, Interleukin-20 family signaling R-MMU-8984722, Interleukin-35 Signalling R-MMU-9020591, Interleukin-12 signaling R-MMU-9020933, Interleukin-23 signaling R-MMU-9020956, Interleukin-27 signaling R-MMU-9027276, Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-MMU-9027284, Erythropoietin activates RAS R-MMU-912526, Interleukin receptor SHC signaling R-MMU-9674555, Signaling by CSF3 (G-CSF) R-MMU-9705462, Inactivation of CSF3 (G-CSF) signaling R-MMU-982772, Growth hormone receptor signaling R-MMU-983231, Factors involved in megakaryocyte development and platelet production |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein kinase JAK2Curated (EC:2.7.10.22 Publications)Alternative name(s): Janus kinase 2 Short name: JAK-2 |
Gene namesi | Name:Jak2Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96629, Jak2 |
VEuPathDBi | HostDB:ENSMUSG00000024789 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Source: InterPro
Cytosol
- cytosol Source: MGI
Nucleus
- nucleolus Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Plasma Membrane
- caveola Source: MGI
- granulocyte macrophage colony-stimulating factor receptor complex Source: Ensembl
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: BHF-UCL
- endomembrane system Source: UniProtKB-SubCell
- euchromatin Source: MGI
- focal adhesion Source: MGI
- glutamatergic synapse Source: MGI
- membrane raft Source: MGI
- postsynapse Source: MGI
Keywords - Cellular componenti
Cytoplasm, Membrane, NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 119 | Y → E: Phosphorylation mimic mutant, leads to dissociation of JAK2 from the erythropoietin receptor complex. 1 Publication | 1 | |
Mutagenesisi | 119 | Y → F: More stably associated with the erythropoietin receptor complex. 1 Publication | 1 | |
Mutagenesisi | 372 | Y → F: About 60% loss of STAT1 phosphorylation by JAK2. 1 Publication | 1 | |
Mutagenesisi | 373 | Y → F: Decreased the ability of JAK2 to autophosphorylate. 1 Publication | 1 | |
Mutagenesisi | 868 | Y → F: Reduced activity in response to growth hormone. 1 Publication | 1 | |
Mutagenesisi | 966 | Y → F: Reduced activity in response to growth hormone. 1 Publication | 1 | |
Mutagenesisi | 972 | Y → F: Reduced activity in response to growth hormone. 1 Publication | 1 | |
Mutagenesisi | 1008 | Y → F: Affects the phosphorylation pattern. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL1649049 |
DrugCentrali | Q62120 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088113 | 1 – 1132 | Tyrosine-protein kinase JAK2Add BLAST | 1132 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 119 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 372 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 373 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 523 | PhosphoserineCombined sources | 1 | |
Modified residuei | 570 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 813 | Phosphotyrosine2 Publications | 1 | |
Modified residuei | 868 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 966 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 972 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 1007 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 1008 | Phosphotyrosine; by autocatalysis1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q62120 |
MaxQBi | Q62120 |
PaxDbi | Q62120 |
PRIDEi | Q62120 |
ProteomicsDBi | 269116 328792 |
PTM databases
iPTMneti | Q62120 |
PhosphoSitePlusi | Q62120 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000024789, Expressed in cleaving embryo and 328 other tissues |
Interactioni
Subunit structurei
Interacts with IL23R, SKB1 and STAM2 (By similarity).
Interacts with EPOR (PubMed:8343951, PubMed:11779507).
Interacts with LYN (PubMed:9573010).
Interacts with SIRPA (PubMed:10842184).
Interacts with SH2B1 (PubMed:17565041, PubMed:16824542).
Interacts with TEC (PubMed:9473212).
Interacts with IFNGR2 (via intracellular domain) (By similarity).
Interacts with LEPR (Isoform B) (PubMed:11923481).
Interacts with HSP90AB1; promotes functional activation in a heat shock-dependent manner.
Interacts with STRA6 (By similarity).
Interacts with ASB2; the interaction targets JAK2 for Notch-induced proteasomal degradation (By similarity).
