UniProtKB - Q62086 (PON2_MOUSE)
Protein
Serum paraoxonase/arylesterase 2
Gene
Pon2
Organism
Mus musculus (Mouse)
Status
Functioni
Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters.By similarity
Catalytic activityi
Cofactori
Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 53 | Calcium 1; catalyticBy similarity | 1 | |
Metal bindingi | 54 | Calcium 2By similarity | 1 | |
Active sitei | 114 | Proton acceptorBy similarity | 1 | |
Metal bindingi | 116 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 167 | Calcium 1; catalyticBy similarity | 1 | |
Metal bindingi | 168 | Calcium 2By similarity | 1 | |
Metal bindingi | 223 | Calcium 1; catalyticBy similarity | 1 | |
Metal bindingi | 268 | Calcium 1; catalyticBy similarity | 1 | |
Metal bindingi | 269 | Calcium 1; catalyticBy similarity | 1 |
GO - Molecular functioni
- acyl-L-homoserine-lactone lactonohydrolase activity Source: UniProtKB-EC
- arylesterase activity Source: GO_Central
- identical protein binding Source: MGI
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- aromatic compound catabolic process Source: MGI
- response to oxidative stress Source: Ensembl
- response to toxic substance Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.8.1, 3474 |
Reactomei | R-MMU-2142688, Synthesis of 5-eicosatetraenoic acids |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Pon2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:106687, Pon2 |
Subcellular locationi
Other locations
- Membrane By similarity; Peripheral membrane protein By similarity
Extracellular region or secreted
- extracellular region Source: InterPro
Lysosome
- lysosome Source: MGI
Mitochondrion
- mitochondrion Source: MGI
Nucleus
- nucleus Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- intracellular membrane-bounded organelle Source: MGI
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000223288 | 1 – 354 | Serum paraoxonase/arylesterase 2Add BLAST | 354 | |
Signal peptidei | 1 – ? | Not cleavedSequence analysis |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 42 ↔ 352 | By similarity | ||
Glycosylationi | 254 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 269 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 323 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Glycosylated.By similarity
The signal sequence is not cleaved.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q62086 |
jPOSTi | Q62086 |
MaxQBi | Q62086 |
PaxDbi | Q62086 |
PeptideAtlasi | Q62086 |
PRIDEi | Q62086 |
PTM databases
GlyConnecti | 2706, 6 N-Linked glycans (2 sites) |
GlyGeni | Q62086, 3 sites |
PhosphoSitePlusi | Q62086 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032667, Expressed in epithelium of stomach and 303 other tissues |
Genevisiblei | Q62086, MM |
Interactioni
Subunit structurei
Homotrimer.
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
IntActi | Q62086, 3 interactors |
MINTi | Q62086 |
STRINGi | 10090.ENSMUSP00000062670 |
Miscellaneous databases
RNActi | Q62086, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the paraoxonase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QUCT, Eukaryota |
GeneTreei | ENSGT00390000008932 |
HOGENOMi | CLU_049839_0_1_1 |
InParanoidi | Q62086 |
OMAi | TWSNVVY |
OrthoDBi | 888266at2759 |
PhylomeDBi | Q62086 |
TreeFami | TF322436 |
Family and domain databases
Gene3Di | 2.120.10.30, 1 hit |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR002640, Arylesterase IPR008364, Paraoxonase2 |
Pfami | View protein in Pfam PF01731, Arylesterase, 1 hit |
PRINTSi | PR01785, PARAOXONASE PR01787, PARAOXONASE2 |
i Sequence
Sequence statusi: Complete.
