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Protein

Serum paraoxonase/lactonase 3

Gene

Pon3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (By similarity).By similarity

Catalytic activityi

A phenyl acetate + H2O = a phenol + acetate.1 Publication
An aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol.1 Publication
An N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine.1 Publication

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Calcium 1; catalyticBy similarity1
Metal bindingi54Calcium 2By similarity1
Active sitei114Proton acceptorBy similarity1
Metal bindingi116Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi167Calcium 1; catalyticBy similarity1
Metal bindingi168Calcium 2By similarity1
Metal bindingi223Calcium 1; catalyticBy similarity1
Metal bindingi268Calcium 1; catalyticBy similarity1
Metal bindingi269Calcium 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.2 3474
3.1.8.1 3474
ReactomeiR-MMU-2142688 Synthesis of 5-eicosatetraenoic acids

Names & Taxonomyi

Protein namesi
Recommended name:
Serum paraoxonase/lactonase 3 (EC:3.1.1.2, EC:3.1.1.81, EC:3.1.8.1)
Gene namesi
Name:Pon3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:106686 Pon3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232911 – 354Serum paraoxonase/lactonase 3Add BLAST354
Signal peptidei1 – ?Not cleavedSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 352By similarity
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei165PhosphoserineBy similarity1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.By similarity
The signal sequence is not cleaved.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ62087
MaxQBiQ62087
PaxDbiQ62087
PeptideAtlasiQ62087
PRIDEiQ62087

PTM databases

iPTMnetiQ62087
PhosphoSitePlusiQ62087

Expressioni

Gene expression databases

BgeeiENSMUSG00000029759 Expressed in 175 organ(s), highest expression level in parotid gland
CleanExiMM_PON3
ExpressionAtlasiQ62087 baseline and differential
GenevisibleiQ62087 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ62087, 2 interactors
MINTiQ62087
STRINGi10090.ENSMUSP00000031773

Structurei

3D structure databases

ProteinModelPortaliQ62087
SMRiQ62087
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paraoxonase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHDV Eukaryota
ENOG4111QK7 LUCA
GeneTreeiENSGT00390000008932
HOGENOMiHOG000252960
HOVERGENiHBG003604
InParanoidiQ62087
KOiK01045
OMAiYFTNFFL
OrthoDBiEOG091G0AV9
PhylomeDBiQ62087
TreeFamiTF322436

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR002640 Arylesterase
IPR008364 Paraoxonase2
PfamiView protein in Pfam
PF01731 Arylesterase, 1 hit
PRINTSiPR01785 PARAOXONASE
PR01787 PARAOXONASE2

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q62087-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKLVALTLL GACLALIGER LLNFRERVST TREIKATEPQ NCHLIEGLEN
60 70 80 90 100
GSEDIDILPS GLAFISTGLK YPGMPAFAPD KPGRIFLMDL NEQNPEAQAL
110 120 130 140 150
EISGGLDQES LNPHGISTFI DKDNTAYLYV VNHPNMDSTV EIFKFEEQQR
160 170 180 190 200
SLIHLKTLKH ELLKSVNDIV VLGPEQFYAT RDHYFTSYFL VLLEMILDPH
210 220 230 240 250
WTSVVFYSPK EVKVVAQGFS SANGITVSLD QKFVYVADVT AKNIHIMKKH
260 270 280 290 300
DNWDLTPVKV IQLGTLVDNL TVDPATGDIL AGCHPNPMKL LIYNPEDPPG
310 320 330 340 350
SEVLRIQDSL SDKPRVSTLY ANNGSVLQGS TVASVYHKRM LIGTIFHKAL

YCDL
Length:354
Mass (Da):39,351
Last modified:July 19, 2004 - v2
Checksum:iD66534EAA4EB10F2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJ12D6RJ12_MOUSE
Serum paraoxonase/lactonase 3
Pon3
74Annotation score:
H3BL07H3BL07_MOUSE
Serum paraoxonase/lactonase 3
Pon3
135Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3K → H in AAC42090 (PubMed:8661009).Curated1
Sequence conflicti8T → P in AAC42090 (PubMed:8661009).Curated1
Sequence conflicti248K → E in AAC42090 (PubMed:8661009).Curated1
Sequence conflicti273D → A in AAC42090 (PubMed:8661009).Curated1
Sequence conflicti297D → G in AAC42090 (PubMed:8661009).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76193 mRNA Translation: AAC42090.1
AK088572 mRNA Translation: BAC40430.1
CH466533 Genomic DNA Translation: EDL13970.1
BC099416 mRNA Translation: AAH99416.1
CCDSiCCDS19899.1
RefSeqiNP_766594.1, NM_173006.1
UniGeneiMm.235511
Mm.9122

Genome annotation databases

EnsembliENSMUST00000031773; ENSMUSP00000031773; ENSMUSG00000029759
GeneIDi269823
KEGGimmu:269823
UCSCiuc009awe.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76193 mRNA Translation: AAC42090.1
AK088572 mRNA Translation: BAC40430.1
CH466533 Genomic DNA Translation: EDL13970.1
BC099416 mRNA Translation: AAH99416.1
CCDSiCCDS19899.1
RefSeqiNP_766594.1, NM_173006.1
UniGeneiMm.235511
Mm.9122

3D structure databases

ProteinModelPortaliQ62087
SMRiQ62087
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62087, 2 interactors
MINTiQ62087
STRINGi10090.ENSMUSP00000031773

PTM databases

iPTMnetiQ62087
PhosphoSitePlusiQ62087

Proteomic databases

EPDiQ62087
MaxQBiQ62087
PaxDbiQ62087
PeptideAtlasiQ62087
PRIDEiQ62087

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031773; ENSMUSP00000031773; ENSMUSG00000029759
GeneIDi269823
KEGGimmu:269823
UCSCiuc009awe.1 mouse

Organism-specific databases

CTDi5446
MGIiMGI:106686 Pon3

Phylogenomic databases

eggNOGiENOG410IHDV Eukaryota
ENOG4111QK7 LUCA
GeneTreeiENSGT00390000008932
HOGENOMiHOG000252960
HOVERGENiHBG003604
InParanoidiQ62087
KOiK01045
OMAiYFTNFFL
OrthoDBiEOG091G0AV9
PhylomeDBiQ62087
TreeFamiTF322436

Enzyme and pathway databases

BRENDAi3.1.1.2 3474
3.1.8.1 3474
ReactomeiR-MMU-2142688 Synthesis of 5-eicosatetraenoic acids

Miscellaneous databases

PROiPR:Q62087
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029759 Expressed in 175 organ(s), highest expression level in parotid gland
CleanExiMM_PON3
ExpressionAtlasiQ62087 baseline and differential
GenevisibleiQ62087 MM

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR002640 Arylesterase
IPR008364 Paraoxonase2
PfamiView protein in Pfam
PF01731 Arylesterase, 1 hit
PRINTSiPR01785 PARAOXONASE
PR01787 PARAOXONASE2
ProtoNetiSearch...

Entry informationi

Entry nameiPON3_MOUSE
AccessioniPrimary (citable) accession number: Q62087
Secondary accession number(s): Q4FZK0, Q8C2I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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