By similarity9 PublicationsBinary interactionsi
Q62120
GO - Molecular functioni
- acetylcholine receptor binding Source: MGI
- growth hormone receptor binding Source: BHF-UCL
- histone binding Source: UniProtKB
- identical protein binding Source: MGI
- insulin receptor substrate binding Source: MGI
- interleukin-12 receptor binding Source: MGI
- peptide hormone receptor binding Source: MGI
- phosphatidylinositol 3-kinase binding Source: MGI
- protein C-terminus binding Source: MGI
- protein kinase binding Source: BHF-UCL
- SH2 domain binding Source: MGI
- signaling receptor binding Source: MGI
- type 1 angiotensin receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 200857, 41 interactors |
ComplexPortali | CPX-388, Interleukin-12-receptor complex CPX-389, Interleukin-23-receptor complex |
CORUMi | Q62120 |
DIPi | DIP-320N DIP-60238N |
IntActi | Q62120, 26 interactors |
MINTi | Q62120 |
STRINGi | 10090.ENSMUSP00000064394 |
Chemistry databases
BindingDBi | Q62120 |
Miscellaneous databases
RNActi | Q62120, protein |
Structurei
3D structure databases
SMRi | Q62120 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q62120 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 37 – 380 | FERMPROSITE-ProRule annotationAdd BLAST | 344 | |
Domaini | 401 – 482 | SH2; atypicalPROSITE-ProRule annotationAdd BLAST | 82 | |
Domaini | 545 – 809 | Protein kinase 1PROSITE-ProRule annotationAdd BLAST | 265 | |
Domaini | 849 – 1124 | Protein kinase 2PROSITE-ProRule annotationAdd BLAST | 276 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 239 | Interaction with cytokine/interferon/growth hormone receptorsAdd BLAST | 239 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, SH2 domainPhylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000155640 |
HOGENOMi | CLU_008155_1_0_1 |
InParanoidi | Q62120 |
OMAi | YKSYLPR |
OrthoDBi | 58906at2759 |
PhylomeDBi | Q62120 |
TreeFami | TF327041 |
Family and domain databases
CDDi | cd13333, FERM_C_JAK2, 1 hit cd05078, PTK_Jak2_rpt1, 1 hit cd14205, PTKc_Jak2_rpt2, 1 hit cd10379, SH2_Jak2, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
IDEALi | IID50091 |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR035963, FERM_2 IPR000299, FERM_domain IPR041155, FERM_F1 IPR041046, FERM_F2 IPR041381, Jak1_PHL_dom IPR037838, JAK2_FERM_C-lobe IPR035860, JAK2_SH2 IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR035588, PTK_Jak2_rpt1 IPR035589, PTKc_Jak2_rpt2 IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016251, Tyr_kinase_non-rcpt_Jak/Tyk2 IPR020693, Tyr_kinase_non-rcpt_Jak2 |
Pfami | View protein in Pfam PF18379, FERM_F1, 1 hit PF18377, FERM_F2, 1 hit PF17887, Jak1_Phl, 1 hit PF07714, PK_Tyr_Ser-Thr, 2 hits PF00017, SH2, 1 hit |
PIRSFi | PIRSF000636, TyrPK_Jak, 1 hit |
PRINTSi | PR01823, JANUSKINASE PR01825, JANUSKINASE2 PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 2 hits |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 2 hits |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 2 hits PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MGMACLTMTE MEATSTSPVH QNGDIPGSAN SVKQIEPVLQ VYLYHSLGQA
60 70 80 90 100
EGEYLKFPSG EYVAEEICVA ASKACGITPV YHNMFALMSE TERIWYPPNH
110 120 130 140 150
VFHIDESTRH DILYRIRFYF PHWYCSGSSR TYRYGVSRGA EAPLLDDFVM
160 170 180 190 200
SYLFAQWRHD FVHGWIKVPV THETQEECLG MAVLDMMRIA KEKDQTPLAV
210 220 230 240 250
YNSVSYKTFL PKCVRAKIQD YHILTRKRIR YRFRRFIQQF SQCKATARNL
260 270 280 290 300
KLKYLINLET LQSAFYTEQF EVKESARGPS GEEIFATIII TGNGGIQWSR
310 320 330 340 350
GKHKESETLT EQDVQLYCDF PDIIDVSIKQ ANQECSNESR IVTVHKQDGK
360 370 380 390 400
VLEIELSSLK EALSFVSLID GYYRLTADAH HYLCKEVAPP AVLENIHSNC
410 420 430 440 450
HGPISMDFAI SKLKKAGNQT GLYVLRCSPK DFNKYFLTFA VERENVIEYK
460 470 480 490 500