Q62086-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRMVALSLL GIGLALLGER FLALRSRLKA SREVESVDLP NCHLIKGIET
60 70 80 90 100
GAEDIDILPN GLAFFSVGLK FPGLHSFAPD KPGGILMMDL KDERPRALEL
110 120 130 140 150
RVSWGFDLAS FNPHGISTFI DDDDTVYLFV VNHPQFKSTV EIFKFQEEEN
160 170 180 190 200
SLLHLKTIKH ELLPSVNDII AVGPTHFYAT NDHYFSDPFL KYLETYLNLH
210 220 230 240 250
WANVVYYSPE EVKLVAEGFD SANGINISPD KKYVYVADIL AHEIHVLEKQ
260 270 280 290 300
PNMNLTQLKV LQLGTLVDNL SIDPSSGDIW VGCHPNGQRL FVYHPNHPPA
310 320 330 340 350
SEVLRIQNIL SEKPSVTTVY INNGSVLQGS SVATIYDRKL LVGTLYQKAL
YCEL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 8 – 14 | SLLGIGL → GFAGHRV in AAC42089 (PubMed:8661009).Curated | 7 | |
Sequence conflicti | 25 | R → S in AAC42089 (PubMed:8661009).Curated | 1 | |
Sequence conflicti | 30 | A → G in AAC42089 (PubMed:8661009).Curated | 1 | |
Sequence conflicti | 91 – 98 | KDERPRAL → DERPPSLE in AAC42089 (PubMed:8661009).Curated | 8 | |
Sequence conflicti | 137 – 138 | KS → SN in AAC42089 (PubMed:8661009).Curated | 2 | |
Sequence conflicti | 148 | E → A in AAC42089 (PubMed:8661009).Curated | 1 | |
Sequence conflicti | 175 | T → A in AAC42089 (PubMed:8661009).Curated | 1 | |
Sequence conflicti | 300 | A → T in AAC42089 (PubMed:8661009).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L48514 mRNA Translation: AAC42089.1 AK146311 mRNA Translation: BAE27066.1 AK171926 mRNA Translation: BAE42735.1 CH466533 Genomic DNA Translation: EDL13967.1 BC037140 mRNA Translation: AAH37140.1 BC055896 mRNA Translation: AAH55896.1 BC062200 mRNA Translation: AAH62200.1 |
CCDSi | CCDS19900.1 |
RefSeqi | NP_899131.1, NM_183308.2 |
Genome annotation databases
Ensembli | ENSMUST00000057792; ENSMUSP00000062670; ENSMUSG00000032667 |
GeneIDi | 330260 |
KEGGi | mmu:330260 |
UCSCi | uc009awf.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L48514 mRNA Translation: AAC42089.1 AK146311 mRNA Translation: BAE27066.1 AK171926 mRNA Translation: BAE42735.1 CH466533 Genomic DNA Translation: EDL13967.1 BC037140 mRNA Translation: AAH37140.1 BC055896 mRNA Translation: AAH55896.1 BC062200 mRNA Translation: AAH62200.1 |
CCDSi | CCDS19900.1 |
RefSeqi | NP_899131.1, NM_183308.2 |
3D structure databases
SMRi | Q62086 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q62086, 3 interactors |
MINTi | Q62086 |
STRINGi | 10090.ENSMUSP00000062670 |
PTM databases
GlyConnecti | 2706, 6 N-Linked glycans (2 sites) |
GlyGeni | Q62086, 3 sites |
PhosphoSitePlusi | Q62086 |
Proteomic databases
EPDi | Q62086 |
jPOSTi | Q62086 |
MaxQBi | Q62086 |
PaxDbi | Q62086 |
PeptideAtlasi | Q62086 |
PRIDEi | Q62086 |
Protocols and materials databases
Antibodypediai | 30147, 403 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000057792; ENSMUSP00000062670; ENSMUSG00000032667 |
GeneIDi | 330260 |
KEGGi | mmu:330260 |
UCSCi | uc009awf.1, mouse |
Organism-specific databases
CTDi | 5445 |
MGIi | MGI:106687, Pon2 |
Phylogenomic databases
eggNOGi | ENOG502QUCT, Eukaryota |
GeneTreei | ENSGT00390000008932 |
HOGENOMi | CLU_049839_0_1_1 |
InParanoidi | Q62086 |
OMAi | TWSNVVY |
OrthoDBi | 888266at2759 |
PhylomeDBi | Q62086 |
TreeFami | TF322436 |
Enzyme and pathway databases
BRENDAi | 3.1.8.1, 3474 |
Reactomei | R-MMU-2142688, Synthesis of 5-eicosatetraenoic acids |
Miscellaneous databases
BioGRID-ORCSi | 330260, 1 hit in 19 CRISPR screens |
ChiTaRSi | Pon2, mouse |
PROi | PR:Q62086 |
RNActi | Q62086, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032667, Expressed in epithelium of stomach and 303 other tissues |
Genevisiblei | Q62086, MM |
Family and domain databases
Gene3Di | 2.120.10.30, 1 hit |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR002640, Arylesterase IPR008364, Paraoxonase2 |
Pfami | View protein in Pfam PF01731, Arylesterase, 1 hit |
PRINTSi | PR01785, PARAOXONASE PR01787, PARAOXONASE2 |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PON2_MOUSE | |
Accessioni | Q62086Primary (citable) accession number: Q62086 Secondary accession number(s): Q3TAD3, Q8CFK3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 19, 2005 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families