HCLITKNENG EYNLSGTKRN FSNLKDLLNC YQMETVRSDS IIFQFTKCCP
510 520 530 540 550
PKPKDKSNLL VFRTNGISDV QISPTLQRHN NVNQMVFHKI RNEDLIFNES
560 570 580 590 600
LGQGTFTKIF KGVRREVGDY GQLHKTEVLL KVLDKAHRNY SESFFEAASM
610 620 630 640 650
MSQLSHKHLV LNYGVCVCGE ENILVQEFVK FGSLDTYLKK NKNSINILWK
660 670 680 690 700
LGVAKQLAWA MHFLEEKSLI HGNVCAKNIL LIREEDRRTG NPPFIKLSDP
710 720 730 740 750
GISITVLPKD ILQERIPWVP PECIENPKNL NLATDKWSFG TTLWEICSGG
760 770 780 790 800
DKPLSALDSQ RKLQFYEDKH QLPAPKWTEL ANLINNCMDY EPDFRPAFRA
810 820 830 840 850
VIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD PTQFEERHLK
860 870 880 890 900
FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE
910 920 930 940 950
ILKSLQHDNI VKYKGVCYSA GRRNLRLIME YLPYGSLRDY LQKHKERIDH
960 970 980 990 1000
KKLLQYTSQI CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV
1010 1020 1030 1040 1050
LPQDKEYYKV KEPGESPIFW YAPESLTESK FSVASDVWSF GVVLYELFTY
1060 1070 1080 1090 1100
IEKSKSPPVE FMRMIGNDKQ GQMIVFHLIE LLKSNGRLPR PEGCPDEIYV
1110 1120 1130
IMTECWNNNV SQRPSFRDLS LRVDQIRDSI AA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A494BBB9 | A0A494BBB9_MOUSE | Tyrosine-protein kinase | Jak2 | 638 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 155 | A → V in AAB41327 (PubMed:8378315).Curated | 1 | |
Sequence conflicti | 468 | K → N in AAB41327 (PubMed:8378315).Curated | 1 | |
Sequence conflicti | 686 | D → N in AAH54807 (PubMed:15489334). | 1 | |
Sequence conflicti | 686 | D → N in AAH59834 (PubMed:15489334). | 1 | |
Sequence conflicti | 1016 | S → R in AAA40014 (PubMed:2466296).Curated | 1 | |
Sequence conflicti | 1024 | E → Q in AAB41327 (PubMed:8378315).Curated | 1 | |
Sequence conflicti | 1042 – 1043 | VV → IP in AAA40014 (PubMed:2466296).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L16956 mRNA Translation: AAB41327.1 Frameshift. AC119228 Genomic DNA No translation available. AC162456 Genomic DNA No translation available. BC054807 mRNA Translation: AAH54807.1 BC059834 mRNA Translation: AAH59834.1 M33423 mRNA Translation: AAA40014.1 |
CCDSi | CCDS37950.1 |
PIRi | A47511 B39577 JH0114 |
RefSeqi | NP_001041642.1, NM_001048177.2 NP_032439.2, NM_008413.3 XP_011245457.1, XM_011247155.2 |
Genome annotation databases
Ensembli | ENSMUST00000025705; ENSMUSP00000025705; ENSMUSG00000024789 ENSMUST00000065796; ENSMUSP00000064394; ENSMUSG00000024789 ENSMUST00000238009; ENSMUSP00000158242; ENSMUSG00000024789 |
GeneIDi | 16452 |
KEGGi | mmu:16452 |
UCSCi | uc008hdb.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L16956 mRNA Translation: AAB41327.1 Frameshift. AC119228 Genomic DNA No translation available. AC162456 Genomic DNA No translation available. BC054807 mRNA Translation: AAH54807.1 BC059834 mRNA Translation: AAH59834.1 M33423 mRNA Translation: AAA40014.1 |
CCDSi | CCDS37950.1 |
PIRi | A47511 B39577 JH0114 |
RefSeqi | NP_001041642.1, NM_001048177.2 NP_032439.2, NM_008413.3 XP_011245457.1, XM_011247155.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2HDX | X-ray | 2.35 | G/H/I/J/K/L | 810-820 | [»] | |
4GL9 | X-ray | 3.90 | A/B/C/D | 836-1129 | [»] | |
SMRi | Q62120 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 200857, 41 interactors |
ComplexPortali | CPX-388, Interleukin-12-receptor complex CPX-389, Interleukin-23-receptor complex |
CORUMi | Q62120 |
DIPi | DIP-320N DIP-60238N |
IntActi | Q62120, 26 interactors |
MINTi | Q62120 |
STRINGi | 10090.ENSMUSP00000064394 |
Chemistry databases
BindingDBi | Q62120 |
ChEMBLi | CHEMBL1649049 |
DrugCentrali | Q62120 |
PTM databases
iPTMneti | Q62120 |
PhosphoSitePlusi | Q62120 |
Proteomic databases
jPOSTi | Q62120 |
MaxQBi | Q62120 |
PaxDbi | Q62120 |
PRIDEi | Q62120 |
ProteomicsDBi | 269116 328792 |
Protocols and materials databases
Antibodypediai | 24086, 1211 antibodies from 48 providers |
DNASUi | 16452 |
Genome annotation databases
Ensembli | ENSMUST00000025705; ENSMUSP00000025705; ENSMUSG00000024789 ENSMUST00000065796; ENSMUSP00000064394; ENSMUSG00000024789 ENSMUST00000238009; ENSMUSP00000158242; ENSMUSG00000024789 |
GeneIDi | 16452 |
KEGGi | mmu:16452 |
UCSCi | uc008hdb.2, mouse |
Organism-specific databases
CTDi | 3717 |
MGIi | MGI:96629, Jak2 |
VEuPathDBi | HostDB:ENSMUSG00000024789 |
Phylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000155640 |
HOGENOMi | CLU_008155_1_0_1 |
InParanoidi | Q62120 |
OMAi | YKSYLPR |
OrthoDBi | 58906at2759 |
PhylomeDBi | Q62120 |
TreeFami | TF327041 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 3474 |
Reactomei | R-MMU-1059683, Interleukin-6 signaling R-MMU-110056, MAPK3 (ERK1) activation R-MMU-112411, MAPK1 (ERK2) activation R-MMU-1170546, Prolactin receptor signaling R-MMU-1433557, Signaling by SCF-KIT R-MMU-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling R-MMU-5673000, RAF activation R-MMU-5673001, RAF/MAP kinase cascade R-MMU-6785807, Interleukin-4 and Interleukin-13 signaling R-MMU-6788467, IL-6-type cytokine receptor ligand interactions R-MMU-69231, Cyclin D associated events in G1 R-MMU-877300, Interferon gamma signaling R-MMU-877312, Regulation of IFNG signaling R-MMU-8854691, Interleukin-20 family signaling R-MMU-8984722, Interleukin-35 Signalling R-MMU-9020591, Interleukin-12 signaling R-MMU-9020933, Interleukin-23 signaling R-MMU-9020956, Interleukin-27 signaling R-MMU-9027276, Erythropoietin activates Phosphoinositide-3-kinase (PI3K) R-MMU-9027284, Erythropoietin activates RAS R-MMU-912526, Interleukin receptor SHC signaling R-MMU-9674555, Signaling by CSF3 (G-CSF) R-MMU-9705462, Inactivation of CSF3 (G-CSF) signaling R-MMU-982772, Growth hormone receptor signaling R-MMU-983231, Factors involved in megakaryocyte development and platelet production |
Miscellaneous databases
BioGRID-ORCSi | 16452, 27 hits in 74 CRISPR screens |
ChiTaRSi | Jak2, mouse |
EvolutionaryTracei | Q62120 |
PROi | PR:Q62120 |
RNActi | Q62120, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024789, Expressed in cleaving embryo and 328 other tissues |
Family and domain databases
CDDi | cd13333, FERM_C_JAK2, 1 hit cd05078, PTK_Jak2_rpt1, 1 hit cd14205, PTKc_Jak2_rpt2, 1 hit cd10379, SH2_Jak2, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
IDEALi | IID50091 |
InterProi | View protein in InterPro IPR019749, Band_41_domain IPR035963, FERM_2 IPR000299, FERM_domain IPR041155, FERM_F1 IPR041046, FERM_F2 IPR041381, Jak1_PHL_dom IPR037838, JAK2_FERM_C-lobe IPR035860, JAK2_SH2 IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR035588, PTK_Jak2_rpt1 IPR035589, PTKc_Jak2_rpt2 IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR016251, Tyr_kinase_non-rcpt_Jak/Tyk2 IPR020693, Tyr_kinase_non-rcpt_Jak2 |
Pfami | View protein in Pfam PF18379, FERM_F1, 1 hit PF18377, FERM_F2, 1 hit PF17887, Jak1_Phl, 1 hit PF07714, PK_Tyr_Ser-Thr, 2 hits PF00017, SH2, 1 hit |
PIRSFi | PIRSF000636, TyrPK_Jak, 1 hit |
PRINTSi | PR01823, JANUSKINASE PR01825, JANUSKINASE2 PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00295, B41, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 2 hits |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 2 hits |
PROSITEi | View protein in PROSITE PS50057, FERM_3, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 2 hits PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | JAK2_MOUSE | |
Accessioni | Q62120Primary (citable) accession number: Q62120 Secondary accession number(s): G5E852, Q62124, Q7TQD0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 10, 2021 | |
Last modified: | February 23, 2022 | |
This is version 216 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families